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Search Results: 1 - 10 of 227385 matches for " Thomas Lindén "
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Development of a Model System to Identify Differences in Spring and Winter Oat
Aakash Chawade, Pernilla Lindén, Marcus Br?utigam, Rickard Jonsson, Anders Jonsson, Thomas Moritz, Olof Olsson
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029792
Abstract: Our long-term goal is to develop a Swedish winter oat (Avena sativa). To identify molecular differences that correlate with winter hardiness, a winter oat model comprising of both non-hardy spring lines and winter hardy lines is needed. To achieve this, we selected 294 oat breeding lines, originating from various Russian, German, and American winter oat breeding programs and tested them in the field in south- and western Sweden. By assaying for winter survival and agricultural properties during four consecutive seasons, we identified 14 breeding lines of different origins that not only survived the winter but also were agronomically better than the rest. Laboratory tests including electrolytic leakage, controlled crown freezing assay, expression analysis of the AsVrn1 gene and monitoring of flowering time suggested that the American lines had the highest freezing tolerance, although the German lines performed better in the field. Finally, six lines constituting the two most freezing tolerant lines, two intermediate lines and two spring cultivars were chosen to build a winter oat model system. Metabolic profiling of non-acclimated and cold acclimated leaf tissue samples isolated from the six selected lines revealed differential expression patterns of 245 metabolites including several sugars, amino acids, organic acids and 181 hitherto unknown metabolites. The expression patterns of 107 metabolites showed significant interactions with either a cultivar or a time-point. Further identification, characterisation and validation of these metabolites will lead to an increased understanding of the cold acclimation process in oats. Furthermore, by using the winter oat model system, differential sequencing of crown mRNA populations would lead to identification of various biomarkers to facilitate winter oat breeding.
Sedentary Behaviour and Physical Activity of People with Stroke in Rehabilitation Hospitals
Anna Sj?holm,Monica Skarin,Leonid Churilov,Michael Nilsson,Julie Bernhardt,Thomas Lindén
Stroke Research and Treatment , 2014, DOI: 10.1155/2014/591897
Abstract: Background. Sedentary behaviour is associated with health risks, independent of physical activity. This study aimed to investigate patterns of sedentary behaviour and physical activity among stroke survivors in rehabilitation hospitals. Methods. Stroke survivors admitted to four Swedish hospital-based rehabilitation units were recruited ≥7 days since stroke onset and their activity was measured using behavioural mapping. Sedentary behaviour was defined as lying down or sitting supported. Results. 104 patients were observed (53% men). Participants spent an average of 74% (standard deviation, SD 21%) of the observed day in sedentary activities. Continuous sedentary bouts of ≥1 hour represented 44% (SD 32%) of the observed day. A higher proportion (30%, SD 7%) of participants were physically active between 9:00 AM and 12:30 PM, compared to the rest of the observed day (23%, SD 6%, ). Patients had higher odds of being physically active in the hall (odds ratio, OR 1.7, ) than in the therapy area. Conclusions. The time stroke survivors spend in stroke rehabilitation units may not be used in the most efficient way to promote maximal recovery. Interventions to promote reduced sedentary time could help improve outcome and these should be tested in clinical trials. 1. Introduction Sedentary behaviour activities with an energy expenditure of ≤1.5 metabolic equivalent units [1, 2], such as lying down or sitting) [3] is associated with a variety of health risks, regardless of physical activity levels and other traditional risk factors such as smoking and high blood pressure. Cardiovascular disease [4, 5], type 2 diabetes [6], metabolic syndrome [7], and breast cancer [8] are a few diseases connected to sedentary behaviour, which further increases all-cause mortality [4, 5, 9, 10]. Each additional hour spent sedentary has been proposed to be associated with a progressive rise in mortality risk [4]. It is, however, not only the total amount of sedentary time which seems to be important, but also the way in which it is accumulated. Prolonged bouts of time in sedentary activities (such as sitting down) have been shown to be particularly harmful, with relative benefits noted from regular brief periods of standing or walking [11]. While it is well established that patients in stroke rehabilitation are very inactive [12], sedentary behaviour, per se, is not commonly investigated [13]. In the hospital setting, a recent review [12] of 24 studies demonstrated that stroke survivors on average are involved in nontherapeutic or low physical activity for as much as 76% of the
Role of ABO Secretor Status in Mucosal Innate Immunity and H. pylori Infection
Sara Lindén,Jafar Mahdavi,Cristina Semino-Mora,Cara Olsen,Ingemar Carlstedt,Thomas Borén ,Andre Dubois
PLOS Pathogens , 2008, DOI: 10.1371/journal.ppat.0040002
Abstract: The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive secretor status; however, the biological function of the ABO blood group system is unknown. Gastric mucosa biopsies of 41 Rhesus monkeys originating from Southern Asia were analyzed by immunohistochemistry. A majority of these animals were found to be of blood group B and weak-secretor phenotype (i.e., expressing both Lewis a and Lewis b antigens), which are also common in South Asian human populations. A selected group of ten monkeys was inoculated with Helicobacter pylori and studied for changes in gastric mucosal glycosylation during a 10-month period. We observed a loss in mucosal fucosylation and concurrent induction and time-dependent dynamics in gastric mucosal sialylation (carbohydrate marker of inflammation), which affect H. pylori adhesion targets and thus modulate host–bacterial interactions. Of particular relevance, gastric mucosal density of H. pylori, gastritis, and sialylation were all higher in secretor individuals compared to weak-secretors, the latter being apparently “protected.” These results demonstrate that the secretor status plays an intrinsic role in resistance to H. pylori infection and suggest that the fucosylated secretor ABH antigens constitute interactive members of the human and primate mucosal innate immune system.
Targeting Interleukin-17A – An Orchestrator of Neutrophil Mobilisation in the Lungs
Anders Lindén
The Open Conference Proceedings Journal , 2010, DOI: 10.2174/2210289201001010021]
Abstract: This presentation briefly summarizes the immunology and the pathology of the T cell cytokine interleukin-17A (IL-17A) in the lungs and addresses the potential of IL-17A as a pharmacotherapeutical target. Accumulating experimental and clinical evidence suggests that IL-17A is of importance for coordinating the adaptive and the innate components of pulmonary host defence in mammals. This evidence also suggests that IL-17 is produced by several subsets of T cells, including the T helper-17 (Th-17) subset. Until now, IL-17A has emerged mainly as an orchestrator of the local accumulation and activity of neutrophils; a role that IL-17A plays by inducing the release of C-X-C chemokines, colony-stimulating factors and IL-6. Even though its true role may be more diverse, the proposed role of IL-17A is relevant not only for pulmonary host defence against bacteria but also for inflammatory conditions in the lungs, such as severe asthma, chronic obstructive pulmonary disease, cystic fibrosis, and lung allograft rejection. From an immunological point-of-view, IL-17A’s position at the interface of adaptive and innate immunity, is intriguing. It forwards the possibility that intervention targeting IL-17A can provide new therapy against inflammatory lung disorders related to poor endogenous control of local neutrophils.
La producción de información laboral en la encrucijada de las representaciones y prácticas del trabajo (el caso de los sectores populares urbanos)
Alicia Lindón Villoria
Papeles de población , 1995,
Una nueva configuración territorial en el antiguo Chalco
Alicia Lindón
Papeles de población , 2001,
Abstract: The analysis ofthe metropolitan phenomena of Mexico City from a territorial perspective shows that the southeast is one ofthe zones of most rapid expansion by the city in the two most recent decades. Since the mid seventies, the Valley ofthe Chalco has been the most dynamic territory within the southeast. On fue other hand, the Old Chalco, from wich the Valley ofChalco was detached, usually has remained eclipsed as an express ion ofthe expansion ofthe city on the periphery. Nevertheless, at the present Old Chalco is the scene of a very wide range process of metropolitan expansion. Even when in Old Chalco urban expansion does not reach the magnitude that the Valley ofChalco has had, there has been unleashed a variety of forms of urban expansion that have not been noticed in other cases and which could represent important processes of change in the metropolitan structure ofMexico City. The combination oran ensemble ofprocesses has resulted in the generation ofthe current territorial configuration, wich is analyzed in this paper.
Del campo de los estudios urbano-regionales y la reestructuración territorial (a modo de presentación)
Alicia Lindón
Economía, sociedad y territorio , 1998,
El trabajo y la vida cotidiana. Un enfoque desde los espacios de vida
Alicia Lindón Villoria
Economía, sociedad y territorio , 1997,
Rese a de "La Geografía como metáfora de la libertad" de Daniel Hiernaux-Nicolas
Alicia Lindón
Economía, sociedad y territorio , 1999,
Alicia Lindón
Economía, sociedad y territorio , 1999,
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