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Search Results: 1 - 10 of 18018 matches for " Thiago Sande Miguel "
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Subacute Cutaneous Lupus Erythematosus in Older Man: Case Report  [PDF]
Debora Trindade Martins, Thiago Sande Miguel, Nayrton Kalys Cruz dos Anjos, Sebasti?o Celio Horta Coelho Filho, Vinicius Moreira Paladino, Bruna Sande Miguel, Vinicius Sande Miguel, Daniel Almeida da Costa, Livia Cristina de Melo Pino
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.510003
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects mainly women, presents several clinical manifestations and has no known exact cause. The skin is one of the organs that can be affected, with subacute cutaneous lupus erythematosus (SCLE) being one of the classifications according to cutaneous lupus erythematosus lesions. SCLE is commonly found in young to middle age women and carries characteristics related to sun exposure. In this report, there is a rare case of a male and elderly patient that presents SCLE subgroup initially asymptomatic, with subsequent appearance of macular skin lesions and vitiligo appearance. This is an important case to alert health professionals that the disease can manifest itself and open its clinical profile even in patients of sex and unusual ages.
Cutaneous Vasculitis with Renal Impairment in Octogenarian  [PDF]
Thiago Sande Miguel, Bruna Sande Miguel, Vinicius Sande Miguel, Jair Baptista Miguel, Sebasti?o Celio Horta Coelho Filho, Nayrton Kalys Cruz dos Anjos, Lívia Cristina de Melo Pino, Paola Stephanie Azevedo de Sá, Vitor Araújo Goulart, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.56004
Abstract: Henoch-Schönlein purpura is a vasculitis of small vessels, characterized by tissue deposition of IgA, affecting predominantly the skin, intestine, joints and kidneys. It mainly affects the pediatric age group, especially from 2 to 11 years old. Most often, it is preceded by episode of upper airway infection from days to weeks. The most common clinical manifestations are purpuric cutaneous lesions located in the lower limbs and buttocks, abdominal pain in colic, nausea, vomiting, diarrhea, in addition to arthralgia/arthritis, usually with spontaneous resolution. Renal impairment usually manifests with hematuria and proteinuria, and renal function may also be impaired. The case described refers to a female patient, 86 years old, with a previous history of infection of the upper airways, followed by purpura in the lower limbs and renal impairment: serum creatinine 3.1 mg/dL (N 0.5 - 1.2 mg/dL); glomerular filtration rate 15 ml/min (N > 60 ml/min); urea 118 mg/dL (N < 40 g/dL); proteinuria 4.497 mg/24h. The present report aims to draw attention to the occurrence of Henoch-Schönlein purpura in an atypical age group, with significant renal impairment, improvement only with conservative treatment, thus avoiding the use of immunosuppressants and the risks of immunosuppression and toxicity related to such drugs.
Importance of Primary Health Care in Medicine: Simultaneous Analysis of Two Colleges, under the Vision of Teachers and Students  [PDF]
Sebasti?o Célio Horta Coelho Filho, Thiago Sande Miguel, Nayrton Kalys Cruz dos Anjos, Mateus de Oliveira Reis, Bruna Sande Miguel, Vinicius Sande Miguel, Aline Gabriela Santos Costa, Lilian Costa Brito, Bruno Fonseca dos Santos, Ver?nica Clemente Villar Martini, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.511002
Abstract: Introduction: The involvement of undergraduate student at the beginning of their training in activities based on Primary Health Care (PHC), provides preventive and health promoting actions, and ensures the evaluation of the vulnerability of communities and people. Objectives: To analyze the opinion of students and teachers of two medicine higher education institutions on the relevance of Primary Health Care in this course. METHODS: Students and teachers should be effectively enrolled in order for the study to be conducted, being chosen in a random manner and without interferences on the part of the researchers so that the work was as reliable as possible. A cross-sectional study was conducted with interviews structured in questionnaires about what they thought about PHC. To some students and teachers of the medical course of Valen?a and Grande Rio University (UNIGRANRIO). Before receiving the questionnaire, all interviewed signed a Free and Informed Consent Term, which included the objectives and methodology of the work. Results: 310 students and 51 teachers participated in the study, where 91.43% of the students and 100% of the teachers affirmed that primary care plays a fundamental role in medical education. 94.86% of students and 97.91% of teachers, claimed that the discipline allows a greater contact between undergraduates and community. When questioned about the encouragement that teachers give to students to pursue a career in PHC, 57.87% of the students and 70.83% of the professors said they lacked in such a stimulus. Conclusion: PHC is still very neglected by governmental policies, educational institutions and by the own teachers, that often, turn they attention only to tertiary medicine and, as a consequence, a discouragement of this area occur. Therefore, a higher PHC value is necessary, allowing a more humane look at the patient, valuing their feelings, anguishes and their pathological framework.
Secondary Syphilis in Man: Prozone Effect  [PDF]
Nayrton Kalys Cruz dos Anjos, Daniel Almeida da Costa, Thiago Sande Miguel, Livia Cristina de Melo Pino, Sebasti?o Célio Horta Coelho Filho, Débora Trindade Martins, Vinicius Sande Miguel, Bruna Sande Miguel, Fernando Ant?nio Galv?o Pereira Junior, Vinicius Moreira Paladino
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.62001
Abstract: Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be made through a direct investigation of the etiologic agent or non-treponemal (VDRL) and treponemal (FTA-Abs) serological tests. False-negative results are rare. Objectives: The present report presents a rare case of a man with a secondary syphilis syndrome who was initially undiagnosed due to the prozone effect, since he presented VDRL in low titers, and was later confirmed with a new diluted serum sample and VDRL and FTA-Abs, which were positive. Conclusion: A close look should be given to patients who, although the clinical condition is compatible, complementary exams may not be, and clinical cases should be carefully evaluated so that the patient is not treated late.
Splenectomy in Patient with Splendid Cysts  [PDF]
Vinícius Moreira Paladino, Thiago Sande Miguel, Débora Trindade Martins, Nayrton Kalys Cruz dos Anjos, Fernando Antonio Galv?o Pereira Junior, Marcia Machado Galv?o Pereira, Carolina Galv?o Teixeira, Vinicius Sande Miguel, Bruna Sande Miguel, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.65013
Abstract: Introduction: Splenic cysts are uncommon and usually do not generate signs and symptoms, being diagnosed by incidental findings. Case report: A 35-year-old, female patient attended the Luiz Gioseffi Jannuzzi School Hospital (HELGJ) presenting episodes of vomiting and abdominal pain in the left hypochondrium. She was hospitalized for diagnostic investigation. Computed tomography showed the splenic cyst. The procedure was the surgical approach by laparotomy with splenectomy. Histopathological confirmed the diagnosis. Discussion: Compared to the scarce reports in literature, the case described presented typical epidemiology and clinical features. Conclusions: Given the rarity of this pathology cases, it is essential to report these in order to elucidate the specificities and also to discuss diagnostic and therapeutic methods.
Evaluation of Cytotoxicity of Gossypium barbadense L. Extract in Bone Cord Cells through the Micronucleus Test  [PDF]
Thiago Dornelas de Oliveira, Joice Meire Rodrigues, Thiago Sande Miguel, Nayrton Kalys Cruz dos Anjos, Juscélio Clemente de Abreu, Lamara Laguardia Valente Rocha, Raquel Xavier Ligeiro Dias, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.57008
Abstract: The cotton plant is a plant belonging to the family Malvaceae and its leaves are often used in folk medicine. The present study aimed to evaluate the mutagenic or antimutagenic activity of the ethanolic extract of Gossypium barbadense L. (EEG) and to analyze its capacity to prevent or repair mutagenic lesions caused by cyclophosphamide (CP). For the Micronucleus test, Swiss mice were divided into 5 groups: negative control; Positive control: treated with 50 mg/kg cyclophosphamide (CP), group receiving EEG 500 mg/kg for 7 days; Group receiving EEG 500 mg/kg for 7 days associated with CP24h before euthanasia; Group who received CP and EEG 500 mg/kg for 7 days. After the treatment period, the animals were euthanized, the bone marrow removed and the blood smear prepared. From this analysis, it was observed that the EEG caused a significant increase in the number of micronucleated erythrocytes, indicating mutagenic activity of the extract. In addition, it was verified that the extract did not present the capacity to prevent, but it presented the capacity of repair of the chromosomal damages caused by CP.
Mesenteric Adenitis as a Differential Appendicitis Diagnosis: Case Report  [PDF]
Vinícius Moreira Paladino, Thiago Sande Miguel, Bruna Sande Miguel, Marcia Machado Galv?o Pereira, Fernando Antonio Galv?o Pereira Junior, Carolina Galv?o Teixeira, Caroline Guida Babinski, Naryrton Kalys Cruz dos Anjos, Daniel Almeida da Costa, Débora Trindade Martins, Bruno Fonseca dos Santos
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.63003
Abstract: Mesenteric adenitis consists of an important differential diagnosis of potentially serious diseases such as acute appendicitis, since they manifest themselves with a similar clinical picture. Case report: A 17-year-old male patient presented with periumbilical abdominal pain for 2 days, of abrupt onset and moderate intensity, who gave away with a common analgesic, which progressed to the right iliac fossa (RIF) and increased of intensity. He also reported liquid diarrhea, with several episodes a day, without mucus and/or blood, 38°C fever, anorexia and vomiting. He was hospitalized for investigating a possible diagnostic of Acute Appendicitis. In the exams, it was considered mesenteric adenitis, and antibiotic therapy was prescribed. The patient had complete improvement at the end of treatment. Conclusions: Given its importance as a differential diagnosis of numerous pathologies, as well as controversial before the therapeutic and diagnostic conduct, it is essential to report these cases in order to elucidate the specificities of this disease.
Gastric Gist as Cause of High Digestive Hemorrhage  [PDF]
Vinícius Moreira Paladino, Thiago Sande Miguel, Vinicius Sande Miguel, Marcia Machado Galv?o Pereira, Fernando Antonio Galv?o Pereira, Carolina Galv?o Teixeira, Caroline Guida Babinski, Nayrton Kalys Cruz dos Anjos, Caio Marcus de Andrade Lopes, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2019, DOI: 10.4236/jbm.2019.71005
Abstract: Introduction: Gastrointestinal stromal tumor (GIST) occurrence is uncommon and usually manifested by nonspecific signs and symptoms, which hinders its reasoning as a diagnostic hypothesis. The objective is to report a case of female GIST with curative treatment through video-laparoscopy with partial gastrectomy. Case report: A 61-year-old female patient attended the Luiz Gioseffi Jannuzzi School Hospital (HELGJ) emergency room, with a sudden onset of upper gastrointestinal bleeding with hemodynamic instability. After stabilization, she was admitted for diagnostic investigation, showing sub-epithelial lesion of antrum in upper digestive endoscopy (UDE) and solid-cystic mass in the gastric antrum to computed tomography (CT). The conduct was the video laparoscopy surgical approach with partial gastrectomy. The histopathological and immunohistochemical aspects of the surgical specimen showed a gastrointestinal stromal tumor (GIST) in a gastric antrum of low grade of malignancy, positive e-Kit and mycotic index (50 cga) < 5. Discussion: Compared to the scarce reports in literature, the case described presented typical epidemiology, but the clinical picture was not the most incident. Conclusions: Given the rarity of this pathology cases, it is essential to report these in order to elucidate the specificities and also to discuss diagnostic and therapeutic methods.
Evaluation of the Therapeutic Response and Improvement in the Quality of Life of the Patient with Darier Disease to Acitretin through an Analogy between Close Relatives  [PDF]
Thiago Sande Miguel, Mateus de Oliveira Reis, Bruno Fonseca dos Santos, Aline da Silva Rocha, Nayrton Kalys Cruz dos Anjos, Lívia Cristina de Melo Pino, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.58004
Abstract: Darier disease (DD), also known as follicular keratosis, is a rare autosomal dominant hereditary acantholytic dermatosis caused by a mutation in the ATP2A2 gene. Skin lesions are characterized by persistent confluent papules, preferentially located on the seborrheic areas of the face, chest and back. The hands, feet and nails are also commonly affected. DD has a chronic course with frequent relapses. Their treatment is often difficult and unsatisfactory. We present the case of a 54-year-old male with a history of keratotic papules with a brownish-black color, with a foul-smelling, pruritic and ardent appearance on the back and trunk, since the age of 19, which worsen in the summer. His 27-year-old daughter has a similar picture with her skin lesions started at age of 17 in the region below the breast, back, trunk, feet and hands. After the skin biopsy, the diagnosis was confirmed and acitretin 30 mg/day was instituted. The importance of this case report is to alert health professionals that the diagnosis of DD should be considered in family members of patients, especially those in the first degree, and also in patients with follicular keratolytic dermatoses, being an important differential diagnosis of this group of patients diseases.
Main Microbial Genres and Its Profile of Resistance and Sensitivity to Antimicrobials Used in the Treatment of Oncological Patients with Febril Neutropenia  [PDF]
Hélvecio Cardoso Póvoa, Richard Raphael Borges Tavares Vieira, Elias Sobreira Sathler, Isabela Nardoni Bernardes, Rafael Batista Ferreira, Mário Henrique Couto Lima, Thiago Sande Miguel, Nayrton Kalys Cruz dos Anjos, Lamara Laguardia Valente Rocha, Daniel Almeida da Costa
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.61005
Abstract: Objective: To determine the main microbial genotypes and their antimicrobial resistance and susceptibility profile commonly used in the treatment of oncologic patients with febrile neutropenia, carried out through the review of the clinical histories of the patients’ medical records at the Hospital do Cancer de Muriaé-Fundacao Cristiano Varella. Methods: Quantitative research, determined the susceptibility profile of microorganisms in patients with febrile neutropenia from April 2007 to April 2008 by reviewing clinical histories of patients’ medical records at the referred hospital. Results: Of the total of 8 patients evaluated with Gram-negative microorganisms, 50% of the patients were female and 50% were male. Of the 18 patients evaluated with Gram-positive microorganisms 66% were female and 34% male. Gram-positive bacteria are prevalent and cause around 60% of documented bacteremias, although Gram-negative bacteria are more common in febrile neutropenic patientes. Conclusion: Exaggerated use of antimicrobials in hospitalized patients leads to the suppression of drug-sensitive microorganisms from the intestinal flora and promotes the persistence and growth of resistant bacteria. The antibiotic should be used in a curative manner with other therapeutic measures with the determined bacterial infection.
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