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Search Results: 1 - 10 of 1874 matches for " Thi-Ngoc-Phuong Huynh "
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QSAR Modeling on Benzo[c]phenanthridine Analogues as Topoisomerase I Inhibitors and Anti-cancer Agents
Khac-Minh Thai,Quang-Huynh Bui,Thanh-Dao Tran,Thi-Ngoc-Phuong Huynh
Molecules , 2012, DOI: 10.3390/molecules17055690
Abstract: Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, hologram-QSAR, 2D-QSAR and 3D-QSAR models were developed for BCPs on topoisomerase I inbibitory activity and cytotoxicity against seven tumor cell lines including RPMI8402, CPT-K5, P388, CPT45, KB3-1, KBV-1and KBH5.0. The hologram, 2D, and 3D-QSAR models were obtained with the square of correlation coefficient R2 = 0.58 ? 0.77, the square of the crossvalidation coefficient q2 = 0.41 ? 0.60 as well as the external set’s square of predictive correlation coefficient r2 = 0.51 ? 0.80. Moreover, the assessment method based on reliability test with confidence level of 95% was used to validate the predictive power of QSAR models and to prevent over-fitting phenomenon of classical QSAR models. Our QSAR model could be applied to design new analogues of BCPs with higher antitumor and topoisomerase I inhibitory activity.
Synthesis and Antibacterial Activity of Some Heterocyclic Chalcone Analogues Alone and in Combination with Antibiotics
Thanh-Dao Tran,Thi-Thao-Nhu Nguyen,Tuong-Ha Do,Thi-Ngoc-Phuong Huynh,Cat-Dong Tran,Khac-Minh Thai
Molecules , 2012, DOI: 10.3390/molecules17066684
Abstract: A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthesized chalcones were established by IR and 1H-NMR analysis. The biological data shows that compounds p5, f6 and t5 had strong activities against both susceptible and resistant Staphylococcus aureus strains, but not activity against a vancomycin and methicillin resistant Staphylococcus aureus isolated from a human sample. The structure and activity relationships confirmed that compounds f5, f6 and t5 are potential candidates for future drug discovery and development.
A Support Vector Machine Classification Model for Benzo[c]phenathridine Analogues with Topoisomerase-I Inhibitory Activity
Khac-Minh Thai,Thuy-Quyen Nguyen,Trieu-Du Ngo,Thanh-Dao Tran,Thi-Ngoc-Phuong Huynh
Molecules , 2012, DOI: 10.3390/molecules17044560
Abstract: Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, a support vector machine model was performed on a series of 73 analogues to classify BCP derivatives according to TOP-I inhibitory activity. The best SVM model with total accuracy of 93% for training set was achieved using a set of 7 descriptors identified from a large set via a random forest algorithm. Overall accuracy of up to 87% and a Matthews coefficient correlation (MCC) of 0.71 were obtained after this SVM classifier was validated internally by a test set of 15 compounds. For two external test sets, 89% and 80% BCP compounds, respectively, were correctly predicted. The results indicated that our SVM model could be used as the filter for designing new BCP compounds with higher TOP-I inhibitory activity.
A Wave Equation Associated with Mixed Nonhomogeneous Conditions: The Compactness and Connectivity of Weak Solution Set
Nguyen Thanh Long,Le Thi Phuong Ngoc
Abstract and Applied Analysis , 2007, DOI: 10.1155/2007/20295
Abstract: The purpose of this paper is to show that the set of weak solutions of the initial-boundary value problem for the linear wave equation is nonempty, connected, and compact.
A High Order Iterative Scheme for a Nonlinear Kirchhoff Wave Equation in the Unit Membrane
Le Thi Phuong Ngoc,Nguyen Thanh Long
International Journal of Differential Equations , 2011, DOI: 10.1155/2011/679528
Abstract: A high-order iterative scheme is established in order to get a convergent sequence at a rate of order (≥1) to a local unique weak solution of a nonlinear Kirchhoff wave equation in the unit membrane. This extends a recent result in (EJDE, 2005, No. 138) where a recurrent sequence converges at a rate of order 2.
Boundary and initial value problems for second-order neutral functional differential equations
Hoan Hoa Le,Thi Phuong Ngoc Le
Electronic Journal of Differential Equations , 2006,
Abstract: In this paper, we consider the three-point boundary-value problem for the second order neutral functional differential equation $$ u''+ f(t,u_t, u'(t))= 0, quad 0 leq tleq 1, $$ with the three-point boundary condition $u_0= phi$, $u(1) = u(eta)$. Under suitable assumptions on the function $f$ we prove the existence, uniqueness and continuous dependence of solutions. As an application of the methods used, we study the existence of solutions for the same equation with a ``mixed" boundary condition $u_0 = phi, u(1) = alpha [u'(eta) - u'(0)]$, or with an initial condition $ u_0 = phi, u'(0) =0$. For the initial-value problem, the uniqueness and continuous dependence of solutions are also considered. Furthermore, the paper shows that the solution set of the initial-value problem is nonempty, compact and connected. Our approach is based on the fixed point theory.
On a fixed point theorem of Krasnosel'skii type and application to integral equations
Ngoc Le Thi Phuong,Long Nguyen Thanh
Fixed Point Theory and Applications , 2006,
Abstract: This paper presents a remark on a fixed point theorem of Krasnosel'skii type. This result is applied to prove the existence of asymptotically stable solutions of nonlinear integral equations.
On a fixed point theorem of Krasnosel'skii type and application to integral equations
Le Thi Phuong Ngoc,Nguyen Thanh Long
Fixed Point Theory and Applications , 2006, DOI: 10.1155/fpta/2006/30847
Abstract: This paper presents a remark on a fixed point theorem of Krasnosel'skii type. This result is applied to prove the existence of asymptotically stable solutions of nonlinear integral equations.
Poisson Summation and Endoscopy for $Sp(4,\mathbb R)$
Do Ngoc Diep,Do Thi Phuong Quynh
Mathematics , 2014,
Abstract: In this paper we analyze the endoscopy for $\Sp(4,\mathbb R)$. The new results are a precise realization of the discrete series representations (in Section 2), a computation of their traces (Section 3) and an exact formula for the noncommutative Poisson summation and endoscopy of for this group (in Sections 4,5).
Poisson Summation and Endoscopy for $SL(3,\mathbb R)$
Do Ngoc Diep,Do Thi Phuong Quynh
Mathematics , 2014,
Abstract: The group is interesting as the first example of split rank 2 semisimple group, all the irreducible unitary representations of which are known. We make a precise realization of the discrete series representations (in Section 2) by using the Orbit Method and Geometric Quantization, a computation of their traces (Section 3) and an exact formula for the noncommutative Poisson summation and endoscopy of for this group (in Section 4).
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