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Search Results: 1 - 10 of 402 matches for " Therese Rider "
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Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency: Implications for Cardiovascular Disease Risk
Robert K. McNamara,Ronald Jandacek,Therese Rider,Patrick Tso
Cardiovascular Psychiatry and Neurology , 2013, DOI: 10.1155/2013/796462
Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency: Implications for Cardiovascular Disease Risk
Robert K. McNamara,Ronald Jandacek,Therese Rider,Patrick Tso,Yogesh Dwivedi,Ghanshyam N. Pandey
Cardiovascular Psychiatry and Neurology , 2013, DOI: 10.1155/2013/796462
Abstract: Deficiency in long-chain omega-3 (LCn ? 3) fatty acids, eicosapentaenoic acid (EPA, 20:5n ? 3) and docosahexaenoic acid (DHA, 22:6n ? 3), has been implicated in the pathoetiology of cardiovascular disease, a primary cause of excess premature mortality in patients with schizophrenia (SZ). In the present study, we determined erythrocyte EPA + DHA levels in adult medication-free patients SZ ( ) and age-matched healthy controls ( ). Erythrocyte EPA + DHA composition exhibited by SZ patients (3.5%) was significantly lower than healthy controls (4.5%, ?22%, ). The majority of SZ patients (72%) exhibited EPA+DHA levels ≤4.0% compared with 37% of controls (Chi-square, ). In contrast, the omega-6 fatty acid arachidonic acid (AA, 20:4 ) (+9%, ) and the AA:EPA + DHA ratio (+28%, ) were significantly greater in SZ patients. Linoleic acid (18:2 ) was significantly lower (?12%, ) and the erythrocyte 20:3/18:2 ratio (an index of delta6-desaturase activity) was significantly elevated in SZ patients. Compared with same-gender controls, EPA + DHA composition was significantly lower in male (?19%, ) but not female (?13%, ) SZ patients, whereas the 20:3/18:2 ratio was significantly elevated in both male (+22%, ) and female (+22%, ) SZ patients. These results suggest that the majority of SZ patients exhibit low LCn ? 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality. 1. Introduction Patients with schizophrenia (SZ) have two- to three-fold higher mortality rates compared with the general population, corresponding to an average 15-year reduction in life expectancy, and cross-sectional epidemiological studies have found that cardiovascular disease is a primary cause of excess premature mortality in SZ patients [1–6]. The etiology of elevated cardiovascular risk in SZ is likely multifactorial, potentially involving excessive smoking and alcohol use, lack of exercise, and poor diets [7, 8]. Moreover, second generation antipsychotic (SGA) medications are associated with cardiovascular risk factors including dyslipidemia, metabolic syndrome, and weight gain [9–13], though these risk factors have also been reported in SGA-na?ve first-episode SZ patients [14–16]. Together, these data highlight an urgent need to identify risk and resilience factors associated with elevated cardiovascular disease risk in SZ. An emerging body of evidence suggests that low levels of long-chain omega-3 (LCn ? 3) fatty acids, principally eicosapentaenoic acid (EPA, 20:5n ? 3) and docosahexaenoic acid (DHA, 22:6n ? 3), are a modifiable risk factor for
The Future of the European University:Liberal Democracy or Authoritarian Capitalism?
Sharon Rider
Culture Unbound : Journal of Current Cultural Research , 2009,
Abstract: This paper examines the prevalent notion that that the production of knowledge, academic research and teaching can and ought to be audited and assessed in the same manner as the production of other goods and services. The emphasis on similarities between industry and the academy leads to a neglect of fundamental differences in their aims and, as a consequence, a tendency to evaluate scientific research in terms of patents and product development and colleges and universities in terms of the labour market. The article examines the idea of the free academy, on the one hand, and compares and contrasts it to the idea of free enterprise, on the other. It is argued that the view of the university as a supplier of specific solutions for pre-determined, non-scientific needs (a workforce with skills currently in demand, innovations for commercial partners, justifications for political decisions, etc) undermines the public legitimacy of university science and weakens the fabric of scientific training and practice. The article proposes that the university’s main purpose must be to provide a recognized neutral, autonomous agency of rigorous, disinterested investigation and scientific education, which constitutes a necessary condition for an enlightened liberal democracy: an informed, capable and critical citizenry.
Deviations from the Circular Law
Brian Rider
Mathematics , 2003,
Abstract: Consider Ginibre's ensemble of $N \times N$ non-Hermitian random matrices in which all entries are independent complex Gaussians of mean zero and variance $\frac{1}{N}$. As $N \uparrow \infty$ the normalized counting measure of the eigenvalues converges to the uniform measure on the unit disk in the complex plane. In this note we describe fluctuations about this {\em Circular Law}. First we obtain finite $N$ formulas for the covariance of certain linear statistics of the eigenvalues. Asymptotics of these objects coupled with a theorem of Costin and Lebowitz then result in central limit theorems for a variety of these statistics.
Formality for the nilpotent cone and a derived Springer correspondence
Laura Rider
Mathematics , 2012,
Abstract: Recall that the Springer correspondence relates representations of the Weyl group to perverse sheaves on the nilpotent cone. We explain how to extend this to an equivalence between the triangulated category generated by the Springer perverse sheaves and the derived category of differential graded modules over a dg-ring related to the Weyl group.
Defining the genre of Mexican business e-mail
Judge, Therese;
Linguagem em (Dis)curso , 2010, DOI: 10.1590/S1518-76322010000300007
Abstract: based on congruencies in the findings of spanish-language writing research and u.s.-english e-mail writing research, this study investigates mexican e-mails. the findings from the literature are formulated as issue statements for the purpose of confirming or denying their applicability to collected mexican e-mails. the study employs both qualitative rhetorical analysis and a quantitative feature presence/absence analysis. of the eight issues statements predicted to describe mexican business e-mails per the literature, only one was affirmed-meaning that the currently available information about mexican workplace e-mails is incorrect and/or incomplete.
Gravida missbrukare i svensk tv ngsv rd
Therese Reitan
Nordic Studies on Alcohol and Drugs , 2011, DOI: 10.2478/v10199-011-0021-4
Abstract: AIM - The aim of this article is to present a first overview of pregnant substance abusers in compulsory care in Sweden. The current legislation does not allow for compulsory care on the grounds of pregnancy, i.e. out of consideration for the foetus. Nonetheless, a number of the women placed in compulsory care every year also "happen to be" pregnant. DATA - Through client screening interviews, which include a question about whether the client is pregnant, and data from the client administrative system of the National Board of Institutional Care, a total of 81 unique pregnancies (79 unique women) were identified between 2001 and 2008. The average age at admission was 28 years and the women for whom such data was available were on average 5.9 months pregnant. RESULTS - Compared to other clients in compulsory care the situation of the pregnant clients was relatively favourable in some domains, such as living conditions, and physical and psychological status. Their drug profile mostly resembled that of the youngest client group in compulsory care, i.e. dominated by heroine and amphetamine. There were, however, relatively speaking fewer pregnant women who never have injected drugs and it was more common among the pregnant clients to have lost custody of a child or to have a child placed in foster care. CONCLUSIONS - More empirical studies are necessary in order to increase our knowledge about this selected group of clients, both follow-ups on the women and their children as well as in-depth studies of how these women are "processed" in the social and legal systems.
What is - really - in a dataset?
Therese Heltberg
Nordic Studies on Alcohol and Drugs , 2011, DOI: 10.2478/v10199-011-0044-x
Abstract: AIM - The article considers methodological problems of working with register data and shows how deficiencies in a quantitative dataset may constitute a tool for discovery if data shortcomings are used as input in a qualitative investigation of data genealogy. DATA - Based on a specific research case example the article demonstrates how qualitative moments are intrinsically embedded both in quantitative datasets and in the statistical processing. CONCLUSIONS - It is argued that statistical analyses of datasets cannot be made without considerations of institutional organisation and perceptions of persons implied in the production of data. Lastly it is suggested that prison-based drug misuse treatment research currently needs to face the paradoxical challenge of excessive statistical programmatic power, which has encouraged formulations of ‘causalist’ research questions. It is further suggested that a reorientation towards theoretical explanation as an addition to the statistical demonstration of factor associations is important if quantitative studies are to further open the black box of treatment.
Presentation PICASSO for COPD: a Dutch national COPD optimisation platform
Therese Noorlander
International Journal of Integrated Care , 2008,
Aggregate analysis of vowel pronunciation in Swedish dialects
Therese Leinonen
Oslo Studies in Language , 2011,
Abstract: In this paper an aggregate analysis of vowel pronunciation in Swedish dialects is proposed by means of multidimensional scaling (MDS). The Gap statistic showed that no statistically significant partitioning of Swedish dialects can be made based on vowel pronunciation, which means that the dialects form a true linguistic continuum. Vowels recorded by 1,170 speakers at 98 sites were analyzed acoustically with principal components of Bark-filtered spectra, and the linguistic distances between varieties were computed as the Euclidean distance of the acoustic variables. The MDS analyses showed that the dialect areas that can be detected based on vowel pronunciation in modern rural varieties of Swedish largely correspond to the traditional Swedish dialect division and divisions of regional varieties of Standard Swedish. The results also show a large-scale ongoing dialect leveling. The change is largest in many central parts of the language area close to the biggest cities, while the dialects in more peripheral areas are relatively stable.
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