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The SPF27 Homologue Num1 Connects Splicing and Kinesin 1-Dependent Cytoplasmic Trafficking in Ustilago maydis
Nikola Kellner,Kai Heimel,Theresa Obhof,Florian Finkernagel,J?rg K?mper
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004046
Abstract: The conserved NineTeen protein complex (NTC) is an integral subunit of the spliceosome and required for intron removal during pre-mRNA splicing. The complex associates with the spliceosome and participates in the regulation of conformational changes of core spliceosomal components, stabilizing RNA-RNA- as well as RNA-protein interactions. In addition, the NTC is involved in cell cycle checkpoint control, response to DNA damage, as well as formation and export of mRNP-particles. We have identified the Num1 protein as the homologue of SPF27, one of NTC core components, in the basidiomycetous fungus Ustilago maydis. Num1 is required for polarized growth of the fungal hyphae, and, in line with the described NTC functions, the num1 mutation affects the cell cycle and cell division. The num1 deletion influences splicing in U. maydis on a global scale, as RNA-Seq analysis revealed increased intron retention rates. Surprisingly, we identified in a screen for Num1 interacting proteins not only NTC core components as Prp19 and Cef1, but several proteins with putative functions during vesicle-mediated transport processes. Among others, Num1 interacts with the motor protein Kin1 in the cytoplasm. Similar phenotypes with respect to filamentous and polar growth, vacuolar morphology, as well as the motility of early endosomes corroborate the genetic interaction between Num1 and Kin1. Our data implicate a previously unidentified connection between a component of the splicing machinery and cytoplasmic transport processes. As the num1 deletion also affects cytoplasmic mRNA transport, the protein may constitute a novel functional interconnection between the two disparate processes of splicing and trafficking.
Symbolic Racism or Self-Interest? Comparing Rural and Urban Worries about Obamacare  [PDF]
Theresa Davidson
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.66019
Abstract: Framed by the theory of symbolic racism versus self-interest, this study sought to investigate differences, if any, between rural and urban residents’ concerns about Obamacare (the Affordable Care Act). First, we found that rural residents are significantly more worried about Obamacare. Second, regarding symbolic racism, ratings of Muslims (but not blacks or immigrants) predicted worry about Obamacare for rural and urban respondents. Third, different self-interest measures were predictive for the rural and urban samples. Rural residents who worried about becoming ill were more worried about Obamacare. Urban residents who worried about money were more worried about Obamacare. We conclude with recommendations for framing health care reform in ways that might reduce concerns among rural and urban people.
Decision Making in International Tertiary Education: The Role of National Image  [PDF]
Jing Cai, Theresa Loo
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.23012
Abstract: The purpose of this paper is to explore the influence of the national image on the image of its tertiary education among non-nationals and on their choice of location for study. We present a conceptual model of how the image of the nation impacts on the image of tertiary education based upon Ajzen & Fishbein’s (1980) “theory of reasoned action”. With data from China & India, a model is developed from a calibration sample and tested against a validation sample using structural equation modelling. The model fits the data well and shows that a national image for Chic (prestigious, refined, elegant) and Enterprise (innovative, cool, trendy) has a positive influence on the beliefs about, attitudes towards and propensity to consume tertiary education offered by the UK. Our work indicates that there will be mileage in investing not just on the image of education itself, but on the image of the nation in the promotion of international tertiary education.
Fraud spurs Cell paper retraction
Theresa Tamkins
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20040213-02
Abstract: "Although the data caused a stir, I think most people's view was that there was some interpretation problem early on, so it really hasn't dramatically changed most people's thinking," said Xi He, of Children's Hospital Boston and Harvard Medical School. "I think it is a bump in the Wnt field, but it has not moved the field several years backwards."Gary Struhl of the Howard Hughes Medical Institute (HHMI) and Columbia University in New York retracted the paper from Cell on February 6. The paper, published in 2002, challenged the conventional theory on Wnt signaling.Wnt protein is thought to bind to its receptor, setting off a signaling pathway in which beta-catenin (or Armadillo in the fruit fly) enters the nucleus and activates transcription factors. Struhl and postdoc Siu-Kwong Chan argued in the paper that Armadillo can be tethered to the membrane and transduce Wnt signals without entering the nucleus.When Struhl recently attempted to replicate the experiments, which were largely conducted by Chan, he "personally obtained the opposite result for the key negative control for the experiments in Figure 5," he writes in the retraction. When confronted, Chan reported that some of the results were "either not performed or gave different results than presented in the paper," according to the retraction.Struhl declined to elaborate further."The retraction says it all," he said in an E-mail message. "Columbia and HHMI have mandated protocols to investigate misconduct when it occurs. I contacted Columbia, HHMI, and Cell Press immediately upon discovering that crucial experiments in the paper had been fabricated." Columbia and HHMI are investigating the incident, Struhl said.Chan, who was at Albert Einstein College of Medicine since November 2003, resigned from his position on January 21. He could not be reached for comment for this article.The retraction coincides with a paper published February 10 in Public Library of Science (PLoS) Biology, in which Princeton University's
A Predictable Unpredictability. The 2009 H1N1 pandemic and the concept of “strategic uncertainty” within global public health
Theresa MacPhail
Behemoth : a Journal on Civilisation , 2010,
Abstract: This essay will examine the seemingly new paradigm shift within global public health from the use of a scientific “certainty” to a biological and situational “uncertainty” as one of the foundations of response to infectious disease outbreaks. During the recent 2009 H1N1 influenza outbreak, national and international public health officials often referred directly to the “uncertainty” surrounding both the virus itself and of the course, duration and severity of the pandemic. The vague and flexible concept of “uncertainty” – especially as it was employed by top virologists and epidemiologists in relationship to questions about the predictability of the influenza virus – provided the scientific foundation for much of the rationale behind both national and international health responses to the global pandemic. Public health officials, epidemiologists, and scientists often deployed a type of “strategic uncertainty” as an effective tool for gaining or retaining trust and scientific authority during the H1N1 pandemic.
Breaking tradition with scientific learning
Theresa Wossler
South African Journal of Science , 2010, DOI: 10.4102/sajs.v106i1/2.46
Human: Half a Million Years of Life in Bucks.
Theresa Wren
Papers from the Institute of Archaeology , 2010, DOI: 10.5334/pia.351
What it Means to be Responsible
Theresa Morris
Theoretical & Applied Ethics , 2011,
John CRABTREE. Fractured Politics: Peruvian Democracy Past and Present . London: Institute for the Study of the Americas, University of London, 2011. 258 pp. ISBN: 978-0-9567-549-05.
América Latina Hoy , 2012,
H ftlinge im Frauenkonzentrationslager Ravensbrück The Ravensbrück Concentration Camp for Women
Theresa Reinold
querelles-net , 2002,
Abstract: Im Zentrum der Arbeit von Christa Schikorra steht die Frage nach den Mechanismen gesellschaftlicher Ausgrenzung asozialer“ Frauen – zur Zeit des Nationalsozialismus, aber auch in der Nachkriegszeit. Wenn auch die Zugeh rigkeit zur Gruppe der Asozialen“ erst im Nationalsozialismus lebensbedrohlich wurde, so lassen sich in der Stigmatisierung und Ausgrenzung von Menschen, die mit dem Etikett asozial“ versehen wurden und werden, gesellschaftliche Traditionslinien erkennen, die schon vor dem Nationalsozialismus wirksam waren und es bis heute sind – so die These der Autorin. Ihre Analyse fragt nach der Entstehung des Stigmas asozial“: Auf welche Vorurteilsstrukturen und Stereotypen gründet eine solche Kategorisierung? Wer tr gt zu ihrer Entstehung bei, d.h. wer sind die Akteure gesellschaftlicher Ausgrenzung? Welche Rolle spielen der Staat und seine Institutionen? Wie funktioniert Normsetzung, und wie manifestiert sich diese? Bezogen auf die konkreten Lebensgeschichten asozialer“ Frauen fragt Schikorra nach dem Leben vor der Haft, nach der Verfolgungsgeschichte, den Erfahrungen im Konzentrationslager, der Stellung in der H ftlingsgesellschaft sowie dem Leben nach dem Umgang mit Ausgrenzung und Benachteiligung auch nach 1945. Concentration camps were instruments of discriminiation and segregation (and, eventually, instruments of extermination). Similarly, research on concentration camps and attempts at coming to terms with this part of German history have fallen prey to discrimination and stigmatization directed against certain groups of victims and survivors. This review introduces two new publications which aim to direct the readers’ attention to long neglected research topics. Both works put those who were persecuted and placed in concentration camps at the centre, rendering visible the experiences and stories of those who had been ignored thus far. Both books deal with the women’s concentration camp, Ravensbrück. Schikorra examines on the particularly difficult situation of those prisoners who had been categorised as “anti-social.” Amesberger and Halbmayer, on the other hand, focus on the fate of Austrian inmates.
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