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Search Results: 1 - 10 of 242964 matches for " Thelus-Jean R "
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Life-course origins of the ages at menarche and menopause
Forman MR, Mangini LD, Thelus-Jean R, Hayward MD
Adolescent Health, Medicine and Therapeutics , 2013, DOI: http://dx.doi.org/10.2147/AHMT.S15946
Abstract: ourse origins of the ages at menarche and menopause Review (1325) Total Article Views Authors: Forman MR, Mangini LD, Thelus-Jean R, Hayward MD Published Date January 2013 Volume 2013:4 Pages 1 - 21 DOI: http://dx.doi.org/10.2147/AHMT.S15946 Received: 30 August 2012 Accepted: 26 October 2012 Published: 18 January 2013 Michele R Forman,1 Lauren D Mangini,1 Rosenie Thelus-Jean,2 Mark D Hayward3 1Nutritional Sciences, The University of Texas at Austin, Austin, TX, 2Office of the Surgeon General, Department of the Army, Washington DC, 3Population Research Center, The University of Texas at Austin, Austin, TX, USA Abstract: A woman's age at menarche (first menstrual period) and her age at menopause are the alpha and omega of her reproductive years. The timing of these milestones is critical for a woman's health trajectory over her lifespan, as they are indicators of ovarian function and aging. Both early and late timing of either event are associated with risk for adverse health and psychosocial outcomes. Thus, the search for a relationship between age at menarche and menopause has consequences for chronic disease prevention and implications for public health. This article is a review of evidence from the fields of developmental biology, epidemiology, nutrition, demography, sociology, and psychology that examine the menarche–menopause connection. Trends in ages at menarche and menopause worldwide and in subpopulations are presented; however, challenges exist in constructing trends. Among 36 studies that examine the association between the two sentinel events, ten reported a significant direct association, two an inverse association, and the remainder had null findings. Multiple factors, including hormonal and environmental exposures, socioeconomic status, and stress throughout the life course are hypothesized to influence the tempo of growth, including body size and height, development, menarche, menopause, and the aging process in women. The complexity of these factors and the pathways related to their effects on each sentinel event complicate evaluation of the relationship between menarche and menopause. Limitations of past investigations are discussed, including lack of comparability of socioeconomic status indicators and biomarker use across studies, while minority group differences have received scant attention. Suggestions for future directions are proposed. As research across endocrinology, epidemiology, and the social sciences becomes more integrated, the confluence of perspectives will yield a richer understanding of the influences on the tempo of a woman's reproductive life cycle as well as accelerate progress toward more sophisticated preventive strategies for chronic disease.
Life-course origins of the ages at menarche and menopause
Forman MR,Mangini LD,Thelus-Jean R,Hayward MD
Adolescent Health, Medicine and Therapeutics , 2013,
Abstract: Michele R Forman,1 Lauren D Mangini,1 Rosenie Thelus-Jean,2 Mark D Hayward31Nutritional Sciences, The University of Texas at Austin, Austin, TX, 2Office of the Surgeon General, Department of the Army, Washington DC, 3Population Research Center, The University of Texas at Austin, Austin, TX, USAAbstract: A woman's age at menarche (first menstrual period) and her age at menopause are the alpha and omega of her reproductive years. The timing of these milestones is critical for a woman's health trajectory over her lifespan, as they are indicators of ovarian function and aging. Both early and late timing of either event are associated with risk for adverse health and psychosocial outcomes. Thus, the search for a relationship between age at menarche and menopause has consequences for chronic disease prevention and implications for public health. This article is a review of evidence from the fields of developmental biology, epidemiology, nutrition, demography, sociology, and psychology that examine the menarche–menopause connection. Trends in ages at menarche and menopause worldwide and in subpopulations are presented; however, challenges exist in constructing trends. Among 36 studies that examine the association between the two sentinel events, ten reported a significant direct association, two an inverse association, and the remainder had null findings. Multiple factors, including hormonal and environmental exposures, socioeconomic status, and stress throughout the life course are hypothesized to influence the tempo of growth, including body size and height, development, menarche, menopause, and the aging process in women. The complexity of these factors and the pathways related to their effects on each sentinel event complicate evaluation of the relationship between menarche and menopause. Limitations of past investigations are discussed, including lack of comparability of socioeconomic status indicators and biomarker use across studies, while minority group differences have received scant attention. Suggestions for future directions are proposed. As research across endocrinology, epidemiology, and the social sciences becomes more integrated, the confluence of perspectives will yield a richer understanding of the influences on the tempo of a woman's reproductive life cycle as well as accelerate progress toward more sophisticated preventive strategies for chronic disease.Keywords: reproductive aging, growth, socioeconomic status, biomarker, ovarian function
Evolution and development: some insights from evolutionary theory
DAVID, JEAN R.;
Anais da Academia Brasileira de Ciências , 2001, DOI: 10.1590/S0001-37652001000300008
Abstract: developmental biology and evolutionary biology are both mature integrative disciplines which started in the 19th century and then followed parallel and independent scientific pathways. recently, a genetical component has stepped into both disciplines (developmental genetics and evolutionary genetics) pointing out the need for future convergent maturation. indeed, the evo-devo approach is becoming popular among developmental biologists, based on the facts that distant groups share a common ancestry, that precise phylogenies can be worked out and that homologous genes often play similar roles during the development of very different organisms. in this essay, i try to show that the real future of evo-devo thinking is still broader. the evolutionary theory is a set of diverse concepts which can and should be used in any biological field. evolutionary thinking trains to ask ? why ? questions and to provide logical and plausible answers. it can shed some light on a diversity of general problems such as how to distinguish homologies from analogies, the costs and benefits of multicellularity, the origin of novel structures (e.g. the head), or the evolution of sexual reproduction. in the next decade, we may expect a progressive convergence between developmental genetics and quantitative genetics.
Integration of services for older people: back to funding
Réjean Hébert
International Journal of Integrated Care , 2012,
Abstract:
Special 10th anniversary edition. PRISMA: a good example of transferring research evidence into public policy
Réjean Hébert
International Journal of Integrated Care , 2011,
Abstract:
Dimensiones ecológicas de la familia: La situación social de los ni os
Réjean Tessier
Revista de Psicología , 1994,
Abstract: El artículo trata de la situación social de las familias y los ni os. El autor usa el paradigma ecológico que intenta comprender el comportamiento como la resultante de un intercambio mutuo y recíproco entre el organismo y el medio. Partiendo de datos estadísticos de la OMS y UNICEF trata de demostrar las consecuencias posibles de ciertas situaciones sociales y del contexto demográfico sobre las oportunidades de desarrollo de los ni os. Se destaca la importancia de los diferentes niveles de las dimensiones ecológicas de la familia y se alerta sobre los efectos nocivos que tienen en los ni os la pobreza extrema y las condiciones familiares de gran adversidad.
Evolution and development: some insights from evolutionary theory
DAVID JEAN R.
Anais da Academia Brasileira de Ciências , 2001,
Abstract: Developmental biology and evolutionary biology are both mature integrative disciplines which started in the 19th century and then followed parallel and independent scientific pathways. Recently, a genetical component has stepped into both disciplines (developmental genetics and evolutionary genetics) pointing out the need for future convergent maturation. Indeed, the Evo-Devo approach is becoming popular among developmental biologists, based on the facts that distant groups share a common ancestry, that precise phylogenies can be worked out and that homologous genes often play similar roles during the development of very different organisms. In this essay, I try to show that the real future of Evo-Devo thinking is still broader. The evolutionary theory is a set of diverse concepts which can and should be used in any biological field. Evolutionary thinking trains to ask why questions and to provide logical and plausible answers. It can shed some light on a diversity of general problems such as how to distinguish homologies from analogies, the costs and benefits of multicellularity, the origin of novel structures (e.g. the head), or the evolution of sexual reproduction. In the next decade, we may expect a progressive convergence between developmental genetics and quantitative genetics.
La fecondite au Quebec et en Ontario: quelques elements de comparaison
Lachapelle, Réjean
Canadian Studies in Population , 1974,
Abstract:
Targeted searches for gravitational waves from radio pulsars
Réjean J. Dupuis
Physics , 2005, DOI: 10.1088/1742-6596/32/1/009
Abstract: An overview of the searches for gravitational waves from radio pulsars with LIGO and GEO is given. We give a brief description of the algorithm used in these targeted searches and provide end-to-end validation of the technique through hardware injections. We report on some aspects of the recent S3/S4 LIGO and GEO search for signals from several pulsars. The gaussianity of narrow frequency bands of S3/S4 LIGO data, where pulsar signals are expected, is assessed with Kolmogorov-Smirnov tests. Preliminary results from the S3 run with a network of four detectors are given for pulsar J1939+2134.
Reference gene selection for quantitative PCR studies in bovine neutrophils  [PDF]
William R. Vorachek, Gerd Bobe, Jean A. Hall
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.410A3002
Abstract:

Reference genes are essential for studying mRNA expression with quantitative PCR (qPCR). We investigated 11 candidate whole-blood neutrophil reference genes (ACTB, B2M, G6PD, GAPDH, GYPC, HPRT, PGK1, RPL19, SDHA, TFRC, and YWHAZ) for beef calves, both males and females, with or without selenium supplementation. Initial screening was based on gene expression level (<28 Cq cycles), variability (SD < 1.5 Cq cycles), excluded GYPC and TFRC from further analysis. Expression stability of the remaining genes was evaluated using four software programs: geNorm, NormFinder, BestKeeper, and the comparative delta Cq method. The neutrophil reference genes, YWHAZ, PGK1, and RPL19, consistently ranked among the top four most stable genes under these experimental conditions. The commonly used reference genes, ACTB and HPRT, were not reliable, underscoring the need to validate neutrophil reference genes under different experimental conditions. Multiple reference genes rather than a single gene may provide more robust and reliable results. The best pair of reference genes in whole-blood neutrophils from beef calves overall was PGK1|YWHAZ.  

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