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Search Results: 1 - 10 of 33971 matches for " Thea CM van Roermund "
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Teachers' ideas versus experts' descriptions of 'the good teacher' in postgraduate medical education: implications for implementation. A qualitative study
Thea CM van Roermund, Fred Tromp, Albert JJA Scherpbier, Ben JAM Bottema, Herman J Bueving
BMC Medical Education , 2011, DOI: 10.1186/1472-6920-11-42
Abstract: Recently, a new competency-based description of the good teacher was developed and introduced in all the Departments of Postgraduate Medical Education for Family Physicians in the Netherlands. We compared the views reflected in the new description with the views of teachers who were required to adopt the new framework.Qualitative study. We interviewed teachers in two Departments of Postgraduate Medical Education for Family Physicians in the Netherlands. The transcripts of the interviews were analysed independently by two researchers, who coded and categorised relevant fragments until consensus was reached on six themes. We investigated to what extent these themes matched the new description.Comparing the teachers' views with the concepts described in the new competency-based framework is like looking into two mirrors that reflect clearly dissimilar images. At least two of the themes we found are important in relation to the implementation of new educational methods: the teachers' identification and organisational culture. The latter plays an important role in the development of teachers' ideas about good teaching.The main finding of this study is the key role played by the teachers' feelings regarding their professional identity and by the local teaching culture in shaping teachers' views and expectations regarding their work. This suggests that in implementing a new teaching framework and in faculty development programmes, careful attention should be paid to teachers' existing identification model and the culture that fostered it.In times of change in medical education, teachers are often asked to adapt to a new concept of what being a good teacher includes [1,2]. These new concepts represent what is considered to be best educational practice and are often developed by experts outside the departments where the changes are to be implemented. The concepts are based on an analysis of the teachers' tasks and/or educational theory and operationalized in competency profi
Anderson Model out of equilibrium: decoherence effects in transport through a quantum dot
Rapha?l Van Roermund,Shiue-yuan Shiau,Mireille Lavagna
Physics , 2010, DOI: 10.1103/PhysRevB.81.165115
Abstract: The paper deals with the nonequilibrium two-lead Anderson model, considered as an adequate description for transport through a d-c biased quantum dot. Using a self-consistent equation-of-motion method generalized out of equilibrium, we calculate a fourth-order decoherence rate $\gamma^{(4)}$ induced by a bias voltage $V$. This decoherence rate provides a cut-off to the infrared divergences of the self-energy showing up in the Kondo regime. At low temperature, the Kondo peak in the density of states is split into two peaks pinned at the chemical potential of the two leads. The height of these peaks is controlled by $\gamma^{(4)}$. The voltage dependence of the differential conductance exhibits a zero-bias peak followed by a broad Coulomb peak at large $V$, reflecting charge fluctuations inside the dot. The low-bias differential conductance is found to be a universal function of the normalized bias voltage $V/T_K$, where $T_K$ is the Kondo temperature. The universal scaling with a single energy scale $T_K$ at low bias voltages is also observed for the renormalized decoherence rate $\gamma^{(4)}/T_K$. We discuss the effect of $\gamma^{(4)}$ on the crossover from strong to weak coupling regime when either the temperature or the bias voltage is increased.
The Influence of Between-Farm Distance and Farm Size on the Spread of Classical Swine Fever during the 1997–1998 Epidemic in The Netherlands
Gert Jan Boender, Rob van den Hengel, Herman J. W. van. Roermund, Thomas J. Hagenaars
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095278
Abstract: As the size of livestock farms in The Netherlands is on the increase for economic reasons, an important question is how disease introduction risks and risks of onward transmission scale with farm size (i.e. with the number of animals on the farm). Here we use the epidemic data of the 1997–1998 epidemic of Classical Swine Fever (CSF) Virus in The Netherlands to address this question for CSF risks. This dataset is one of the most powerful ones statistically as in this epidemic a total of 428 pig farms where infected, with the majority of farm sizes ranging between 27 and 1750 pigs, including piglets. We have extended the earlier models for the transmission risk as a function of between-farm distance, by adding two factors. These factors describe the effect of farm size on the susceptibility of a ‘receiving’ farm and on the infectivity of a ‘sending’ farm (or ‘source’ farm), respectively. Using the best-fitting model, we show that the size of a farm has a significant influence on both farm-level susceptibility and infectivity for CSF. Although larger farms are both more susceptible to CSF and, when infected, more infectious to other farms than smaller farms, the increase is less than linear. The higher the farm size, the smaller the effect of increments of farm size on the susceptibility and infectivity of a farm. Because of changes in the Dutch pig farming characteristics, a straightforward extrapolation of the observed farm size dependencies from 1997/1998 to present times would not be justified. However, based on our results one may expect that also for the current pig farming characteristics in The Netherlands, farm susceptibility and infectivity depend non-linearly on farm size, with some saturation effect for relatively large farm sizes.
Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks
Gonnie Nodelijk, Herman JW van Roermund, Lucien JM van Keulen, Bas Engel, Piet Vellema, Thomas J Hagenaars
Veterinary Research , 2011, DOI: 10.1186/1297-9716-42-5
Abstract: Classical scrapie in sheep is the eldest known transmissible spongiform encephalopathy (TSE) and is present in all sheep-producing countries except Australia and New Zealand [1,2]. Infection mostly occurs at very young age and clinical signs of this fatal disease are visible after a variable incubation period of one or more years dependent of genotype [3]. Frequently observed clinical signs are uncoordinated movement (ataxia), abnormal posture and severe scratching and rubbing. During the incubation period the prion protein PrPSc slowly accumulates in the animal and can be detected for most sheep genotypes in lymphoid organs such as tonsils before clinical signs become visible [4,5].Scrapie control became a priority in many countries some ten years ago. This was motivated in part by the theoretical possibility that bovine spongiform encephalopathy (BSE) may in the past have been introduced into sheep through consumption of feed supplements, with potential consequences to public health [6,7]. This possibility became apparent after experimental infection of sheep with BSE showed that sheep can be infected via the oral route and that the resulting clinical symptoms are very similar to scrapie [8,9].The susceptibility to scrapie is modulated by polymorphisms of the sheep prion protein (PrP) gene. For classical scrapie strains the most relevant polymorphisms occur at codons 136, 154 and 171 of the PrP gene [10-13], and for the recently discovered atypical scrapie an additional polymorphism has been identified at codon 141 [14-16]. For atypical strains the between-animal transmissibility in the field, if at all present, is likely to be very low [2].In this study we focus on classical scrapie and thus on the three aforementioned codons. Four alleles (VRQ, ARQ, AHQ and ARR) were observed in this study, and each one of the corresponding 10 possible genotypes occurred in the study flocks. The VRQ allele confers high susceptibility to most strains of classical scrapie, the ARQ
Analysis of the structural diversity of the microbial community in a paper-mill water system
Thea Van der Merwe, Karl-Heinz Riedel, Francois Wolfaardt
Water SA , 2002,
Abstract: Microbial populations in paper-mill water systems are usually enumerated using microbiological techniques such as plate counts and the most probable number technique. These conventional methods can only quantify a limited percentage of the microbial populations and the microbial numbers are, therefore, generally underestimated. One possible alternative to these methods involves the analysis of signature lipid biomarkers to study the structural diversity of microbial populations. The aim of this study was, therefore, to evaluate the applicability of signature lipid biomarker analysis in a paper-mill water system. Samples from the sessile and planktonic phases were collected over a period of one year at the Sappi Cape Kraft paper-mill. The samples were subjected to analysis of signature lipid biomarkers as well as conventional culturing. Analysis of the phospholipid fatty acids revealed the presence of a large diversity of micro-organisms. The same trends in the number of cultured cells and the counts obtained with signature lipid biomarker analysis were observed, although the numbers obtained with signature lipid biomarker analysis were at least 1 000 times higher. Profiles of signature lipid biomarkers reflected changes in production and water management practices, which could not be detected with culturing techniques. The analysis of signature lipid biomarkers provided more information for the characterisation of microbial communities in paper-mill water systems and has potential for application in other industrial water systems. WaterSA Vol.28(4) 2002: 407-412
Analysis of the functional diversity of the microbial communities in a paper-mill water system
Thea Van der Merwe, Francois Wolfaardt, Karl-Heinz Riedel
Water SA , 2003,
Abstract: Most microbiological studies of wastewater treatment systems rely on methods that are dependent on culturing. However, due to the limitation of conventional microbiological methods, alternative assays, such as the analysis of the functional diversity of the microbial communities using Biolog substrate utilisation profiles, have been proposed. The Biolog method was thus evaluated in a paper-mill water system. The influence of the production of various paper grades, biocide combinations and monthly maintenance shut-downs on the functional diversity of the microbial communities were determined using the Biolog technique. The communities in the planktonic as well as the sessile phases were analysed approximately every second week for a period of one year. The average well colour development (AWCD) technique was used to transform the data obtained from the Biolog plates prior to multivariate statistical analysis. Our results indicated that different microbial communities developed during the production of the different paper grades. A difference in substrate utilisation was evident after a single day of production of fluting or linerboard in the planktonic communities, while differences in the sessile communities only became significant after an extended period of production. The effect of the application of different biocides was more distinct in the planktonic than in the sessile populations. No clear trends concerning the influence of maintenance shut-downs and cleaning of machines could be observed in the sessile phase, while a shift in the microbial community could be observed in the planktonic phase. Biodiversity indices indicated that a high functional diversity existed in both the planktonic and sessile phases. It was concluded that the substrate utilisation profiles obtained with Biolog plates were a sensitive measure, which enabled the detection of shifts in the microbial community function and possibly structure within the same water system. Water SA Vol.29(1) 2003: 31-34
Research projects and capacity building
CM Breen, JJ Jaganyi, BW Van Wilgen, E Van Wyk
Water SA , 2004,
Abstract: A World Bank long-term perspective study on Sub-Saharan Africa highlighted the need to build human and institutional capacity in virtually all sectors and countries. In South Africa, establishment of a democratic government in 1994 saw increased emphasis placed on capacity building. This led to the revision of policies and legislation directing human resources development. This emphasis on capacity development is reflected in procurement policies to the extent that it is increasingly difficult to successfully bid for funding from government and parastatal organisations unless there is both a plan and a commitment to capacity building in the previously marginalised sectors. There are currently no guidelines to support researchers in their attempts to support the intentions of legislation and policy. It has been assumed that researchers have the understanding and expertise to effectively promote capacity building. Under such conditions the expectations of research administrators are neither clearly structured nor are they understood by researchers. Not surprisingly, researchers often fail to meet the expectations of administrators. In an attempt to contribute towards developing a structured approach, this paper interprets what is meant by capacity building in the context of research projects. Based on this interpretation, reasonable and unreasonable expectations with respect to the extent to which capacity building can be achieved within a given project duration are discussed. A model is suggested, which would improve understanding and delivery and in doing so, achieve better congruence between expectations and outcomes. Key Words: Capacity building, Research, Change, Performance, Innovation WaterSA Vol.30(4) 2004: 429-434
Reflections on Establishing South Africa's Ecotourism legislative System
CM van der Bank,M van der Bank
Business Management Dynamics , 2012,
Abstract: Ecotourism has developed extensively in recent years. Ecotourism is the developing direction of tourism industry in our country. Irrational exploitation has devastated the ecotourism resources. Confronted with the up surging ecotourism market, we are lacking in corresponding legislative control and legislative link. Forming the legal system of ecotourism as soon as possible and having laws to abide by can ensure the sustainable development of ecotourism in our country. Section 24 of the Constitution attempts to achieve two objectives. The first objective of this section is to guarantee that everyone has the right to an environment that is not harmful to their health and well-being. Secondly in subsection 24(b) it is presumed that there is a specific mandate placed on the State (including municipalities) to take the necessary steps to consummate the aim in subsection 24(a). In this context aiming to reach sustainability means an integrated holistic effort in which all participants are present: hosts, government, business entrepreneurs, natural resources and environment in a related equal importance in which all human groups think, decide, compromise, act assume related responsibilities.Section 24 of the Constitution attempts to achieve two objectives. The first objective of this section is to guarantee that everyone has the right to an environment that is not harmful to their health and well-being. Secondly in subsection 24(b) it is presumed that there is a specific mandate placed on the State (including municipalities) to take the necessary steps to consummate the aim in subsection 24(a). In this context aiming to reach sustainability means an integrated holistic effort in which all participants are present: hosts, government, business entrepreneurs, natural resources and environment in a related equal importance in which all human groups think, decide, compromise, act assume related responsibilities.
Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir
Eefje Jong, Joost CM Meijers, Eric CM van Gorp, C Arnold Spek, Jan W Mulder
AIDS Research and Therapy , 2010, DOI: 10.1186/1742-6405-7-9
Abstract: Patients treated with ABC and a matched control group treated without ABC were selected retrospectively. Vascular endothelial growth factor (VEGF) and markers of endothelial cell activation (von Willebrand factor (vWF), factor VIII), fibrin formation (fibrinogen, D-dimer, prothrombin fragment 1+2 (F1+2), endogenous thrombin potential (ETP)), anticoagulation markers (protein C and S, activated protein C sensitivity ratio (APCsr)) and inflammation markers (IL-6, hsCRP) were measured in citrated plasma.A total of 81 patients were included of whom 27 patients used an ABC-containing regimen and 54 used a non-ABC-containing regimen. Patient characteristics were not significantly different between the groups except for longer duration of use of the current antiretroviral regimen in the ABC group (p = 0.01). The median time on ABC was 68 months (interquartile range 59-80 months). No differences in coagulation and inflammation markers according to ABC use were observed. For the whole patient group elevated vWF and F1+2 levels were observed in 23% and 37%, respectively. Compared to the reference ranges for the general population increased APCsr was found in 79% and lower protein C and VEGF levels in 40% and 43%, respectively. Patients in the high-risk category for cardiovascular disease with hsCRP levels > 3 mg/L had significantly higher fibrinogen, D-dimer, F1+2 and ETP levels compared to patients from the low-risk category with hsCRP levels < 1 mg/L.HIV-infected patients using ABC showed no specific abnormalities in coagulation or inflammation markers that might explain the increased risk of myocardial infarction. For the whole group, regardless of ABC use, evidence of a prothrombotic state was observed. Thirty-three percent of patients with long-term use of antiretroviral treatment had hsCRP levels above 3 mg/L, which is strongly associated with cardiovascular disease in HIV-uninfected individuals.The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study, an ob
Distal femoral opening-wedge osteotomy for lateral compartment osteoarthritis of the knee
Dirk HPW Das, Thea Sijbesma, Henk J Hoekstra, Willem M van Leeuwen
Open Access Surgery , 2008, DOI: http://dx.doi.org/10.2147/OAS.S3888
Abstract: tal femoral opening-wedge osteotomy for lateral compartment osteoarthritis of the knee Original Research (14229) Total Article Views Authors: Dirk HPW Das, Thea Sijbesma, Henk J Hoekstra, Willem M van Leeuwen Published Date November 2008 Volume 2008:1 Pages 25 - 29 DOI: http://dx.doi.org/10.2147/OAS.S3888 Dirk HPW Das1, Thea Sijbesma2, Henk J Hoekstra2, Willem M van Leeuwen2 1Department of Orthopaedics and Traumatology, Máxima Medisch Centrum Veldhoven, The Netherlands; 2Department of Orthopaedic Surgery, The St Anna Hospital, Geldrop, The Netherlands Abstract: We retrospectively evaluated 12 patients with lateral gonarthritis after a distal femoral lateral opening osteotomy using a Puddu-plate. Thirteen patients with lateral gonarthritis and genu valgum were operated upon. One patient died during follow-up. We used the Lysholm score and the adapted Hospital for Special Surgery (HSS) clinical and functional score. At 34 months follow up, all patients had a functional and clinical evaluation. All patients responded to a questionnaire over the telephone regarding the survival, Lysholm, and functional HSS score at 74 months follow-up. The average age at operation was 52 years. The average correction angle was 11° (16° to 5°). At 34 months follow up, the functional HSS score improved from 58 to 72 points. At 74 months follow up, the Lysholm score improved from 64 to 77 points. The clinical horizon scanning system score improved from 42 points presurgery to 64 postsurgery. Two knees were converted to total knee arthroplasty due to persisting postoperative pain. Lateral supracondylar opening-wedge osteotomy is a satisfying treatment for lateral osteoarthritis of the knee with genu valgum in younger patients.
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