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Search Results: 1 - 10 of 160 matches for " Thashlin Govender "
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The Impact of Densification by Means of Informal Shacks in the Backyards of Low-Cost Houses on the Environment and Service Delivery in Cape Town, South Africa
Thashlin Govender, Jo M. Barnes and Clarissa H. Pieper
Environmental Health Insights , 2012, DOI: 10.4137/EHI.S7112
Abstract: This paper investigates the state-sponsored low cost housing provided to previously disadvantaged communities in the City of Cape Town. The strain imposed on municipal services by informal densification of unofficial backyard shacks was found to create unintended public health risks. Four subsidized low-cost housing communities were selected within the City of Cape Town in this cross-sectional survey. Data was obtained from 1080 persons with a response rate of 100%. Illegal electrical connections to backyard shacks that are made of flimsy materials posed increased fire risks. A high proportion of main house owners did not pay for water but sold water to backyard dwellers. The design of state-subsidised houses and the unplanned housing in the backyard added enormous pressure on the existing municipal infrastructure and the environment. Municipal water and sewerage systems and solid waste disposal cannot cope with the increased population density and poor sanitation behaviour of the inhabitants of these settlements. The low-cost housing program in South Africa requires improved management and prudent policies to cope with the densification of state-funded low-cost housing settlements.
Antimicrobial properties of the skin secretions of frogs
Thashlin Govender,Abeda Dawood,Adriaan J. Esterhuyse,David R. Katerere
South African Journal of Science , 2012, DOI: 10.4102/sajs.v108i5/6.795
Abstract: Antimicrobial resistance results in increased morbidity and mortality, and increased health-care costs. Therefore the need to develop new classes of antibiotics is indispensable. Antimicrobial peptides are a relatively new class of potential antibiotics which are fast acting, possess broad-spectrum activity and are able to escape many of the currently known mechanisms of drug resistance. They have been shown to be active against Gram-negative and Gram-positive bacteria, fungi, enveloped viruses and even cancer cells. However, toxicity to healthy host cells remains a concern and has affected the clinical development of therapeutics based on antimicrobial peptides. The purpose of this review is to discuss recent advances in research focused on antimicrobial peptides from frogs and the challenges in conducting research in this area in southern Africa. An extensive literature review of relevant articles published between 1980 and the present was conducted using PubMed, ScienceDirect, Sabinet, Elsevier and GoogleScholar. There has been little research done on anurans from southern Africa which are endemic to the region, and there is therefore a need to focus on this group for the purposes of bioprospecting for potentially new antimicrobial peptide compounds.
The Impact of Densification by Means of Informal Shacks in the Backyards of Low-Cost Houses on the Environment and Service Delivery in Cape Town, South Africa
Thashlin Govender,Jo M. Barnes,Clarissa H. Pieper
Environmental Health Insights , 2011,
Abstract:
A survey of corticosteroid use for the management of septic shock
K Govender
Southern African Journal of Anaesthesia and Analgesia , 2012,
Abstract: Background: Critical illness is associated with pituitary-adrenal axis dysfunction, and may cause adrenal insufficiency that manifests as septic shock that is poorly responsive to fluid or inotropic therapy. Administering a low-dose corticosteroid to these patients results in faster shock resolution, but there is controversy regarding its effect on patient mortality. This survey aimed to describe how survey respondents are interpreting the current literature and using corticosteroids in patient management. Method: A survey was conducted during the 2011 annual congress of the South African Society of Anaesthesiologists. Results: Of the 65 respondents who completed the survey, all (except one specialist) had a background in anaesthesia or critical care. The majority of respondents agreed with the Surviving Sepsis Campaign definitions for sepsis and septic shock. A “typical” respondent would administer a total daily dose of 200 mg hydrocortisone, in boluses, to septic shock patients requiring inotropic support, or who were poorly responsive to inotropes. They would not use an adrenocorticotropic hormone stimulation test to identify these patients. Once shock resolved, or inotropes were no longer required, they would wean the hydrocortisone. More than 40% of respondents would use corticosteroids in clinical scenarios in which no patient benefit has been shown, and which might cause patient harm. Conclusion: Respondents use corticosteroids as recommended by the Surviving Sepsis Campaign guidelines, but would extend this use to other clinical scenarios, i.e. sepsis without hypotension and for non-septic shock, which might cause patient harm. When making clinical decisions, more emphasis should be placed on patient-important outcomes than on surrogate outcomes.
Mass hysteria among South African primary school
I Govender
South African Family Practice , 2010,
Abstract: During August 2002, at a primary school in Kwa-Dukuza, KwaZulu-Natal, 27 children who had been well when they left their homes collapsed at school, displaying tremors and shivers throughout their bodies. Many of the children also presented with abdominal cramps and nausea. Almost all the children experienced a feeling of tightness in their chests as well as hyperventilation, which was then followed by fainting. This hysteria spread by line of sight (that is, other children seeing this also collapsed). Mass hysteria had presented similarly, with only a mild variation in the hallucinations, in secondary schools in Mangaung, Bloemfontein, during 2000 and in Gauteng during 2009. Radio stations, such as Radio 702, presented these incidents for discussion and for concerned parents’ questions to be answered. In all three episodes, the majority of the affected children were girls. Witchcraft, poisoning, insect bites – in the case of Mangaung – and gas leaks were proposed as causes of this strange behaviour by the previously well children. Experts who investigated these possibilities, however, excluded any identifiable cause. Nearly all the children were well again the next day. The assessment after the incidents was an outbreak of mass hysteria. The parents and the lay media, however, refused to accept this diagnosis, which added to the stress and the anxiety that the children faced when they returned to school. Mass hysteria can be taxomised into two broad categories: the explosive type, which typically appears in small, institutionalised social networks; and the large, diffused type, during which false rumours and beliefs overwhelm a community. This discussion focuses on the second category – that which affects people in one institution. The discussion includes the rare outbreak in Kwa-Dukuza, together with the common presentations and symptoms of mass hysteria. Also discussed are the consequences of not managing this condition well immediately on presentation. These consequences entail a perpetuation of the condition, spreading to a greater number of children, to the parents and to the teachers. This may then lead to a disruption in learning at the schools affected and, possibly, later on, to anxiety disorders.
HIV-associated opportunistic fungal infections: a guide to using the clinical microbiology laboratory
N Govender
Southern African Journal of HIV Medicine , 2007,
Abstract: This review aims to provide a guide for clinicians to using the clinical microbiology laboratory for management of common HIV-associated opportunistic fungal infections, e.g. mucosal candidiasis, cryptococcosis, Pneumocystis jirovecii pneumonia (PCP), histoplasmosis, etc. Laboratory tests provide valuable guidance at various stages of management of HIV-infected patients with fungal infections: (i ) establishing a diagnosis, (ii) guiding appropriate antifungal therapy in selected circumstances, (iii) providing laboratory prognostic markers, (iv) monitoring response to therapy; and (v ) detecting relapses. However, the laboratory is not always able to provide reliable answers to clinically relevant questions, and these limitations must be considered in the interpretation of test results. Southern African Journal of HIV Medicine Vol. 8 (3) 2007: pp. 18-23
The universe: yours to discover
Kevin Govender
South African Journal of Science , 2009, DOI: 10.4102/sajs.v105i1/2.28
Abstract:
Enhancing Service Production And Service Quality
Krishna Govender
South African Journal of Industrial Psychology , 2002, DOI: 10.4102/sajip.v28i1.36
Abstract: This article sheds light on a possible strategy to enhance service production and service quality by reporting on an exploratory mail survey conducted among a sample of 1000 commercial bank customers. It became apparent that by using formal and informal strategies to socialize their customers, service providers could positively influence their customers’perception of service quality. Opsomming Hierdie artikel werp lig op’n moontlike strategie om diensproduksie en -kwaliteit te bevorder deur die rapportering van’n eksploratiewe pos-opname onder ’n steekproef van 1000 handelsbankkliente. Dit het duidelik geword deur die gebruik van formele en informele strategiee om kliente te sosialiseer dat diensverskaffers hulle kliente se persepsie van dienskwaliteit positief kon beinvloed.
Basic research in orthopedics: South Africa
Govender Shunmugam
Indian Journal of Orthopaedics , 2009,
Abstract:
Radiating spherical collapse with heat flow
M. Govender
Physics , 2002, DOI: 10.1142/S0218271803003086
Abstract: We present here a simple model of radiative gravitational collapse with radial heat flux which describes qualitatively the stages close to the formation of a superdense cold star. Starting with a static general solution for a cold star, the model can generate solutions for the earlier evolutionary stages. The temporal evolution of the model is specified by solving the junction conditions appropriate for radiating gravitational collapse.
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