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Search Results: 1 - 10 of 104 matches for " Thakre Minal "
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Necrotizing fasciitis in an HIV-infected patient
Surjushe Amar,Vasani Resham,Thakre Minal,Saple D
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Hand-foot syndrome due to capecitabine
Surjushe Amar,Vasani Resham,Medhekar Sudhir,Thakre Minal
Indian Journal of Dermatology , 2009,
Hand-foot syndrome due to capecitabine
Surjushe Amar,Vasani Resham,Medhekar Sudhir,Thakre Minal
Indian Journal of Dermatology , 2008,
Hutchinson-Gilford syndrome (progeria)
Surjushe Amar,Thakre Minal,Vasani Resham,Saple Dattatray
Indian Journal of Dermatology , 2009,
Abstract: Progeria is a rare, autosomal dominant, progeroid disorder. In the world literature less than 100 cases have been reported to date. We present this case because of its rarity.
Evaluation of chemiluminescence, toluidine blue and histopathology for detection of high risk oral precancerous lesions: A cross-sectional study
Shweta Ujaoney, Mukta B Motwani, Shirish Degwekar, Vijay Wadhwan, Prajakta Zade, Minal Chaudhary, Vinay Hazarey, Tushar P Thakre, Manju Mamtani
BMC Clinical Pathology , 2012, DOI: 10.1186/1472-6890-12-6
Abstract: We conducted a cross-sectional study to compare the performance of chemiluminescence, toluidine blue and histopathology for detection of high-risk precancerous oral lesions. We evaluated 99 lesions from 55 patients who underwent chemiluminescence and toluidine blue tests along with biopsy and histopathological examination. We studied inter-as well as intra-rater agreement in the histopathological evaluation and then using latent class modeling, we estimated the operating characteristics of these tests in the absence of a reference standard test.There was a weak inter-rater agreement (kappa < 0.15) as well as a weak intra-rater reproducibility (Pearson's r = 0.28, intra-class correlation rho = 0.03) in the histopathological evaluation of potentially high-risk precancerous lesions. When compared to histopathology, chemiluminescence and toluidine blue retention had a sensitivity of 1.00 and 0.59, respectively and a specificity of 0.01 and 0.79, respectively. However, latent class analysis indicated a low sensitivity (0.37) and high specificity (0.90) of histopathological evaluation. Toluidine blue had a near perfect high sensitivity and specificity for detection of high-risk lesions.In our study, there was variability in the histopathological evaluation of oral precancerous lesions. Our results indicate that toluidine blue retention test may be better suited than chemiluminescence to detect high-risk oral precancerous lesions in a high-prevalence and low-resource setting like India.Oral malignancies continue to burden the clinical and economic dimensions of health care around the world [1,2]. In India, for example, oral cancers constitute 40% of all cancers and rank as the most common cancer in men and third most common cancer in women [3,4]. The reason why oral cavity cancers occupy a strategic position in the health care systems is that an early detection of these lesions is theoretically possible and practically useful [5-8]. Such early detection is generally associ
Systemic fungal infections emerging infection in newborn
R Thakre
Journal of Universal College of Medical Sciences , 2013, DOI: 10.3126/jucms.v1i4.9579
Abstract: DOI: http://dx.doi.org/10.3126/jucms.v1i4.9579 Journal of Universal College of Medical Sciences (2013) Vol.1 No.04: 61-65
Dimensional reduction of non-linear Seiberg-Witten equations
Varun Thakre
Mathematics , 2015,
Abstract: Mathematical properties of a dimensional reduction of non-linear Seiberg-Witten equations in dimension four are studied. The resulting equations produce an extra Higgs field. In the absence of the Higgs field, the equations reduce the Symplectic Vortex equations, with holomorphic curves taking values in a complex submanifold of the target manifold. Under suitable regularity assumptions, the moduli space of solutions to the reduced equations is shown to carry a natural Kahler structure. Using the Quillen's determinant line-bundle construction, we construct a pre-quantum line bundle over the moduli space of solutions. Regarding the moduli space as the phase space, we define the Hilbert space quantization of of the same as the space of holomorpic sections of the Quillen determinant line-bundle.
Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications
Minal Vaish
Molecular Cancer , 2007, DOI: 10.1186/1476-4598-6-26
Abstract: Gurdon first introduced the concept of stemness state of the cells while successfully achieving the generation of all cell lineages of a living tadpole after transferring the nuclei from intestinal epithelial cells of feeding Xenopus tadpoles to activated enucleated eggs [1,2]. These types of cells were later on characterized as indispensable entities, identified in multicellular organisms. The stem cell phenotype is contributed by the unique features that include (1) self-renewal which means that after cell division, one of the daughter cells must have the same genetic material as that of the parent cell, (2) differentiation i.e. capability to differentiate into multiple lineages and (3) extensive proliferation. The adult stem cells are identified in variety of tissues and organs in humans including – bone marrow, brain, skin/hair follicles, heart, lung, intestine, liver, pancreas, mammary glands, ovaries, prostrate, and testis [3].The multipotency of stem cells to maintain tissue homeostasis and its differentiation into mature cell types is under a tightly controlled system and is associated with restricted expression profile. The expression of transport proteins – ABC (ATP-binding cassette) transporter proteins and multidrug resistant proteins that protect cells against toxins and are associated with the efflux of xenobiotic toxins, low rate of cell division and active DNA repair are the innate properties of normal development of stem cells. Besides hormonal stimulation, DNA damage is one of the key factors for stem cell activation. DNA accumulates errors either from environmental factors, which could be the exposure to radiation, chemicals or drugs, viruses and bacteria or DNA replication errors [4]. This would result in complex cellular responses that include loss of cell cycle regulation, transcription induction and DNA repair mechanisms for maintaining genomic and chromosomal stability. But in absence of efficient DNA repair machinery, the stem cells accumula
MicroRNAs, stem cells and cancer stem cells
Minal Garg
World Journal of Stem Cells , 2012, DOI: 10.4252/wjsc.v4.i7.62
Abstract: This review discusses the various regulatory characteristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells. It controls the stem cell functions by controlling a wide range of pathological and physiological processes, including development, differentiation, cellular proliferation, programmed cell death, oncogenesis and metastasis. Through either mRNA cleavage or translational repression, miRNAs alter the expression of their cognate target genes; thereby modulating cellular pathways that affect the normal functions of stem cells, turning them into cancer stem cells, a likely cause of relapse in cancer patients. This present review further emphasizes the recent discoveries on the functional analysis of miRNAs in cancer metastasis and implications on miRNA based therapy using miRNA replacement or anti-miRNA technologies in specific cancer stem cells that are required to establish their efficacy in controlling tumorigenic potential and safe therapeutics.
External validation of Indian diabetes risk score in a rural community of central India  [PDF]
Bharati Taksande, Minal Ambade, Rajnish Joshi
Journal of Diabetes Mellitus (JDM) , 2012, DOI: 10.4236/jdm.2012.21017
Abstract: Aim: To find whether the individuals of 45 years and more of rural area who are in higher tertile of Indian Diabetes Risk Score i.e. of IDRS of >60 as compared to those who are in lower tertile i.e. of <30, have high frequency of hyperglycemia, impaired glucose tolerance, and manifest diabetes mellitus. Methods: A cross-sectional community based study. The study was conducted in three pre-identified villages. For all consenting and the eligible subjects, the medical student visited their house and the fasting capillary blood glucose was done by One touch blood glucose monitoring system. Four simple questions and one anthropometric measurement for waist circumference helped in deriving the information for Indian Diabetes Risk Score from the same subject. Results: The Indian Diabetes Risk Score (IDRS) (consisting of the factors like age, abdominal obesity, physical inactivity and the family history) which predicted diabetes mellitus in the subject, its sensitivity was 97.50% and specificity of 87.89% when the score of >/+ 60 was externally validated on our rural population. Conclusion: Our study demonstrated that the Indian Diabetes Risk Score (IDRS) can be reliably applied as effective tool for the mass screening of diabetes in the community.
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