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Search Results: 1 - 10 of 334 matches for " Thabah Molly "
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Usefulness of anti -CCP antibodies in rheumatic diseases in Indian patients
Gupta Rajiva,Thabah Molly,Aneja Ritu,Kumar Ashok
Indian Journal of Medical Sciences , 2009,
Abstract: Background: The usefulness of anti-cyclic citrullinated peptide antibodies (anti-CCP antibodies) to identify rheumatic arthritis (RA) from other rheumatic diseases presenting with joint pain is not well studied. Aims: We aimed to determine the sensitivity and specificity of anti-CCP antibodies in Indian RA patients with respect to non-RA rheumatic diseases and to study the relationship of anti-CCP antibodies and IgG, IgM and IgA rheumatoid factor in RA. Settings and Design: Case-control cross-sectional study carried out in the rheumatology division of All India Institute of Medical Sciences.Materials and Methods: Sixty-three patients with rheumatoid arthritis (RA) and 51 patients with non-RA rheumatic diseases having joint pain were included in the study. Sera were tested for anti-CCP antibodies (IgG) and IgA, IgM, IgG rheumatoid factor, using a commercially available enzyme-linked immunosorbent assay. Statistical Analysis: Statistical analysis was performed using SPSS statistical software version 11.5. Results: Fifty-four of 63 RA patients (85.71%) were positive for anti-CCP antibodies. In the non-RA group, anti-CCP antibody was positive in only 5 of 51 patients (9.8%). Our study found a sensitivity of 85% and a specificity of 90.19% with regard to the use of anti-CCP antibodies assay in patients with joint pain to correctly identify RA. Anti-CCP antibodies positive patients did not have more erosive disease. IgM-RF-positive patients had more erosion when compared to the IgM-RF-negative group. Thirty-two of 57 (56.1%) IgM-RF-positive patients had erosions, while no patient (0/6 patients) had erosions in the IgM-RF-negative group (P = 0.01) Conclusion: Anti-CCP antibodies have high sensitivity and specificity for diagnosis of RA, in Indian patients. Anti-CCP antibodies positive patients did not have more erosive disease in our study.
Administering Anesthesia for Patients with ALS Having a Diaphragmatic Pacemaker Placed: Special Considerations  [PDF]
Molly Kraus, Lopa Misra
Open Journal of Anesthesiology (OJAnes) , 2014, DOI: 10.4236/ojanes.2014.49032
Abstract: Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease is a relentlessly progressive, fatal disease. Progression of the disease results 3 - 5 years after diagnosis, often from respiratory failure. The diaphragm pacing system (DPS) is a device that stimulates the diaphragm to maximally contract so patients can breathe more effectively. It has been used in patients with neurologic injuries such as spinal cord injury and ALS. From an anesthetic perspective, both the surgery and the patient population present several unique challenges. This case series describes three patients with ALS who had the diaphragmatic pacemaker placed and the anesthetic management during those surgeries.
Managing the Classroom for Creativity  [PDF]
Molly A. James
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.610102
Abstract: Enhancing student creativity is an educational goal, and increasingly, a global imperative. In the current educational context of the United States, this is a formidable task. I have struggled with this issue as an MA student, and as an educator. As an MA student I examined learning environments that support and enhance creativity, and received my Masters in Creative Thinking. As an educator at an academically rigorous N-12 grade school, I endeavor daily to encourage deep thinking, academic excellence, and great creativity in my students. This paper expresses the voice of the researcher, and the voice of the passionate educator. This paper suggests it is possible to establish creativity-enhancing learning environments. It offers an understanding of creativity and its inherent connection to learning. Teresa Amabile’s highly regarded workplace assessment inventory, KEYS, is presented and explored as a classroom management style that encourages creativity and achievement. Her theory suggests we, as educators, have the power to enhance our students’ creativity by positively impacting our classroom environment. I map her approach onto two highly successful creative learning approaches—El Sistema and Reggio Emilia, and then interrogate and reflect upon the presence of KEYS in my own practice. Finally I offer suggestions for pre-service and in-service professional development to support educators as we work to empower our students to grow their creativity now and in the future.
Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans
Molly Craxton
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-259
Abstract: I collected and compared plant Syt-like sequences from the primary nucleotide sequence databases at NCBI. The collection comprises six groups of plant genes conserved in embryophytes: NTMC2Type1 to NTMC2Type6. I collected and compared metazoan FAM62 sequences and identified some similar sequences from other eukaryotic lineages. I found evidence of RNA editing and alternative splicing. I compared the intron patterns of Syt genes. I also compared Rabphilin and Doc2 genes.Genes encoding proteins with N-terminal-transmembrane-C2 domain architectures resembling synaptotagmins, are widespread in eukaryotes. A collection of these genes is presented here. The collection provides a resource for studies of intron evolution. I have classified the collection into homologous gene families according to distinctive patterns of sequence conservation and intron position. The evolutionary histories of these gene families are traceable through the appearance of family members in different eukaryotic lineages. Assuming an intron-rich eukaryotic ancestor, the conserved intron patterns distinctive of individual gene families, indicate independent origins of Syt, FAM62 and NTMC2 genes. Resemblances among these large, multi-domain proteins are due not only to shared ancestry (homology) but also to convergent evolution (analogy). During the evolution of these gene families, duplications and other gene rearrangements affecting domain composition, have occurred along with sequence divergence, leading to complex family relationships with accordingly complex functional implications. The functional homologies and analogies among these genes remain to be established empirically.Synaptotagmins (Syts) share a common structure: an N-terminal transmembrane (TM) sequence followed by a variable length linker and two tandem, distinctly conserved C2 domains, C2A and C2B. Syt1 [1] identified as a protein component of synaptic vesicles, is known to be required for nervous system function, acting crucially
A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes - an open access resource for neuroscience and evolutionary biology
Molly Craxton
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-37
Abstract: 46 metazoan genomes were examined and their complement of Syt, Esyt, Rph3a, Rph3al, Doc2 and Dblc2 genes identified. All of the sequences were compared, named, then examined in detail. Esyt genes were formerly named Fam62. The species in this collection are Trichoplax, Nematostella, Capitella, Helobdella, Lottia, Ciona, Strongylocentrotus, Branchiostoma, Ixodes, Daphnia, Acyrthosiphon, Tribolium, Nasonia, Apis, Anopheles, Drosophila, Caenorhabditis, Takifugu, Tetraodon, Gasterosteus, Oryzias, Danio, Xenopus, Anolis, Gallus, Taeniopygia,Ornithorhynchus, Monodelphis, Mus and Homo. All of the data described in this paper is available as additional files.Only a subset of synaptotagmin proteins appear able to function as calcium triggers. Syt1, Syt7 and Syt9 are ancient conserved synaptotagmins of this type. Some animals carry extensive repertoires of synaptotagmin genes. Other animals of no less complexity, carry only a small repertoire. Current understanding does not explain why this is so. The biological roles of many synaptotagmins remain to be understood. This collection of genes offers prospects for fruitful speculation about the functional roles of the synaptotagmin repertoires of different animals and includes a great range of biological complexity. With reference to this gene collection, functional relationships among Syt, Esyt, Rph3a, Rph3al, Doc2 and Dblc2 genes, which encode similar proteins, can better be assessed in future.Synaptotagmin (Syt) proteins participate in regulated membrane fusion events in multicellular organisms. Syt research dates back to 1981, when the first Syt was identified as an integral protein of synaptic vesicles [1]. Since then, much effort has gone into discovering the function and the detailed mechanism of action of this protein, Syt1. Numerous experimental approaches have shown that Syt1 is crucially involved in fast neurotransmitter release at synapses [reviewed in [2-6]]. Syt1 binds calcium, serving as the calcium sensor which tr
Synaptotagmin gene content of the sequenced genomes
Molly Craxton
BMC Genomics , 2004, DOI: 10.1186/1471-2164-5-43
Abstract: I have compiled a detailed list of the Synaptotagmin genes of Caenorhabditis, Anopheles, Drosophila, Ciona, Danio, Fugu, Mus, Homo, Arabidopsis and Oryza by examining genomic and transcript sequences from public sequence databases together with some transcript sequences obtained by cDNA library screening and RT-PCR. I have compared all of the genes and investigated the relationship between plant Synaptotagmins and their non-Synaptotagmin counterparts.I have identified and compared 98 Synaptotagmin genes from 10 sequenced genomes. Detailed comparison of transcript sequences reveals abundant and complex variation in Synaptotagmin gene expression and indicates the presence of Synaptotagmin genes in all animals and land plants. Amino acid sequence comparisons indicate patterns of conservation and diversity in function. Phylogenetic analysis shows the origin of Synaptotagmins in multicellular eukaryotes and their great diversification in animals. Synaptotagmins occur in land plants and animals in combinations of 4–16 in different species. The detailed delineation of the Synaptotagmin genes presented here, will allow easier identification of Synaptotagmins in future. Since the functional roles of many of these genes are unknown, this gene collection provides a useful resource for future studies.Synaptotagmin (Syt) 1 was initially found as a protein component of synaptic vesicles [1]. New members of the Syt gene family have subsequently been discovered by DNA sequence similarity [2-15]. Syts encode proteins which share a common structure: an N-terminal transmembrane sequence joined to a variable length linker, followed by two tandemly arranged, distinct C2 domains, C2A and C2B. At present, a great deal more is known about Syt1 than the other Syts because it functions crucially in synaptic vesicle trafficking in the nervous systems of animals [16]. Other Syts are implicated in trafficking events in the nervous system as well as in various other tissues [17,18]. Certain Syts
Whether Earthquakes are Loveable: Knowing Nature in the Wake of Disaster
Molly Sturdevant
Perspectives : International Postgraduate Journal of Philosophy , 2012,
Abstract: This essay examines the question of whether and how philosophical thinking is equipped to countenance in a meaningful way what for Spinoza is nature’s brutally manifest indifference to whether one likes it or not. Nature’s indifference to human pleasure, as well as its uniquely unsettling challenge for conceptualization, must be investigated if nature is to be a meaningful category for environmental ethics. In search of a way to conceptualize nature as it is, I take up an explication of key passages from Spinoza’s Ethics, and thereby maintain that earthquakes are “lovable.” I hold this position to be true for two reasons. In brief, earthquakes areontologically contiguous with the same power and force whereby all entities are maintained; secondly, love, understood intellectually and through a Spinozistic lens, is that modality of relating which understands power primordially and is able to act ethically without belaboring judgments of pleasure or pain, or even holding nature at a distance in order to revere it as something to save.
TheDigitalShift:HoweBooksande-ContentAreChangingReadersandLibraries
Molly Raphael
中国图书馆学报 , 2013,
Abstract: 此文为英文,以作者2012年11月在华期间的演讲稿为基础形成。编译后的中文版在《中国图书馆学报》2013年第1期发表,题为《数字化转变:电子书和电子内容对读者和图书馆的影响》。此英文版一并放在网络上供读者对比阅读。
creatingadigitalpreservationnetworkwithsharedstewardshipandcost:theexperienceofpartnershipsinthenationaldigitalinformationinfrastructureandpreservationprogram
molly,johnson
现代图书情报技术 , 2008,
Abstract: ?thenationaldigitalinformationinfrastructureandpreservationprogram(ndiipp)wasinitiatedindecember2000whentheu.s.congressauthorizedthelibraryofcongresstoworkwithabroadrangeofinstitutionstodevelopanationalstrategyforthepreservationofimportantat-riskborndigitalcontent.guidedbyastrategyofbroadcollaborationsanditerativelearning,thelibraryofcongressbegancatalyzinganationalnetworkofpartnersdedicatedtocollectingandpreservingimportantborn-digitalinformation.overthelastsixyears,thelibraryanditspartnershavebeenengagedinlearningthroughaction.ourinvestmentsinpreservationpartnerships,publicpolicydeliberationsrelatedtointellectualpropertychallenges,basictechnicalresearch,andnetworkarchitecturemodelshaveincreasedourunderstandingofthesustainingrolesandfunctionsforanationalnetworkofdiversestakeholders.theemergingnetworkofnetworksiscomplexandinclusiveofavarietyofstakeholders:contentproducers,contentstewardsandserviceprovidersfromthepublicandprivatesectors.
Creating a Digital Preservation Network with Shared Stewardship and Cost: The Experience of Partnerships in the National Digital Information Infrastructure and Preservation Program
MOLLY JOHNSON,
MOLLY
,JOHNSON

现代图书情报技术 , 2008,
Abstract: The National Digital Information Infrastructure and Preservation Program (NDIIPP) was initiated in December 2000 when the U.S. Congress authorized the Library of Congress to work with a broad range of institutions to develop a national strategy for the preservation of important at-risk born digital content. Guided by a strategy of broad collaborations and iterative learning, the Library of Congress began catalyzing a national network of partners dedicated to collecting and preserving important born-digital information. Over the last six years, the Library and its partners have been engaged in learning through action. Our investments in preservation partnerships, public policy deliberations related to intellectual property challenges, basic technical research, and network architecture models have increased our understanding of the sustaining roles and functions for a national network of diverse stakeholders. The emerging network of networks is complex and inclusive of a variety of stakeholders: content producers, content stewards and service providers from the public and private sectors.
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