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Search Results: 1 - 10 of 408463 matches for " Teresa M Gunn "
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Functional annotation and ENU
Teresa M Gunn
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-580
Identification and preliminary characterization of mouse Adam33
Teresa M Gunn, Arezou Azarani, Philip H Kim, Richard W Hyman, Ronald W Davis, Gregory S Barsh
BMC Genetics , 2002, DOI: 10.1186/1471-2156-3-2
Abstract: In a 48 kb region of mouse DNA adjacent to the Attractin gene on mouse chromosome 2, we identified sequences very similar to human ADAM33. A full-length mouse cDNA was identified by a combination of gene prediction programs and RT-PCR, and the probable full-length human cDNA was identified by comparison to human genomic sequence in the homologous region on chromosome 20p13. Mouse ADAM33 is 44% identical to Xenopus laevis ADAM13, however a phylogenetic alignment and consideration of functional domains suggests that the two genes are not orthologous. Mouse Adam33 is widely expressed, most highly in the adult brain, heart, kidney, lung and testis.While mouse ADAM33 is similar to Xenopus ADAM13 in sequence, further examination of its embryonic expression pattern, catalytic activity and protein interactions will be required to assess the functional relationship between these two proteins. Adam33 is expressed in the mouse adult brain and could play a role in complex processes that require cell-cell communication.The metalloprotease-disintegrin family of proteins (called ADAMs, or MDC proteins) consists of over 30 members identified in various species. These proteins are membrane-anchored glycoproteins, named for two of the motifs they carry: adisintegrin domain, and ametalloprotease domain [1]. ADAM proteins also contain a single transmembrane domain, a C-rich region and an EGF-like repeat. These domains suggest roles in adhesive interactions, cell fusion, proteolysis and/or intracellular signaling and implicate this family of proteins in numerous biological processes including fertilization, neurogenesis, myoblast fusion, and protein-ectodomain shedding of cytokines and other cell surface proteins [2-5]. While some ADAM proteins, such as Kuzbanian (ADAM 10) and TACE (ADAM 17), have active metalloprotease domains and are thought to be required for proteolytic processing of other proteins [3,6,7], other ADAM proteins, including fertilin β, do not have active metalloproteas
A Comparative Study of Medium Access Control Protocols for Wireless Sensor Networks  [PDF]
Meghan GUNN, Simon G. M. KOO
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2009, DOI: 10.4236/ijcns.2009.28080
Abstract: One of the major constraints in wireless sensor networks (WSNs) is power consumption. In recent years, a lot of efforts have been put into the design of medium access control (MAC) protocols for WSN, in order to reduce energy consumption and enhance the network’s lifetime. In this paper, we surveyed some MAC protocols for WSN and compared their design tradeoffs. The goal is to provide a foundation for future MAC design, and to identify important design issues that allow us to improve the overall performances.
Levels of the Mahogunin Ring Finger 1 E3 Ubiquitin Ligase Do Not Influence Prion Disease
Derek Silvius, Rose Pitstick, Misol Ahn, Delisha Meishery, Abby Oehler, Gregory S. Barsh, Stephen J. DeArmond, George A. Carlson, Teresa M. Gunn
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055575
Abstract: Prion diseases are rare but invariably fatal neurodegenerative disorders. They are associated with spongiform encephalopathy, a histopathology characterized by the presence of large, membrane-bound vacuolar structures in the neuropil of the brain. While the primary cause is recognized as conversion of the normal form of prion protein (PrPC) to a conformationally distinct, pathogenic form (PrPSc), the cellular pathways and mechanisms that lead to spongiform change, neuronal dysfunction and death are not known. Mice lacking the Mahogunin Ring Finger 1 (MGRN1) E3 ubiquitin ligase develop spongiform encephalopathy by 9 months of age but do not become ill. In cell culture, PrP aberrantly present in the cytosol was reported to interact with and sequester MGRN1. This caused endo-lysosomal trafficking defects similar to those observed when Mgrn1 expression is knocked down, implicating disrupted MGRN1-dependent trafficking in the pathogenesis of prion disease. As these defects were rescued by over-expression of MGRN1, we investigated whether reduced or elevated Mgrn1 expression influences the onset, progression or pathology of disease in mice inoculated with PrPSc. No differences were observed, indicating that disruption of MGRN1-dependent pathways does not play a significant role in the pathogenesis of transmissible spongiform encephalopathy.
Mapping spin-charge separation without constraints
J. I. Chandler,J. M. F. Gunn
Physics , 1997,
Abstract: The general form of a mapping of the spin and charge degrees of freedom of electrons onto spinless fermions and local `spin'-1/2 operators is derived. The electron Hilbert space is mapped onto a tensor productspin-charge Hilbert space. The single occupancy condition of the t-J model is satisfied exactly without the constraints between the operators required with slave particle methods and the size of the Hilbert space (four states per site) is conserved. The connection and distinction between the physical electron spin and the ``pseudospin'' used in these maps is made explicit. Specifically the pseudospin generates rotations both in spin space and particle-hole space. A geometric description (up to sign) is provided using two component spinors. The form of the mapped t-J Hamiltonian involves the coupling of spin and spinless fermion currents, as one expects.
`Baryonic' bound-state instability in trapped fermionic atoms
A. S. Stepanenko,J. M. F. Gunn
Physics , 1999,
Abstract: We consider a homogeneous gas of spin-S fermionic atoms, as might occur near the center of an optical trap. In the case where all scattering lengths are negative and of the same magnitude we demonstrate the instability of the Fermi sea to the condensation of bound `baryonic' composites containing 2S+1 atoms. The gap in the excitation spectrum is calculated.
Rotating molecules in optical lattices, alignment and monopole crystals
J. R. Holt,J. M. F. Gunn
Physics , 2007,
Abstract: The recent progress towards production of near-ground state quantum-degenerate molecules raises the issue of how such "small" molecules behave in an optical lattice. In this Letter we show that the coupling of the molecular orientation to the local electric field direction will provide severalnew phenomena. In the case where the lasers forming different crystallographic directions of the lattice are incoherent, the orientation of the molecules is conserved (for L = 1) and a novel form of anisotropic superfluidity can be expected. When the lasers are coherent, and the optical lattice is such that the splitting of the rotational levels is large compared to the centre of mass energies,an adiabaic description of the molecular orientation is appropriate. This leads to geometric vector potentials, pseudo-magnetic monopoles and a frustrated band structure with degenerate minima.
Fractional dimensional Hilbert spaces and Haldane's exclusion statistics
K. N. Ilinski,J. M. F. Gunn
Physics , 1995,
Abstract: We examine the notion of Haldane's dimension and the corresponding statistics in a probabilistic spirit. Motivated by the example of dimensional-regularization we define the dimension of a space as the trace of a diagonal `unit operator', where the diagonal matrix elements are not, in general, unity but are probabilities to place the system into a given state. These probabilities are uniquely defined by the rules of Haldane's statistics. We calculate the second virial coefficient for our system and demonstrate agreement with Murthy and Shankar's calculation. The partition function for an ideal gas of the particles, a state-counting procedure, the entropy and a distribution function for the particles are investigated using our probabilistic definition. We compare our results with previous calculations of exclusion statistics.
Fractional dimensional Fock space and Haldane's exclusion statistics. q/p case
K. N. Ilinski,J. M. F. Gunn
Physics , 1995, DOI: 10.1016/S0375-9601(96)80005-3
Abstract: The discussion of Fractional dimensional Hilbert spaces in the context of Haldane exclusion statistics is extended from the case \cite{IG} of $g=1/p$ for the statistical parameter to the case of rational $g=q/p$ with $q,p$-coprime positive integers. The corresponding statistical mechanics for a gas of such particles is constructed. This procedure is used to define the statistical mechanics for particles with irrational $g$. Applications to strongly correlated systems such as the Hubbard and $t-J$ models are discussed.
Instabilities and "phonons" of optical lattices in hollow optical fibers
N. K. Wilkin,J. M. F. Gunn
Physics , 2013,
Abstract: Instabilities are predicted for a sufficiently long hollow photonic optical fiber, or "cavity", containing a one dimensional Bose-gas in the presence of a classical, far red-detuned, confined weak electromagnetic mode. We examine both a single beam with Bose gas (a type of Brillouin instability) and the case of a standing wave, or optical lattice. The instabilities of these driven systems have pronounced spatial structure, of combined modulational instabilities in the electromagnetic and Bose density fields. Near the critical wave vectors for the instability the coupled modes of the BEC and light can be interpreted as "phonons" of the optical lattice. We conjecture these spatially-structured instabilities for the optical lattice, which we predict at weak fields, develop into the source of spatially homogeneous heating predicted for strong fields.
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