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Search Results: 1 - 10 of 1770 matches for " Tejas Patil "
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On the ontological assumptions of the medical model of psychiatry: philosophical considerations and pragmatic tasks
Tejas Patil, James Giordano
Philosophy, Ethics, and Humanities in Medicine , 2010, DOI: 10.1186/1747-5341-5-3
Abstract: In this paper, we explicate that realism, naturalism, reductionism, and essentialism are core ontological assumptions of the medical model of psychiatry. We argue that while naturalism, realism, and reductionism can be reconciled with advances in contemporary neuroscience, essentialism - as defined to date - may be conceptually problematic, and we pose an eidetic construct of bio-psychosocial order and disorder based upon complex systems' dynamics. However we also caution against the overuse of any theory, and claim that practical distinctions are important to the establishment of clinical thresholds. We opine that as we move ahead toward both a new edition of the Diagnostic and Statistical Manual, and a proposed Decade of the Mind, the task at hand is to re-visit nosologic and ontologic assumptions pursuant to a re-formulation of diagnostic criteria and practice.Psychiatry is uniquely problematic because debates over what mental disorders are have presented substantial challenges to medical praxis and ethics. In many ways, the question of what constitutes a mental disorder is related to uncertainties about the nature of mental experience, and the underlying relationship(s) of body, brain and mind. Traditionally, medicine has been successful in establishing etiology of diseases and disorders, and developing focal therapies based upon such mechanistic conceptualizations. The acts of medicine (i.e.- diagnosis, therapeutics, and prognosis) depend upon the ability to distinguish between what is "normal" and what is pathologic, and the evolution and practice of psychiatry has attempted to adopt and utilize the medical model in this regard.Yet, as neuroscience probes ever deeper into the workings of the brain, it becomes evident that the "mind" remains somewhat enigmatic, and thus, any attempt to link mental events to biology must confront what Chalmers has referred to as the "hard problem" of consciousness [1]. But given the continued ambiguity of the brain-mind relation
EFFECT OF AQUEOUS MACERATIVES OF SEED POWDER OF SYZIGIUM CUMINI (L) ON THE PROTEIN CONTENTS AND MID GUT ENZYME ACTIVITIES IN THE FIFTH INSTAR LARVAE OF SILK WORM, BOMBYX MORI (L) (RACE: PM X CSR2)
Tejas C Korade, Manali T Patil, Kavita H Nimbalkar
International Journal of Bioassays , 2013,
Abstract: Different concentrations (5.0 ppm; 10.0 ppm; 20.0 ppm & 50.0 ppm) of the aqueous solution of seed powder of Syzigium cumini (L) concentrations was used to treat the leaves of mulberry & fed to the fifth instar larvae of polyvoltine, crossbreed silkworm, Bombyx mori (L) (Race : PM x CSR2 ) for first three days; second day & third day; third day (only). The larvae fed with untreated & water treated leaves were also maintained. Bioassays of proteins (S.P. & T.P.) & enzymes (protease & amylase) were carried out on fifth day through the use of mid gut homogenate. Treating the mulberry leaves with herbal preparations (Syzigium cumini) & feeding them to fifth instar larvae was found reflected into significant improvement in the levels of proteins (S.P. & T.P.) & velocities of biochemical reactions catalyzed by protease & amylase. The pattern of increase in soluble proteins & total proteins in the mid gut tissue were 32.147 to 90.074 percent & 5.657 to 39.052 percent respectively. The activities of mid gut protease & amylase were increased by 21.444 to 83.706 percent and 14.54 to 52.257 percent respectively. The nutrient contents of seed powder of Syzigium cumini (L) serve to improve the digestibility & exert the influence of efficient metabolism in the fifth instar larvae of silkworm, Bombyx mori (L). The Syzigium seed powder treatment may gear overall biochemical constituency of silkworm larvae, through the significant improvement in the velocity of mid gut enzyme catalyzed biochemical reactions.
On Expressing the Probabilities of Categorical Responses as Linear Functions of Covariates  [PDF]
Tejas A. Desai
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411200
Abstract:

Logistic regression is usually used to model probabilities of categorical responses as functions of covariates. However, the link connecting the probabilities to the covariates is non-linear. We show in this paper that when the cross-classification of all the covariates and the dependent variable have no empty cells, then the probabilities of responses can be expressed as linear functions of the covariates. We demonstrate this for both the dichotmous and polytomous dependent variables.

Establishment of a Tongue Squamous Cell Carcinoma Cell Line from Indian Gutka Chewer
Tejas T. Patil,Pradnya K. Kowtal,Abhijeet Nikam,Madan S. Barkume,Asawari Patil,Shubhada V. Kane,Aarti S. Juvekar,Manoj B. Mahimkar,Jyoti J. Kayal
Journal of Oral Oncology , 2014, DOI: 10.1155/2014/286013
Abstract: CD cell line has been established from a poorly differentiated squamous cell carcinoma of tongue. This is a first ever cell line established from an Indian gutka chewer. Cell line was characterized for morphology, ultrastructure, doubling time, expression of epithelial markers, DNA content, karyotyping, STR markers, p53 mutations, HPV status, and tumorigenicity in SCID mice with all-trans-retinoic acid and cisplatin. The epithelial phenotype of the cell line was confirmed with surface markers and ultrastructure. The cell line is hyperploid with chromosomal alterations like gain of chromosomes 8q and 11q. CD cell line shows a unique pattern on STR genotyping and carries a missense mutation R273C in TP53. It does not show genomic integration of HPV. The cells are nontumorigenic to SCID mice and show growth inhibition upon treatment with cisplatin, and all-trans-retinoic acid. This cell line may be useful as an in vitro tool to understand the molecular changes associated with oral cancers. 1. Introduction Cancer of oral cavity is the third most common cancer in India (http://globocan.iarc.fr/Pages/online.aspx). The important risk factors identified so far are tobacco use and alcohol consumption, which seem to have a synergistic effect. Statistics for head and neck squamous cell cancers (HNSCCs) throughout the world show these cancers to be prevalent in areas where consumption of tobacco and alcohol is high [1]. The process of oral carcinogenesis is multifactorial with interplay of various environmental factors. Though treatment modalities have shown an advancement, the survival rates of oral cancer patients have not improved markedly over the past few decades [2]. Tumor derived cell lines form a useful resource as model systems with reflections of the original tumors [3]. Therefore, development of cell lines from tumor tissues will aid in understanding the events associated with development of cancer. Moreover, cell lines are required to study the effects of various known and novel drug formulations and help in studying future treatment strategies. In spite of these advantages, there are very few cell lines developed from Indian oral cancer patients [4–6]. We have established an oral cancer cell line CD from a young gutka chewer. Gutka is a dry mixture of areca nut, catechu, and slaked lime with tobacco. Due to its easy availability and low cost, it has become popular chewing substitute in young Indian tobacco habitués. Use of gutka has been strongly implicated in increased incidence of oral submucous fibrosis, a precancerous lesion, which has a high rate
Comparing two models that reduce the number of nephrology fellowship positions in the United States
Tejas Desai
PeerJ , 2015, DOI: 10.7287/peerj.preprints.592v1
Abstract: There has been a steady decline in the number of applications to nephrology training programs. One solution is to decrease the number of available fellowship positions. Proponents believe that training programs have grown too big but the method for reduction has not been established. This investigation analyzes two models that decrease the number of available training positions and compares them head-to-head to identify the least burdensome method by which this reduction should occur. In the survival of the fittest model (SotFM) fellowship positions are eliminated if they were unfilled in the National Residency Match Program’s (NRMP) 2013 Specialty Match. In the equal proportions model (EPM) a formula is used to calculate a priority score using ESRD prevalence data from the 2013 USRDS Report and the geometric mean between a given jurisdiction’s current apportionment (n) and its next position (n+1). The least burdensome model is that which results in the 1) least number of jurisdictions losing fellow positions and 2) lowest percent reduction for any single jurisdiction. There were 416 nephrology positions offered and 47 unfilled in 2013. In the SotFM, 23 jurisdictions would sacrifice these 47 positions. In the EPM, 369 positions were apportioned (=416-47); only 9 jurisdictions would experience a reduction. The largest single-jurisdiction reduction in fellow positions was 67% (SotFM) and 50% (EPM). The EPM results in a less burdensome reduction of fellow positions nationwide. The EPM is a time-tested model that injects fairness into the painful process of reducing the total number of fellow positions across America.
Comparing two models that reduce the number of nephrology fellowship positions in the United States
Tejas Desai
PeerJ , 2015, DOI: 10.7717/peerj.720
Abstract: There has been a steady decline in the number of applications to nephrology training programs. One solution is to decrease the number of available fellowship positions. Proponents believe that training programs have grown too big but the method for reduction has not been established. This investigation analyzes two models that decrease the number of available training positions and compares them head-to-head to identify the least burdensome method by which this reduction should occur. In the survival of the fittest model (SotFM) fellowship positions are eliminated if they were unfilled in the National Residency Match Program’s (NRMP) 2013 Specialty Match. In the equal proportions model (EPM) a formula is used to calculate a priority score using ESRD prevalence data from the 2013 USRDS Report and the geometric mean between a given jurisdiction’s current apportionment (n) and its next position (n + 1). The least burdensome model is that which results in the (1) least number of jurisdictions losing fellow positions and (2) lowest percent reduction for any single jurisdiction. There were 416 nephrology positions offered and 47 unfilled in 2013. In the SotFM, 23 jurisdictions would sacrifice these 47 positions. In the EPM, 369 positions were apportioned (=416–47); only 9 jurisdictions would experience a reduction. The largest single-jurisdiction reduction in fellow positions was 67% (SotFM) and 50% (EPM). The EPM results in a less burdensome reduction of fellow positions nationwide. The EPM is a time-tested model that injects fairness into the painful process of reducing the total number of fellow positions across America.
Euler characteristic and quadrilaterals of normal surfaces
Tejas Kalelkar
Mathematics , 2008, DOI: 10.1007/s12044-008-0015-7
Abstract: Let $M$ be a compact 3-manifold with a triangulation $\tau$. We give an inequality relating the Euler characteristic of a surface $F$ normally embedded in $M$ with the number of normal quadrilaterals in $F$. This gives a relation between a topological invariant of the surface and a quantity derived from its combinatorial description. Secondly, we obtain an inequality relating the number of normal triangles and normal quadrilaterals of $F$, that depends on the maximum number of tetrahedrons that share a vertex in $\tau$.
Incompressibility and normal minimal surfaces
Tejas Kalelkar
Mathematics , 2008,
Abstract: In this paper we describe a procedure for refining the given triangulation of a 3-manifold that scales the PL-metric according to a given weight function while creating no new normal surfaces. It is known that an incompressible surface $F$ in a triangulated 3-manifold $M$ is isotopic to a normal surface that is of minimal PL-area in the isotopy class of $F$. Using the above scaling refinement we prove the converse. If $F$ is a surface in a closed 3-manifold $M$ such that for any triangulation $\tau$ of $M$, $F$ is isotopic to a $\tau$-normal surface $F(\tau)$ that is of minimal PL-area in its isotopy class, then we show that $F$ is incompressible.
Synthesis and Characterization of novel 6-[3,5-bis(trifluoromethyl)phenyl]-4-(substitutedphenyl)-1,4-dihydropyrimidin-2-ol
Tejas Vyas,Kartik Vyas
International Journal For Pharmaceutical Research Scholars , 2012,
Abstract: Synthesis of various pyrimidines 3(a-o) from (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted)phenylprop-2-en-1-one and Urea in presence of NaOH. The structures of the synthesized compounds were confirmed on the basis of spectral and elemental analysis. The synthesized compounds were screened for antimicrobial activity.
Synthesis and Characterization of novel 4-[3,5-bis(trifluoromethyl)phenyl]-6-(Substituted phenyl)-1,6-dihydropyrimidine-2-thiol
Tejas Vyas,Kartik Vyas
International Journal For Pharmaceutical Research Scholars , 2012,
Abstract: Synthesis of various dihydropyrimidine-2-thiol from (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(substituted)phenylprop-2-en-1-one and thiourea in presence of NaOH. The structures of thesynthesized compounds were confirmed on the basis of spectral and elemental analysis.
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