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Search Results: 1 - 10 of 328630 matches for " Taylor S Blachley "
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Age distribution, polyps and rectal cancer in the Egyptian population-based cancer registry
Darlene Veruttipong,Amr S Soliman,Samuel F Gilbert,Taylor S Blachley
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i30.3997
Abstract: AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population’s statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER) data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105) while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively). The vast majority of tumors (97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55%) than rural (45%) areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.
Risk Factors for Chronic Mastitis in Morocco and Egypt
Hanna N. Oltean,Amr S. Soliman,Omar S. Omar,Tamer F. Youssef,Mehdi Karkouri,Azza Abdel-Aziz,Ahmad Hablas,Taylor Blachley,Ali Tahri,Sofia D. Merajver
International Journal of Inflammation , 2013, DOI: 10.1155/2013/184921
Abstract: Chronic mastitis is a prolonged inflammatory breast disease, and little is known about its etiology. We identified 85 cases and 112 controls from 5 hospitals in Morocco and Egypt. Cases were women with chronic mastitis (including periductal, lobular, granulomatous, lymphocytic, and duct ectasia with mastitis). Controls had benign breast disease, including fibroadenoma, benign phyllodes, and adenosis. Both groups were identified from histopathologically diagnosed patients from 2008 to 2011, frequency-matched on age. Patient interviews elicited demographic, reproductive, breastfeeding, and clinical histories. Cases had higher parity than controls (OR = 1.75, 1.62–1.90) and more reported history of contraception use (OR = 2.73, 2.07–3.61). Cases were less likely to report wearing a bra (OR = 0.56, 0.47–0.67) and less often used both breasts for breastfeeding (OR = 4.40, 3.39–5.72). Chronic mastitis cases were significantly less likely to be employed outside home (OR = 0.71, 0.60–0.84) and more likely to report mice in their households (OR = 1.63, 1.36–1.97). This is the largest case-control study reported to date on risk factors for chronic mastitis. Our study highlights distinct reproductive risk factors for the disease. Future studies should further explore these factors and the possible immunological and susceptibility predisposing conditions. 1. Introduction Chronic mastitis (CM) is a group of diseases characterized by chronic inflammation of the breast, affecting mainly women of reproductive age in their fourth decade [1–3]. CM is histopathologically defined as inflammation of the breast, with the microabscess formation and/or the presence of granulomas [1]. This disease generally involves the breast unilaterally and may affect every quadrant region except for the subareolar area [2]. Cases mainly present with a breast mass, which may involve the overlying skin or penetrate the underlying pectoralis muscle with nipple retraction, sinus formation, and axillary lymphadenopathy [1]. Other symptoms may include galactorrhea, inflammation, pain, peau d’orange, tumorous indurations, nipple retraction and/or discharge, diffuse heaviness and enlargement, and ulcerations of the skin [4]. The disease may be locally aggressive with a recurrence rate between 16% and 50% [1]. Due to this variable clinical presentation and these similarities in symptoms as well as clinical and radiological findings with inflammatory breast cancer, diagnosis is difficult and must be confirmed histopathologically after surgical excision or core biopsy [1]. Diagnosis of CM should be
What Is Innovation? A Study of the Definitions, Academic Models and Applicability of Innovation to an Example of Social Housing in England  [PDF]
S. P. Taylor
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.511010
Abstract:
Throughout history innovation has been conceived, defined, interpreted and understood in different ways but what is it? This study looks at innovation starting with a brief history of innovation. It then looks at a sample of the multiple definitions that there are of innovation throughout the literature and from these develops a composite definition. From this composite definition, key components such as the creative process and academic models of creativity are looked at. The research then looks at the applicability of innovation through highlighting two studies carried out in England of innovation being applied within a social housing organisation. Through the application by a two dimensional typology of social innovation they had identified innovation being applied to new services and improvements to existing services. The research concludes that innovation can be identified with the creation of a new product or service or an improvement of an existing product or service.
Stress Concentrations for Slotted Plates in Bi-Axial Stress  [PDF]
D. W. A. Rees, Bahai, S. Taylor
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.42009
Abstract: The photo-elastic method has been employed to determine stress concentration factor (SCF) for square plates containing holes and inclined slots when the plate edges are subjected to in-plane tension combined with compression. Analyses given of the isochromatic fringe pattern surrounding the hole provides the SCF conveniently. The model material is calibrated from the known solution to the stress raiser arising from a small circular hole in a plate placed under biaxial tension-compression. These results also compare well with a plane stress FE analysis. Consequently, photo-elasticity has enabled SCF’s to be determined experimentally for a biaxial stress ratio, nominally equal to –4, in plates containing a long, thin slot arranged to be in alignment with each stress axis. The two, principal stresses lying along axes of symmetry in the region surrounding the notch are separated within each isochromatic fringe by the Kuske method [1]. FE provides a comparable full-field view in which contours of maximum shear stress may be identified with the isochromatic fringe pattern directly. The principal stress distributions referred to the plate axes show their maximum concentrations at the notch boundary. Here up to a fourfold magnification occurs in the greater of the two nominal stresses under loads applied to the plate edges. Thus, it is of importance to establish the manner in which the tangential stress is distributed around the slot boundary. Conveniently, it is shown how this distribution is also revealed from an isochro-matic fringe pattern, within which lie the points of maximum tension and maximum compression.
Behavior Intervention Flow Chart: A Strategic Tool for Managing Challenging Behaviors  [PDF]
Shanon S. Taylor, Tammy V. Abernathy
Creative Education (CE) , 2016, DOI: 10.4236/ce.2016.716232
Abstract: Research has determined that behavioral intervention plans (BIP) based on functional behavioral assessments (FBA) are the most effective interventions for problem behavior in K-12 classrooms. Special education teachers generally learn the FBA/BIP process in preservice behavior management courses. However, most general education teachers take more generic classroom management classes. General education teachers are not typically required to take courses focused on managing challenging behavior and often do not receive preservice or inservice training in behavioral supports. This article will review the use of the Behavior Intervention Flow Chart (BIFC), initially developed as a tool to be used to teach behavioral decision-making skills to preservice teachers in a university class.
More biology from the sequence
Martin S Taylor
Genome Biology , 2001, DOI: 10.1186/gb-2001-2-8-reports4018
Abstract: We are now clearly within the genomic era. Large-scale sequencing centers are running efficiently and are able to churn out several fold coverage of a eukaryotic genome by shotgun sequencing in a few months. This is an impressive technical and logistical tour de force, but for genome biology as a whole it represents just the data-acquisition phase. The shift from a data-starved field with a need for better sequencing-related technologies to a field with an avalanche of data and the need to interpret it has been reflected over the past few years by the changing emphasis at the annual Cold Spring Harbor Genome Sequencing and Biology meeting. Predictably, finishing and annotating the human genome was a major discussion point this year. The other big themes were comparative genomics, highly parallel investigations of gene expression and function, and the variability of genomes.Although not immediately obvious from the title, this meeting has traditionally had a substantial slant towards eukaryotes and particularly humans. Although that trend continued this year, the genomes of other organisms have also been sharing the center stage. Of particular note was the entertaining keynote speech by Paul Nurse (Imperial Cancer Research Fund, London, UK) announcing the completion of the Schizosaccharomyces pombe genome. Unusually but not uniquely for a eukaryotic genome, 'complete' means finished in this case; it is all there, from one end of each chromosome to the other, without gaps.It is widely 'known' that the human genome is finished; it has been on many news reports, and in the newspapers there have even been heads of state patting their own backs for the achievement. It was, then, interesting to hear the progress being made in the actual finishing and assembly of the human genome. Ian Dunham (Sanger Centre, Hinxton, UK) reported the progress in filling the gaps in the human chromosome 22 sequence (the second human chromosome to be 'finished'). When published last year, ther
Three in one: safety, efficacy, and patient acceptability of triple fixed-dose combination medicine in the management of hypertension
Taylor AA, Ragbir S
Patient Preference and Adherence , 2012, DOI: http://dx.doi.org/10.2147/PPA.S14764
Abstract: ee in one: safety, efficacy, and patient acceptability of triple fixed-dose combination medicine in the management of hypertension Review (1697) Total Article Views Authors: Taylor AA, Ragbir S Published Date August 2012 Volume 2012:6 Pages 555 - 563 DOI: http://dx.doi.org/10.2147/PPA.S14764 Received: 18 May 2012 Accepted: 07 July 2012 Published: 01 August 2012 Addison A Taylor, Shawn Ragbir Department of Medicine, Baylor College of Medicine, Houston, TX, USA Abstract: Hypertensive patients whose blood pressures are more than 20 mmHg above their goal will often require three or more medications. Careful selection of medications whose actions are complementary or have an improved adverse effect profile when combined can affect not only the blood pressure but also patient acceptance, thus improving persistence in taking the medications as prescribed. This review will highlight the three single-pill three-drug combinations currently available in the US and will address their efficacy, safety, and tolerability. All three include the dihydropyridine calcium-channel blocker, amlodipine, and the thiazide diuretic, hydrochlorothiazide. They each contain a different renin–angiotensin system blocker. One includes the angiotensin-receptor blocker, olmesartan, while another contains valsartan. The third combination includes the direct renin inhibitor, aliskiren. All three fixed-dose combinations (FDC) at maximum doses of each component lowers the blood pressure of patients with stage II hypertension by 37 to 40 mmHg systolic and 21 to 25 mmHg diastolic, which is superior to any two of the components that comprise the three-drug FDC. These drugs are effective in males and females, the elderly, diabetics, minority populations, and patients with metabolic syndrome. Triple-drug FDCs are well tolerated with a low incidence of adverse effects, the most common being peripheral edema related to amlodipine. Extrapolation of data from two-drug FDC suggests that medication compliance (adherence and persistence) should be better with these FDCs than with the individual components taken as separate medications, although additional studies are necessary to confirm this.
Three in one: safety, efficacy, and patient acceptability of triple fixed-dose combination medicine in the management of hypertension
Taylor AA,Ragbir S
Patient Preference and Adherence , 2012,
Abstract: Addison A Taylor, Shawn RagbirDepartment of Medicine, Baylor College of Medicine, Houston, TX, USAAbstract: Hypertensive patients whose blood pressures are more than 20 mmHg above their goal will often require three or more medications. Careful selection of medications whose actions are complementary or have an improved adverse effect profile when combined can affect not only the blood pressure but also patient acceptance, thus improving persistence in taking the medications as prescribed. This review will highlight the three single-pill three-drug combinations currently available in the US and will address their efficacy, safety, and tolerability. All three include the dihydropyridine calcium-channel blocker, amlodipine, and the thiazide diuretic, hydrochlorothiazide. They each contain a different renin–angiotensin system blocker. One includes the angiotensin-receptor blocker, olmesartan, while another contains valsartan. The third combination includes the direct renin inhibitor, aliskiren. All three fixed-dose combinations (FDC) at maximum doses of each component lowers the blood pressure of patients with stage II hypertension by 37 to 40 mmHg systolic and 21 to 25 mmHg diastolic, which is superior to any two of the components that comprise the three-drug FDC. These drugs are effective in males and females, the elderly, diabetics, minority populations, and patients with metabolic syndrome. Triple-drug FDCs are well tolerated with a low incidence of adverse effects, the most common being peripheral edema related to amlodipine. Extrapolation of data from two-drug FDC suggests that medication compliance (adherence and persistence) should be better with these FDCs than with the individual components taken as separate medications, although additional studies are necessary to confirm this.Keywords: calcium-channel blockers, hypertension, patient tolerability, renin–angiotensin system antagonists, safety, triple-drug combinations
Small flow rate can supply inwardly migrating shortest-period planets
Taylor S.F.
EPJ Web of Conferences , 2013, DOI: 10.1051/epjconf/20134702003
Abstract: The number of exoplanets found with periods as short as one day and less was surprising given how fast these planets had been expected to migrate into the star due to the tides raised on the star by planets at such close distances. It has been seen as improbable that we would find planets in such a small final fraction of their lives [1]. The favored solution has been that the tidal dissipation is much weaker than expected, which would mean that the final infall would be a larger fraction of the planets’ life. We find no reason, however, to exclude the explanation that a small number of planets are continuously sent migrating inwards such that these planets indeed are in the last fraction of their lives. Following the observation that the distribution of medium planets disfavors tidal dissipation being significantly weaker than has been found from observations of binary stars [2], we now show that the numbers of planets in such a “flow” of excess planets migrating inwards is low enough that even depletion of the three-day pileup is a plausible source. Then the shortest period occurrence distribution would be shaped by planets continuously being sent into the star, which may explain the depletion of the pileup in the Kepler field relative to the solar neighborhood [3]. Because Kepler observes above the galactic plan, [3] suggested the Kepler field may include an older population of stars. The tidal dissipation strength in stars due to giant planets may be not greatly weaker than it is in binary stars.
Self-consistent Gravitational Lens Reconstruction
S. Dye,A. Taylor
Physics , 1998, DOI: 10.1046/j.1365-8711.1998.02056.x
Abstract: We present a new method for directly determining accurate, self-consistent cluster lens mass and shear maps in the strong lensing regime from the magnification bias of background galaxies. The method relies upon pixellisation of the surface mass density distribution which allows us to write down a simple, solvable set of equations. We also show how pixellisation can be applied to methods of mass determination from measurements of shear and present a simplified method of application. The method is demonstrated with cluster models and applied to magnification data from the lensing cluster Abell 1689.
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