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PHYSICOCHEMICAL CHARECTARIZATION OF VANGA BHASMA
Lagad C. E.,Sawant R. S.,Tayade A. N.,Wadodkar D. S.
International Research Journal of Pharmacy , 2013,
Abstract: Bhasma is very effective when prepared by appropriate method and used in accurate therapeutic dose. Vanga Bhasma [VB]is being used in genitor-urinary disorders since long in Ayurveda. The pharmaceutical processing of VB was performed by four steps i.e. Samanya Shodhana, Vishesh Shodhana, Jarana&Marana.To assure the quality of bhasma,rasa shastra quality control tests like rekhapurna, varitara, Niruttha, etc., were used. After the bhasma complied with these tests, the bhasma was analyzed [Physcicochemical characterization] using ICP-AES, X-ray Diffraction (XRD) revealed that Vanga bhasma contains major compound SnO2and Thermo Gravimetric analysis (TGA) with DTA showed no weight loss and no physical or chemical changes so it can be an alternative and supportive to Niruttha Pariksha. It may be concluded that raw Vanga is a Simple compound which gets converted into a mixture of complex compounds after the particular process of marana.
Study of Rotifers for bio-monitoring the organic pollution of the Tipeshwar lake of Tipeshwar wild life sanctuary
RAJANI N. TAYADE
Golden Research Thoughts , 2012, DOI: 10.9780/22315063
Abstract: Rotifers are used as indicators for the assessment of water quality of the aquatic ecosystem to follow the trends in changes of water quality. Their reproductive cycle is short enough to enable the study through several generations in a relatively short time and respond more rapidly to environmental changes than fishes, which have been traditionally used as indicators of water quality. Due to their important role in fast emerging concept of environmental management as bio-indicators and bio-monitors Khan and Sheshagiri Rao (1981), Mahajan (1981).Their abundance in diversity and distribution are important parameters in understanding tropodynamic and tropic progression of water bodies for quality assessment (Mathew, 1975, Verma and Munshi, 1987). The Tipeshwar Lake is situated between 19°53'44.23"N 78°30'37.06"E of the Deccan peninsular Ever increasing pressure of community needs over this lake causes its deterioration, decomposition of large amount of organic matter cause oxygen depletion produces toxic gases and greatly deteriorates the water quality and hence increases in Zooplanktonic (Rotifer) pollution indicator species. Population and types of these species are significant parameters in monitoring the extent of pollution in this water body and useful in drawing sustainable wetland management strategies. So that it would help in future planning for the reclamation.
Development and evaluation of artemether parenteral microemulsion
Tayade N,Nagarsenker Mangal
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: The objective of the present investigation was to develop a parenteral microemulsion delivering artemether, a hydrophobic antimalarial drug and to evaluate antimalarial activity of the microemulsion in comparison to the marketed oily injection of artemether (Larither ). The microemulsion was evaluated for various parameters such as globule size, ability to withstand centrifugation and freeze-thaw cycling and effect of sterilization method on the drug content and globule size. The in vivo antimalarial activity of the microemulsion was evaluated in P. berghei infected mice in comparison to the Larither . The stability of the microemulsion was evaluated at 5o for 1 month. The microemulsion exhibited globule size of 113 nm and it could successfully withstand centrifugation and freeze-thaw cycling. The method of sterilization did not have any significant effect on the artemether content and globule size of the microemulsion. The microemulsion showed around 1.5-fold higher antimalarial activity and higher survival as compared to that of marketed artemether injection Larither and it showed a good stability at the end of 1 month.
A comparative solubility enhancement profile of valdecoxib with different solubilization approaches
Modi A,Tayade P
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: Solubility enhancement of poorly aqueous soluble drug is an important aspect of formulation development. Although there is plethora of reports of solubility improvement using different techniques, a comparative study of different solubilization approaches are few. Valdecoxib chemically designated as 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonamide is a novel potent COX-2 inhibitor having poor aqueous solubility (10 mg/ml). Since it is poorly water-soluble, various techniques could be applied to increase its aqueous solubility. Objective of present study was to provide a comparison of effect of various solubilization techniques, namely micellar solubilization, cyclodextrin complexation and cosolvency, on solubility of valdecoxib. Solubility of valdecoxib was determined in various ionic and nonionic surfactants using phase solubility analysis. Similar type of study was performed using different water:cosolvent mixture. In addition, solubility improvement by use of 2 novel hydrophilic β -cyclodextrin derivatives, hydroxypropyl β -cyclodextrin and sulfobutyl ether-7-β -cyclodextrin was examined. Results showed that highest solubility (70 fold) was achieved with use of Cremophor EL followed by Tween 80 and sulfobutyl ether-7-β -cyclodextrin. It was found that surfactants with higher HLB values were better solubilizers. Solubilization capacity was found to increase with increase in hydrocarbon chain of surfactant, suggesting hydrocarbon core of micelles as locus of solubilization. Similarly, less polar solvents were found to increase solubility by greater extent, thus accentuating hydrophobic interaction mechanism. Among cyclodextrin, higher binding constant and solubility enhancement was obtained by use of sulfobutyl ether-7-β -cyclodextrin. Thus, the study generated an important dataset so as to compare effect of various solubilizers on solubility of valdecoxib.
Characteristic of style: sentence– length
Tayade A.Y.,Prabhu-Ajgaonkar S.G.
Advances in Computational Research , 2009,
Abstract: This paper is a contribution to stylostatistics which has, as a discipline, established itself in therecent years. We have considered probability distribution to the data of sentence-length collected from thebook of late Pandit Jawaharlal Nehru.
Green Synthesis of Acid Esters from Furfural via Stobbe Condensation
Shubhra Banerjee,Ravibabu A. Tayade,Bhagyashree D. Sharma
Journal of Chemistry , 2013, DOI: 10.1155/2013/152370
Abstract:
Magnetization reversal in exchange-spring bilayer system under circularly polarized microwave field
R Tayade,A Pasko,C Serpico,F Mazaleyrat,M Lobue
Physics , 2015, DOI: 10.1109/TMAG.2014.2325059
Abstract: Microwave assisted magnetization reversal are studied in the bulk bilayer exchange coupled system. We investigate the nonlinear magnetization reversal dynamics in a perpendicular exchange spring media using Landau-Lifshitz equation. In the limit of the infinite thickness of the system, the propagation field leads the reversal of the system. The reduction of the switching field and the magnetization profile in the extended system are studied numerically. The possibility to study the dynamics analytically is discussed and an approximation where two P-modes are coupled by an interaction field is presented. The ansatz used for the interaction field is validated by comparison with the numerical results. This approach is shown to be equivalent to two exchange coupled macrospins.
THE SIGNIFICANCE OF MECONIUM STAINED AMNIOTIC FLUID – A CROSS SECTIONAL STUDY IN A RURAL SETUP
Surekha Tayade
International Journal of Biomedical and Advance Research , 2013, DOI: 10.7439/ijbar.v3i12.838
Abstract: Background: The significance of meconium in amniotic fluid is a widely debated subject. Traditionally meconium has been viewed as a harbinger of impending or ongoing fetal compromise; however some investigators believe that it is not associated with fetal hypoxia, acidosis or fetal distress. Others have found lower Apgar scores in meconium stained neonates. Objectives: To study the correlation of meconium in amniotic fluid with perinatal outcome. Methods: 120 consecutive, term, labouring women with meconium stained amniotic fluid on spontaneous/artificial rupture of membranes were monitored during labour with fetal heart rate abnormalities, one and five minute apgar score , umbilical cord pH at birth and neonatal complications, as outcome variables. Results:. Fetal heart rate variations were more often in cases with thick meconium (86.36%) than with thin meconium (9.75%%) (p value < 0.005). Thick meconium group neonates had lower Apgar scores as compared to moderate and thin meconium group. The umbilical cord blood pH was below 7.2 in 4(11.4%) neonates of thin meconium, 15(42.85%) in moderate meconium g and 30(68.18%) in thick meconium group (P value below 0.001). Neonatal complications were found in 36.36% of thick meconium group as compared to 14.28% of moderate meconium and none in thin meconium. Conclusions: Thick meconium should suggest immediate intervention, need for skilled paediatrician at the time of delivery and intensive care in the neonatal period to give a positive outcome
Are Natural Killer Cells Distributed in Relationship to Nerve Fibers in the Pregnant Mouse Uterus?
A.K. Sheikhi,C. Tayade,V.A. Paffaro,B.A. Croy
Pakistan Journal of Biological Sciences , 2007,
Abstract: Specialized lymphocytes, called uterine Natural Killer (uNK) cells, appear in human and rodent uteri and become abundant at implantation sites during decidualization and early pregnancy. The hallmark of human uNK cells is intense expression of CD56, a neural cell adhesion glycoprotein (NCAM-1) while mature (granulated) mouse uNK cells express asialoGM1, a brain ganglioside. Murine uNK cells initiate the normal structural changes induced in maternal spiral arteries by pregnancy but regulation of their recruitment, localization and activation is incompletely understood. To address whether uNK cell distribution is co-localized with nerve fiber distribution, sections of gestation day (gd) 6-12 implantation sites from C57BL/6 (B6) mice were studied. Nerve fibers reactive with antibodies to pan neurofilament 150 kD or with tyrosine hydroxylase, an enzyme restricted to sympathetic fibers, were present the walls of branches from the uterine artery in the mesentery. Reactivity was lost as the vessels crossed the myometrium and entered endometrium/decidua. Periodic Acid Schiff’s reactive uNK cells were absent from the mesentery and enriched in decidua basalis where they transcribed NCAM-1 and associated with non-innervated segments of the uterine arteries, including spiral arteries. These data suggest that the localization and activation of mature uNK cells are unlikely to be neurotransmitter regulated.
Clinical profile and obstetric outcome in pregnancies complicated by heart disease: a five year Indian rural experience
Nilajkumar D. Bagde,Madhuri N. Bagde,Poonam Varma Shivkumar,Surekha Tayade
International Journal of Reproduction, Contraception, Obstetrics and Gynecology , 2013, DOI: 10.5455/2320-1770.ijrcog20130209
Abstract: Background: Cardiac diseases are a major cause of morbidity and mortality in pregnant women in the developing world. This study illustrates the problem in rural India focusing on patterns of diseases, clinical features, and pregnancy outcome in these women. Methods: A retrospective analysis of five year data, from 2006 to 2010 for all patients admitted with cardiac disease in pregnancy. Results: Past history of heart disease was present in 70%. Rheumatic heart disease was predominant type in 83% and the chief complaint at admission was breathlessness in 44%. Mitral stenosis was the commonest lesion in 55% and mitral regurgitation with or without stenosis in 48%. Preeclampsia was seen in 20% and preterm labor in 10%. Spontaneous vaginal delivery was seen in 41% and cesarean in 20.6%. Conclusions: Heart disease in pregnancy is a high risk condition has a major impact on pregnancy. Associated obstetric complications along with lack of knowledge and ignorance regarding the pathology lead to unpleasant obstetric outcomes. [Int J Reprod Contracept Obstet Gynecol 2013; 2(1.000): 52-57]
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