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IVS8 Polyt and M470V Polymorphisms in Healthy Individuals and Cystic fibrosis Patients in Mazandaran Province, Iran
Kholghi Oskooei V,Esmaeeli Douki MR,Tabaripour R,Tavakkoly Bazzaz J
Tehran University Medical Journal , 2012,
Abstract: Background: Cystic fibrosis (CF) is a multiorgan autosomal recessive disorder. As CF is highly heterogeneous in Iran and many mutations have a low frequency, routine molecular diagnostic methods are not very efficient. The use of highly polymorphic intragenic markers not only can facilitate phenotype prediction in prenatal diagnosis by gene tracking, but also can lead to the demonstration of possible associations between haplotypes and specific mutations. We determined IVS8 polyT and M470V polymorphisms in exon 10 of CFTR gene in this case-control study. Methods: Polymorphisms of IVS8 polyT in 53 patients with CF were referred to Amirkola children's Hospital of Babol University of Medical Sciences, 2007 to 2011 and 49 fertile healthy individuals were determined by reverse dot blot method. M470V polymorphism was analyzed by PCR-RFLP. Results: In IVS8 polyT study, T7 was the most frequent allele in healthy individuals than patients with CF (respectively, 82.8% Vs. 77.2%). T9 was more abundant in patients with CF than normal individuals (respectively, 21.7% Vs. 7.4%, P=0.005). T9/T9 genotype was more frequent in patients than healthy individuals (respectively, 15.1% and 2%, P=0.032). Study for M470V polymorphism showed that M/V was the most common genotype in normal individuals and patients with CF (respectively, 49% and 40.4%). M-T9 haplotype was highly associated with the disease in both patients with CF and normal individuals (respectively, 19.1% and 2.4%, (P<0.001 Conclusion: The allelic distribution and heterozygosity results suggest that both M470V and IVS8 polyT can be helpful in the prenatal diagnosis of CF in Northern Iranians with a positive family history of the disease.
Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
Amoli, Mahsa M.;Amiri, Parvin;Tavakkoly-Bazzaz, Javad;Charmchi, Elham;Hafeziyeh, Jila;Keramatipour, Mohammad;Abiri, Maryam;Ranjbar, Shirin Hasani;Larijani, Bagher;
Genetics and Molecular Biology , 2010, DOI: 10.1590/S1415-47572010005000056
Abstract: the transcription factor 7-like 2 gene (tcf7l2) rs7903146 t allele is constantly associated with type 2 diabetes in various populations and ethnic groups. nevertheless, this has not been observed in two studies involving arab populations. the aim of the present study was to investigate the association between tcf7l2 rs7903146 in an iranian population. type 2 diabetes patients (n = 258) and normal healthy control subjects (n = 168) from the same area, were examined. the arms-pcr (amplification refractory mutation system) technique, subsequently validated by direct sequencing, was used for genotyping. allele and genotype frequencies were significantly different between patients and controls tt vs. ct + cc [p 0.0081 or 3.4 95%ci (1.27-11.9)] and t vs. c allele [p 0.02 or 1.4 95%ci (1.03-1.9)]. our data thus confirm the association between the rs7903146 t allele and t2d in an iranian population, contrary to previous reports in arab populations. this can possibly be attributed to differences in ethnic background or the effects of environmental factors.
Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population
Bazzaz J,Nazari M,Nazem H,Amiri P
Journal of Postgraduate Medicine , 2010,
Abstract: Background: Apolipoprotein E (APOE) is known as a major regulator of blood lipid levels in humans. A number of APOE gene allelic variants have been reported including E2, E3 and E4. Recent studies suggested a role for APOE in obesity and increased Body Mass Index (BMI) and plasma lipid levels in obese children. Aim: The aim of this study was to examine the association between APOE genetic variants and the BMI and lipid profile in an Iranian cohort. Setting and Design: Samples were obtained from subjects who participated in a study based on the WHO-designed MONICA (multinational monitoring of trends and determinants in cardiovascular disease) study for coronary artery disease risk assessment in Zone 17 of Tehran. The study was approved by the local ethical committee. Informed consent was obtained from all subjects included in this study. Materials and Methods: Subjects (n=320) were recruited. The level of triglyceride (TG) and total serum cholesterol was tested for all subjects in this study. Genotyping for APOE was carried using polymerase chain reaction-Restriction fragment length polymorphism (PCR-RFLP)technique. Statistical Analysis: Levels of significance were determined using contingency tables by either Chi-square or Fisher exact analysis using the STATA (v8) software. The analysis of regression and significance of differences for level of cholesterol and TG was established by one-way analysis of variance followed by Dunnett post hoc multiple comparison tests using SPSS software Version 11.5. Results: The frequency of allele E2 was significantly higher in patients with total serum cholesterol level <200 mg/dl (P 0.01 OR 2.1 95% CI 1.1-4.2). Conclusion: The association found in this study between allele E2 and lower total cholesterol level had been reported in previous studies. We have also observed that the frequency of genotype E2/E3 and E2/E4 was significantly higher in patients with normal total serum cholesterol level compared to patients with abnormal cholesterol (P=0.003 OR 2.4 95% CI; 1.3-4.6). Our data needs to be repeated in a larger population with more information for serum LDL and HDL levels and their subgroups.
Fairness of IELTS Test Scores in University Admission
Motahar Khodashenas Tavakkoly
Higher Education Studies , 2011, DOI: 10.5539/hes.v1n2p107
Abstract: The editorial board announced that this article has been retracted on March 16, 2012. If you have any further question, please contact us at: hes@ccsenet.org
Stage of urinary bladder cancer at first presentation
Al-Bazzaz Pishtewan
Saudi Journal of Kidney Diseases and Transplantation , 2009,
Abstract: The stage of urinary bladder cancer is an important factor in determining prognosis of the disease. This prospective study was performed to determine the stage of bladder cancer at first presentation at the Rizgary Hospital in the Erbil governorate in Iraqi Kurdistan. We evaluated 72 patients with bladder cancer. The grades and stages of bladder cancer of these patients were determined through physical examination and investigations. We found that 47.2% of patients had superficial cancer, 19.4% had tumor with invasion into the lamina propria and 30.6% of patients had tumor with invasion to muscle wall. Regional or distant metastases were found in 2.8% of patients. Well differentiated tumor was seen in 44.4% of the patients, moderately differentiated tumor was found in 38.9% and poorly differentiated tumor was found in 16.7% of the patients. Our study suggests that bladder cancer is diagnosed at a relatively early stage in the Erbil governorate. However, the situation can be further improved by adopting proper screening programs and performing appropriate investigations.
Kidney transplantation in Erbil, Iraq: A single-center experience
Al-Bazzaz Pishtewan
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Abstract: Kidney transplantation is associated with improved quality of life and better survival among patients with end-stage renal disease. The aim of this study is to assess the experience of kidney transplant program in a single center in Erbil, Iraq. The records of 83 pairs, donors and reci-pients, treated with kidney transplantation at the Zheen Hospital in Erbil, over a two-year period were collected and analyzed. The mean donor age was 28.5 ± 7.34 years (range 19-49 years) and re-cipient age was 37.6 ± 14.9 years (range 12-66 years). The male to female ratio was 6.5:1 among donors and 3.2:1 among recipients. Among the 83 pairs studied, the donors and recipients were genetically related in seven cases (8.5%) and emotionally related in one case (1.2%). Delayed graft function was seen in 3.2% of cases and acute rejection in 5.3% of cases. Graft survival at six months was 88% while patient survival at the same period was 90%. In conclusion, even though experience related to kidney transplantation in Erbil is limited, the reported results are encouraging for a promising future.
The Use of Verb Noun Collocations in Writing Stories among Iranian EFL Learners
Fatemeh Bazzaz,Arshad Samad
English Language Teaching , 2011, DOI: 10.5539/elt.v4n3p158
Abstract: An important aspect of native speakers’ communicative competence is collocational competence which involves knowing which words usually come together and which do not. This paper investigates the possible relationship between knowledge of collocations and the use of verb noun collocation in writing stories because collocational knowledge distinguishes native speakers and foreign language learners and is a significant factor in productive skills especially writing. This study examined the correlation between knowledge of verb noun collocations and their use in written essays. The participants in the study were 27 PhD Iranian students in a Malaysian university. A specially constructed C-test measured the subjects’ collocational knowledge and the use of collocations was measured by the number of collocations used in essays written by the subjects. For this purpose, participants wrote six different stories in six weeks based on a writing task designed to illicit verb noun collations. The statistical results demonstrate that there exists a strong positive relationship between knowledge of collocations and the use of verb noun collocation in the writing stories
A Survey on Chemical Hazards and Liver Function in Rubber Industry Workers in Iran  [PDF]
Ehsan Rafeemanesh, Mojtaba Mousavi Bazzaz, Farhoud Sadrossadat, Fatemeh Ahmadi
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.65045
Abstract:
Rubber industries workers are at risk of hepatic dysfunction from exposure to rubber dust and a mixture of different hydrocarbons. This study aimed to evaluate the relation between chemical hazards in workplace and serum hepatic transaminases in rubber industry workers in Iran. This historical cohort study was conducted in a rubber-manufacturing industry in Mashhad. It con-sisted of 91 workers with chemical substances exposure and 85 workers not exposed to chemicals. Hepatic transaminases including alanine transaminase (ALT) and aspartate transaminase (AST) were compared between these two groups. Required data were collected through questionnaire, liver enzymes evaluation, and environmental monitoring of chemical substances. The data were analyzed with SPSS 11.5. A total of 176 workers enrolled in this study included 113 (64.2%) male and 73 (35.8%) female. The mean of age and employment duration in exposed group were 29.22 ± 3.99 and 5.41 ± 2.77 and in non-exposed group were 30.33 ± 4.11 and 5.29 ± 2.77 respectively. The mean of ALT in exposed and non-exposed groups was 31.3 ± 8.04 and 23.8 ± 10.42 (p = 0.01) and the mean of AST was 29.6 ± 9.7 and 27.3 ± 8.2 (p = 0.1) respectively. A significant difference was shown between mean of ALT at the date of employment and at the time of the study in exposed group. According to our findings evaluation of serum transaminases is a useful screening method which might be beneficial in early detection of hepatocellular injuries in rubber industry workers.
Exam Stress Induces Hormonal Changes amongst Students of the Al-Haweeja Technical College  [PDF]
Zainab A. Hassan, Ayoub A. Bazzaz, Noorhan A. Chelebi
Advances in Bioscience and Biotechnology (ABB) , 2015, DOI: 10.4236/abb.2015.612076
Abstract: Sixty students from both genders aged 19 - 22 years old at College of Technology undertaking halfterm exams of 2012-2013 are encountered in this study. Blood samples were collected twice, i.e. before the exam inside the halls and during the rest time, to compare levels of some hormones, e.g. cortisol from all students, testosterone in male only and both estrogen and progesterone in female students. The female group was further subdivided into two subgroups, 15 each i.e. at the first half of the menstrual cycle (follicular phase) and second group at the second half of the menstrual cycle (luteal phase). The levels of cortisol had significantly (p ≤ 0.05) raised from 12.3 ± 3.6 to 32.3 ± 4.2 ng/mL and from 11.6 ± 1.8 to 31.6 ± 7.3 ng/mL in both male and female students, respectively during exams in comparison with rest times. However, the levels of testosterone had significantly dropped (p ≤ 0.05) from 6.63 ± 1.8 to 2.1 ± 0.4 ng/mL during the test-time. In female students, the levels of both estrogens and progesterone had significantly (p ≤ 0.05) increased, i.e. in follicular from 202 ± 38 to 365 ± 22 and from 64.6 ± 8.0 to 160 ± 37 ng/mL at luteal phases, respectively and from 0.74 ± 0.03 to 1.5 ± 0.04 in follicular and 14.4 ± 2.4 to 29 ± 4.2 ng/mL at luteal phase, respectively in progesterone during the exam in comparison with rest times. These results indicate that all students had sustained stress during the exam-time which might have disturbed the regulation of various hormones in both genders consequently leading to further health effects.
Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice  [PDF]
Madgida A. Ganash, Muhammad I. Mujallid, Ali A. Al-Robai, Ayoub A. Bazzaz
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.53032
Abstract:

The protectivity of the natural honey has been assessed against the toxicity of Doxorubicin (DOX) in liver tissues of 106 male Albino mice Mus musculus strain weighing 37 ± 3 gm. The body and liver weights, morphological behavior changes, liver function and pathological effects on liver were recorded. Toxicity study of DOX showed that the LD50 and LD were 20 and 30 mg/Kg, respectively. Intra-peritoneal (i.p.) injection of DOX induced significant (p ≤ 0.01-0.001) pathological changes in the health, i.e. general weakness, a few morphological changes associated with bleedings, ulceration of skin, hair loss, dimorphism of limbs and bosselation. Daily ingestion of natural honey for seven weeks has led to significant (p ≤ 0.01-0.001) improvement of these symptoms which appeared as increases in both body and liver weights in comparison with control animals. The natural honey had enhanced the function of liver in treated animals with DOX + honey and reduced the pathological effects of DOX on the above morphological symptoms as well as in the hepatocytes. It is concluded that the ingestion of natural honey has a protective potency against the toxic effects of DOX.

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