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Search Results: 1 - 10 of 541 matches for " Tatyana Kanyshkova "
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Modulation of Calcium-Dependent Inactivation of L-Type Ca2+ Channels via β-Adrenergic Signaling in Thalamocortical Relay Neurons
Vladan Rankovic, Peter Landgraf, Tatyana Kanyshkova, Petra Ehling, Sven G. Meuth, Michael R. Kreutz, Thomas Budde, Thomas Munsch
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027474
Abstract: Neuronal high-voltage-activated (HVA) Ca2+ channels are rapidly inactivated by a mechanism that is termed Ca2+-dependent inactivation (CDI). In this study we have shown that β-adrenergic receptor (βAR) stimulation inhibits CDI in rat thalamocortical (TC) relay neurons. This effect can be blocked by inhibition of cAMP-dependent protein kinase (PKA) with a cell-permeable inhibitor (myristoylated protein kinase inhibitor-(14–22)-amide) or A-kinase anchor protein (AKAP) St-Ht31 inhibitory peptide, suggesting a critical role of these molecules downstream of the receptor. Moreover, inhibition of protein phosphatases (PP) with okadaic acid revealed the involvement of phosphorylation events in modulation of CDI after βAR stimulation. Double fluorescence immunocytochemistry and pull down experiments further support the idea that modulation of CDI in TC neurons via βAR stimulation requires a protein complex consisting of CaV1.2, PKA and proteins from the AKAP family. All together our data suggest that AKAPs mediate targeting of PKA to L-type Ca2+ channels allowing their phosphorylation and thereby modulation of CDI.
Activity Modes in Thalamocortical Relay Neurons are Modulated by Gq/G11 Family G-proteins – Serotonergic and Glutamatergic Signaling
Philippe Coulon,Tatyana Kanyshkova,Tilman Broicher,Thomas Munsch,Nina Wettschureck,Thomas Seidenbecher,Sven G. Meuth,Stefan Offermanns,Hans-Christian Pape,Thomas Budde
Frontiers in Cellular Neuroscience , 2010, DOI: 10.3389/fncel.2010.00132
Abstract: In thalamocortical relay (TC) neurons, G-protein-coupled receptors play an important part in the control of activity modes. A conditional Gαq knockout on the background of a constitutive Gα11 knockout (Gαq/Gα11?/?) was used to determine the contribution of Gq/G11 family G-proteins to metabotropic serotonin (5-HT) and glutamate (Glu) function in the dorsal part of the lateral geniculate nucleus (dLGN). In control mice, current clamp recordings showed that α-m-5-HT induced a depolarization of Vrest which was sufficient to suppress burst firing. This depolarization was concentration-dependent (100 μM: +6 ± 1 mV, n = 10; 200 μM: +10 ± 1 mV, n = 7) and had a conditioning effect on the activation of other Gαq-mediated pathways. The depolarization was significantly reduced in Gαq/Gα11?/? (100 μM: 3 ± 1 mV, n = 11; 200 μM: 5 ± 1 mV, n = 6) and was apparently insufficient to suppress burst firing. Activating Gαq-coupled muscarinic receptors affected the magnitude of α-m-5-HT-induced effects in a reciprocal manner. Furthermore, the depolarizing effect of mGluR1 agonists was significantly reduced in Gαq/Gα11?/? mice. Immunohistochemical stainings revealed binding of 5-HT2CR- and mGluR1α-, but not of 5-HT2AR-specific antibodies in the dLGN of Gαq/Gα11?/? mice. In conclusion, these findings demonstrate that transmitters of ascending brainstem fibers and corticofugal fibers both signal via a central element in the form of Gq/G11-mediated pathways to control activity modes in the TC system.
The Software for Constructing Trails with Local Restrictions in Graphs  [PDF]
Tatyana Panyukova, Igor Alferov
Open Journal of Discrete Mathematics (OJDM) , 2013, DOI: 10.4236/ojdm.2013.32017

The present research considers the problem of covering a graph with minimal number of trails satisfying the pre-defined local restrictions. The research is devoted to the problem of graph covering by minimal number of trails satisfying some local restrictions. Algotithm of allowed Eulerian cycle construction is considered. The authors showed that it is possible to recognize the system of transitions and solve the problem of constructing the allowable path by linear time. Its also possible to find allowable Eulerian cycle for Eulerian graph or to proclaim that such a cycle does not exist by the time O(|V(G).|E(G)|). All presented algorithms have the software realization.

Analysis of the Integral Efficiency Indicator for Information Systems of the Cyclic Type Accounting for Weights  [PDF]
Tatyana Yuldashevа, Juliya Doronina
Journal of Data Analysis and Information Processing (JDAIP) , 2013, DOI: 10.4236/jdaip.2013.12002
Abstract: The article is dedicated to the task of developing efficient means to analyze functioning of an information system of the cyclic type based on determining the integral performance criterion. We consider the subject area related to the analysis of moments of peak loads in teaching (admissions, conducting tests and examinations, accreditation of a university, etc.). The criterion is developed based on the analysis of all the processes occurring in the information system (IS) of a university and based on the selection of main factors affecting the change in the effective functioning of the university departments. Certain qualitative and quantitative parameters affecting the integral index of efficiency are considered at various times, since functioning of the whole system is cyclical. A weight for each criterion is accounted for in the integral indicator of efficiency. The proposed approach will allow for simplification of the research of efficiency characteristics of the information systems of the cyclic type based on the analysis of the integral coefficient.
An Extreme Value Analysis of Wind Speed over the European and Siberian Parts of Arctic Region  [PDF]
Alexander Kislov, Tatyana Matveeva
Atmospheric and Climate Sciences (ACS) , 2016, DOI: 10.4236/acs.2016.62018
Abstract: Multiyear observed time series of wind speed for selected points of the Arctic region (data of station network from the Kola Peninsula to the Chukotka Peninsula) are used to highlight the important peculiarities of wind speed extreme statistics. How largest extremes could be simulated by climate model (the INM-CM4 model data from the Historical experiment of the CMIP5) is also discussed. Extreme value analysis yielded that a volume of observed samples of wind speeds are strictly divided into two sets of variables. Statistical properties of one population are sharply different from another. Because the common statistical conditions are the sign of identity of extreme events we therefore hypothesize that two groups of extreme wind events adhere to different circulation processes. A very important message is that the procedure of selection can be realized easily based on analysis of the cumulative distribution function. The authors estimate the properties of the modelled extremes and conclude that they consist of only the samples, adhering to one group. This evidence provides a clue that atmospheric model with a coarse spatial resolution does not simulate special mechanism responsible for appearance of largest wind speed extremes. Therefore, the tasks where extreme wind is needed cannot be explicitly solved using the output of climate model. The finding that global models are unable to capture the wind extremes is already well known, but information that they are members of group with the specific statistical conditions provides new knowledge. Generally, the implemented analytical approach allows us to detect that the extreme wind speed events adhere to different statistical models. Events located above the threshold value are much more pronounced than representatives of another group (located below the threshold value) predicted by the extrapolation of law distributions in their tail. The same situation is found in different areas of science where the data referring to the same nomenclature are adhering to different statistical models. This result motivates our interest on our ability to detect, analyze, and understand such different extremes.
Reporting of results of interventional studies by the information service of the National Institutes of Health
Tatyana Shamliyan
Clinical Pharmacology: Advances and Applications , 2010, DOI: http://dx.doi.org/10.2147/CPAA.S12398
Abstract: rting of results of interventional studies by the information service of the National Institutes of Health Original Research (3341) Total Article Views Authors: Tatyana Shamliyan Published Date September 2010 Volume 2010:2 Pages 169 - 176 DOI: http://dx.doi.org/10.2147/CPAA.S12398 Tatyana Shamliyan Division of Health Policy and Management, University of Minnesota School of Public Health, MN, USA Abstract: The Food and Drug Administration Amendments Act of 2007 mandated that sponsors of applicable studies must provide results within one year of study completion. We aimed to analyze the factors associated with reporting of results from interventional studies registered on ClinicalTrials.gov. On May 20, 2010, we retrieved 20 available fields from 57,233 closed studies on the website and identified 31,161 interventional studies that were required to post results. We compared the proportion of studies with results versus studies without results by age, gender, and disease status of participants, by interventions, sponsors, phase of clinical trials, and completion dates. The results of studies were reported for 4.7% of applicable studies, 8% of industry-sponsored studies, 7.5% of Phase II and 6.5% of Phase IV clinical trials, 4.9% of drug studies, and 0% of genetic studies. Withdrawn (n = 486) and suspended (n = 414) interventions did not provide results. The percentage of studies with results varied from 0% to 21% among different sponsors. The first studies with results were completed in 1992. The proportion of studies with results increased over time. Completion dates were not available for 7446 studies. The database does not have fields available to facilitate routine analysis of the rate of compliance with federal law for posting results. The analysis of accuracy of the protocols in relation to the results and publications is not possible without time-consuming evaluation of individual postings and individual publications.
Adverse drug effects in hospitalized elderly: Data from the Healthcare Cost and Utilization Project
Tatyana Shamliyan
Clinical Pharmacology: Advances and Applications , 2010, DOI: http://dx.doi.org/10.2147/CPAA.S8779
Abstract: dverse drug effects in hospitalized elderly: Data from the Healthcare Cost and Utilization Project Original Research (4725) Total Article Views Authors: Tatyana Shamliyan Published Date May 2010 Volume 2010:2 Pages 41 - 63 DOI: http://dx.doi.org/10.2147/CPAA.S8779 Tatyana Shamliyan Division of Health Policy and Management, University of Minnesota School of Public Health and Minnesota Evidence-based Practice Center, Minneapolis, MN, USA Abstract: We aimed to analyze trends in hospital admissions due to adverse drug effects between the years 2000 to 2007 among the elderly using the National Inpatient Sample (NIS) of the Healthcare Cost and Utilization Project. We identified the discharges with the principal and all listed diagnoses related to adverse drug effects and associated hospital charges using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) codes. Between 2000 and 2007, 321,057 patients over 65 years were discharged with a principal diagnosis related to an adverse drug effect. Hospital charges were $5,329,276,300 or $666,159,537 annual cost. The number of discharges and total hospital charges did not change over the examined years, while mean charge per discharge increased on average by $1064 ± 384 per year. Total hospital charges for drug-induced gastritis with hemorrhage increased the most by $11,206,555 per year among those 66–84 years old and by $8,646,456 per year among those older than 85 years. During 2007, 791,931 elderly had adverse treatment effects among all listed diagnoses with hospital charges of $937,795,690. Effective drug management interventions are needed to improve safety of treatments in the elderly.
Toeplitz Operators, K hler Manifolds, and Line Bundles
Tatyana Foth
Symmetry, Integrability and Geometry : Methods and Applications , 2007,
Abstract: This is a survey paper. We discuss Toeplitz operators in K hler geometry, with applications to geometric quantization, and review some recent developments.
Social Work in Republic of Buryatia/Russia
Bazarova, Tatyana
Social Work and Society , 2003,
Abstract: The Republic of Buryatia is situated in Eastern Sibiria, the eastern coast of Baikal Lake. The total area of the republic is 351 thousand square kilometers. The capital of Republic is Ulan-Ude. The modern social-economic situation in Russia is extremely paradoxical and multiaspectual - negative processes take place almost in all spheres of the society. The introduction of market economy principles, the process of privatisation, and the last economic crises in the Federation of Russia have brought many social phenomena - among them increasing poverty, homelessness and still high rate of unemployment are the worst one. It makes the changes in the state social welfare programmes and functioning patterns be implemented. Social problems are especially very important in the so-called "depressive" regions of Russia (Buryatia Republic is among those regions). The most important is the staff supplement of social services and the level of professionalism of people who work there. This problem consists of two aspects: first, the number of specialists with professional education of social workers is not enough; second, the level of professionalism of the workers is very low.
The methods of development of students' cognitive independence pedagogical universities in teaching Informatics tools remote sensing technologies
Tatyana Rihter
Koncept : Scientific and Methodological e-magazine , 2013,
Abstract: The article is devoted to the development of methods of cognitive independence of future teachers for teaching computer science by means of remote sensing technologies: the creation of problem situations by means of the network of electronic educational resources; remote group participation in the forums, newsgroups, contests and competitions on the subject, the use of differentiated and multi-level independent work by means of remote courses.
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