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Effect of Starvation-Refeeding Status on Cholesterol Metabolism in Rats Fed High-Cholesterol Diet  [PDF]
Reiko Inai, Tatsuhiro Matsuo
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.22016
Abstract: The present study investigated the effect of starvation-refeeding status on cholesterol metabolism in rats fed a high-cholesterol diet or a cholesterol-free diet. Twenty male and 20 female Donryu rats (age 5 weeks) were fed a cho-lesterol-free diet for 14 days. Then the male and female rats were each divided into two groups: feeding and starva-tion-refeeding groups. The feeding groups were fed the experimental diet for 3 days, and the starvation-refeeding groups fasted for 2 days followed by 3 days of feeding. Half of each of groups was fed a cholesterol-free diet and the other half was fed a high-cholesterol diet. Starvation-refeeding significantly increased the plasma free cholesterol and HDL-cholesterol concentrations in both the high-cholesterol-diet-fed rats and the cholesterol-free-diet-fed rats. In the female rats, plasma total cholesterol and cholesteryl ester concentrations were significantly higher in the high-cholesterol groups than in the cholesterol-free groups, whereas TG concentration and total cholesterol/TG ratio were not significantly different among all of the groups. Liver total cholesterol and cholesteryl ester were significantly higher in the high-cholesterol groups than in the cholesterol-free groups in both male and female rats. These results suggest that starvation-refeeding affected cholesterol metabolism at least in part. The reactivity of the cholesterol me-tabolism may be different between male and female rats.
Effects of High-Fat Diets Containing Different Fats on Cholesterol Metabolism in Starvation-Refeeding Rats  [PDF]
Reiko Inai, Tatsuhiro Matsuo
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.26090
Abstract: The present study was performed to investegate the effects of high-fat diets containing different fats on cholesterol metabolism in starvation-refeeding rats. Forty female Donryu rats were divided into two groups and then fed high-fat diets containing beef tallow or corn oil without cholesterol for 14 days. Then, 10 rats from each group were divided into high-cholesterol and cholesterol-free groups (Experiment 1). Another 10 rats from beef tallow and corn oil groups were divided into high-cholesterol and high-cholesterol-cholestyramine groups (Experiment 2). All rats were fasted for 2 days followed by 3 days of feeding. In Experiment 1, the high-cholesterol diet caused significant increases in plasma total cholesterol and cholesteryl ester concentrations in the beef tallow diet group. In Experiment 2, dietary cholestyramine markedly decreased plasma and liver cholesterol levels; however, these cholesterol levels were higher in the beef tallow diet group even if cholestyramine was added to the diet. These results suggested that the cholesterol- lowering effect of dietary corn oil may not be due solely to reabsorption of bile acids. This study suggested that high-fat diets containing different fats affected cholesterol metabolism under conditions of starvation-refeeding.
The effects of 90-day feeding of D-psicose syrup in male wistar rats  [PDF]
Tatsuhiro Matsuo, Reika Ishii, Yoko Shirai
Open Journal of Preventive Medicine (OJPM) , 2011, DOI: 10.4236/ojpm.2011.12010
Abstract: D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute and chronic toxicity testing in rats, D-psicose is classified as an ordinary and safe substance. Recently, we developed a high D-psicose syrup (PS) made from high fructose corn syrup (HFCS) by the alkaline isomerization method. However, the safety of PS as a food additive has not been demonstrated. In this study, we investigated the effects of 90-day feeding of PS in male Wistar rats. The rats were fed diets containing 3% D-psicose (control) or 4.3% PS for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the control and PS group. The weights of the tissues did not differ between the two dietary groups. In clinical chemistry and hematological analyses, no differences were found between the control and PS groups. No gross pathological findings were evident at dietary doses of 4.3% PS. Therefore, the present study found no adverse effects of PS in rats fed a diet containing 4.3% PS for 90 days.
Dietary BCAAs Do Not Prevent Skeletal Muscle Atrophy in Rats Injected with Glucocorticoid
Masaru Ochiai,Tatsuhiro Matsuo
Asian Journal of Clinical Nutrition , 2009,
Abstract: This study investigated the effects of the combination of a voluntary resistance exercise (climbing) and the feeding of a high protein snack rich in Branched-Chain Amino Acids (BCAAs) on skeletal muscle weights in rats injected with glucocorticoid as a model of age-related sarcopenia (Experiment 1). Moreover, we examined whether BCAAs in the diet and/or BCAAs in snacks prevent sarcopenia in sedentary rats (Experiment 2). Male Wistar rats were injected with prednisolon (2 mg kg-1) every day. Rats in the exercise groups climbed voluntarily in the tower cage for 8 weeks. BCAAs were exchanged partly for casein in the experimental diets. Glucocorticoid injection decreased final body weight and muscle mass. The body weight gain did not differ among glucocorticoid-injected rats. Climbing exercise markedly prevented the loss of muscle mass, but the BCAA snack did not facilitate the effects of exercise (Experiment 1). In the sedentary rats, either BCAA in the diet or BCAA in the snack decreased mass and protein content of muscle (Experiment 2). These results suggest that resistance exercise is the most effective way to inhibit sarcopenia in rats. BCAAs did not depress muscle mass loss without resistance exercise. BCAAs should be used on the condition that all other essential amino acids are fully available in the diet.
On Supersymmetry of the Covariant 3-Algebra Model for M-Theory  [PDF]
Matsuo Sato
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.311226
Abstract: We examine a natural supersymmetric extension of the bosonic covariant 3-algebra model for M-theory proposed in [1]. It possesses manifest SO(1,10) symmetry and is constructed based on the Lorentzian Lie 3-algebra associated with the U(N) Lie algebra. There is no ghost related to the Lorentzian signature in this model. It is invariant under 64 supersymmetry transformations although the supersymmetry algebra does not close. From the model, we derive the BFSS matrix theory and the IIB matrix model in a large N limit by taking appropriate vacua.
Zariski 3-Algebra Model of M-Theory  [PDF]
Matsuo Sato
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.44A006

We review on Zariski 3-algebra model of M-theory. The model is obtained by Zariski quantization of a semi-light-cone supermembrane action. The model has manifest N=1 supersymmetry in eleven dimensions and its relation to the supermembrane action is clear.

The zero-energy Landau levels in graphene as BPS-saturated states
Tatsuhiro Misumi
Physics , 2008,
Abstract: This paper has been withdrawn by the author, due to the crucial mistake of the discussion in Sec IV.
Phase structure for lattice fermions with flavored chemical potential terms
Tatsuhiro Misumi
Physics , 2012, DOI: 10.1007/JHEP08(2012)068
Abstract: We discuss the chiral phase diagram in the parameter space of lattice QCD with minimal-doubling fermions, which can be seen as lattice fermions with flavored chemical potential terms. We study strong-coupling lattice QCD with the Karsten-Wilczek formulation, which has one relevant parameter $\mu_{3}$ as well as gauge coupling and a mass parameter. We find a nontrivial chiral phase structure with a second-order phase transition between chiral symmetric and broken phases. To capture the whole structure of the phase diagram, we study the related lattice Gross-Neveu model. The result indicates that the chiral phase transition also exists in the weak-coupling region. From these results we speculate on the $\mu_{3}$-$g^{2}$ chiral phase diagram in lattice QCD with minimal-doubling fermions, and discuss their application to numerical simulations.
New fermion discretizations and their applications
Tatsuhiro Misumi
Physics , 2012,
Abstract: We review the recent progress in new lattice fermion formulations. We focus on the following three types which have possibility of improving lattice simulations. (1) Flavored-mass fermions are a generalization of Wilson fermions with species-splitting mass terms. In particular, staggered-Wilson fermions initiated by Adams have possibilities of reducing numerical costs in overlap fermions and the influence of taste-breaking in staggered fermions. (2) Central-branch Wilson fermions, in which additive mass renormalization is forbidden by extra axial symmetry, could enable us to perform Wilson-fermion lattice QCD without fine-tuning. (3) Minimally doubled fermions, which reduce the number of species by species-dependent chemical potential terms, realizes a ultra-local chiral fermion at the price of hypercubic symmetry. These setups reveal unknown aspects of lattice fermions, and we obtain a deeper understanding of lattice field theory.
Fermion Actions extracted from Lattice Super Yang-Mills Theories
Tatsuhiro Misumi
Physics , 2013, DOI: 10.1007/JHEP12(2013)063
Abstract: We revisit 2D $\mathcal{N}=(2,2)$ super Yang-Mills lattice formulation (Sugino model) to investigate its fermion action with two (Majorana) fermion flavors and exact chiral-$U(1)_{R}$ symmetry. We show that the reconcilement of chiral symmetry and absence of further species-doubling originates in the 4D clifford algebra structure of the action, where 2D two flavors are spuriously treated as a single 4D four-spinor with four 4D gamma matrices introduced into kinetic and Wilson terms. This fermion construction based on the higher-dimensional clifford algebra is extended to four dimensions in two manners: (1) pseudo-8D sixteen-spinor treatment of 4D four flavors with eight 8D gamma matrices, (2) pseudo-6D eight-spinor treatment of 4D two flavors with five out of six 6D gamma matrices. We obtain 4D four-species and two-species lattice fermions with unbroken subgroup of chiral symmetry and other essential properties. We discuss their relations to staggered and Wilson twisted-mass fermions. We also discuss their potential feedback to 4D super Yang-Mills lattice formulations.
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