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Herpes Encephalitis Masquerading as Tumor
Tasneem Peeraully,Joseph C. Landolfi
ISRN Neurology , 2011, DOI: 10.5402/2011/474672
Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence
Tasneem Peeraully, Eng-King Tan
Translational Neurodegeneration , 2012, DOI: 10.1186/2047-9158-1-6
Abstract: The common features of dopaminergic dysfunction and response to dopaminergic agents in RLS and PD, together with comorbidity in some patients has fuelled the concept that these two diseases may share the same pathophysiology [1]. We review the clinical, imaging and genetic evidence, exploring the link between RLS (restless legs syndrome) and PD (Parkinson's disease).PD is a progressive neurodegenerative disorder characterised by pathologic intraneuronal alpha-synuclein-positive Lewy bodies and neuronal cell loss. In particular, involvement of dopaminergic cells in the substantia nigra pars compacta is associated with development of the motor features of the disease. The cardinal clinical symptoms and signs of PD are bradykinesia, rigidity, tremor, postural instability and freezing attacks [2]. The prevalence of PD increases with age, affecting 1-2% of the population over the age of 65 years, and 3% of those over 85 years [3]. Several monogenic forms of PD and numerous genetic susceptibility factors have been identified [4,5]. Sleep disturbances have been widely reported in PD, although an increased incidence of periodic leg movements of sleep (PLMS) is debatable, with polysomnography studies revealing mixed findings [6-10].Restless legs syndrome (RLS) was initially described by Ekbom [11] in 1945. It tends to present in mid to later life and has a prevalence of 2.7-10% in Western populations [12,13]. It is reportedly much less common amongst Asians [14]. Four essential diagnostic criteria were proposed by the International Restless Legs Syndrome Study Group (IRLSSG) in 1995; 1. An urge to move the legs associated with paresthesias, 2. motor restlessness, 3. worsening at rest with at least partial relief by activity, and 4. worsening at night [15,16]. In 2003, at a consensus conference at National Institute of Health, USA, these criteria were modified and new criteria developed for the diagnosis of RLS in the cognitively impaired elderly and in children [17]. Additio
Performance Study of a Distributed Web Server: An Analytical Approach  [PDF]
Sarah Tasneem, Reda Ammar
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.511099
Abstract: With the rapid expansion of the Internet, Web servers have played a major role in accessing the enormous mass of Web pages to find the information needed by the user. Despite the exponential growth of the WWW, a very negligible amount of research has been conducted in Web server performance analysis with a view to improve the time a Web server takes to connect, receive, and analyze a request sent by the client and then sending the answer back to client. In this paper, we propose a multi-layer analytical approach to study the web server performance. A simple client-server model is used to represent the WWW server in order to demonstrate how to apply the proposed approach. We developed a systematic, analytical methodology to quantify the communication delay and queuing overhead in a distributed web server system. The approach uses the Computation Structure Model to derive server processing time required to process a request sent from a client and queueing model to analyze the communication between the clients and the server.
The Professional Medical Journal , 2004,
Abstract: Objective: To detect and manage Pre-cancerouscervical change in order to prevent invasive cancer in a symptomatic sexually active women ofreproductive age group. Study design: An observational study. Place and duration of study: Study wasconducted in Gynae unit 11 of Bolan Medical College Complex Quetta from June 2002 to May2004.Patients and Methods: 370 women visiting either Gynae OPD or antenatal clinic were includedin study. Positive smears were followed by biopsy and histopathology. Results: 198(53.51%) smears werereported to be normal, 126(34%) inflammatory, 20(5.40%) borderline, mild dyskaryosis was seen in6(1.62%) moderate in 5(1.35%) and severe dyskaryosis in 3(0.81%). 14 smears were considered inadequatebecause of blood stained specimen or due to other artifacts. Patients with mild dyskaryosis were advisedto come for follow up and to repeat smear after three months.8(2.16%) patients with moderate to severedyskaryosis had punch biopsy. Histopathology revealed CIN-II in four cases of moderate dyskaryosisand CIN-III in one case of severe dyskaryosis. Two patients with moderate dyskaryosis were managedby local destructive procedure with electrocautry. While two patients with CIN-II and three patientswith severe dyskaryosis had total abdominal hysterectomy due to continuous pain lower abdominal andexcessive vaginal discharge. Conclusion: Cervical cancer screening by pap smear is a simple and effectivemethod of detecting pre malignant lesions. If it is done routinely in asymptomatic patients at regularintervals, it may help to decrease the incidence of the invasive cancer.
The Professional Medical Journal , 2006,
Abstract: Objective: To find out the possible association between levels of cholesterol and tea consumptionin the general population known to consume large amount of tea in a day. Place and Duration: The study wasconducted in the periphery areas of Multan district from 1990 to 1993. Materials and Methods: The data was obtainedon 550 (300 (20-40 years) male subjects and 250 older age group (41-65 years) male subjects. Information collectedon each subject included detailed demographic data, personal habits including smoking, frequency of participation inleisure time, physical activity, a detailed history of daily tea intake and weekly egg consumption. They were alsoquestioned about medication and special dietary intake (such a low salt, low cholesterol, low saturated fat or weightreducing diets).Height and weight were measured. Relative weight was defined by Quetelet index (weight in g) / (heightin cm2). Blood samples, obtained by venepuncture, were drawn in vacuum tubes without additive, with the subjectsupine and after fasting for between 9 and 10h. Serum was separated from the whole blood within 2h of being drawn.Sera separated from the whole blood were frozen at -70oC until analyzed. Total cholesterol (TC) was estimated byenzymes assay (Boehringer Knoll kit, Mannheim, FRG). HDL-cholesterol (HDL-C) was measured after precipitation withheparin and manganese chloride.. Triglycerides were estimated by enzyme assay (Boehringer Knoll kit, Mannheim,FRG). Serum low density lipoproteins cholesterol (LDL-C) was estimated. Quality control methods were employedthroughout all the analyses. The data presented here are for the those subjects who were not an any special diet,medication or suffering from any endocrine disease. The association between tea intake and other dietary variableswere tested using the Chi square test. An analysis of covariance was used to examine the association between teaintake and lipid levels. Separate analyses of covariance were carried out in each of two age groups 20-40 years and41-65 years. Results: A negative association between drinking of tea and TC levels were found in both age groupsstudied. The difference was found to be entirely due to a difference in LDL-cholesterol levels. The negative associationbetween tea consumption and TC levels was significant in heavy drinkers of tea with or without smoking. Conclusion:General population is known to consume large amounts of tea. It was concluded that tea consumption may be anindependent factor influencing serum lipid levels because there was a negative association between tea consumptionand serum
The Professional Medical Journal , 2004,
Abstract: Objective: To evaluate incidence, morbidity andmortality associated with Eclampsia. Design: Prospective study of 98 cases of eclampsia. Setting: departmentof obstetrics and gynaecology unit II Bolan Medical Collage Complex Quetta. Patients: 98 cases were admittedwith eclampsia during two years and six months period from 1st June 2001 to December 2003. Results: Totalno of admissions were 6952. 98 patients presented with eclampsia making a frequency of 1.40%. Of these 98cases of eclampsia 58 % were primigravidas, mean age of eclamptic patients was 34 years. Gestational age atadmission was less than 35 weeks in 80(78.4%) cases. 54(55%) patients had intrapartum eclampsia.64 (66.7%)patients received diazepam and rest received Magnesium sulphate as anticonvulsant. Caesarean section was donein 10 (11.49%) cases rest delivered vaginally. Fetal loss was seen in 72(82.75%) patients, while 7(7.14%) mothersdied of eclampsia. Conclusion: Maternal and perinatal mortality and morbidity is very high in eclempticpatients. Magnesium sulphate is good anticonvulsant, helpful in reducing maternal morbidity and mortalityconsiderably. Good antenatal practices, maternal education and awareness, provision of better health facilitiesand their utilization will definitely improve maternal and fetal outcome.
The Professional Medical Journal , 2008,
Abstract: Objectives: Lipids are common conjugates of serum lipoproteins while sialic acid is present in combination with lipids andproteins as glycolipids and glycoproteins respectively. This study was aimed to get some preliminary information regarding the possiblecorrelation between serum sialic acid and lipid profile in cardiac patients to investigate the possibility of using these parameters to aid thediagnosis and prognosis. Material and methods: Normal subjects (15) and Cardiac patients (42) were estimated. Total cholesterol , Totallipid, Triglycerides , HDL-C and Serum Sialic acid was measured. Duration and place :One year (Jan-Dec. 2005) at POF Hospital ,Wah Cantt.Results: Total lipids 523.4 ± 136.2 mg/dl, Total Cholesterol 142.7 ± 43.3 mg/dl, Triglyceride 81.5 ± 51.6 mg/dl, HDL-C 25.51 ± 10.3 mg/dl andSialic acid was estimated to be 150.8 ± 41.1 mg/dl in normal subjects, while in cardiac patients (n = 42) the level of total lipid was 747.5 ± 247.8mg/dl, total cholesterol 174.0 ± 43.4 mg/dl, triglyceride 154.5 ± 147.8 mg/dl and HDL-cholesterol was 18.1 ± 10.6 mg/dl while Sialic acid wasestimated to be 216.1 ± 57.0 mg/dl in cardiac patients. Conclusion: Results indicate that all the parameters i.e. total lipid, cholesterol,triglyceride and sialic acid except HDL-cholesterol, studied were significantly higher in cardiac patients (P < 0.01) while HDL-cholesterol wassignificantly lower in these patients (P < 0.01).One possible explanation to this could be the dietary habits of the people of this area who preferto consume vegetable oils which are considered to be rich in polyunsaturated fatty acids, rather than a lower intake of fat rich diet. In additionto this, these people consume substantially large quantities of garlic and onions which again are considered to generate hypocholesterolemiceffects.
The Professional Medical Journal , 2002,
Abstract: Platelets have been implicated in the genesis of vascular complications of diabetes mellitus. This is shown by platelethyperaggregability in diabetic subjects. We studied the platelet aggregation pattern in 200 diabetic subjects. 100 withdiabetic retinopathy and 100 without retinopathy. Platelet aggregation was found to be enhanced in all 200 subjectsstudied. ADP, epinephrine, collagen and arachidonic acid were used as agonists to induce platelet aggregation. The resultswere compared with 50 healthy age, sex matched non diabetic controls. We did not find any significant difference betweenthe platelet aggregation of diabetic patients with and without diabetic retinopathy.
The Professional Medical Journal , 2008,
Abstract: Objective: To evaluate iron status in pregnancy induced hypertension and role of iron in the etiologyand pathogenesis of pre-eclampsia. Design: Coefficient correlation study. Place and Duration. At Department ofBiochemistry, Frontier Medical College, Abbottabad with collaboration of Department of Obstetrics and Gynecology,Ayub Medical Complex, Abbottabad from March 2006-March 2007. Material and Methods: Study was performed onhundred pregnant women of age ranging between 15-35 years and having gestational age between28 to 34 weeks.Fifty obstetric patients were identified as having pre-eclampsia. Fifty healthy pregnant subjects were taken as controls,having uncomplicated pregnancies and were normotensive throughout gestation and without proteinuria. Results:Results depicts that mean age of pre-eclamptic group was significantly low (P<0.001) as compared to control. Bothparameters, Hemoglobin and Haematocrit were significantly higher (P<0.05) in pre-eclamptic as compared to controls.Serum iron, serum ferritin and transferrin saturation were significantly higher (P<0.001) in pre-eclamptic in comparisonwith control group. Total iron binding capacity and unsaturated iron binding capacity were significantly lower (P<0.001)in pre-eclamptic group when compared to control group. Correlation coefficient between serum iron, total iron bindingcapacity (TIBC), serum ferritin, unsaturated iron binding capacity (UIBC) and systolic and diastolic blood pressure inpre-eclamptic group showed no significant positive correlation in any parameter. Conclusion: It is concluded thathemoglobin, haematocrit, serum iron, serum ferritin and transferrin saturation are significantly increased in pregnantwomen that later develops pre-eclampsia. Excess iron is postulated as casual factor in the oxidative stress ie; in itsradical form, which may be involved in the pathogenesis of pre-eclampsia. Therefore, iron status of pregnant womenshould be assessed before giving iron supplements as these may cause more harm than benefit.
Mathematical Modeling for the Design of Greenbelts for Air Pollution Control: An Engineering Perspective
Tasneem Abbasi
Bonfring International Journal of Industrial Engineering and Management Science , 2012, DOI: 10.9756/bijiems.1085
Abstract: If trees and smaller plants are viewed as if they are pollution control devices in the hands of environmental engineers, they can be perceived as biopumps, particulate traps, reactive absorbers of pollutants, and cooling towers. But whereas the usual engineering devices do not make a pretty sight and can?t launch a thousand poems, trees and other vegetation can. Nor can the usual pollution control devices attract birds and other colourful fauna as trees do. From the environmental engineer?s perspective, the species of trees and shrubs can be scientifically chosen and planted in a pattern around a source of air pollutant, and in a manner so as to effectively reduce the pollution caused by that source. The entire system can be optimized to ensure maximum pollutant removal of target pollutants at minimum utilization of land and other costs. In this paper the work of this group on the design of greenbelts based on mathematical modeling has been summarized in the context of the global stat-of-the-art.
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