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Search Results: 1 - 10 of 462367 matches for " Tarek A. Leil "
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Virtual Systems Pharmacology (ViSP) software for mechanistic system-level model simulations
Sergey Ermakov,Peter Forster,Marko Miladinov,Rebecca Baillie,Tarek A. Leil
Frontiers in Pharmacology , 2014, DOI: 10.3389/fphar.2014.00232
Abstract: Multiple software programs are available for designing and running large scale system-level pharmacology models used in the drug development process. Depending on the problem, scientists may be forced to use several modeling tools that could increase model development time, IT costs and so on. Therefore, it is desirable to have a single platform that allows setting up and running large-scale simulations for the models that have been developed with different modeling tools. We developed a workflow and a software platform in which a model file is compiled into a self-contained executable that is no longer dependent on the software that was used to create the model. At the same time the full model specifics is preserved by presenting all model parameters as input parameters for the executable. This platform was implemented as a model agnostic, therapeutic area agnostic and web-based application with a database back-end that can be used to configure, manage and execute large-scale simulations for multiple models by multiple users. The user interface is designed to be easily configurable to reflect the specifics of the model and the user's particular needs and the back-end database has been implemented to store and manage all aspects of the systems, such as Models, Virtual Patients, User Interface Settings, and Results. The platform can be adapted and deployed on an existing cluster or cloud computing environment. Its use was demonstrated with a metabolic disease systems pharmacology model that simulates the effects of two antidiabetic drugs, metformin and fasiglifam, in type 2 diabetes mellitus patients.
Seismicity and Geologic Structures Indubitable in Wadi Hagul, North Eastern Desert, Egypt  [PDF]
Tarek A. Seleem, Hamdy A. Aboulela
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.21006
Abstract: Paleo and recent earthquakes have been recorded in Wadi Hagul area and its environs, which have left behind geologic structures of deformation preserved in exposed sedimentary rocks. To evaluate such deformation and surface break, different techniques and data types are used compromising image processing techniques, Geographic Information Systems (GIS), seismicity data, as well as, field investigation. The field investigation clarified that the study area is enriched with soft-sediment deformation structures encompassing two types of geologic structures; brittle and viscoplastic structures. The analysis of the various types of data elucidate that, the earthquakes of Wadi Hagul are frequently distributed at an average depth ranging from (1 to 35 km) within the top of the Earth’s crust which are mainly controlled by existing Hagul fault zone. The study gives new insight for a better understanding of the seismic activity in the study area which helps in the seismic hazard assessment
Study of Minimal Residual Disease in Adults with B-Lineage Acute Lymphoblastic Leukemia by Flowcytometry  [PDF]
Rania A. Ghonaim, Tarek A. Elgohary
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.84033
Abstract: Background: After achieving morphological remission, existence of few number of leukemic cells in the patient’s blood represents the minimal residual disease (MRD) and its monitoring helps in evaluating early treatment response and future relapse. Patients and methods: Eighty seven newly diagnosed (B-ALL) cases were enrolled in the present study in the time period from October 2013 to October 2016. A panel of 4 monoclonal antibodies (CD10FITC, CD19PE, CD34PercP and CD45APC) were defined at diagnosis and after morphological remission for tracing of minimal residual disease (MRD). Results: Eighty seven newly diagnosed B-ALL cases were included in the present study of which 73 (84%) showed positive expression to CD45 in combination with (CD10, CD19 and CD34) at diagnosis, which allow us to use this combination for further assessment of MRD after morphological remission. In our study 65% of patients had negative MRD (<0.01), while 35% of patients had positive MRD (≥0.01). The DFS and OS for patients with MRD-ve were significantly higher than those with MRD + ve (P = 0.01 & P = 0.04) respectively. Conclusion: MRD detection by flow cytometry using the combination of CD45 with CD10, CD19 & CD34 is an easy and reliable method. Patients with positive MRD are at higher risk of relapse and have inferior overall survival rates compared to those with MRD-ve. Future studies focusing on treatment intensification for the group of patients with +ve MRD aiming to improve the treatment outcome are warranted.
Severe pediatric ocular injury due to explosion of a firecracker inside a soda bottle
Tarek A Shazly
Open Access Emergency Medicine , 2010, DOI: http://dx.doi.org/10.2147/OAEM.S14689
Abstract: e pediatric ocular injury due to explosion of a firecracker inside a soda bottle Case report (3370) Total Article Views Authors: Tarek A Shazly Published Date October 2010 Volume 2010:2 Pages 83 - 85 DOI: http://dx.doi.org/10.2147/OAEM.S14689 Tarek A Shazly Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA Abstract: This case report describes a penetrating ocular injury, followed by endophthalmitis, in a four-year-old girl, resulting from explosion of a small K0201 match-cracker inside a soda bottle. The patient presented with two corneal lacerations, ruptured crystalline lens, multiple intraocular foreign bodies, and hyphema of the right eye, for which immediate surgical exploration and repair was performed. The patient developed aggressive endophthalmitis that led to atrophy of the eye within a few weeks. Severe ocular injuries can result from small, relatively “safe” firecrackers. Therefore, this type of firework should not be used, especially by minors.
A Recurrence Technique for Computing the Effective Indexes of the Guided Modes of Coupled Single-Mode Waveguides
Tarek A. Ramadan
PIER M , 2008, DOI: 10.2528/PIERM08063005
Abstract: The recurrence dispersion equation of coupled single-mode waveguides is modified by eliminating redundant singularities from the dispersion function. A recurrence zero-bracketing (RZB) technique is proposed in which the zeros of the dispersion function at one recurrence step bracket those of the next recurrence step. Numerical examples verify the utility of the RZB technique in computing the roots of the dispersion equation of the TE and TM modes of both uniform and non-uniform arrays.
Severe pediatric ocular injury due to explosion of a firecracker inside a soda bottle
Tarek A Shazly
Open Access Emergency Medicine , 2010,
Abstract: Tarek A ShazlyDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USAAbstract: This case report describes a penetrating ocular injury, followed by endophthalmitis, in a four-year-old girl, resulting from explosion of a small K0201 match-cracker inside a soda bottle. The patient presented with two corneal lacerations, ruptured crystalline lens, multiple intraocular foreign bodies, and hyphema of the right eye, for which immediate surgical exploration and repair was performed. The patient developed aggressive endophthalmitis that led to atrophy of the eye within a few weeks. Severe ocular injuries can result from small, relatively “safe” firecrackers. Therefore, this type of firework should not be used, especially by minors.Keywords: pediatric trauma, endophthalmitis, firecracker
Monochromatic Infrared Photo Energy in Diabetic Peripheral Neuropathy
Tarek A. Ammar
ISRN Rehabilitation , 2012, DOI: 10.5402/2012/484307
Abstract:
Interpreting Recoil For Undergraduate Students
Tarek A. Elsayed
Physics , 2007, DOI: 10.1119/1.3694068
Abstract: In this paper, I outline some problems in the students' understanding of the explanation of recoil motion when introduced to them in the context of Newton's third law. I propose to explain the origin of recoil from a microscopic point of view, which emphasizes the exact mechanism leading to recoil. This mechanism differs from one system to another. Several examples that can be easily implemented in the classroom environment are given in this paper. Such a profound understanding of the origin of recoil help students avoid some of the misconceptions that might arise from the phenomenological approach, and stimulates their thinking in the fundamental origins of other physical phenomena.
Experimental Study of Filling Ratio Effect on the Thermal Performance in a Multi-Heat Pipe with Graphene Oxide/Water Nanofluids  [PDF]
Mohamed Salem, Tarek A. Meakhail, Magdy A. Bassily, Shuichi Torii
World Journal of Nano Science and Engineering (WJNSE) , 2016, DOI: 10.4236/wjnse.2016.64014
Abstract: This experimental study is performed to investigate heat transfer performance of a multi-heat pipe cooling device in the condition of different filling ratios (40%, 60%, 80% and 100%) and different constant heat fluxes (10 - 30 W). Here, pure water (distilled water) and graphene oxide (GO)/water nanofluids are employed respectively as working fluid. GO/water nanofluids were synthesized by the modified Hummers method with 0.05%, 0.10%, 0.15%, and 0.20% volume concentrations. Multi-heat pipe is fabricated from copper; the heating and cooling sections are the same size and both are connected by four circular parallel tubes. Temperature fields and thermal resistance are measured for different filling ratio, heat fluxes and volume concentrations. The results indicated that the thermal performance of heat pipe increased with increasing the concentration of GO nanoparticles in the base fluid, while the maximum heat transfer enhancement was observed at 0.20% volume concentration. GO/water nanofluids showed lower thermal resistance compared to pure water; the optimal thermal resistance was obtained at 100% filling charge ratio with 0.20% volume concentration. Studies were also demonstrated that heat transfer coefficient of the heat pipe significantly increases with increasing the input heat flux and GO nanoparticles concentration.
Perception of Character Education: The Case of Lebanese School Leaders  [PDF]
Najah A. R. Ghamrawi, Norma Ghamrawi, Tarek Shal
Open Journal of Leadership (OJL) , 2015, DOI: 10.4236/ojl.2015.44012
Abstract: This study explored the perception of Lebanese public school leaders pertaining to character education, and their expected role within its development and effective implementation. The sample included 153 randomly selected public school principals from all the Lebanese districts (Mouhafazat). The purpose is to provide a general overview of their understanding, expectations, their knowledge of character education prescribed in the Lebanese curriculum goals, and their opinion as to the principal’s role in addressing character development. The study was quantitative in nature and utilized a survey instrument that consisted of 39 items classified into 12 domains of character. The first domain targeted the knowledge of school principals pertaining to the character development goals within the Lebanese curriculum, besides their perception of school’s educational mission. The other eleven domains were developed based on “The Eleven Principles of Effective Character Education” constructed by the character education partnership organization (CEP, 2014). SPSS 18.0 for windows was employed to calculate the mean and the standard deviation of responses in order to determine the perceptions of the Lebanese public school leaders related to character education. Findings suggested that Lebanese public school principals were generally not fully aware of the character goals outlined in the Lebanese curriculum and the school’s educational mission concerning building students’ character. Their perception on effective character education unmatched a wide scope of the eleven principles of character education. The study recommends a reform of character education in the Lebanese public schools involving the school principals as leaders of change.
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