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Search Results: 1 - 10 of 141841 matches for " Taral K. Patel "
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Left Atrial Appendage Exclusion for Stroke Prevention in Atrial Fibrillation
Taral K. Patel,Clyde W. Yancy,Bradley P. Knight
Cardiology Research and Practice , 2012, DOI: 10.1155/2012/610827
Abstract: The public health burden of atrial fibrillation (AF) and associated thromboembolic stroke continues to grow at alarming rates. AF leads to a fivefold increase in the risk of stroke. Therefore, stroke prevention remains the most critical aspect of AF management. Current standard of care focuses on oral systemic anticoagulation, most commonly with warfarin and now with newer agents such as dabigatran, rivaroxaban, and apixaban. However, the challenges and limitations of oral anticoagulation have been well documented. Given the critical role of the left atrial appendage (LAA) in the genesis of AF-related thromboembolism, recent efforts have targeted removal or occlusion of the LAA as an alternative strategy for stroke prevention, particularly in patients deemed unsuitable for oral anticoagulation. This paper highlights recent advances in mechanical exclusion of the LAA. The problem of AF and stroke is briefly summarized, followed by an explanation for the rationale behind LAA exclusion for stroke prevention. After briefly reviewing the history of LAA exclusion, we highlight the most promising LAA exclusion devices currently available. Finally, we discuss future challenges and opportunities in this growing field. 1. Introduction: Atrial Fibrillation and Stroke Atrial fibrillation (AF) is the most common arrhythmia in modern clinical practice, currently affecting up to 5 million people in the United States [1, 2]. The prevalence rises sharply with age, from approximately 1% among people aged 55–59 years to over 10% among those aged greater than 80 years [3]. Importantly, the burden of AF is expected to rise threefold by 2050 to an estimated 12–16 million Americans [4]. The most feared clinical consequence of AF is stroke due to thromboembolism. Stroke is the third leading cause of death and the number one cause of major disability in the United States [5]. AF is a powerful risk factor for stroke; a diagnosis of AF increases stroke risk fivefold and conveys an overall stroke rate of 5% per year [5]. Of the estimated 800,000 annual strokes in the USA, the percentage attributable to AF ranges from 1.5% (50–59 years old) to 23.5% (80–89 years old) [5]. As AF is commonly silent and undiagnosed, the influence of AF on stroke is almost certainly underestimated. 2. The Role of the Left Atrial Appendage AF promotes thromboembolism through a variety of mechanisms, most significantly mechanical dysfunction in the atria leading to impaired blood flow and stasis. Additional factors including endothelial dysfunction, inflammation, platelet activation, and a
Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity  [PDF]
Ketan S. Patel, Jiten C. Patel, Hitesh R. Dholariya, Vishal K. Patel, Kanuprasad D. Patel
Open Journal of Metal (OJMetal) , 2012, DOI: 10.4236/ojmetal.2012.23008
Abstract: Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H- chromen-2-one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.
Future implications: Compliance and failure with antiretroviral treatment
Patel Atul,Patel K
Journal of Postgraduate Medicine , 2006,
Abstract: HIV management is currently in an era of effective, potent antiretroviral therapy. Modern drug discovery and development have transformed HIV-1 disease into a treatable, chronic infectious disease. Complete suppression of viral replication is critical for long-term durability of antiretroviral therapy. Partial suppression, even at very low levels, is likely to lead to virologic failure and ultimately to the appearance of drug resistance. The relationship between adherence and resistance to HIV antiretroviral therapy is more complex than to state ′non-adherence increases the risk of drug resistance.′ In many patients who fail to respond to initial therapy, the primary reason for failure is their inability to take the prescribed drug regimen or nonadherence.
Prognosis of Open Type 3-B Tibia Fractures By Ilizarov Technique: A Prospective Study
Janak Rathod, Taral Shah
National Journal of Community Medicine , 2012,
Abstract: Background: Open fractures of the tibial shaft are both common and may be fraught with complications. Open fractures of the tibia, with associated vascular injuries, have historically had a very poor outcome. Malunion, delayed union, nonunion, and infection are all seen regularly after open tibia fractures. Objectives: Objective of the study is to explore advantage of primary or early ilizarov surgery in Open type 3- B fracture tibia. Methodology: A follow up study of 10 cases of open type 3-B tibia fractures between 20 to 60 years of age treated with primary or early ilizarov surgery in SMIMER Hospital, Surat. Results: Among 10 patients, 9 patients showed union between 8 to 10 months. Two patients developed pin track infection which was managed with oral antibiotics and daily pin tract dressings. One patient developed disuse calf muscle atrophy and 2 patient developed equines deformity in ankle joint due to soft tissue contracture. Conclusion: Ilizarov surgery in open type 3-B tibia fracture having higher union rate with less chance of infection and obscure amputation of limb though it is technically demanding and time consuming procedure.
A central limit theorem via differential equations
Taral Guldahl Seierstad
Mathematics , 2009, DOI: 10.1214/08-AAP557
Abstract: In a paper from 1995, Wormald gave general criteria for certain parameters in a family of discrete random processes to converge to the solution of a system of differential equations. Based on this method, we show that if some further conditions are satisfied, the parameters converge to a multivariate normal distribution.
New Approach for the Determination of Tricyclic Antidepressant Amitriptyline Using β-Cyclodextrin-PEG System via Spectrophotomerty  [PDF]
Pankaj Soni, Santosh K. Sar, Rajmani Patel
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2012, DOI: 10.4236/jasmi.2012.22019
Abstract: A new and simple procedure for the spectrophotometric determination of the tricyclic antidepressant drug amitriptyline is proposed. The method is based on enhancement of sensitivity of the [AMIYTP]+ β-cyclodextrin and PEG molecules involved in formation of molecules inclusion complex, in presence of polyethylene glycol (PEG) medium. The mole ratio of [AMIYTP]+ β-cyclodextrin and PEG molecules in inclusion complex were determined by the curve fitting method. The value of molar absorptivity of {[AMIYTP: (β CD)] PEG} complex in term of the drug lies in rage of (2.20 - 2.23) × 104 L·mole–1·cm–1 at absorption maximum 242 nm. The slope, intercept and correlation co-efficient were found to be 14.21, 0.0046, and 0.998, respectively. The effect of analytical variables on the determination of the drug and composition of the ion associated complex are discussed in the paper. This method is applicable in the determina-tion of amitriptyline in the pharmaceutical preparations.
Estimation of duloxetine hydrochloride in pharmaceutical formulations by RP-HPLC method
Patel Sejal,Patel N,Patel K,Patel P
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Simple, specific, accurate and precise method, namely, reverse phase high performance liquid chromatography was developed for estimation of duloxetine HCl in pharmaceutical formulations. For the high performance liquid chromatography method, Phenomenox C-18, 5 μm column consisting of 250x4.6 mm i.d. in isocratic mode, with mobile phase containing 0.01M 5.5 pH phosphate buffer: acetonitrile (60:40 v/v) and final pH adjust to 5.5±0.02 with phosphoric acid was used. The flow rate was 1.2 ml/min and effluent was monitored at 231 nm. The retention time was 5.61 min. The method was validated in terms of linearity, accuracy and precision. The linearity curve was found to be linear over 0.25-4 μg/ml. The limit of detection and limit of quantification were found to be 0.10 and 0.25 μg/ml respectively. The proposed method was successfully used to determine the drug content of marketed formulations.
International Journal of Engineering Science and Technology , 2011,
Abstract: Now days, fast growth of the manufacturing industry is possible by rapid development and advancement in material handling equipment for their accurate and productive operations. There are different industrial sectors like timber, waste, aggregate, general trucking, mining; construction etc. uses the trailer for material handling. Some of the common problems are faced by such above applications likeunder loading, over loading, loading time loss, traffic fines, pay load over legal limits etc. The above problem can be eliminated by designing and implementing of on board weighing system.
New agents for the treatment of hepatitis C virus – focus on telaprevir
Thompson AJ, Patel K
Virus Adaptation and Treatment , 2012, DOI: http://dx.doi.org/10.2147/VAAT.S12707
Abstract: gents for the treatment of hepatitis C virus – focus on telaprevir Review (1102) Total Article Views Authors: Thompson AJ, Patel K Published Date November 2012 Volume 2012:4 Pages 75 - 84 DOI: http://dx.doi.org/10.2147/VAAT.S12707 Received: 21 May 2012 Accepted: 06 July 2012 Published: 01 November 2012 AJ Thompson,1–3 K Patel3 1Department of Gastroenterology, St Vincent's Hospital, University of Melbourne, 2Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia; 3Duke Clinical Research Institute and Department of Gastroenterology, Duke University Medical Center, Durham, NC, USA Abstract: Antiviral therapy for hepatitis C virus (HCV) is rapidly evolving with the advent of direct-acting antiviral agents. Telaprevir is a first-generation linear ketoamide inhibitor of HCV NS3 protease. Approved in 2011 as standard-of-care for the treatment of patients chronically infected with HCV genotype 1, telaprevir represents a major therapeutic advance. Used in combination with PEGylated interferon-alfa and ribavirin, telaprevir-based regimens cured > 75% of treatment-na ve patients in the Phase III registration studies. Telaprevir is also effective for patients who have previously failed interferon-based therapy. Telaprevir presents a number of new challenges for clinicians, including a more demanding dosing schedule, telaprevir-specific adverse events, potential for drug–drug interactions, and selection of drug-resistant HCV variants.
International Journal of Engineering Science and Technology , 2012,
Abstract: Here, we study about, influence of various machining parameters like tool speed, tool feed, depth of cut and tool diameter. In the present study, experiments are conducted on AL 6351 –T6 material with four factors and five levels and try to find out optimum surface roughness by using taguchi method. This paper attempts to introduce how Taguchi parameter design could be used in identifying the significant processing parameters and optimizing the surface roughness of end-milling operations. In this study, it was observed that, the order of significance of the main variables is as A1 > B4 > C4 > D1(tool feed (A), tool speed (B), tool diameter(C), depth of cut (D)).
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