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Search Results: 1 - 10 of 117833 matches for " Tarah T Colaizy "
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Growth in VLBW infants fed predominantly fortified maternal and donor human milk diets: a retrospective cohort study
Tarah T Colaizy, Susan Carlson, Audrey F Saftlas, Frank H Morriss Jr
BMC Pediatrics , 2012, DOI: 10.1186/1471-2431-12-124
Abstract: Retrospective cohort study.171 infants with median gestational age 27 weeks (IQR 25.4, 28.9) and median birthweight 899 g (IQR 724, 1064) were included. 97% of infants received human milk, 51% received > 75% of all enteral intake as human milk. 16% of infants were small-for-gestational age (SGA, < 10th percentile) at birth, and 34% of infants were SGA at discharge. Infants fed >75% human milk had a greater negative change in weight z-score from birth to discharge compared to infants receiving < 75% (?0.6 vs, -0.4, p = 0.03). Protein and caloric supplementation beyond standard human milk fortifier was related to human milk intake (p = 0.04). Among infants receiving > 75% human milk, there was no significant difference in change in weight z-score by milk type (donor ?0.84, maternal ?0.56, mixed ?0.45, p = 0.54). Infants receiving >75% donor milk had higher rates of SGA status at discharge than those fed maternal or mixed milk (56% vs. 35% (maternal), 21% (mixed), p = 0.08).VLBW infants can grow appropriately when fed predominantly fortified human milk. However, VLBW infants fed >75% human milk are at greater risk of poor growth than those fed less human milk. This risk may be highest in those fed predominantly donor human milk.Maternal milk diets have been associated with advantages for extremely low birthweight (ELBW) infants. ELBW infants fed maternal milk have lower rates of necrotizing enterocolitis (NEC) [1-3], the combined outcome of NEC or death [4], late onset sepsis [2,5,6], and have superior neurodevelopmental outcomes compared with those fed preterm formulas [7,8].However, maternal milk diets have also been associated with inferior in-hospital growth when compared with preterm formula. Studies performed prior to the current practice of human milk fortification demonstrated poorer growth in maternal–milk-fed infants compared with those fed formula [9], although neurodevelopmental advantages were associated with human milk intake [7,10]. Results of subsequent
The Goggles Project: Using Street Theatre to Engage University Stakeholders in Discussions about Sustainability  [PDF]
Tarah Wright, Gary Markle, Peter Wuench
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.47A2012

Sustainable development has become a global priority. While a sustainable future cannot be achieved through changes and actions in one sector alone, education is a key component in working toward this goal. Universities in particular have a moral task as leaders in the ESD movement, and are important catalysts for moving towards a sustainable future. However, research shows that there is a general lack of engagement in, and knowledge of sustainability within the university community at large. This manuscript describes the Goggles Project which used street theatre as a creative way to engage the whole university community in discussions regarding sustainability and the role universities can and/or should play in achieving a sustainable future.

Grade 1 Endometrioid Endometrial Carcinoma Presenting with Pelvic Bone Metastasis: A Case Report and Review of the Literature
My-Linh T. Nguyen,Christopher J. LaFargue,Tarah L. Pua,Sean S. Tedjarati
Case Reports in Obstetrics and Gynecology , 2013, DOI: 10.1155/2013/807205
Abstract: Most grade 1 endometrioid endometrial cancers are confined to the uterus at the time of diagnosis and confer a good prognosis. Rarely will a grade 1 endometrioid endometrial carcinoma present with distant metastasis, especially to the bone. We present the case of a 56-year-old woman with postmenopausal bleeding and right hip pain due to metastatic grade 1 endometrioid uterine cancer invading into the right ischium. We discuss treatment options as well as provide a review of prior published reports on bony metastasis in grade 1 endometrioid endometrial cancers. To date, this case is one of 10 others which demonstrates that even a well-differentiated, low-grade endometrioid endometrial carcinoma can progress in a highly aggressive manner. 1. Introduction Endometrial cancer is the most common malignancy of the female genital tract and the fourth most common cancer in women [1]. Factors which typically confer a better prognosis and outcome are surgical stage I, low histologic grade, nonserous or nonclear cell morphology, and superficial or no invasion of the myometrium [1]. While surgical staging remains the primary modality for determining the extent of disease, the histological grade is an important prognostic indicator and is highly predictive in determining propensity for metastasis [1]. In the largest series to date on grade 1 endometrioid endometrial cancers, the incidence of pelvic lymph node involvement, pelvic metastasis, and distant metastasis specific to grade 1 tumors is estimated at 3.3%, 4.6%, and 2.4%, respectively [2]. Considering the relative rarity of distant metastasis in grade 1 endometrial carcinomas, we present a case of grade 1 endometrioid endometrial cancer presenting with bone metastasis to the ischium. 2. Case A 56 year-old para 2002 presented with a 30-pound weight loss, postmenopausal bleeding, and right-sided hip pain for two years and increasing difficulty walking. Upon exam, a tender right pubic bone, a 4?cm palpable nodule at the anterior vaginal wall, and a 2?cm nodule at the cervicovaginal junction were noted. These nodules and the endometrium were biopsied. Pathology revealed FIGO grade 1 endometrioid endometrial adenocarcinoma (EEC) from all biopsy sites. Immunohistochemical staining revealed tumor cells positive for estrogen receptor (ER) and progesterone receptor (PR) and scatteredly positive for p53. Ki-67 showed high proliferative index. PET/CT imaging demonstrated enlarged retroperitoneal lymph nodes along the aorta and inferior vena cava (SUV > 8). The uterus (SUV > 16) contained a soft tissue lesion invading the
From Talloires to Turin: A Critical Discourse Analysis of Declarations for Sustainability in Higher Education
Paul Sylvestre,Rebecca McNeil,Tarah Wright
Sustainability , 2013, DOI: 10.3390/su5041356
Abstract: Declarations for sustainability in higher education are often seen as a set of guiding principles that aid institutions of higher learning to incorporate the concept of sustainability into their various institutional dimensions. As the Decade of Education for Sustainable Development draws to a close and in the shadow of the 20th anniversary of the Earth Summit in Rio de Janeiro, it seems appropriate to re-evaluate how these declarations have changed over the past two decades. In this study, we apply critical discourse analysis to examine how sustainability and the university are socio-politically constructed within these documents. Our analysis uncovers evidence of ideological assumptions and structures that are potentially misaligned with notions of sustainability often discussed in the Sustainability in Higher Education (SHE) literature. It is not the purpose of this study to provide a definitive reading of the documents, but rather to ply a novel critical lens to help elucidate how some taken-for-granted assumptions present in the declarations may work against their stated goals.
Canadian STARS-Rated Campus Sustainability Plans: Priorities, Plan Creation and Design
Lauri Lidstone,Tarah Wright,Kate Sherren
Sustainability , 2015, DOI: 10.3390/su7010725
Abstract: The use of integrated sustainability plans is an emerging trend in higher education institutions (HEIs) to set sustainability priorities and to create a work plan for action. This paper analyses the sustainability plans of 21 Canadian HEIs that have used the Sustainability Tracking, Assessment and Rating System (STARS) from the Association for the Advancement of Sustainability in Higher Education (AASHE). The plans were coded thematically with a focus on the sustainability goals, process of plan creation, and aspects of plan design outlined in the texts. This paper finds that sustainability goals focused on the environmental aspects of sustainability, while social and economic aspects were less emphasized. Further, most plans were described as being created through a broad stakeholder-consultation process, while fewer plans assigned timelines and parties responsible to sustainability goals. This paper contributes to our understanding of the priorities of Canadian HEI institutions at the end of the Decade of Education for Sustainable Development and is useful for practitioners interested in developing their own sustainability plans.
Sustainable Development: A Bird’s Eye View
Tom Waas,Jean Hugé,Aviel Verbruggen,Tarah Wright
Sustainability , 2011, DOI: 10.3390/su3101637
Abstract: At the turn of the millennium, the world’s political leadership adopted sustainable development as a leading model for societal development. However, the terms “sustainable development”, “sustainability” and “sustainable” are sometimes over- and misused despite wide consensus about the concept’s meaning among sustainability scholars and practitioners. While the concept allows various sustainability views to co-exist, random conceptualizations which do not respect the fundamental sustainability principles undermine the concept’s objective to steer action. This lack of understanding of sustainability arguably inhibits its practical realization and a proper understanding of sustainability is urgently needed. In this paper we aim to contribute to a better understanding of sustainability by adopting a bird’s eye perspective. We review the rich contemporary literature, with a specific focus on the terminology, genesis, fundamental principles, mainstream views of sustainability, and several governing aspects. Further, using the evolving body of sustainability literature, the paper provides arguments to combat common misconceptions of sustainability.
Human isolates of Bartonella tamiae induce pathology in experimentally inoculated immunocompetent mice
Leah Colton, Nordin Zeidner, Tarah Lynch, Michael Y Kosoy
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-229
Abstract: Three groups of four Swiss Webster female mice aged 15-18 months were each inoculated with 106-7 colony forming units of one of three B. tamiae isolates [Th239, Th307, and Th339]. A mouse from each experimental group was sampled at 3, 4, 5 and 6 weeks post-inoculation. Two saline inoculated age-matched controls were included in the study. Samples collected at necropsy were evaluated for the presence of B. tamiae DNA, and tissues were formalin-fixed, stained with hematoxylin and eosin, and examined for histopathology.Following inoculation with B. tamiae, mice developed ulcerative skin lesions and subcutaneous masses on the lateral thorax, as well as axillary and inguinal lymphadenopathy. B. tamiae DNA was found in subcutaneous masses, lymph node, and liver of inoculated mice. Histopathological changes were observed in tissues of inoculated mice, and severity of lesions correlated with the isolate inoculated, with the most severe pathology induced by B. tamiae Th239. Mice inoculated with Th239 and Th339 demonstrated myocarditis, lymphadenitis with associated vascular necrosis, and granulomatous hepatitis and nephritis with associated hepatocellular and renal necrosis. Mice inoculated with Th307 developed a deep dermatitis and granulomas within the kidneys.The three isolates of B. tamiae evaluated in this study induce disease in immunocompetent Swiss Webster mice up to 6 weeks after inoculation. The human patients from whom these isolates were obtained had clinical presentations consistent with the multi-organ pathology observed in mice in this study. This mouse model for B. tamiae induced disease not only strengthens the causal link between this pathogen and clinical illness in humans, but provides a model to further study the pathological processes induced by these bacteria.Bartonella bacteria are small, fastidious, aerobic, Gram negative coccobacilli in the family Bartonellaceae, class Alphaproteobacteria. As of 2009 there are 24 named or proposed species in the gen
Greening the Ivory Tower: A Review of Educational Research on Sustainability in Post-Secondary Education
Philip Vaughter,Tarah Wright,Marcia McKenzie,Lauri Lidstone
Sustainability , 2013, DOI: 10.3390/su5052252
Abstract: There is a deficit of multi-site studies examining the integration of sustainability in the policies and practices of post-secondary institutions. This paper reviews what comparative empirical research has been undertaken on sustainability in post-secondary education (PSE) within eight leading international journals publishing on sustainability and education. Three predominant themes of research on the topic are identified within the review: research comparing sustainability curricula across institutions (both within specific disciplines of study and across disciplines); research comparing campus operations policies and practice across multiple institutions; and research on how to best measure or audit approaches and outputs in sustainability in PSE. This review of the research literature supports the contention within the literature on sustainability in PSE that most research on the topic is focused on case studies rather than comparison of multiple institutions. The comparative research that is emerging from the field is concentrated on assessing measurable outputs for environmental externalities within institutional operations, with little examination of sustainability uptake and outcomes across broader institutional policies and practices.
A Murine Model of Variant Late Infantile Ceroid Lipofuscinosis Recapitulates Behavioral and Pathological Phenotypes of Human Disease
Jeremy P. Morgan, Helen Magee, Andrew Wong, Tarah Nelson, Bettina Koch, Jonathan D. Cooper, Jill M. Weimer
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078694
Abstract: Neuronal ceroid lipofuscinoses (NCLs; also known collectively as Batten Disease) are a family of autosomal recessive lysosomal storage disorders. Mutations in as many as 13 genes give rise to ~10 variants of NCL, all with overlapping clinical symptomatology including visual impairment, motor and cognitive dysfunction, seizures, and premature death. Mutations in CLN6 result in both a variant late infantile onset neuronal ceroid lipofuscinosis (vLINCL) as well as an adult-onset form of the disease called Type A Kufs. CLN6 is a non-glycosylated membrane protein of unknown function localized to the endoplasmic reticulum (ER). In this study, we perform a detailed characterization of a naturally occurring Cln6 mutant (Cln6nclf) mouse line to validate its utility for translational research. We demonstrate that this Cln6nclf mutation leads to deficits in motor coordination, vision, memory, and learning. Pathologically, we demonstrate loss of neurons within specific subregions and lamina of the cortex that correlate to behavioral phenotypes. As in other NCL models, this model displays selective loss of GABAergic interneuron sub-populations in the cortex and the hippocampus with profound, early-onset glial activation. Finally, we demonstrate a novel deficit in memory and learning, including a dramatic reduction in dendritic spine density in the cerebral cortex, which suggests a reduction in synaptic strength following disruption in CLN6. Together, these findings highlight the behavioral and pathological similarities between the Cln6nclf mouse model and human NCL patients, validating this model as a reliable format for screening potential therapeutics.
IL-10 Signaling Blockade Controls Murine West Nile Virus Infection
Fengwei Bai,Terrence Town equal contributor,Feng Qian equal contributor,Penghua Wang,Masahito Kamanaka,Tarah M. Connolly,David Gate,Ruth R. Montgomery,Richard A. Flavell,Erol Fikrig
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000610
Abstract: West Nile virus (WNV), a mosquito-borne single-stranded RNA flavivirus, can cause significant human morbidity and mortality. Our data show that interleukin-10 (IL-10) is dramatically elevated both in vitro and in vivo following WNV infection. Consistent with an etiologic role of IL-10 in WNV pathogenesis, we find that WNV infection is markedly diminished in IL-10 deficient (IL-10?/?) mice, and pharmacologic blockade of IL-10 signaling by IL-10 neutralizing antibody increases survival of WNV-infected mice. Increased production of antiviral cytokines in IL-10?/? mice is associated with more efficient control of WNV infection. Moreover, CD4+ T cells produce copious amounts of IL-10, and may be an important cellular source of IL-10 during WNV infection in vivo. In conclusion, IL-10 signaling plays a negative role in immunity against WNV infection, and blockade of IL-10 signaling by genetic or pharmacologic means helps to control viral infection, suggesting a novel anti-WNV therapeutic strategy.
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