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Search Results: 1 - 10 of 138743 matches for " Taofeek K. Owonikoko "
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Rising Incidence of Mucosal Melanoma of the Head and Neck in the United States
David M. Marcus,Rebecca P. Marcus,Roshan S. Prabhu,Taofeek K. Owonikoko
Journal of Skin Cancer , 2012, DOI: 10.1155/2012/231693
Rising Incidence of Mucosal Melanoma of the Head and Neck in the United States
David M. Marcus,Rebecca P. Marcus,Roshan S. Prabhu,Taofeek K. Owonikoko,David H. Lawson,Jeffrey Switchenko,Jonathan J. Beitler
Journal of Skin Cancer , 2012, DOI: 10.1155/2012/231693
Abstract: Background. While it is established that the incidence of cutaneous melanoma has risen over time in the United States, the incidence trend for mucosal melanoma of the head and neck (MMHN) is unknown. Methods. We used the Surveillance, Epidemiology, and End Results (SEER) database to determine incidence trends for MMHN from 1987 to 2009 in the United States. We determined annual percent change (APC) by weighted least squares and joinpoint regression analysis. Results. MMHN incidence increased from 1987 to 2009 (APC 2.4%; ). Nasal cavity lesions increased in incidence (APC 2.7%; ) over this duration, while the incidence of non-nasal cavity lesions remained stable. The highest rate of increase was in white females ages 55 to 84 (APC 5.1%; ). Conclusions. The incidence of MMHN in the United States has been rising since 1987. This trend is driven primarily by increased incidence of nasal cavity melanomas. 1. Introduction Malignant melanoma is a relatively common malignancy in the United States and is responsible for the majority of skin cancer deaths. Approximately 70,230 cases of melanoma were diagnosed, and approximately 8,790 people died from melanoma in the United States in 2011 [1]. The incidence of cutaneous melanoma in the United States has been steadily rising since 1975 [2, 3], with the most prominent risk factor being sun exposure [4]. Mucosal melanoma of the head and neck (MMHN) is a rare and aggressive disease that makes up less than 1% of all melanoma cases in the United States [5, 6]. To date, it is unknown whether the incidence of MMHN, which occurs outside of sun exposed areas, has followed the same incidence trend over time as cutaneous melanoma. In our study, we describe trends in incidence rates (IRs) for MMHN in the United States using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. 2. Materials and Methods We identified patients using the SEER 9 registries, which encompass nine geographic regions in the United States (Atlanta, Connecticut, Detroit, Hawaii, Iowa, New Mexico, San Francisco-Oakland, Seattle-Puget Sound, and Utah) and include approximately 9.5% of the US population. The SEER 9 population accurately represents the US population in most regards [2]. The SEER 9 registries were chosen for this purpose because each of the member registries has been continuously active throughout the duration of the study period. Using SEER*Stat Version 7.0.9, we identified patients within the SEER 9 registries with International Classification of Diseases in Oncology (ICD-0–3) diagnosis codes for all
The Combination of RAD001 and NVP-BEZ235 Exerts Synergistic Anticancer Activity against Non-Small Cell Lung Cancer In Vitro and In Vivo
Cheng-Xiong Xu,Yikun Li,Ping Yue,Taofeek K. Owonikoko,Suresh S. Ramalingam,Fadlo R. Khuri,Shi-Yong Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020899
Abstract: The phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling axis has emerged as a novel target for cancer therapy. Agents that inhibit PI3K, mTOR or both are currently under development. The mTOR allosteric inhibitor, RAD001, and the PI3K/mTOR dual kinase inhibitor, BEZ235, are examples of these agents. We were interested in developing strategies to enhance mTOR-targeted caner therapy. In this study, we found that BEZ235 alone effectively inhibited the growth of rapamycin-resistant cancer cells. Interestingly, the combination of sub-optimal concentrations of RAD001 and BEZ235 exerted synergistic inhibition of the growth of human lung cancer cells along with induction of apoptosis and G1 arrest. Furthermore, the combination was also more effective than either agent alone in inhibiting the growth of lung cancer xenografts in mice. The combination showed enhanced effects on inhibiting mTOR signaling and reducing the expression of c-Myc and cyclin D1. Taken together, our results suggest that the combination of RAD001 and BEZ235 is a novel strategy for cancer therapy.
Statistical learning methods as a preprocessing step for survival analysis: evaluation of concept using lung cancer data
Madhusmita Behera, Erin E Fowler, Taofeek K Owonikoko, Walker H Land, William Mayfield, Zhengjia Chen, Fadlo R Khuri, Suresh S Ramalingam, John J Heine
BioMedical Engineering OnLine , 2011, DOI: 10.1186/1475-925x-10-97
Abstract: A small set of clinical variables (CVs) for stage-1 non-small cell lung cancer patients was used to evaluate an approach for using SL methods as a preprocessing step for survival analysis. A stochastic method of training a probabilistic neural network (PNN) was used with differential evolution (DE) optimization. Survival scores were derived stochastically by combining CVs with the PNN. Patients (n = 151) were dichotomized into favorable (n = 92) and unfavorable (n = 59) survival outcome groups. These PNN derived scores were used with logistic regression (LR) modeling to predict favorable survival outcome and were integrated into the survival analysis (i.e. Kaplan-Meier analysis and Cox regression). The hybrid modeling was compared with the respective modeling using raw CVs. The area under the receiver operating characteristic curve (Az) was used to compare model predictive capability. Odds ratios (ORs) and hazard ratios (HRs) were used to compare disease associations with 95% confidence intervals (CIs).The LR model with the best predictive capability gave Az = 0.703. While controlling for gender and tumor grade, the OR = 0.63 (CI: 0.43, 0.91) per standard deviation (SD) increase in age indicates increasing age confers unfavorable outcome. The hybrid LR model gave Az = 0.778 by combining age and tumor grade with the PNN and controlling for gender. The PNN score and age translate inversely with respect to risk. The OR = 0.27 (CI: 0.14, 0.53) per SD increase in PNN score indicates those patients with decreased score confer unfavorable outcome. The tumor grade adjusted hazard for patients above the median age compared with those below the median was HR = 1.78 (CI: 1.06, 3.02), whereas the hazard for those patients below the median PNN score compared to those above the median was HR = 4.0 (CI: 2.13, 7.14).We have provided preliminary evidence showing that the SL preprocessing may provide benefits in comparison with accepted approaches. The work will require further evalu
Folic Acid Supplementation Ameliorates Inflammation and Apoptosis in Ethanol-Induced Gastric Ulceration in Rats  [PDF]
K. O. Ajeigbe, L. E. Jaja, A. A. Onifade, P. O. Obabueki, W. M. Owonikoko
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.512011
Abstract: Although the gastroprotective potential of folic acid has been reported, little is known about the role of inflammation and apoptosis in the said activity. This study, therefore, assessed lipid peroxidation (LPO), Neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP) as markers of inflammation and, p53 and BCl-2 as markers of apoptosis in ethanol-induced gastric ulcer pretreated with Folic acid (FA) for twenty-one (21) days. Adult male Wistar rats were arranged into experimental groups (n = 5) viz: 1) Control; 2) Ulcer control; 3) 2FA (2 mg/kg folic acid + Ulcer); 4) 3FA (3 mg/kg folic acid + Ulcer); 5) OMEP (20 mg/kg omeprazole + Ulcer); 6) 2FA + OMEP + Ulcer; and 7) 3FA + OMEP + Ulcer. Ulcer score, LPO, NLR, serum CRP were all determined one hour post ulcer induction. Paraffin gastric sections were stained first with H & E, then immunostained for p53 and BCl-2. Ethanol caused gastric lesion with an index of 3.0 ± 0.2. Ulcer severity and LPO was significantly decreased in the 2FA, 3FA, OMEP, 2FA + OMEP and 3FA + OMEP groups. NLR reduced significantly in the 2FA, 3FA, OMEP and OMEP + 3FA group. Qualitatively, there was absence of C-reactive protein in the 2FA group while quantitatively, presence of CRP appeared sustained in the 3FA and OMEP treated groups. Unlike p53, the expression and labeling index of BCl-2 were significantly enhanced more in the FA and OMEP combination than OMEP alone. Folic acid ameliorates the development of gastric ulcer in rats via its anti-inflammatory and anti-apoptotic activities.
A Review of an Expert System Design for Crude Oil Distillation Column Using the Neural Networks Model and Process Optimization and Control Using Genetic Algorithm Framework  [PDF]
Lekan Taofeek Popoola, Gutti Babagana, Alfred Akpoveta Susu
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.32020

This paper presents a comprehensive review of various traditional systems of crude oil distillation column design, modeling, simulation, optimization and control methods. Artificial neural network (ANN), fuzzy logic (FL) and genetic algorithm (GA) framework were chosen as the best methodologies for design, optimization and control of crude oil distillation column. It was discovered that many past researchers used rigorous simulations which led to convergence problems that were time consuming. The use of dynamic mathematical models was also challenging as these models were also time dependent. The proposed methodologies use back-propagation algorithm to replace the convergence problem using error minimal method.

Antiseptic Skin Preparation for Preventing Surgical Site Infection at Caesarean Section  [PDF]
Olufemi Aworinde, Kehinde Olufemi-Aworinde, Akintunde Fehintola, Babalola Adeyemi, Musliudin Owonikoko, Adewale Samson Adeyemi
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.64031
Abstract: Purpose: To compare the effect of chlorhexidine-alcohol and povidone iodine on surgical site infection (SSI) after caesarean section. Methodology: A randomized control trial of 374 patients (188 in the chlorhexidine-alcohol group and 186 in the povidone iodine group) who had elective caesarean section with no overt risk for SSI was done. Patients were followed up until thirty days after delivery to assess for symptoms and signs of SSI. Results: Fifty-one (13.6%) of the study population developed SSI. Although the incidence of SSI was lower in the chlorhexidine-alcohol group than the povidone iodine group (12.2% vs. 15.1%; p = 0.26); the difference was not statistically significant. The incidence of adverse skin reaction in Chlorhexidine-alcohol vs. povidone iodine was also not statistically significant (4.0% vs. 5.4%; p = 0.40). Conclusion: The study demonstrates that there was no statistically significant difference in antiseptic property and side effect profile of chlorhexidine-alcohol and povidone-iodine when used as skin antisepsis in caesarean section.
Case Report: Uterus bicornis unicollis; Occurrence of consecutive viable pregnancies in separate horns.
Oi Morhason-Bello, IE Ojoko, KM Owonikoko, O Owonikoko, AO Omigbodun
Annals of Ibadan Postgraduate Medicine , 2007,
Abstract: A case of two-consecutive viable pregnancies in separate horns of bicornuate unicollis uterus of a Nigerian is presented. The problem of misdiagnosis associated with the anomaly is noted. This case further demonstrates that women with such anomaly may not have unhindered reproductive carrier and antenatal care will improve their chance.
The Use of Appropriate Communication Channels to Understand Life Threatening Diseases: A Study of Viral Hepatitis Infection among Onikolobo Residents in Abeokuta, Nigeria  [PDF]
Amos Kolawole, Amoo John Kehinde, Adegboyega Taofeek Tope, Agu Georgia Chinemenwa, Tejuosho Wasiu
Advances in Infectious Diseases (AID) , 2015, DOI: 10.4236/aid.2015.54024
Abstract: This work examines the use of communication channels to sensitize the people about life threatening diseases with special emphasis on Hepatitis. It becomes very topical at this moment because most of the viral infections wreak havoc such as Acquired Immune Deficiency Syndrome (AIDS) and more recently, Ebola Virus Disease (EVD) assumed an epidemic proportion because the people were not adequately sensitized with precautionary measures against them. One of such measures is dissemination of useful information on how to avoid or contain such viral infections. It also concerns itself with hepatitis because of its contagious nature and the way it attacks the liver. The study reviews relevant concepts to information dissemination. It discovers that as deadly as the disease is, most people, including some health attendants in hospitals do not understand what it means and how it is contracted. In addition, it was discovered that 60% of the total respondents did not know about hepatitis. 73% of those who claimed they knew about it knew through friends and not through the media. 80% of those who claimed they sought health information from the media did not know about hepatitis. 65% of those who claimed they had high access to radio did not really seek health information from the radio. In the communities in Nigeria, we suggest that there should be increased public awareness about viral diseases, complete immunization against viral hepatitis and better sanitation facilities. Other efforts by the Government should include the provision of safe drinking water; expansion of well-equipped hospitals among other health developmental programmes will go a long way in the reduction of hepatitis in communities, among pregnant women as well as its associated maternal effects in the communities.
Discontinuation pattern of Norplant among implant acceptors at the family planning clinic, University College Hospital, Ibadan, Nigeria
MA Okunlola, KM Owonikoko, AO Adekunle, IO Morhason-Bello
Annals of Ibadan Postgraduate Medicine , 2006,
Abstract: No Abstract.
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