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Search Results: 1 - 10 of 602101 matches for " Tanya A. de Jong-Curtain "
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Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis
Yeliz Boglev,Andrew P. Badrock,Andrew J. Trotter,Qian Du,Elsbeth J. Richardson,Adam C. Parslow,Sebastian J. Markmiller,Nathan E. Hall,Tanya A. de Jong-Curtain,Annie Y. Ng,Heather Verkade,Elke A. Ober,Holly A. Field,Donghun Shin,Chong H. Shin,Katherine M. Hannan,Ross D. Hannan,Richard B. Pearson,Seok-Hyung Kim,Kevin C. Ess,Graham J. Lieschke,Didier Y. R. Stainier,Joan K. Heath
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003279
Abstract: Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel zebrafish mutant, titania (ttis450), which harbours a recessive lethal mutation in pwp2h, a gene encoding a protein component of the small subunit processome. The biochemical impacts of this lesion are decreased production of mature 18S rRNA molecules, activation of Tp53, and impaired ribosome biogenesis. In ttis450, the growth of the endodermal organs, eyes, brain, and craniofacial structures is severely arrested and autophagy is up-regulated, allowing intestinal epithelial cells to evade cell death. Inhibiting autophagy in ttis450 larvae markedly reduces their lifespan. Somewhat surprisingly, autophagy induction in ttis450 larvae is independent of the state of the Tor pathway and proceeds unabated in Tp53-mutant larvae. These data demonstrate that autophagy is a survival mechanism invoked in response to ribosomal stress. This response may be of relevance to therapeutic strategies aimed at killing cancer cells by targeting ribosome biogenesis. In certain contexts, these treatments may promote autophagy and contribute to cancer cells evading cell death.
The kingdom of God and modern society
J.A. de Jong
In die Skriflig , 2001, DOI: 10.4102/ids.v35i2.557
Abstract: The kingdom of God implies God’s rule in the regenerated heart. Consideration of the kingdom and modern society should be understood ecclesiologically. Herman Ridderbos’ notion of the relation of church and kingdom (sign, first-fruits, and instrument) is helpful, but must be applied in the context of nine realities of modern society. Corporate, modern discipleship is created when the church institute attends to all the features of its calling. This includes imparting biblical principles and giving general direction for modern social programmes and practices, but refraining from expressing itself on the specifics of complex programmes.
Cropping frequency and N fertilizer effects on soil water distribution from spring to fall in the semiarid Canadian prairies  [PDF]
R. de Jong, C. A. Campbell, R. P. Zentner, P. Basnyat, B. Grant, R. Desjardins
Agricultural Sciences (AS) , 2011, DOI: 10.4236/as.2011.23031
Abstract: In the semiarid Canadian prairies, water is the most limiting and nitrogen (N) the second most limiting factor influencing spring wheat (Triticum aestivum L.) production. The efficiency of water-and nitrogen use needs to be assessed in order to maintain this production system. The effects of cropping frequency and N fertilization on trends in soil water distribution and water use were quantified for an 18-yr (1967-1984) field experiment conducted on a medium textured Orthic Brown Chernozem (Aridic Haploboroll) in southwestern Saskatchewan, Canada. Soil water contents were measured eight times each year and plant samples were taken at five phenological growth stages. The treatments studied were continuous wheat (Cont W), summer fallow - wheat, F-(W) and summer fallow - wheat - wheat, F-W-(W) each receiving recommended rates of N and phosphorus (P) fertilizer, and (F)-W-W and (Cont W) each receiving only P fertilizer, with the examined rotation phase shown in parentheses. Soil water conserved under fallow during the summer months averaged 25 mm in the root zone, and was related to the initial water content of the soil, the amount of precipitation received, its distribution over time, and potential evapotranspiration. Under a wheat crop grown on fallow, soil water contents between spring and the five-leaf stage remained relatively constant at about 250 mm, but those under a stubble crop, with 40 mm lower spring soil water reserves, increased slightly until about the three-leaf stage. During the period of expansive crop growth (from the five-leaf to the soft dough stage) soil water was rapidly lost from all cropped phases at rates of 1.87 mm.day–1 for F-(W) (N+P), 1.23 mm.day–1 for Cont W (N+P) and 1.17 mm.day–1 for Cont W (+P). The initial loss was from the 0 - 0.3 m depth, but during the latter half of the growing season from deeper depths, although rarely from the 0.9 - 1.2 m depth. In very dry years (e.g., 1973, with 87 mm precipitation between spring and fall) summer fallow treatments lost water. In wet years with poor precipitation distribution (e.g., 1970, with 287 mm precipitation between spring and fall but 142 mm of this in one week between the three- and five-leaf stage) even cropped treatments showed evidence of leaching. The above-ground biomass water use efficiency for Cont W was 19.2 and 16.7 kg.ha–1.mm–1, respectively, for crops receiving (N+P) and P fertilizer only. Grain yield water use efficiency (8.91
Militaire hervormingen in het Staatse leger en de opbouw van het wapenbedrijf, 1585-1621
M.A.G. de Jong
BMGN : Low Countries Historical Review , 2003,
Abstract: M. A. G. de Jong, Military reforms in the State army and the growth of the arms industry, 1585-1621 This article looks at the consequences of the military reforms carried out under Prince Maurice of Orange upon the demand and supply of arms and munitions for the State army, especially the infantry. Five key aspects of these military reforms were examined: the increasing use of firearms; the standardization of arms; the growth of the State army; the increasingly important role that sieges had come to play in warfare; and, regular payments to the troops. When combined, these developments influenced the scale and nature of the demand made by the army in particular and, subsequently, the development of the arms industry as a whole. In their efforts to address this rapid increase in demand, a clear tendency towards concentration became evident among the entrepreneurs in the arms industry. The increased level of production that was required led to a number of important changes in the structure and organisation of the arms industry: standardization, granting buyers credit in the form of raw materials, fixed contracts, the distribution/dispersal and division of labour. During this process, the Dutch authorities consistently played an expressly guiding role. Through the direct link between the troops of the State army and the suppliers of arms on the one hand, and the provincial authorities on the other, the decentralised state system could furnish the State army with its requirements in an efficient and effective manner.
Divisor classes and the virtual canonical bundle for genus 0 maps
A. J. de Jong,Jason Michael Starr
Mathematics , 2006,
Abstract: Some divisor class relations are proved and used to compute the Cartier divisor class of the virtual canonical bundle for genus 0 maps to a smooth target.
Higher Fano manifolds and rational surfaces
A. J. de Jong,Jason Michael Starr
Mathematics , 2006,
Abstract: For a Fano manifold of pseudo-index at least 3 and $c_1^2-2c_2$ nef, we show irreducibility of certain spaces of curves on the Fano manifold implies the manifold is a union of rational surfaces.
Very twisting families of pointed lines on Grassmannians
A. J. de Jong,Jason Michael Starr
Mathematics , 2006,
Abstract: There exist very twisting families of lines on Grassmannians and isotropic Grassmannians. This is a key step in proving existence of a rational section of a family of isotropic Grassmannians over a surface with vanishing Brauer obstruction.
A note on Fano manifolds whose second Chern character is positive
A. J. de Jong,Jason Michael Starr
Mathematics , 2006,
Abstract: This note outlines some first steps in the classification of Fano manifolds for which $c_1^2-2c_2$ is positive or nef.
Invariant rings through categories
Jarod Alper,A. J. de Jong
Mathematics , 2010,
Abstract: We formulate a notion of "geometric reductivity" in an abstract categorical setting which we refer to as adequacy. The main theorem states that the adequacy condition implies that the ring of invariants is finitely generated. This result applies to the category of modules over a bialgebra, the category of comodules over a bialgebra, and the category of quasi-coherent sheaves on a finite type algebraic stack over an affine base.
On the Geometry of Principal Homogeneous Spaces
A. J. de Jong,Robert Friedman
Mathematics , 2008,
Abstract: Let $B$ be a curve defined over an algebraically closed field $k$ and let $X\to B$ be an elliptic surface with base curve $B$. We investigate the geometry of everywhere locally trivial principal homogeneous spaces for $X$, i.e. elements of the Tate-Shafarevich group. If $Y$ is such a principal homogeneous space of order $n$, we find strong restrictions on the $\mathbb{P}^{n-1}$ bundle over $B$ into which $Y$ embeds. Examples for small values of $n$ show that, in at least some cases, these restrictions are sharp. Finally, we determine these bundles in case $k$ has characteristic zero, $B = \mathbb{P}^1$, and $X$ is generic in a suitable sense.
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