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Modelling and optimization of the surface roughness in the dry turning of the cold rolled alloyed steel using regression analysis
Taniki, Dejan;Marinkovi?, Velibor;
Journal of the Brazilian Society of Mechanical Sciences and Engineering , 2012, DOI: 10.1590/S1678-58782012000100006
Abstract: surface quality of the machined parts is one of the most important product quality indicators and one of the most frequent customer requirements. the average surface roughness (ra) represents a measure of the surface quality, and it is mostly influenced by the following cutting parameters: the cutting speed, the feed rate, and the depth of cut. quantifying the relationship between surface roughness and cutting parameters is a very important task. in this study regression analysis was used for modelling and optimization of the surface roughness in dry single-point turning of the alloyed steel, using coated tungsten carbide inserts. the experiment has been designed and carried out on the basis of a three-level full factorial design. the linear, the quadratic and the power (non-linear) mathematical models were selected for the analysis. obtained results are in good accordance with the experimentally obtained data, confirming the effectiveness of regression analysis in modelling and optimization of surface roughness in the turning process. the general conclusion is that the surface roughness has a clear downward trend with the cutting speed increase and decrease in the feed rate and the depth of cut.
Geometry of straight lines pencils
Jani? Milan,Taniki? Dejan
Facta Universitatis Series : Architecture and Civil Engineering , 2002, DOI: 10.2298/fuace0204291j
Abstract: This paper considers a pencil of straight Unes in the Euclidean plane as well as the same pencil of straight lines in the projective plane where the projective geometry model M" is defined with its points forming the sets of (n-l) collinear points, whose supporting straight lines belong to the considered pencil of straight lines.
Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus
Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Noriko Sakasegawa, Yuko Murakami, Po-sung Chu, Shingo Usui, Yuka Ishibashi, Yuko Wakayama, Nobuhito Taniki, Hiroko Murata, Yoshimasa Saito, Masayoshi Fukasawa, Kyoko Saito, Yoshiyuki Yamagishi, Takaji Wakita, Hiroshi Takaku, Toshifumi Hibi, Hidetsugu Saito, Takanori Kanai
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094460
Abstract: Most of experiments for HCV infection have been done using lytic infection systems, in which HCV-infected cells inevitably die. Here, to elucidate metabolic alteration in HCV-infected cells in a more stable condition, we established an HCV-persistently-infected cell line, designated as HPI cells. This cell line has displayed prominent steatosis and supported HCV infection for more than 2 years, which is the longest ever reported. It enabled us to analyze metabolism in the HCV-infected cells integrally combining metabolomics and expression arrays. It revealed that rate-limiting enzymes for biosynthesis of cholesterol and fatty acids were up-regulated with actual increase in cholesterol, desmosterol (cholesterol precursor) and pool of fatty acids. Notably, the pentose phosphate pathway was facilitated with marked up-regulation of glucose-6-phosphate dehydrogenase, a rete-limiting enzyme, with actual increase in NADPH. In its downstream, enzymes for purine synthesis were also up-regulated resulting in increase of purine. Contrary to common cancers, the TCA cycle was preferentially facilitated comparing to glycolysis pathway with a marked increase of most of amino acids. Interestingly, some genes controlled by nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a master regulator of antioxidation and metabolism, were constitutively up-regulated in HPI cells. Knockdown of Nrf2 markedly reduced steatosis and HCV infection, indicating that Nrf2 and its target genes play important roles in metabolic alteration and HCV infection. In conclusion, HPI cell is a bona fide HCV-persistently-infected cell line supporting HCV infection for years. This cell line sustained prominent steatosis in a hypermetabolic status producing various metabolites. Therefore, HPI cell is a potent research tool not only for persistent HCV infection but also for liver metabolism, overcoming drawbacks of the lytic infection systems.
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