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Search Results: 1 - 10 of 3089 matches for " Takeshi Kondo "
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A case of lipomatous pleomorphic adenoma in the parotid gland: a case report
Takeshi Kondo
Diagnostic Pathology , 2009, DOI: 10.1186/1746-1596-4-16
Abstract: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.This is the sixth case of lipomatous pleomorphic adenoma in the English literature. Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management. On CT scan, it may not be detected possibly due to the extensive fatty component.Pleomorphic adenoma is the most common benign neoplasm of the salivary glands, with the highest predilection for the parotid gland. The term 'pleomorphic' refers to both histogenesis and histology of the tumor. As the term 'pleomorphic' shows, the tumor is characteristic of the diversity of the histology. Lipomatous component can be included in pleomorphic adenoma. Extensive lipomatous involvement of the tumor is, however, a very rare finding in pleomorphic adenoma, with only five cases in the English literature [1-5]. Herein, I present the pathological findings of lipomatous pleomorphic adenoma.A 14-year-old Japanese woman presented with an asymptomatic slowly growing mass in the right preauricular region. CT scan was not performed. The patient then underwent excision of the deep lobe of the parotid gland. Grossly, the smooth surfaced lipomatous mass measured approximately 2 cm and had a uniform yellow cut surface (Fig. 1). Microscopic examination revealed a thick fibrous capsule completely surrounding the lesion (Fig. 2A). The well-encapsulated tumor consisted predominantly of mature adipose tissue (more than 95% of the entire lesion) with slight myxoid change containing only a scant epithelial element arranged in islands (Fig. 2B). Histologic images of higher magnification are shown in Fig. 3. Nuclear atypia or mitotic activity of epithelial cells was not identified. Adipocytes were univacuolar in shape, and no lipoblasts or malignant findings were identified. The tumor cells were negative for several special stains including PAS reaction (not shown). Although additiona
Hemangioma related to Maffucci syndrome in a man: a case report
Takeshi Kondo
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-224
Abstract: The case of a 43-year-old Japanese man with multiple chondromas and hemangiomas (Maffucci syndrome) is reported. One of the hemangiomas was removed and examined pathologically. The morphological picture was an admixture of cavernous hemangioma and spindle cell hemangioma without cytological atypia or mitosis. Sheets of vacuolated endothelial cells were also observed.A rare case of hemangioma associated with Maffucci syndrome, focusing on the pathologic nature of the submitted tissue, is reported.Maffucci syndrome is a rare clinical entity (approximately 200 cases have been reported in the medical literature) [1]. It consists of combined occurrence of multiple enchondromas and vascular tumors. This syndrome is not inherited and shows female predilection.A 43-year-old Japanese man presented with multiple chondromas and hemangiomas. His disease had been diagnosed as Maffucci syndrome. His available clinical information, however, was limited. One of the hemangiomas was removed and examined pathologically. Macroscopically, the lesion showed a serpentine appearance (Figure 1A). The cut surface of the lesion showed a blackish area filled with blood and a whitish area (Figure 1B).The morphological picture was an admixture of cavernous hemangioma (Figure 2A) and spindle cell hemangioma (Figure 2B) without cytological atypia or mitosis. Sheets of vacuolated endothelial cells were also observed (Figure 2C). In the cavernous component, organized thrombosis was observed (image not shown). No epithelioid hemangiomatous area was found.Most patients with Maffucci syndrome present at birth or in early childhood with hemangiomas varying in size from a few millimeters to several centimeters which are typically located in the dermis or subcutaneously on the distal parts of the limbs. Hemangiomas, however, may also be found in internal organs [2]. The most common vascular lesions to occur in association with Maffucci syndrome are spindle cell hemangiomas, although occasional cases of ly
Lung adenocarcinoma with giant cyst formation showing a variety of histologic patterns: a case report
Takeshi Kondo
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-377
Abstract: A 60-year-old Japanese woman was admitted to hospital complaining of dyspnea and died of respiratory failure. She had been suffering from lung cancer with pleural effusion for five years. Autopsy analysis revealed lung adenocarcinoma with large cyst formation showing a variety of histologic patterns.Autopsy analysis of this atypical case of lung cancer may provide insight and lead to a better understanding of the heterogeneity and clonal expansion of lung adenocarcinoma.Lung adenocarcinoma with large cyst formation is relatively rare and only a few cases have been reported [1-6]. This report is from an autopsy of a patient with lung adenocarcinoma with large cyst formation showing a variety of histologic patterns. It is believed that this type of lung cancer has not been reported in English language medical literature.A 60-year-old Japanese woman was admitted to hospital complaining of dyspnea. She had lung cancer with pleural effusion. A tumor was identified in the middle lobe of her right lung with pleural effusion. At that time, cytological examination was performed on the pleural effusion and the tumor was diagnosed as a conventional adenocarcinoma (the cytological specimen is not available). The pleural effusion had been controlled by drainage and chemotherapy. The lesion on her right lung showed an atypical appearance with giant pseudocyst formation, probably containing pleural effusion. She died of respiratory failure. An autopsy was immediately conducted to determine the pathological character of the pulmonary lesion with an atypical appearance.Macroscopically, her right lung, weighing 655 g, had a large cyst containing pleural effusion (950 ml) and necrotic tissue (385 g) (Figure 1A, B). Aggressive metastasis was confirmed at various loci including her left lung, myocardium (Figure 2F), left adrenal gland, subcutaneous tissue around her right humerus, and bone (Figure 2E). Bone metastases were found in her lumbar vertebrae (L4/5) and the distal end of her r
Traumatic funicular phlebitis of the thoracic wall resembling Mondor's disease: a case report
Takeshi Kondo
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-127
Abstract: The author presents a case of a 35-year-old male Japanese patient with cord-like induration in the right lateral thoracic wall. This lesion was diagnosed as traumatic funicular phlebitis, resembling Mondor's disease.Traumatic funicular phlebitis, resembling Mondor's disease, is a clinical entity which may give suggestive insight to the etiology of Mondor's disease itself.Mondor's disease is a peculiar form of superficial thrombophlebitis, first reported in 1939 [1] as a thrombophlebitis involving a superficial vein in the subcutaneous fat of the breast or anterior chest wall, especially in women [2]. Classic Mondor's disease involves the lateral thoracic, thoracoepigastric, or superior epigastric veins [3]. It usually occurs as a sudden, subcutaneous tender, painless, cord-like swelling of the vein [2]. The process is usually unilateral, but very rarely bilateral manifestations have been found. The histologic changes are limited to a "subcutaneous vein showing thrombosis and organisation" [4]. This article will describe a case which can be called traumatic funicular phlebitis.A 35-year-old Japanese man, working for a pathological laboratory, noticed tenderness in his right lower lateral thoracic wall and a palpable cord-like lesion extending from the painful point (on the right seventh rib) to the axillar fossa. Physical examination revealed the presence of a curvilinear subcutaneous cord-like induration in the right lateral chest wall. The lesion was approximately 15 cm long, originating from the painful position (on the right seventh rib) with rather old subcutaneous hemorrhage to the axillar fossa (Figure 1). The old subcutaneous hemorrhage suggested the traumatic origin, although the patient did not remember the traumatic event. Based on the color, consistency and shape of the hemorrhage (or ecchymosis), the possible traumatic event had occurred two or three weeks before. The funicular lesion anatomically corresponded to the right thoracodorsal vein. The overlyi
Aggressive angiomyxoma in the inguinal region: a case report
Takeshi Kondo
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-396
Abstract: We report the case of a 68-year-old Japanese man with a slowly growing inguinal swelling. At surgery, a huge mass in the soft tissue of the inguinal region was found, not involving the adjacent organs. The morphologic picture was compatible with aggressive angiomyxoma of the inguinal region.Aggressive angiomyxoma is a very rare, locally infiltrative neoplasm. Thus, after surgery, close follow-up is needed because of a high risk of local recurrence.Aggressive angiomyxoma is a rare mesenchymal tumor of the pelvis and perineum that occurs almost exclusively in adult women [1]. It preferentially arises from the soft tissue of the pelvic region, perineum, and genital area. Its incidence is approximately sixfold higher in women, and 24 male cases have been reported in the literature [1]. The tumor is usually locally infiltrative and has a high rate of local recurrence after surgical excision [1]. The adjective "aggressive" emphasizes the neoplastic character of the blood vessels, its locally infiltrative nature, and the high risk of local recurrence, not indicating a malignant potential of the lesion. Rarely, this tumor appears in men, simulating inguinal hernia, testicular neoplasm, spermatic cord neoplasm, hydrocele, or spermatocele [2,3].A 68-year-old healthy Japanese man presented with a slowly growing swelling of the soft tissue in the inguinal region (Figure 1). The duration of symptoms was about five years. At surgery, a large encapsulated mass (7.5 cm) was found, not involving the adjacent structure. The tumor was easily removed, as it was discrete and without adhesions. The cut surface of the tumor was smooth, homogeneous, and gray-white (Figure 2a). Histologically, it was a paucicellular (hypocellular) tumor composed of fibrotic and myxoid areas, showing a sparse population of spindle-shaped tumor cells without significant cytologic atypia or mitosis (Figure 2b). Foci of thick-walled blood vessels of various sizes were identified. The tumor cells were positive f
Ureteral polypoid endometriosis causing hydroureteronephrosis
Kondo Takeshi
Indian Journal of Pathology and Microbiology , 2009,
Abstract: A 44-year-old Japanese woman presented with a left low back pain. Abdominal ultrasonography revealed the left hydroureteronephrosis. She had the past history of endometriosis interna 3 years before. Retrograde pyelography showed the defect in the ureter, and on ureteroscopy, a polypoid mass was identified. Biopsy specimen from the ureteral mass showed endometrioid epithelia and edematous endometrial stroma, immunohistochemically positive for progesterone receptor (PgR), estrogen receptor (ER), and CD 10. For the lesion (endometrioma), partial resection of the ureter and ureteroneocystostomy with Boari flap were performed. The resected specimen showed a 2-cm polypoid mass. Histologically, the lesion was ureteral endometriosis. The postoperative course was uneventful, the patient showed no evidence of local recurrence after the initial resection and continues to be under close follow up. Urinary tract involvement of endometriosis is uncommon. Endometriosis should be included in the differential diagnosis of ureteral strictures in sexually active young females.
Efficacy and Tolerability of Candesartan Cilexetil and Amlodipine in Patients with Poorly Controlled Essential Hypertension  [PDF]
Kazuaki Nishio, Takeshi Kondo, Youichi Kobayashi
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22012
Abstract: Current treatment guidelines for hypertension in both Europe and the USA stress the importance of aggressive blood pressure control. When monotherapy is not enough to reach treatment targets, there is a need for combination regi-mens that have both high efficacy and good tolerability. The aim of this study is to evaluate the efficacy and toler-ability of the combination therapy candesartan and amlodipine in patients with hypertension not satisfactorily controlled by monotherapy. Patients with uncomplicated essential hypertension not satisfactorily controlled by monotherapy, which is candesartan 8 mg or amlodipine 5 mg, were eligible. Candesartan 8 mg and amlodipine 5 mg were given for 12 weeks. 13 patients who received candesartan 8 mg previoursly were assigned to the candesartan group and 8 patients who received amlodipine 5 mg previoursly were assigned to the amlodipine group. Sitting systolic blood pressure (SBP) at baseline was 151.9 ± 11.6 mmHg in the candesartan group, and 154.6 ± 7.6 mmHg in the amlodipine group. Sitting diastolic blood pressure (DBP) was 93.2 ± 13.1 in the candesartan group, and 80.4 ± 14.7 in the amlodipine group. DBP in the amlodipine group was lower than that in the cadesartan group (P = 0.036). After the combination therapy, SBP was significantly reduced in the two groups. DBP showed significant reduction in the amlodipine group. The rate of achieving blood pressure goals was 4% at baseline and significantly increased to 58% after the combination therapy. These results showed that candesartan 8 mg/amlodipine 5 mg are effective lowering blood pressure after 12 weeks in patients not adequately controlled by monotherapy.
The effect of the feedback cycle between the soil organic carbon and the soil hydrologic and thermal dynamics  [PDF]
Kensuke Mori, Takeshi Ise, Miyuki Kondo, Yongwon Kim, Hiroyuki Enomoto
Open Journal of Ecology (OJE) , 2012, DOI: 10.4236/oje.2012.22011
Abstract: Biogeochemical feedback processes between soil organic carbon (SOC) in high-latitude organic soils and climate change is of great concern for projecting future climate. More accurate models of the SOC stock and its dynamics in organic soil are of increasing importance. As a first step toward creating a soil model that accurately represents SOC dynamics, we have created the Physical and Biogeochemical Soil Dynamics Model (PB-SDM) that couples a land surface model with a SOC dynamics model to simulate the feedback cycle of SOC accumulation and thermal hydrological dynamics of high-latitude soils. The model successfully simulated soil temperatures for observed data from a boreal forest near Fairbanks, and 2000 year simulations indicated that the effect of the feedback cycle of SOC accumulation on soil thickness would result in a significant differences in the amount of SOC.
Sensitive Electrochemical Detection of Glucose at Glucose Oxidase-Cobalt Phthalocyanine-Modified Boron-Doped Diamond Electrode
Takeshi Kondo,Masaru Horitani,Makoto Yuasa
International Journal of Electrochemistry , 2012, DOI: 10.1155/2012/943957
Abstract: Electrochemical detection of glucose was achieved at a glucose oxidase (GOx)-cobalt phthalocyanine (CoPc)-modified boron-doped diamond (BDD) electrode without any additional electron mediator in the electrolyte solution. The surface of the hydrogen-terminated BDD thin film prepared by microwave plasma-assisted CVD was modified with 4-vinylpyridine (4VP) via photochemical modification. The 4VP-BDD was then immersed in a CoPc solution to obtain CoPc-BDD. A poly(p-phenylenediamine) (PPD) thin film containing GOx was coated on the CoPc-BDD electrode surface via electropolymerization. At the GOx/PPD-CoPc-BDD electrode, anodic current for glucose oxidation was observed with a sigmoidal voltammetric curve, indicating successful electron mediation of H2O2 generated as the result of glucose oxidation at GOx. The signal-to-background ratio for voltammetric current of glucose detection was larger at the GOx/PPD-CoPc-BDD electrode than at the GOx/PPD-modified platinum electrode due to the smaller background current of the modified BDD electrode. 1. Introduction Highly boron-doped diamond (BDD) electrodes have been known to be a promising electrode material for sensitive electroanalysis based on the wide potential window and low background current as well as physical and chemical stability and biocompatibility [1]. Glucose is a compound, whose concentration is one of the most desired to be determined via electrochemical methods in relation to increasing demands for diabetes care [2]. In order to use BDD electrode for glucose detection, one should modify the surface with catalysts or enzymes due to the large overpotential for direct glucose oxidation at unmodified BDD electrodes. For glucose detection at BDD electrodes using electrocatalysts, Cu [3–5] and Ni [6–9] have been used for modification of the surfaces. Immobilization of particles or line patterns of these metals with micrometer or nanometer scale onto BDD surface enables sensitive glucose detection with low background current. On the other hand, BDD electrodes modified with glucose oxidase (GOx) [10–13] are advantageous because of their selectivity and sensitivity of the glucose molecule. In some cases, additional mediators, such as ferrocene carboxylic acid [11], were employed for glucose detection at GOx-modified BDD electrodes. Glucose detection without any additional reagents to samples is possible for simple analysis systems, and especially for monitoring concentration. Hydrogen peroxide is a product of glucose oxidation at GOx and thus can act as an electroactive mediator for electrochemical detection
Phase II Study of Carboplatin and Pemetrexed Followed by Gefitinib for Patients with Advanced Non-Small Cell Lung Cancer Harboring Sensitive EGFR Mutation  [PDF]
Saki Manabe, Fumihiro Oshita, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Takeshi Kaneko, Kouzo Yamada
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.615132
Abstract: We conducted a phase II study of combination chemotherapy with carboplatin (Cb) and pemetrexed (Pem) followed by gefitinib (Gef) to determine the effects and toxicities in patients with non-small cell lung cancer (NSCLC) harboring sensitive EGFR mutation. Eligible patients received four courses of Cb at a dose corresponding to a target area under the curve equal to 6 mg/mL·min and 500 mg/m2 Pem on day 1 every three to four weeks followed by sequential Gef 250 mg once a day until tumor progression. Sixteen of registered 28 patients responded to Cb and Pem combination. Twenty-seven patients received sequential Gef and 8 non-responders to Cb and Pem achieved PR. The overall response rate was 85.7%. Among the major toxicities, grade 3 SGPT elevation, nausea and thrombosis were observed in 3, 3 and 1 patients, respectively, who received Cb and Pem, and grade 3 SGPT elevation and dry skin were observed in 5 and 1 patients, respectively, who received Gef. There was no febrile neutropenia and no treatment-related death. The median progression-free survival time was 19.1 months. Among 21 patients who were followed up for more than 2 years, 14 survived during that time. Cb and Pem followed by Gef maintenance are recommended for further evaluation for patients with metastatic NSCLC harboring sensitive EGFR mutation.
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