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Search Results: 1 - 10 of 929 matches for " Takenori Ogawa "
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A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane
Yuriko Saiki,Takenori Ogawa,Kiyoto Shiga,Makoto Sunamura,Toshimitsu Kobayashi,Akira Horii
International Journal of Otolaryngology , 2011, DOI: 10.1155/2011/521852
Abstract: Recently, an inverse relationship between resistance to platinum-based chemotherapeutic agents and taxanes has been implicated in breast and ovarian cancers, and a possible pivotal role for BRCA1 has also been suggested. Because cis-diamminedichloroplatinum (CDDP) and taxanes are the most active antitumor agents against head and neck squamous cell carcinoma (HNSCC), we analyzed the sensitivity of nine HNSCC cell lines and their previously established derived CDDP-resistant cell lines to two representative taxanes: docetaxel and paclitaxel. None of the nine original cell lines showed any cross resistance between CDDP and taxanes, but one of the CDDP-resistant cell lines, RPMI2650CR, demonstrated hypersensitivity to both taxanes when compared to the parental cell line, RPMI2650. Furthermore, RPMI2650CR exhibited increased expression of BRCA1. These data suggest that (i) taxanes are a good candidate for a second-line therapeutic drug for HNSCC patients with acquired CDDP resistance and (ii) BRCA1 can be a candidate marker for predicting an inverse CDDP/taxane sensitivity phenotype in HNSCC.
A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane
Yuriko Saiki,Takenori Ogawa,Kiyoto Shiga,Makoto Sunamura,Toshimitsu Kobayashi,Akira Horii
International Journal of Otolaryngology , 2011, DOI: 10.1155/2011/521852
Abstract: Recently, an inverse relationship between resistance to platinum-based chemotherapeutic agents and taxanes has been implicated in breast and ovarian cancers, and a possible pivotal role for BRCA1 has also been suggested. Because cis-diamminedichloroplatinum (CDDP) and taxanes are the most active antitumor agents against head and neck squamous cell carcinoma (HNSCC), we analyzed the sensitivity of nine HNSCC cell lines and their previously established derived CDDP-resistant cell lines to two representative taxanes: docetaxel and paclitaxel. None of the nine original cell lines showed any cross resistance between CDDP and taxanes, but one of the CDDP-resistant cell lines, RPMI2650CR, demonstrated hypersensitivity to both taxanes when compared to the parental cell line, RPMI2650. Furthermore, RPMI2650CR exhibited increased expression of BRCA1. These data suggest that (i) taxanes are a good candidate for a second-line therapeutic drug for HNSCC patients with acquired CDDP resistance and (ii) BRCA1 can be a candidate marker for predicting an inverse CDDP/taxane sensitivity phenotype in HNSCC. 1. Introduction Cisplatin (cis-diamminedichloroplatinum, CDDP), a DNA damaging drug, is the most active antitumor agent for treating patients with head and neck squamous cell carcinoma (HNSCC). However, acquired resistance to CDDP is one of the major problems in the clinical management of such patients [1]. CDDP-resistance has been reported to be associated with decreased cellular accumulation of the drug, increased levels of glutathione, DNA repair, and antiapoptotic activity [2]. Hence we focused on factors or molecules that are closely associated with sensitivity and/or resistance to CDDP, and we identified IGF2 as one of the candidate molecules for acquired CDDP resistance [3]. Ultimately, we need to find a way to deduce the molecular mechanisms for acquisition of resistance. In the meantime, it is also very important to find alternative drug(s) or method(s) for defeating the acquired resistance. Stordal et al. highlighted an inverse relationship between CDDP and taxane resistance [4]. These drugs function in different phases of the cell cycle; thus CDDP and taxanes are often applied as combined chemotherapy [5, 6]. Herein, we studied the inverse relationships of resistance between CDDP and taxanes in HNSCC cell lines and observed that one of our cell lines with acquired CDDP resistance showed increased taxane sensitivity when compared with its parental cell line. Furthermore, dramatic upregulation of BRCA1 was also observed in these CDDP-resistant cells. Although
Carbon Dioxide Capture and Utilization for Gas Engine  [PDF]
Takashi Ogawa
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.510064
Abstract:

Sodium glycinate absorption and ethylene carbonate synthesis from a mixture gas of ethylene oxide and carbon dioxide are evaluated as carbon dioxide capture and utilization system for gas engine flue gas. The energy requirement for CO2 capture is estimated at 3.3 GJ/tonne CO2. The ethylene carbonate synthesis utilizes more than 90% of the captured CO2 and supply 2.5 GJ/tonne CO2 of thermal energy, which is 76% of the energy requirement for CO2 capture. The thermal integration of the sodium glycinate absorption and the ethylene carbonate synthesis reduces the energy requirement for CO2 capture from 3.3 GJ/tonne CO2 to 0.8 GJ/tonne CO2. The energy requirement for the CO2 capture is supplied using the steam saturated at 0.78 MPa from the gas engine without its electric power reduction.

Suprabasin Is Hypomethylated and Associated with Metastasis in Salivary Adenoid Cystic Carcinoma
Chunbo Shao,Marietta Tan,Justin A. Bishop,Jia Liu,Weiliang Bai,Daria A. Gaykalova,Takenori Ogawa,Ami R. Vikani,Yuri Agrawal,Ryan J. Li,Myoung Sook Kim,William H. Westra,David Sidransky,Joseph A. Califano,Patrick K. Ha
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048582
Abstract: Salivary gland adenoid cystic carcinoma (ACC) is a rare cancer, accounting for only 1% of all head and neck malignancies. ACC is well known for perineural invasion and distant metastasis, but its underlying molecular mechanisms of carcinogenesis are still unclear.
Transport Properties of Bi$_2$Sr$_{2-x}$La$_x$CaCu$_2$O$_{8+δ}$ Single Crystals Grown by a Floating-Zone Method
Takenori Fujii,Ichiro Terasaki
Physics , 2003, DOI: 10.1016/S0921-4534(03)00836-0
Abstract: A parent insulator of the Bi-based high-$T_c$ superconductor Bi$_2$Sr$_{2-x}$La$_x$CaCu$_2$O$_{8+\delta}$ was successfully grown by a traveling solvent floating zone method. The in-plane resistivity $\rho_{ab}$ shows metallic behavior ($d\rho_{ab}/dT >$ 0) near room temperature, although the magnitude of the resistivity is far above the Mott limit for metallic conduction. The Hall mobility of the parent insulator does not so much differ from that of an optimally doped sample. These results suggest that the system is not a simple insulator with a well-defined gap, and the hole in the parent insulator is essentially itinerant, as soon as it is doped.
Large Transport Properties of Bi$_2$Sr$_{2-x}$La$_x$CaCu$_2$O$_{8+δ}$ Single Crystals Grown by a Floating-Zone Method
Takenori Fujii,Ichiro Terasaki
Physics , 2003,
Abstract: A parent insulator of the Bi-based high-$T_c$ superconductor Bi$_2$Sr$_{2-x}$La$_x$CaCu$_2$O$_{8+\delta}$ was successfully grown by a traveling solvent floating zone method. The in-plane resistivity $\rho_{ab}$ shows metallic behavior ($d\rho_{ab}/dT >$ 0) near room temperature, although the magnitude of the resistivity is far above the Mott limit for metallic conduction. The Hall mobility of the parent insulator does not so much differ from that of an optimally doped sample. These results suggest that the system is not a simple insulator with a well-defined gap, and the hole in the parent insulator is essentially itinerant, as soon as it is doped.
Block-Layer Concept for the Layered Co Oxide: A Design for Thermoelectric Oxides
Takenori Fujii,Ichiro Terasaki
Physics , 2002,
Abstract: High-Tc Cu oxides consist of the alternating stack of the superconductive CuO2 layer and the block layer, such as Bi2Sr2O4 or La2-xSrxO2. By changing the block layer, we can change their physical properties, such as transition temperature Tc. The thermoelectric Co oxides have a similar layered structure composed of the conductive CoO2 layer and the blocking layer. Thus, we propose that their thremoelectric properties can be finely tuned by modifying the block layer.
The Effects of the Misfit Structure on Thermoelectric Properties of Bi2-xPbxSr2Co2Oy Single Crystals
Takenori Fujii,Ichiro Terasaki
Physics , 2002,
Abstract: In-plane anisotropy of the resistivity and thermopower was measured for single crystal Bi2-xPbxSr2Co2Oy. There is large in-plane anisotropy, which is attributed to the anisotropic pseudogap formation due to the different crystal symmetry between the square Bi2Sr2O4 layer and the triangular CuO2 layer. The magnitude of the thermopower both along a- and b-axis direction increases with Pb doping from x=0 to 0.4, where we observe discontinuous shrink of b-axis length. We attribute this to the enhancement of the misfitness. Thus, we can improve the thermoelectric properties by tuning the misfitness.
Thermodynamic limit of the Nekrasov-type formula for E-string theory
Takenori Ishii,Kazuhiro Sakai
Mathematics , 2013, DOI: 10.1007/JHEP02(2014)087
Abstract: We give a proof of the Nekrasov-type formula proposed by one of the authors for the Seiberg-Witten prepotential for the E-string theory on R^4 x T^2. We take the thermodynamic limit of the Nekrasov-type formula following the example of Nekrasov-Okounkov and reproduce the Seiberg-Witten description of the prepotential. The Seiberg-Witten curve obtained directly from the Nekrasov-type formula is of genus greater than one. We find that this curve is transformed into the known elliptic curve by a simple map. We consider the cases in which the low energy theory has E_8, E_7+A_1 or E_6+A_2 as a global symmetry.
Trends in age distribution of participants in a self-covered and a public expense-covered health check-up programs in Japan  [PDF]
Maki Ogawa, Atsushi Imai
Health (Health) , 2012, DOI: 10.4236/health.2012.49088
Abstract: Objective: In Japan, there are unique facilities (namely Ningen Dock) of health check-up, where asymptomatic participants undergo a medical examination at their own expense. The earlier occurrence of cervical cancer and the concern on screening prompted us compare to the age distribution in the self-covered system with that of free physical check-up programs at public expense. Methods: We analyzed medical records of Japanese women, who underwent gynecological examinations at self-covered expense and at public expense between for the periods 2002-2011 and 2005-2009, respectively, restricting examinee’s age group. Results: For self-covered system, approximately 80% of the overall examinee population was occupied with three age groups 30-39, 40-49 and 50-59. The participants was extremely fewer in the over 60 years age group accounting for 10%, compared to those for the public expense-covered system, the over 60 years age group being 25%. Participant under the age of 30 years seemed to increase in chronological order in both systems. Conclusion: The level of knowledge on sexually transmitted infections may contribute to screening promotion for the younger women, while the elderly over 60 years’ attitudes toward screening may be mainly related to social-economic status and/or public expense support.
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