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Search Results: 1 - 10 of 1315 matches for " Takayuki Kajita "
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cDNA Cloning of Paramyosin from Several Kinds of Squid Mantle Muscle  [PDF]
Takayuki Kajita, Yoshiko Takeda, Saki Yoshida, Koki Yamada, Masahiro Matsumiya, Hideto Fukushima
Advances in Bioscience and Biotechnology (ABB) , 2018, DOI: 10.4236/abb.2018.91002
Abstract: Paramyosin is a rod-shaped muscle protein found exclusively in invertebrates, with α-helices coiled around each other to form a coiled-coil structure. Marine organisms in which the primary structure of paramyosin has been determined are mollusks, including abalone (Haliotis discus), mussels (Mytilus galloprovincialis), octopus (Octopus bimaculoides), and oyster (Crassostrea gigas). In contrast, the primary structure of squid paramyosin, which is of particular interest, has yet to be reported. In the present study, cDNA cloning of paramyosins from four squid species, the neon flying squid (Ommastrephes bartramii), the Humboldt squid (Dosidicus gigas), the golden cuttlefish (Sepia esculenta), and the clawed armhook squid (Gonatus onyx
Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab
Toshiyuki Oshitari,Fusae Kajita,Aya Tobe,Makiko Itami,Jiro Yotsukura,Takayuki Baba,Shuichi Yamamoto
Case Reports in Ophthalmological Medicine , 2012, DOI: 10.1155/2012/968180
Abstract: Although multicentric Castleman disease is a rare but life-threatening disease, eye complications are extremely uncommon. We present a case of refractory uveitis accompanied with Castleman disease successfully treated with tocilizumab. A 58-year-old man with Castleman disease was introduced for refractory uveitis to Chiba University Hospital. Large cells were detected in the anterior chamber and increased vascular permeability of retinal vessels has been found in both eyes. Although the patient was treated with oral and eye drop steroid treatment, the uveitis symptoms had not decreased. The serum levels of CRP and IL-6 were increased. The level of IL-6 concentration in the anterior chamber was the same as the serum level of IL-6. The humanized anti-IL-6 receptor-antibody (tocilizumab) was administrated for the patient because of poor general condition. After tocilizumab treatment, large cells in the anterior chamber were undetectable and vascular permeability was improved in FA. The serum levels of CRP and IL-6 decreased and the general condition improved. The side effect of tocilizumab was not observed during the treatment. Tocilizumab treatment was significantly effective for uveitis accompanied with Castleman disease. Although it is extremely rare, uveitis accompanied with Castleman disease may be one of the hallmarks to consider tocilizumab treatment.
Development of Macular Holes after Rhegmatogenous Retinal Detachment Repair in Japanese Patients
Mamiko Shibata,Toshiyuki Oshitari,Fusae Kajita,Takayuki Baba,Eiju Sato,Shuichi Yamamoto
Journal of Ophthalmology , 2012, DOI: 10.1155/2012/740591
Abstract: Purpose. To determine the factors associated with the development of a macular hole (MH) after successful rhegmatogenous retinal detachment (RRD) surgery. Methods. Of 1260 eyes that underwent surgery for RRD between April 2005 and March 2010 in our hospital, the medical records of 4 cases from our hospital and one case from another hospital that had undergone RRD surgery and later developed MH were reviewed. This is a retrospective study. Results. 837 eyes underwent pars plana vitrectomy (PPV) with or without scleral buckling (SB), and 423 eyes underwent SB. The four cases that developed MH had PPV alone and one case had PPV with SB. After including the results of three earlier reports, the mean interval for the MH to develop after SB alone was significantly shorter than after PPV alone or after PPV with SB. Conclusions. The SB procedures might accelerate the development of MH after RRD surgery.
Development of Macular Holes after Rhegmatogenous Retinal Detachment Repair in Japanese Patients
Mamiko Shibata,Toshiyuki Oshitari,Fusae Kajita,Takayuki Baba,Eiju Sato,Shuichi Yamamoto
Journal of Ophthalmology , 2012, DOI: 10.1155/2012/740591
Abstract: Purpose. To determine the factors associated with the development of a macular hole (MH) after successful rhegmatogenous retinal detachment (RRD) surgery. Methods. Of 1260 eyes that underwent surgery for RRD between April 2005 and March 2010 in our hospital, the medical records of 4 cases from our hospital and one case from another hospital that had undergone RRD surgery and later developed MH were reviewed. This is a retrospective study. Results. 837 eyes underwent pars plana vitrectomy (PPV) with or without scleral buckling (SB), and 423 eyes underwent SB. The four cases that developed MH had PPV alone and one case had PPV with SB. After including the results of three earlier reports, the mean interval for the MH to develop after SB alone was significantly shorter than after PPV alone or after PPV with SB. Conclusions. The SB procedures might accelerate the development of MH after RRD surgery. 1. Introduction Idiopathic macular holes (MHs) develop from tangential anteroposterior traction by the vitreous [1, 2]. This has been supported by histopathological studies and optical coherence tomographic (OCT) images [3, 4]. However even after pars plana vitrectomy (PPV) with removal of all tractions, MHs can develop in several diseases [5]. Thus, the development of a MH appears to be independent of a vitreofoveal traction in some cases. Lipham and Smiddy suggested that cystic degeneration accompanied by glial proliferation along the margins of the MHs may be associated with the formation of an atypical macular shape after PPV [5]. However, it should take long time to develop full-thickness MH by the traction of glial plaques and membrane formation. In fact, Sheth and Bainbridge reported the cases of the delayed development of MH after PPV for rhegmatogenous retinal detachment (RRD) [6]. They explain that the delayed onset may cause gradual retinal glial tissue contraction surrounding the full-thickness MH [6]. Previous studies indicate that a MH can develop after rhegmatogenous retinal detachment (RRD) repair by scleral buckling (SB) [7, 8]. The development of a MH after RRD repair has been found after PPV with or without concomitant SB [6, 9–11]. We noticed that there appeared to be a difference in the time for the MH to develop after RRD repair among the eyes that had undergone SB, PPV, or PPV with SB. We hypothesized that the time at which MH develops after RRD surgery is an important factor that is related to the pathogenesis of a MH. We reviewed our surgical records for the past 6 years and determined the incidence of MH development after RRD repair in
Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab
Toshiyuki Oshitari,Fusae Kajita,Aya Tobe,Makiko Itami,Jiro Yotsukura,Takayuki Baba,Shuichi Yamamoto
Case Reports in Ophthalmological Medicine , 2012, DOI: 10.1155/2012/968180
Abstract: Although multicentric Castleman disease is a rare but life-threatening disease, eye complications are extremely uncommon. We present a case of refractory uveitis accompanied with Castleman disease successfully treated with tocilizumab. A 58-year-old man with Castleman disease was introduced for refractory uveitis to Chiba University Hospital. Large cells were detected in the anterior chamber and increased vascular permeability of retinal vessels has been found in both eyes. Although the patient was treated with oral and eye drop steroid treatment, the uveitis symptoms had not decreased. The serum levels of CRP and IL-6 were increased. The level of IL-6 concentration in the anterior chamber was the same as the serum level of IL-6. The humanized anti-IL-6 receptor-antibody (tocilizumab) was administrated for the patient because of poor general condition. After tocilizumab treatment, large cells in the anterior chamber were undetectable and vascular permeability was improved in FA. The serum levels of CRP and IL-6 decreased and the general condition improved. The side effect of tocilizumab was not observed during the treatment. Tocilizumab treatment was significantly effective for uveitis accompanied with Castleman disease. Although it is extremely rare, uveitis accompanied with Castleman disease may be one of the hallmarks to consider tocilizumab treatment. 1. Introduction Multicentric Castleman disease (MCD) is widespread lymphadenopathy accompanied by chronic fever, severe fatigue, night sweats, weight loss, and anorexia. MCD is a rare but life-threatening disease, and eye complications are extremely rare [1–3]. We present a patient with MCD with refractory uveitis that was successfully treated with tocilizumab, a humanized anti-interleukin 6 (IL-6) receptor antibody. We evaluated the therapeutic effects of tocilizumab by standard ophthalmological examinations, fluorescein angiography (FA), Goldmann perimetry, and optical coherence tomography (OCT). 2. Case Report A 58-year-old man who was diagnosed with MCD in the Chiba Cancer Center was referred to the Chiba University Hospital in December 2010 to treat his refractory uveitis. He had chronic fever, general fatigue, and refractory pulmonary infiltrations (Figure 1(a)) even after oral steroid treatment. The histopathological findings of pulmonary lymph nodes performed in the Chiba Cancer Center showed infiltrations of polyclonal plasma cells surrounding the mantle zones (Figure 1(b)). The level of serum C-reactive protein (CRP) was 21.0?mg/dl, and the level of serum IL-6 was 46.6?pg/ml (normal;
Atmospheric Neutrinos
Takaaki Kajita
Advances in High Energy Physics , 2012, DOI: 10.1155/2012/504715
Abstract: Atmospheric neutrinos are produced as decay products in hadronic showers resulting from collisions of cosmic rays with nuclei in the atmosphere. Electron-neutrinos and muon-neutrinos are produced mainly by the decay chain of charged pions to muons to electrons. Atmospheric neutrino experiments observed zenith angle and energy-dependent deficit of muon-neutrino events. It was found that neutrino oscillations between muon-neutrinos and tau-neutrinos explain these data well. This paper discusses atmospheric neutrino experiments and the neutrino oscillation studies with these neutrinos. 1. Introduction Neutrinos are produced in various places such as in the Sun, the Earth, the atmosphere, and during the core collapse of a massive star. In addition neutrinos are produced in nuclear power plants and with beams of high energy protons. These neutrinos have been studied by various neutrino experiments. One of these experiments is called atmospheric neutrino experiments. These experiments study neutrinos produced by cosmic ray interactions in the atmosphere. It has been recognized that the small but finite neutrino masses can be understood naturally by the Seesaw mechanism [1–3] by introducing super-heavy neutral particles. Therefore, it is widely understood that the experimental study of neutrino masses and mixing angles are one of the few ways to explore the physics beyond the standard model. One of the most sensitive methods to observe small neutrino masses is to study neutrino flavor oscillations [4, 5]. If neutrinos have finite masses, each flavor eigenstate (e.g., ) can be expressed by a combination of mass eigenstates ( , , and ). The relation between the mass eigenstates ( , , and ) and the flavor eigenstates ( , , and ) can be expressed by where is the mixing matrix. The mixing matrix is expressed by where and represent and , respectively. For simplicity, let us discuss two flavor neutrino oscillations. The probability for a neutrino produced in a flavor state to be observed in a flavor state after traveling a distance through the vacuum is where is the neutrino energy, is the mixing angle between the flavor eigenstates and the mass eigenstates, and is the mass-squared difference of the neutrino mass eigenstates (≡ ). It can be immediately noticed that, in order to study small neutrino masses, one has to study neutrino oscillations with a long neutrino flight length or with a low energy neutrino beam. Atmospheric neutrinos are unique, because they travel very long distances of up to 12,800?km, that is, the diameter of the Earth. The typical energy of
A cost-optimal scenario of CO2 sequestration in a carbon-constrained world through to 2050  [PDF]
Takayuki Takeshita
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.52A043
Abstract:

In this paper, a regionally disaggregated global energy system model with a detailed treatment of the whole chain of CO2 capture and storage (CCS) is used to derive the cost-optimal global pattern of CO2 sequestration in regional detail over the period 2010-2050 under the target of halving global energy-related CO2 emissions in 2050 compared to the 2005 level. The major conclusions are the following. First, enhanced coalbed methane recovery will become a key early opportunity for CO2 sequestration, so coalrich regions such as the US, China, and India will play a leading role in global CO2 sequestration. Enhanced oil recovery will also have a participation in global CO2 sequestration from the initial stage of CCS deployment, which may be applied mainly in China, southeastern Asia, and West Africa in 2030 and mainly in the Middle East in 2050. Second, CO2 sequestration will be carried out in an increasing number of world regions over time. In particular, CCS will be deployed extensively in today’s developing countries. Third, an increasing amount of the captured CO2 will be stored in aquifers in many parts of the world due to their abundant and widespread availability and their low cost. It is shown that the share of aquifers in global CO2 sequestration reaches 82.0% in 2050.

Prospects for Renewable and Fossil-Based Electricity Generation in a Carbon-Constrained World  [PDF]
Takayuki Takeshita
International Journal of Clean Coal and Energy (IJCCE) , 2013, DOI: 10.4236/ijcce.2013.22B008
Abstract: In this paper, a regionally disaggregated global energy system model with a detailed treatment of the electricity supply sector is used to derive the cost-optimal choice of electricity generation technologies for each of 70 world regions over the period 2010-2050 under a constraint of halving global energy-related CO2 emissions in 2050 compared to the 2000 level. It is first shown that the long-term global electricity generation mix under the CO2 constraint becomes highly diversified, which includes coal, natural gas, nuclear, biomass, hydro, geothermal, onshore and offshore wind, solar photovoltaics (PV), and concentrated solar power (CSP). In this carbon-constrained world, 89.9% of the electricity generation from coal, natural gas, and biomass is combined with CO2 capture and storage (CCS) in 2050. It is then shown that the long-term electricity generation mix under the CO2 constraint varies significantly by world region. Fossil fuels with CCS enter the long-term electricity generation mix in all world regions. In contrast, there is a sharp regional difference in the renewable generation technology of choice in the long term. For example, the world regions suitable for PV plants include the US, Western Europe, Japan, Korea, and China, while those suitable for CSP plants include the Middle East, Africa, Australia, and western Asia. Offshore wind is deployed on a large scale in the UK, Ireland, Nordic countries, the southern part of Latin America, and Japan.
Prospects for Coalbed Methane and Shale Gas in a Carbon-Constrained World: A Preliminary Analysis  [PDF]
Takayuki Takeshita
International Journal of Clean Coal and Energy (IJCCE) , 2013, DOI: 10.4236/ijcce.2013.22B007
Abstract:

Using a regionally disaggregated global energy system model with a detailed treatment of the natural gas resource base, this paper analyzes the competitiveness of coalbed methane and shale gas in the global primary energy mix and the cost-optimal pattern of their production in regional detail over the period 2010-2050 under a constraint of halving global energy-related CO2 emissions in 2050 compared to the 2000 level. It is first shown that neither coalbed methane nor shale gas could become an important fuel in the global primary energy mix throughout the time horizon, although each of them could become an important source of world natural gas production from around 2030 onwards. It is then shown that unlike findings of previous studies, coalbed methane would be more attractive than shale gas as a primary energy source globally under the CO2 constraint used here. The results indicate that North America continues to be the world’s largest coalbed methane producer until 2030, after which China overtakes North America and retains this position until 2050. Also, India, Russia, South Africa, and Australia contribute noticeably to world coalbed methane production. The results also indicate that North America continues to dominate world shale gas production until 2040, after which a number of world regions, notably India, Europe, and China, begin to participate visibly in world shale gas production.


Application of Fast N-Body Algorithm to Option Pricing under CGMY Model  [PDF]
Takayuki Sakuma
Journal of Mathematical Finance (JMF) , 2017, DOI: 10.4236/jmf.2017.72016
Abstract: The N-body problem is an active research topic in physics for which there are two major algorithms for efficient computation, the fast multipole method and treecode, but these algorithms are not popular in financial engineering. In this article, we apply a fast N-body algorithm called the Cartesian treecode to the computation of the integral operator of integro-partial differential equations to compute option prices under the CGMY model, a generalization of a jump-diffusion model. We present numerical examples to illustrate the accuracy and effectiveness of the method and thereby demonstrate its suitability for application in financial engineering.
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