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Search Results: 1 - 10 of 4356 matches for " Takashi Miyagawa "
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Analytic properties of generalized Mordell-Tornheim type of multiple zeta-functions and L-functions
Takashi Miyagawa
Mathematics , 2015,
Abstract: Analytic properties of three types of multiple zeta functions, that is, the Euler-Zagier type, the Mordell-Tornheim type and the Apostol-Vu type have been studied by a lot of authors. In particular, in the study of multiple zeta functions of the Apostol-Vu type, a generalized multiple zeta function, including both the Euler-Zagier type and the Apostol-Vu type, was introduced.In this paper, similarly we consider generalized multiple zeta-functions and $ L $-functions, which include both the Euler-Zagier type and the Mordell-Tornheim type as special cases.We prove the meromorphic continuation to the multi-dimensional complex space, and give the results on possible singularities.
Distribution of Deviation Distance to Alternative Fuel Stations  [PDF]
Masashi Miyagawa
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.33033
Abstract: This paper derives the distribution of the deviation distance to visit an alternative fuel station. Distance is measured as the Euclidean distance on a continuous plane. The distribution explicitly considers the vehicle range and whether the round trip between origin and destination can be made. Three cases are examined: fuel is available at both origin and destination, fuel is available at either origin or destination, and fuel is available at neither origin nor destination. The analytical expressions for the distribution demonstrate how the vehicle range, the shortest distance, and the refueling availability at origin and destination affect the deviation distance. The distribution will thus be useful to estimate the number of vehicles refueled at a station.

Oral administration of γ-aminobutyric acid affects heat production in a hot environment in resting humans
Taiki Miyazawa, Takashi Kawabata, Kazunobu Okazaki, Takashi Suzuki, Daiki Imai, Takeshi Hamamoto, Shinya Matsumura, Toshiaki Miyagawa
Journal of Physiological Anthropology , 2012, DOI: 10.1186/1880-6805-31-3
Abstract: Eight male participants drank a 200-ml sports drink with 1 g of GABA (trial G) or without GABA (trial C), then rested for 30 minutes in a sitting position in a hot environment (ambient air temperature 33°C, relative humidity 50%).We found that changes in esophageal temperature from before drinking the sports drink were lower in trial G than in trial C (-0.046 ± 0.079°C vs 0.001 ± 0.063°C; P < 0.05), with lower heat production calculated by oxygen consumption (41 ± 5 W/m2 vs 47 ± 8 W/m2; P < 0.05).In this study, we have demonstrated that a single oral administration of GABA induced a larger decrease in body core temperature compared to a control condition during rest in a hot environment and that this response was concomitant with a decrease in total heat production.γ-aminobutyric acid (GABA) is an amino acid that is widely distributed throughout the central nervous system (CNS) and is the most important depressive neurotransmitter [1]. GABA has important roles concerning temperature regulation in the hypothalamus. In experimental animals, it has been reported that central pharmacological stimulation of GABA in the dorsomedial hypothalamus (DMH) and the posterior hypothalamus (PH) inhibits heat production [2,3]. On the contrary, it has been reported that central pharmacological stimulation of GABA in the preoptic (PO) area and anterior hypothalamus (AH) increases heat production [4,5]. On the basis of these reports, it is assumed that central GABA stimulation to the hypothalamic region has some practical effect on temperature regulation.Few studies have examined the influence of systemic GABA stimulation on temperature regulation in either experimental animals or humans because the blood-brain barrier is impermeable to GABA [6] and it has long been thought that systemic administration of GABA cannot affect GABA's availability in the CNS [7,8]. However, it has been suggested that GABA could access certain areas of the brain that lack the blood-brain barrier [9-11], su
From bench to bedside, work in cell-based myocardial regeneration therapy  [PDF]
Shigeru Miyagawa, Yoshiki Sawa
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.72012
Abstract:

In clinical cellular cardiomyoplasty, bone marrow cells and myoblasts are introduced mainly to ischemic cardiomyopathy tissue via several cell delivery systems, such as needle injection or catheter. These clinical studies have demonstrated the safety and feasibility of this technique, but its effectiveness for treating heart failure, especially in the long term, is still under discussion. Neither of these cell types can differentiate into cardiomyocytes; rather, they improve the failing heart mainly by the paracrine effects of some cytokines, such as Hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF). Thus, many researchers have a great interest in stem cells, which exist in bone marrow, circulating blood, atrium, and adipose tissue, and can differentiate into cardiomyocytes. Although several stem cells with the potential to differentiate into various cell types have been reported, few can differentiate into cardiomyocytes. Moreover, beating cells that can demonstrate synchronized contraction with native cardiomyocytes are critical for the complete repair of severe heart failure. Therefore, stem cells with a high differentiation capacity should be explored for the goal of completely repairing severely damaged myocardium. In this review, we summarize the clinical protocols and basic experiments for cellular cardiomyoplasty using bone marrow cells, myoblasts, and other stem cells.

Experimental Therapeutic Trial of an Antibody against the Cell Adhesion Molecule Gicerin for Lymphomas Using a Murine Cell Line  [PDF]
Yasuhiro Tsukamoto, Yukiko Miyagawa, Osamu Maeda
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.910066
Abstract: Chemotherapy, occasionally combined with radiotherapy, is a major method for treating lymphoma but frequently produces side-effects in patients. Thus, novel therapeutics should be developed as an alternative the chemotherapy in lymphoma patients. Although the cell adhesion molecule gicerins are almost entirely absent in most mature tissues, except for muscle and endothelial cells, various neoplastic cells strongly express gicerin in their cell membranes. This suggests the potential function of gicerin in the progression of tumors, including tumor growth, invasion and metastasis to distant organs from primary sites. In the present study, we assessed therapeutic effects of anti-gicerin antibodies on the murine lymphoma cell line YAC1. Gicerin was found to be expressed in the cell membrane of YAC1 cells and promoted the cell adhesion activity of the YAC1 cells on HUVECs, an endothelial cell line. In addition, YAC1 cells were implanted sub-cutaneously in mice in order to examine the therapeutic effects of anti-gicerin antibodies on lymphoma progression
The Relationship between Living Environment and Oral Function in Elderly Japanese  [PDF]
Naoko Morisaki, Hiroe Uchida, Akiko Miyagawa
Advances in Applied Sociology (AASoci) , 2019, DOI: 10.4236/aasoci.2019.92006
Abstract: This study aims to clarify the current state of oral function among elderly people and to analyze the relation with basic attributes. The subjects of the survey were dependent elderly people receiving nursing care in Japan. We examined the subjects’ age, sex, level of care required, living environment (home or facility), and oral functions. Tongue pressure and oral diadochokinesis (OD) were used to evaluate oral function. The relationship between the basic attributes of the elderly subjects and the oral function evaluation value was analyzed by multiple regression analysis. The average value of tongue pressure was 24.70 ± 10.20 Pa. The average value of OD was 4.7 ± 1.4 for /pa/, 4.6 ± 1.3 for /ta/, and 4.3 ± 1.3 for /ka/. Tongue pressure was found to be significantly related to the degree of care required (p < 0.01). The OD recognized syllables of /pa/, /ta/, /ka/ were significantly related to the degree of need for care and living environment (p < 0.05). The living environment is thought to affect oral function.
Advances in therapeutics for liver metastasis from colorectal cancer
Akira Kobayashi,Shinichi Miyagawa
World Journal of Gastrointestinal Oncology , 2010,
Abstract: The evolution of chemotherapeutic regimens that include targeted molecular agents has resulted in a breakthrough in the management of advanced colorectal liver metastasis (CLM), improving the progression-free survival after liver resection, and rendering initially unresectable liver tumors resectable, with reported resection rates ranging from 13% to 51%. In addition, the criteria used for selecting patients for hepatectomy have been expanding because of advances in surgical techniques and improvements in chemotherapy. However, the increasing use of chemotherapy has raised concern about potential hepatotoxicities such as steatosis, chemotherapy-associated steatohepatitis, and sinusoidal obstruction syndrome, and their deleterious effects on postoperative outcome. The present review focuses on the advantages and disadvantages of chemotherapy, strategies for the prevention and diagnosis of chemotherapy-associated liver injury, and the adoption of more aggressive surgical approaches, which have changed the traditional paradigm for CLM.
$S$-matrix poles near the $ΛN$ and $ΣN$ Thresholds in the Coupled \\$ΛN-ΣN$ System
K. Miyagawa,H. Yamamura
Physics , 1999, DOI: 10.1103/PhysRevC.60.024003
Abstract: We search $t$-matrix poles for $\Lambda N-\Sigma N$ coupling interactions using two soft core models of the Nijmegen group which bind the hypertriton at the correct binding energy, and hard core models which are still influential in hypernuclear physics. To treat the hard core potentials, a useful method for calculating the off-shell $t$-matrix is proposed. We find poles close to the $\Sigma N$ threshold in the second or third quadrant of the complex plane of the $\Sigma N$ relative momentum. The relation between the poles and the shape of the $\Lambda N$ elastic total cross section is discussed based on a so-called uniformization by which two-channel $t$-matrices become single-valued on a complex valuable. We also find poles near the $\Lambda N$ threshold. These are correlated to the $S$-wave $\Lambda N$ scattering lengths, the values of which have yet to be determined.
Antisymmetry in Strangeness -1 and -2 Three-Baryon Systems
W. Gloeckle,K. Miyagawa
Physics , 2000, DOI: 10.1007/s006010170006
Abstract: Using the generalized Pauli principle by adding particle labels to the usual space and spin labels a symmetric Hamiltonian and a corresponding antisymmetric wavefunction is constructed for systems of three baryons in the strangeness sectors $S=-1$ and -2. Applications are the $\Xi NN-\Lambda\Lambda N$ and $NN\Lambda -NN\Sigma$ systems. Minimal sets of generalized coupled Faddeev equations for breakup and rearrangement operators as well as (possible) bound states are derived which have the ordinary Pauli principle among identical particles built in. The equations found confirm our previous sets of coupled Faddeev equations for those systems whose derivation was carried through for distinguishable particles and not using the generalized Pauli principle.
Precise calculation of the two-step process for K- d -> pi Sigma N in the Lambda (1405) resonance region
K. Miyagawa,J. Haidenbauer
Physics , 2012, DOI: 10.1103/PhysRevC.85.065201
Abstract: The reaction K- d -> pi Sigma N is investigated taking into account single scattering and the two-step process due to Kbar N -> pi Sigma rescattering. The influence of some common approximations are examined. It is found that the treatment of the kinematics in the Green's function that appears in the loop integral of the rescattering process has a rather strong impact on the resulting lineshape of the pi Sigma invariant mass spectrum. Specifically, a calculation with correct kinematics where the three-body unitarity cut due to the nK- p threshold occurs at the physical value yields a pronounced peak in the invariant mass spectrum at this threshold and, at the same time, suppresses the signal in the region of the Lambda(1405) resonance. On the other hand, an approximation applied in past calculations shifts that threshold down and, consequently, leads to an accidental and therefore erroneous enhancement of the signal of the Lambda(1405) in the pi Sigma invariant mass spectrum.
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