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Search Results: 1 - 10 of 243 matches for " Taisuke Akamatsu "
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Usefulness of Fractional Exhaled Nitric Oxide-Guided Treatment in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap  [PDF]
Taisuke Akamatsu, Toshihiro Shirai, Yuko Tanaka, Hirofumi Watanabe, Yoshinari Endo, Yukiko Shimoda, Takahito Suzuki, Rie Noguchi, Mika Saigusa, Akito Yamamoto, Yuichiro Shishido, Takefumi Akita, Satoru Morita, Kazuhiro Asada
Open Journal of Respiratory Diseases (OJRD) , 2018, DOI: 10.4236/ojrd.2018.81001
Abstract:
Background: Some patients present clinical features of both asthma and chronic obstructive pulmonary disease (COPD), which has led to the recent proposal of asthma-COPD overlap (ACO) as a diagnosis. Fractional exhaled nitric oxide (FeNO) is a candidate biomarker to diagnose ACO. We assessed the effect of an add-on treatment with budesonide/formoterol (BUD/FM) combination in patients with ACO, which was diagnosed by FeNO. Methods: This was a prospective, single-arm, open-label, before and after comparison study. Subjects included 83 patients with COPD who attended outpatient clinics for routine checkups at Shizuoka General Hospital between June and November 2016. All patients fulfilled the GOLD definition of COPD and were receiving long-acting muscarinic antagonist (LAMA) or LAMA/long-acting β2 agonist (LABA) combinations. After an 8-week run-in period, BUD/FM was added to the patients with FeNO levels of ≥35 ppb, defined as having ACO. For patients receiving LAMA/LABA, BUD/FM was added after the discontinuation of LABA. The modified British Medical Research Council (mMRC) score, COPD assessment test (CAT) score, spirometric indices, forced oscillation parameters, and FeNO were assessed before and after 8 weeks of BUD/ FM add-on treatment. Results: Twenty-four patients (28.9%) had FeNO levels ≥ 35 ppb, and 17 patients completed the study (mean age: 73 years and GOLD I/II/III/IV, 5/10/1/1). The mean CAT scores significantly improved (9.2 to 5.4, p = 0.015) and 10 patients (58.8%) showed ≥2 points improvement, a minimal clinically important difference. The mean FeNO levels significantly decreased from 63.0 to 34.3 ppb (p < 0.006). However, there were no changes in mMRC scores, spirometric indices, or forced oscillation parameters. Conclusions: FeNO-guided treatment with BUD/FM improves symptoms in patients with ACO.
Motivations Underlying the Snack Choices of Japanese Junior High School Students: A Study Based on Cluster Analysis  [PDF]
Rie Akamatsu
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.27096
Abstract: The aims of the present study were to group junior high school students according to factors influencing their snack choice and identify differences between the characteristics and snack choice behaviors of the groups. An anonymous self-report questionnaire was administered to 1936 students (13 - 15 years old) in eight junior high schools in Tokyo, Japan. The students responded to the Snack Choice Questionnaire (SCQ) as well as questions concerning snacking behaviors, lifestyles, and demographics. Cluster analysis was applied to sort the sample according to SCQ scores. Each cluster’s characteristics were examined by gender using the χ2 test or the Kruskal-Wallis test with a Bonferroni adjustment. Participants were divided into four groups: high in all factors, low in all factors, low value in health, and value in health. The “value in health” group was composed of more girls than boys and the “low in all factors” group had fewer girls than boys. Those in the “high in all factors” and “low value in health” groups indicated that they consumed more snacks. Moreover, gender differences were revealed. By assessing the SCQ prior to providing nutrition education, we can obtain valuable information to make nutrition education planning.
Association between Children’s Appetite Patterns and Maternal Feeding Practices  [PDF]
Tomomi Ainuki, Rie Akamatsu
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.23032
Abstract: This study explored associations between children’s appetites and maternal feeding practices. The participants, 614 parents of 3- to 6-year-old children from kindergartens in Tokyo, Japan, completed self-administered questionnaires. The children’s appetites were measured using the Enjoyment of Food (EF) and Food Responsiveness (FR) scales of the Child Eating Behaviour Questionnaire. Using cluster analysis, we examined three appetite patterns (“both low,” “high EF and low FR,” and “both high”). The three appetite patterns were associated with children’s obesity index. The “both low” pattern was associated with the highest maternal pressure to eat. The “high EF and low FR” patterns were related to an established snack time. The “both high” pattern was associated with higher maternal instrumental feeding compared with the “high EF and low FR” types. The results of this study will facilitate the development of targeted interventions and better parental guidance on maternal feeding practices and their association with children’s eating behaviours.
Fiscal Sustainability of Japanese Prefectural Government Debt  [PDF]
Rena Akamatsu, Kazuki Hiraga
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.38009
Abstract: This paper investigates whether the Japanese local government debt is sustainable. We apply the fiscal stabilization rule that each local government improves their primary balance in the current year when they issue additional debt the previous year. We check it using panel data of the Japanese prefectural governments. We find that Japanese prefectural governments were not sustainable across 1956-2007, though were sustainable across 1956-1989.
Effects of Direct Switching Dual Bronchodilators between Dry Powder and Soft Mist Inhalers in COPD Patients  [PDF]
Taisuke Akamatsu, Toshihiro Shirai, Hiromasa Nakayasu, Kanami Tamura, Toshihiro Masuda, Shingo Takahashi, Yuko Tanaka, Hirofumi Watanabe, Yutaro Kishimoto, Kyohei Oishi, Mika Saigusa, Akito Yamamoto, Satoru Morita, Kazuhiro Asada
Open Journal of Respiratory Diseases (OJRD) , 2020, DOI: 10.4236/ojrd.2020.101002
Abstract: Objective: Dual bronchodilation with long-acting muscarinic antagonist and long-acting β2-agonist combinations are available worldwide in COPD patients. However, the choice of agents remains under debate. We hypothesized that switching devices between dry powder and soft mist inhalers without a wash-out period to mimic clinical practice would improve clinical symptoms and lung function. The aim of this study was to examine the effects of switching between once-daily glycopyrronium/indacaterol (GLY/IND) or umeclidinium/vilanterol (UMEC/VI), dry powder inhalers, and tiotropium/olodaterol (TIO/OLO), a soft mist inhaler, in COPD patients. Methods: This was a prospective, open-label, 8-week, observational study with follow-up. Subjects included 57 COPD patients, who attended outpatient clinics at Shizuoka General Hospital for routine check-ups between February and December 2015, receiving GLY/IND (50/110 μg) or UMEC/VI (62.5/25 μg). After an 8-week run-in period, medications were switched to TIO/OLO (5/5 μg). Study outcomes included patient’s global rating (PGR), modified MRC (mMRC), COPD assessment test (CAT), and spirometric and forced oscillatory parameters after 8 weeks. PGR used in this study was a 7-point scale ranging from 1 to 7, with 4 in the middle. Patients who consented to switch from TIO/OLO to GLY/IND or UMEC/VI were followed-up thereafter. Results: In total, 53 patients completed the study (mean age, 75 years; 48 males and 5 females; GOLD 1/2/3/4 = 19/27/6/1; mMRC 0/1/2/3/4 = 14/22/12/4/1; UMEC/VI 26, GLY/IND 27). PGR, mMRC, and CAT improved in 20 (38%), 9 (17%), and 15 patients (28%), respectively. Respiratory system resistance at 5 Hz (R5), 20 Hz (R20), and the difference between R5 and R20 (R5 - R20) significantly improved. In a follow-up of 16 patients after switching from TIO/OLO to UMEC/VI (9) or GLY/IND (7), PGR, mMRC, and CAT improved in 5 (31%), 3 (12%), and 4 patients (25%), respectively, and R20 significantly improved (p = 0.011). Conclusions: Switching dual bronchodilators between dry powder and soft mist inhalers improves symptoms and airway narrowing in some COPD patients.
Synthesis of Titanium Phosphates with Additives and Their Powder Properties for Cosmetics  [PDF]
Hiroaki Onoda, Taisuke Yamaguchi
Materials Sciences and Applications (MSA) , 2012, DOI: 10.4236/msa.2012.31003
Abstract: As a white pigment, titanium oxide is used for cosmetic application. This oxide is well known to have the photo catalytic activity. Therefore a certain degree of sebum is decomposed by the ultraviolet radiation in sunlight. In this work, titanium phosphates were prepared with additives (urea, sodium lactate, and glycerin) as a novel white pigment. Their chemical composition, powder properties, photo catalytic activity, moisture retention, and smoothness were studied. These white pigments had little photo catalytic activity. The addition of sodium lactate and glycerin improved the moisture retention of titanium phosphates. The slipping resistance of samples became small by the addition of sodium lactate and glycerin. The roughness of samples became small by heating.
Preparation of Titanium Phosphates with Sodium Triphosphate in Hydrothermal Process and Their Powder Properties for Cosmetics  [PDF]
Hiroaki Onoda, Taisuke Yamaguchi
Advances in Materials Physics and Chemistry (AMPC) , 2013, DOI: 10.4236/ampc.2013.31001
Abstract:

As a white pigment, titanium oxide is used for cosmetic application. This oxide is well known to have the photo catalytic activity. Therefore, a certain degree of sebum on the skin is decomposed by the ultraviolet radiation in sunlight. In this work, titanium phosphates were prepared with titanium chloride and sodium triphosphate in hydrothermal process as a novel white pigment. Their chemical composition, powder properties, photo catalytic activity, color phase, and smoothness were studied. The obtained phosphates had little photo catalytic activity. The particle size of phosphate pigments consisted a normal distribution at 2 μm by the hydrothermal treatment for 4 and 8 hours. The slipping resistance of samples became small by the hydrothermal treatment.

Langevin dynamics and decoherence of heavy quarks at high temperatures
Yukinao Akamatsu
Physics , 2015,
Abstract: A Langevin equation of heavy quarks in high-temperature quark-gluon plasma is derived. The dynamics of heavy quark color is coupled with the phase space dynamics and causes a macroscopic superposition state of heavy quark momentum. Decoherence of the superposition state allows one to use a classical description. The time scale of decoherence gives an appropriate discretization time scale $\Delta t\sim \sqrt{M/C_{\rm F}\gamma}$ for the classical Langevin equation, where $M$ is heavy quark mass and $\gamma$ is heavy quark momentum diffusion constant.
Heavy quark master equations in the Lindblad form at high temperatures
Yukinao Akamatsu
Physics , 2014, DOI: 10.1103/PhysRevD.91.056002
Abstract: We derive the quantum master equations for heavy quark systems in a high-temperature quark- gluon plasma in the Lindblad form. The master equations are derived in the influence functional formalism for open quantum systems in perturbation theory. These master equations have a wide range of applications, such as decoherence of a heavy quarkonium and Langevin dynamics of a heavy quark in the quark-gluon plasma. We also show the equivalence between the quarkonium master equations in the recoilless limit and the Schroedinger equations with stochastic potential.
In-medium QCD forces at high temperature
Yukinao Akamatsu
Physics , 2013,
Abstract: We derive the quantum dynamics of heavy quark systems in quark-gluon plasma as open quantum systems. The scatterings of a heavy quark with the hard medium particles give rise to Debye screened QCD force and drag force and its fluctuation. We present a unified quantum description of these in-medium QCD forces at high temperature in the leading-order perturbation on the basis of the influence functional formalism.
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