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Search Results: 1 - 10 of 8818 matches for " Tae-ho Jang "
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Purification, Crystallization and Preliminary X-ray Crystallographic Studies of RAIDD Death-Domain (DD)
Tae-ho Jang,Hyun Ho Park
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10062501
Abstract: Caspase-2 activation by formation of PIDDosome is critical for genotoxic stress induced apoptosis. PIDDosome is composed of three proteins, RAIDD, PIDD, and Caspase-2. RAIDD is an adaptor protein containing an N-terminal Caspase-Recruiting-Domain (CARD) and a C-terminal Death-Domain (DD). Its interactions with Caspase-2 and PIDD through CARD and DD respectively and formation of PIDDosome are important for the activation of Caspase-2. RAIDD DD cloned into pET26b vector was expressed in E. coli cells and purified by nickel affinity chromatography and gel filtration. Although it has been known that the most DDs are not soluble in physiological condition, RAIDD DD was soluble and interacts tightly with PIDD DD in physiological condition. The purified RAIDD DD alone has been crystallized. Crystals are trigonal and belong to space group P3121 (or its enantiomorph P3221) with unit-cell parameters a = 56.3, b = 56.3, c = 64.9 ? and γ = 120°. The crystals were obtained at room temperature and diffracted to 2.0 ? resolution.
Novel Disulfide Bond-Mediated Dimerization of the CARD Domain Was Revealed by the Crystal Structure of CARMA1 CARD
Tae-ho Jang, Jin Hee Park, Hyun Ho Park
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079778
Abstract: CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important role of the CARMA1 signalosome during lymphocyte activation and proliferation, limited structural information is available. Here, we report the dimeric structure of CARMA1 CARD at a resolution of 3.2 ?. Interestingly, although CARMA1 CARD has a canonical six helical-bundles structural fold similar to other CARDs, CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism.
A Fully Integrated Sensor SoC with Digital Calibration Hardware and Wireless Transceiver at 2.4 GHz
Dong-Sun Kim,Sung-Joon Jang,Tae-Ho Hwang
Sensors , 2013, DOI: 10.3390/s130506775
Abstract: A single-chip sensor system-on-a-chip (SoC) that implements radio for 2.4 GHz, complete digital baseband physical layer (PHY), 10-bit sigma-delta analog-to-digital converter and dedicated sensor calibration hardware for industrial sensing systems has been proposed and integrated in a 0.18-μm CMOS technology. The transceiver’s building block includes a low-noise amplifier, mixer, channel filter, receiver signal-strength indicator, frequency synthesizer, voltage-controlled oscillator, and power amplifier. In addition, the digital building block consists of offset quadrature phase-shift keying (OQPSK) modulation, demodulation, carrier frequency offset compensation, auto-gain control, digital MAC function, sensor calibration hardware and embedded 8-bit microcontroller. The digital MAC function supports cyclic redundancy check (CRC), inter-symbol timing check, MAC frame control, and automatic retransmission. The embedded sensor signal processing block consists of calibration coefficient calculator, sensing data calibration mapper and sigma-delta analog-to-digital converter with digital decimation filter. The sensitivity of the overall receiver and the error vector magnitude (EVM) of the overall transmitter are ?99 dBm and 18.14%, respectively. The proposed calibration scheme has a reduction of errors by about 45.4% compared with the improved progressive polynomial calibration (PPC) method and the maximum current consumption of the SoC is 16 mA.
Differences in Learning Facilitatory Effect of Motor Imagery and Action Observation of Golf Putting
Tae-Ho Kim,Angelita Cruz,Jun-Ho Ha
Journal of Applied Sciences , 2011,
Abstract: ith improvements maintained in the delayed post-test. As a result of the putting movements, the AO-PP group improved further from the immediate to the delayed post-test. These results suggest that the learning facilitatory effect of cognitive intervention can be maximized when performed together with physical practice and that physical practice with action observation is more efficient than that with motor imagery. Simultaneous performance of action observation and physical practice thus appears to be the most effective practice condition, by providing a combined learning effect, which cannot be obtained by either cognitive intervention or physical practice alone.
Scaling of Coulomb pseudo-potential in s-wave narrow-band superconductors
Tae-Ho Park,Han-Yong Choi
Physics , 2001, DOI: 10.1103/PhysRevB.65.052504
Abstract: The Coulomb pseudo-potential $\mu^*$ is extracted by fitting the numerically calculated transition temperature $T_c$ of the Eliashberg-Nambu equation which is extended to incorporate the narrow-band effects, that is, the vertex correction and the frequency dependence of the screened Coulomb interaction. It is shown that even for narrow-band superconductors, where the fermi energy $ \epsilon_F$ is comparable with the phonon frequency $ \omega_{ph}$, the Coulomb pseudo-potential is a pertinent parameter, and is still given by $\mu^* = \mu/[1+\mu \ln(\epsilon_F/\omega_{ph})] $, provided $\omega_{ph}$ is appropriately scaled.
Context Modulation of Facial Emotion Perception Differed by Individual Difference
Tae-Ho Lee, June-Seek Choi, Yang Seok Cho
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032987
Abstract: Background Certain facial configurations are believed to be associated with distinct affective meanings (i.e. basic facial expressions), and such associations are common across cultures (i.e. universality of facial expressions). However, recently, many studies suggest that various types of contextual information, rather than facial configuration itself, are important factor for facial emotion perception. Methodology/Principal Findings To examine systematically how contextual information influences individuals’ facial emotion perception, the present study estimated direct observers’ perceptual thresholds for detecting negative facial expressions via a forced-choice psychophysical procedure using faces embedded in various emotional contexts. We additionally measured the individual differences in affective information-processing tendency (BIS/BAS) as a possible factor that may determine the extent to which contextual information on facial emotion perception is used. It was found that contextual information influenced observers' perceptual thresholds for facial emotion. Importantly, individuals’ affective-information tendencies modulated the extent to which they incorporated context information into their facial emotion perceptions. Conclusions/Significance The findings of this study suggest that facial emotion perception not only depends on facial configuration, but the context in which the face appears as well. This contextual influence appeared differently with individual’s characteristics of information processing. In summary, we conclude that individual character traits, as well as facial configuration and the context in which a face appears, need to be taken into consideration regarding facial emotional perception.
GBParsy: A GenBank flatfile parser library with high speed
Tae-Ho Lee, Yeon-Ki Kim, Baek Hie Nahm
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-321
Abstract: We developed a library, GBParsy, which was C language-based and parses GBF files. The parsing speed was maximized by using content-specified functions in place of regular expressions that are flexible but slow. In addition, we optimized an algorithm related to memory usage so that it also increased parsing performance and efficiency of memory usage. GBParsy is at least 5 - 100× faster than current parsers in benchmark tests.GBParsy is estimated to extract annotated information from almost 100 Mb of a GenBank flatfile for chromosomal sequence information within a second. Thus, it should be used for a variety of applications such as on-time visualization of a genome at a web site.Large volumes of information have been rapidly accumulating since the shotgun DNA sequencing technology was introduced [1,2]. Currently, GenBank volume size is rapidly increasing, with more than 370 complete microbial genomes and over 104 assemblies of eukaryote genomes deposited over the year 2006 alone [3]. This has led to the question of how this invaluable information can be dealt with by computer programs. One of the primary concerns is how to efficiently convey huge volumes of sequence data and their annotated information to researchers. For these reasons, many sequence formats such as Abstract Syntax Notation One (ASN.1), Extensible Markup Language (XML) and GenBank flatfile (GBF) format have been used to manage sequences for distinct purposes and usages. Among these, the ASN.1 and XML format files are generally known to be difficult for a user to directly get information since the formats are designed to specify complex data structures in a machine and programming language. Thus, they are used for storing and exchanging data between computer systems. In contrast, GBF format has become one of the most popular because of its detailed sequence features and ease of readability and accessibility unlike machine-friendly ASN.1 or XML format. The format has been widely adopted to describe not
An On-Time Power-Aware Scheduling Scheme for Medical Sensor SoC-Based WBAN Systems
Tae-Ho Hwang,Dong-Sun Kim,Jung-Guk Kim
Sensors , 2013, DOI: 10.3390/s130100375
Abstract: The focus of many leading technologies in the field of medical sensor systems is on low power consumption and robust data transmission. For example, the implantable cardioverter-defibrillator (ICD), which is used to maintain the heart in a healthy state, requires a reliable wireless communication scheme with an extremely low duty-cycle, high bit rate, and energy-efficient media access protocols. Because such devices must be sustained for over 5 years without access to battery replacement, they must be designed to have extremely low power consumption in sleep mode. Here, an on-time, energy-efficient scheduling scheme is proposed that performs power adjustments to minimize the sleep-mode current. The novelty of this scheduler is that it increases the determinacy of power adjustment and the predictability of scheduling by employing non-pre-emptible dual priority scheduling. This predictable scheduling also guarantees the punctuality of important periodic tasks based on their serialization, by using their worst case execution time) and the power consumption optimization. The scheduler was embedded into a system on chip (SoC) developed to support the wireless body area network—a wakeup-radio and wakeup-timer for implantable medical devices. This scheduling system is validated by the experimental results of its performance when used with life-time extensions of ICD devices.
Analysis of the Contribution of Wind Drift Factor to Oil Slick Movement under Strong Tidal Condition: Hebei Spirit Oil Spill Case
Tae-Ho Kim, Chan-Su Yang, Jeong-Hwan Oh, Kazuo Ouchi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087393
Abstract: The purpose of this study is to investigate the effects of the wind drift factor under strong tidal conditions in the western coastal area of Korea on the movement of oil slicks caused by the Hebei Spirit oil spill accident in 2007. The movement of oil slicks was computed using a simple simulation model based on the empirical formula as a function of surface current, wind speed, and the wind drift factor. For the simulation, the Environmental Fluid Dynamics Code (EFDC) model and Automatic Weather System (AWS) were used to generate tidal and wind fields respectively. Simulation results were then compared with 5 sets of spaceborne optical and synthetic aperture radar (SAR) data. From the present study, it was found that highest matching rate between the simulation results and satellite imagery was obtained with different values of the wind drift factor, and to first order, this factor was linearly proportional to the wind speed. Based on the results, a new modified empirical formula was proposed for forecasting the movement of oil slicks on the coastal area.
Numerical renormalization group study of the symmetric Anderson-Holstein model: phonon and electron spectral functions
Gun Sang Jeon,Tae-Ho Park,Han-Yong Choi
Physics , 2002, DOI: 10.1103/PhysRevB.68.045106
Abstract: We study the symmetric Anderson-Holstein (AH) model at zero temperature with Wilson's numerical renormalization group (NRG) technique to study the interplay between the electron-electron and electron-phonon interactions. An improved method for calculating the phonon propagator using the NRG technique is presented, which turns out to be more accurate and reliable than the previous works in that it calculates the phonon renormalization explicitly and satisfies the boson sum rule better. The method is applied to calculate the renormalized phonon propagators along with the electron propagators as the onsite Coulomb repulsion $U$ and electron-phonon coupling constant $g$ are varied. As $g$ is increased, the phonon mode is successively renormalized, and for $g \gtrsim g_{co}$ crosses over to the regime where the mode splits into two components, one of which approaches back to the bare frequency and the other develops into a soft mode. The initial renormalization of the phonon mode, as $g$ is increased from 0, depends on $U$ and the hybridization $\Delta$; it gets softened (hardened) for $U \gtrsim (\lesssim) U_s (\Delta)$. Correlated with the emergence of the soft mode is the central peak of the electron spectral function severely suppressed. These NRG calculations will be compared with the standard Green's function results for the weak coupling regime to understand the phonon renormalization and soft mode.
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