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Search Results: 1 - 10 of 1922 matches for " TOSHIO TAKEUCHI "
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Late Quaternary Geomorphology of the Tonami Plain and Activity of the Tonami-Heiya Fault Zone, Toyama Prefecture, Central Japan  [PDF]
Toshio Kamishima, Akira Takeuchi
International Journal of Geosciences (IJG) , 2016, DOI: 10.4236/ijg.2016.77073
Abstract: The Holocene alluvial fans and flood plains formed by the Sho and Oyabe Rivers spread out in the Tonami plain from the central through the northern parts in the Toyama Prefecture, central Japan. Along the foot of the surrounding mountains and hills, higher, middle and lower terraces of late Pleistocene-Holocene in age are distributed. These terraces have been displaced, by the reverse dip-slip activities of Tonami-heiya fault zone in a sense of upheaval in the mountains side, even during the Holocene time. We examined stratigraphic cross section utilizing borehole data and geomorphologically analyzed 5 m-DEM data in order to elucidate the fault trace of the Isurugi fault which Tonami-heiya fault zone. As the results, the northern segment of Isurugi fault seems to run along the northeastern foot of Hodatsu Hills and extends underground through the lower-most Oyabe River into the Toyama Bay. Consequently, its total length reaches about 30 km. In the southern segment, a continuous fault scarplet was recognized to cut across the lower dissected fans. The slip-rate of Isurugi fault is estimated to be 0.31 - 0.64 m/kyr. In the Hokuriku region, reverse faulting and related folding with strike in a NE-SW direction have occurred during the late Quaternary. The hinge line of block movement due to the activities of the Tonami-heiya fault zone is revealed to have shifted from the mountain side into the plain side within the Holocene time. In conclusion, the Quaternary folding and faulting associated with the crustal warping at a wavelength of about 20 km is currently in progress, causing both the subsidence of Tonami plain and the upheaval of surrounding mountains and hills.
Assessment of the Relationship between ESR Signal Intensity and Grain Size Distribution in Shear Zones within the Atotsugawa Fault System, Central Japan  [PDF]
Emilia B. Fantong, Akira Takeuchi, Toshio Kamishima, Ryosuke Doke
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.511106
Abstract: For the first time, a relationship between ESR signal intensity and grain size distribution (sieve technique) in shear zones within the Atotsugawa fault system have been investigated using fault core rocks. The grain size distributions were estimated using the sieve technique and microscopic observations. Stacks of sieves with openings that decrease consecutively in the order of 4.75 mm, 1.18 mm, 600 μm, 300 μm, 150 μm and 75 μm were chosen for this study. Grain size distributions analysis revealed that samples further from the slip plane have larger d50 (average gain size) (0.45 mm at a distance of 30 - 50 mm from the slip plane) while those close to the slip plane have smaller d50 values (0.19 mm at a distance of 0 - 10 mm from the slip plane). This is due to intensive crushing that is always associated with large displacement during fault activities. However, this pattern was not respected in all shear zones in that, larger d50 values were instead observed in samples close to the slip plane due to admixture of fault rocks from different fault activities. Results from ESR analysis revealed that the relatively finer samples close to the slip plane have low ESR signals intensity while those further away (coarser) have relatively higher signal intensity. This tendency however, is not consistence in some of the shear zones due to a complex network of anatomizing faults. The variation in grain size distribution within some of the shear zones implies that, a series of fault events have taken place in the past thus underscoring the need for further investigation of the possibility of reoccurrence of faults.
Phospholipids Effect on Survival and Molting Synchronicity of Larvae Mud Crab Scylla serrata
HAYATI Journal of Biosciences , 2012,
Abstract: Effect of phospholipids on survival and molting synchronicity of mud crab larvae Scylla serrata were examined using Artemia enriched with five treatments of emulsion oil i.e. treatment with different level of soybean lecithin (SL) together with a level of DHA70G (referred to as DHA-SL0, 20 and 40) and treatment with SL and cuttle fish phospholipids (CPL) at 40 uL/L without DHA70G (referred to as WDHA-SL and WDHA-CPL). Survival rate, intermolt period, carapace width, and molting synchronicity were evaluated. Additionally, lipid classes and fatty acid composition of enriched Artemia were analyzed. Survival rate, intermolt period, and carapace width at the first crab (FC) stage of mud crab larvae fed DHA-SL0 to 40 were similar to that of WDHA-CPL but higher than that of WDHA-SL (P < 0.05). Moreover, mud crab larvae fed DHA-SL20, DHA-SL40, and WDHA-CPL had a significantly higher molting synchronicity index compared to that of larvae fed WDHA-SL and DHA-SL0. It can be concluded that combination of phospholipids and essential fatty acids exhibited an additive effect in improving molting synchronicity of mud crab larvae.
Cholesterol Effect on Survival and Development of Larval Mud Crab Scylla serrata
HAYATI Journal of Biosciences , 2012,
Abstract: The effect of cholesterol on the survival and development of larval mud crab Scylla serrata were examined by feeding larvae with Artemia enriched with different level of cholesterol. Artemia enriched with four stated levels of cholesterol i.e., 0, 5, 10, and 20 ul/l (Chol 0, 5, 10, and 20). All treatments were mixed with DHA70G at 25 ul/l. All the oil was adjusted to 100 ul/l by adding the oleic acid. Survival rate, intermolt period, and carapace width at the fisrt crab stage of mud crab larvae fed Chol 0, 5, and 10 were higher compared to that of Chol 20 (P < 0.05). We suggest that free sterol contained in Artemia at 1.37% was harmful to the growth performance of mud crab larvae. This study suggests that mud crab larvae required at least 0.61% cholesterol for maintaining good survival and development and therefore no need to enrich Artemia by cholesterol for the practical purpose.
Heralded single photon source at 1550 nm from pulsed parametric down conversion
Alexandre Soujaeff,Shigeki Takeuchi,Keiji Sasaki,Toshio Hasegawa,Mitsuru Matsui
Physics , 2006, DOI: 10.1080/09500340600742239
Abstract: Heralding of single photon at 1550 nm from pump pulsed non degenerate spontaneous parametric downconversion is demonstrated. P(1) and P(2) of our source are 0.1871 and 2.4 x 10 ^-3 respectively. Triggering of our source is 2.16 x 10^5 trigger.s^-1. This source may be used in QKD system.
Intussusception among Japanese children: an epidemiologic study using an administrative database
Masato Takeuchi, Toshio Osamura, Hideo Yasunaga, Hiromasa Horiguchi, Hideki Hashimoto, Shinya Matsuda
BMC Pediatrics , 2012, DOI: 10.1186/1471-2431-12-36
Abstract: We screened the database for eligible cases ≤ 18 years of age, who were coded with a discharge diagnosis of intussusception (International Classification of Diseases, 10th revision: K-561) between July to December in 2007 and 2008. We then selected cases according to Level 1 of the diagnostic certainty criteria developed by the Brighton Collaboration Intussusception Working Group. We examined the demographics, management, and outcomes of cases, and estimated the incidence of intussusception.We identified 2,427 cases of intussusception. There were an estimated 2,000 cases of infantile intussusception annually in Japan, an incidence of 180-190 cases per 100,000 infants. The median age at diagnosis was 17 months, and two-thirds of the patients were male. Treatment with an enema was successful in 93.0% of cases (2255/2427). The remainder required surgery. Secondary cases accounted for 3.1% (76/2427). Median length of hospital stay was 3 days. Of the 2,427 cases, we found 2 fatal cases associated with intussusception.This is currently the largest survey of childhood intussusception in Asia using a standardized case definition. Our results provide an estimate of the baseline risk of intussusception in Japan, and it is higher than the risk observed in other countries.Intussusception is the most common cause of intestinal obstruction among infants and young children, and can also affect older children and adolescents [1]. Improvements have been made in the diagnosis and treatment of intussusception [2]; however, poor outcomes can still occur, even in developed countries [3].In 1999, Rotashield (the first-generation rotavirus vaccine licensed in the United States) was withdrawn from the market because of a potential increased risk of intussusception [4]. Two recent studies investigated whether the second-generation Rotavirus vaccine was also associated with an increased risk of intussusception [5,6], and revealed conflicting results. One post-marketing survey reported a smal
An Electrosurgical Endoknife with a Water-Jet Function (Flushknife) Proves Its Merits in Colorectal Endoscopic Submucosal Dissection Especially for the Cases Which Should Be Removed En Bloc
Yoji Takeuchi,Toshio Shimokawa,Ryu Ishihara,Hiroyasu Iishi,Noboru Hanaoka,Koji Higashino,Noriya Uedo
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/530123
Abstract: Background. Previously, we reported that the Flushknife (electrosurgical endoknife with a water-jet function) could reduce the operation time of colorectal endoscopic submucosal dissection (ESD) however, suitable situation for the Flushknife was obscure. This subgroup analysis of a prospective randomized controlled trial was aimed to investigate the suitable situation for the Flushknife. Methods. A total of 48 superficial colorectal neoplasms that underwent ESD using either the Flexknife or the Flushknife in a referral center were enrolled. The differences of operation time between the Flexknife and the Flushknife groups in each subgroup (tumor size, location, and macroscopic type) were analyzed. Results. Median (95% CI) operation time calculated using survival curves was significantly shorter in the Flushknife group than in the Flexknife group (55.5?min [41, 78] versus 74.0 [57, 90]?min; , Hazard Ratio HR: 0.53; 95% CI (0.29–0.97)). In particular, the HR in patients with laterally spreading tumors-nongranular type (LST-NG) in the Flushknife group was significantly smaller than in the Flexknife group (HR: 0.165 0.17; 95% CI (0.04–0.66)). There was a trend of decreasing HRs according to larger lesion size. Conclusions. The Flushknife proved its merits in colorectal ESD especially for the lesions which should be removed en bloc (LST-NG and large lesion). 1. Introduction Endoscopic submucosal dissection (ESD) is one of the standard treatments for large upper gastrointestinal superficial neoplasms in Japan and South Korea [1–5] because of its high en bloc resection (entire tumor resection in one piece) rate. ESD is also considered as a promising procedure in Western countries [6]. Although there are some reports on ESD for colorectal superficial neoplasms [7–9], ESD has not been a standard therapy for large colorectal superficial neoplasms, even in Japan. The reason is that it is time consuming, technically difficult, and related to a higher incidence of complications (perforation and bleeding) than conventional endoscopic mucosal resection (EMR) [10]. Flushknife (DK2618JN15, Fujifilm Medical, Tokyo, Japan) is a short needle electrosurgical endo-knife combined with a water-jet function (Figure 1(a)) [11]. We have reported that the Flushknife could reduce the operation time of colorectal ESD for patients with large colorectal superficial neoplasms [12], compared with a standard electrosurgical endo-knife (Flexknife; KD-630L, Olympus Medical Systems, Tokyo, Japan, Figure 1(b)) [13, 14]. In the study, we enrolled lesions larger than 20?mm and smaller than
Studies on the role of peptidase and powder soybean lecithin in microparticle diets for red sea bream Pagrus major larvae

WANG Qiu-Rong,Toshio Takeuchi,Hirofumi Furuita,

水生生物学报 , 2006,
Abstract: 本研究以酪蛋白分解物为蛋白源配制三种微粒子饲料MD-S、MD-T和MD-U对真鲷开口仔鱼进行饲养试验。以MD-S的配方为基准,MD-T采用粉状大豆卵磷脂和麸质代替液状大豆卵磷脂;MD-U则另外添加0.1%的肽酶。结果表明,微粒子饲料在水中浸泡15min后,MD-T的溶出率(35.5%)低于MD-S(46.8%)和MD-U(45.8%);实验结束时(20日龄),仔鱼的成活率以生物饵料(轮虫)组为最高(86.3%),其次是MD-T组为20.7%,显著高于(P<0.05)MD-S组(13.3%)和MD-U组(13.6%);生物饵料组的仔鱼全长(6.14±0.49mm)显著大于微粒子饲料组(4.23±0.30mm~4.46±0.30mm),各微粒子饲料组之间仔鱼的全长并不存在显著差异(P>0.05)。在孵化后第12d,微粒子饲料组的仔鱼肠上皮细胞发育良好,但至孵化后第18d,仔鱼肠上皮细胞大部分萎缩、并发生脱落。鱼体的蛋白质、DNA与RNA日间增长率微粒子饲料MD-T组高于MD-S和MD-U组,但都低于生物饵料组。由此可见,微粒子饲料中添加肽酶并无助真鲷仔鱼对其消化吸收;可是,使用粉状大豆卵磷脂与麸质代替液状卵磷脂能增强微粒子饲料的黏合性,可减少其营养成分的溶出率,从而提高微粒子饲料的饲育效果。
Gene therapy strategies for treating brain tumors: Retroviruses are still good candidates for therapeutic vectors  [PDF]
Toshio Yawata, Keiji Shimizu
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.32A1002

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. In the past few decades, many efforts have been made to improve the prognosis of GBM, however, with limited success. Many gene therapy strategies for GBM have been developed and a few have progressed to clinical trials. Retroviral vectors have superior features for gene therapy in brain cancers, including tumor specificity, immunogenicity, and longer half-life. Early gene therapy trials in GBM patients based on transplantation of retrovirus-producing cells into the brain failed to prove efficacious. Adenoviral vectors, which can be prepared as high-titer virus solutions and undergo efficient transduction in tumor cells, failed in clinical trials, likely due to immunogenicity and instability of gene expression. Alternative therapeutics such as oncolytic viruses that specifically target and destroy cancer cells are currently under investigation. In addition to novel vectors, retroviral vectors are still attractive candidates for use in gene therapy against brain tumors. Since yields of properly-packaged viral particles from virus-producing cells have been very limited so far, gene therapy by direct injection of hightiter retroviral vectors into the patients’ brains was not possible. To overcome these disadvantages, a packaging cell line that yields high-titer retroviral solutions was established by our group, enabling the direct injection of massive retroviral vector stocks directly into the brain. Mouse glioma models were effectively cured with a combination of a suicide gene/ prodrug system and a highly-concentrated retrovirus solution. Preclinical assessments, including that of replication-competent retroviruses and tumorigenicity of the combination method, have confirmed the safety of the highly-concentrated retrovirus solution. Addi tional studies are needed to address the clinical utility of such combination gene therapies. Taken together, these data suggest that retroviral vectors are still good candidates for development in gene therapy applications.

Numerical Study on Heat Transfer Characteristics of Heated/Cooled Rods Having a Composite Board in between: Effect of Thermal Vias  [PDF]
Yasushi Koito, Toshio Tomimura
Journal of Electronics Cooling and Thermal Control (JECTC) , 2017, DOI: 10.4236/jectc.2017.74008
Abstract: By placing a sample between a heated and a cooled rod, a thermal conductivity of the sample can be evaluated easily with the assumption of a one-dimensional heat flow. However, a three-dimensional constriction/spreading heat flow may occur inside the rods when the sample is a composite having different thermal conductivities. In order to investigate the thermal resistance due to the constriction/spreading heat flow, the three-dimensional numerical analyses were conducted on the heat transfer characteristics of the rods. In the present analyses, a polymer-based composite board having thermal vias was sandwiched between the rods. From the numerical results, it was confirmed that the constriction/spreading resistance of the rods was strongly affected by the thermal conductivity of the rods as well as the number and size of the thermal vias. A simple equation was also proposed to evaluate the constriction/spreading resistance of the rods. Fairly good agreements were obtained between the numerical results and the calculated ones by the simple equation. Moreover, the discussion was also made on an effective thermal conductivity of the composite board evaluated with the heated and the cooled rod.
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