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Search Results: 1 - 10 of 4028 matches for " THERRIEN JACQUES "
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Experiência e competência no ensino: pistas de reflex?es sobre a natureza do saber-ensinar na perspectiva da ergonomia do trabalho docente
Educa??o & Sociedade , 2001, DOI: 10.1590/S0101-73302001000100009
Abstract: the aim of this paper is to reflect over an emergent field of research, one which is necessary in order to understand the meaning of experience related to knowledge of teaching in teacher's work, according to the perspective of ergonomic inspired by a situated learning process. in the context of the new format of the brazilian educational policies in the field of educational reforms, this study highlights the debate over teacher education and its recent tendencies. this brings conceptual and methodological issues aimed at investigating the nature of knowledge of teaching, focusing on teaching competences in the context of knowledge in the basis of this practice.
Experiência e competência no ensino: pistas de reflex es sobre a natureza do saber-ensinar na perspectiva da ergonomia do trabalho docente
Educa??o & Sociedade , 2001,
Abstract: O texto prop e-se a desenvolver uma reflex o sobre um campo de investiga o emergente e necessário para a compreens o do significado da experiência no saber-ensinar: o trabalho docente segundo a perspectiva da ergonomia, inspirada na cogni o situada. Contextualizando os novos contornos da política educacional brasileira no cenário das reformas educacionais, o estudo privilegia o debate sobre a forma o docente e suas atuais tendências. A reflex o traz elementos conceituais e teórico-metodológicos destinados à investiga o da natureza do saber-ensinar, focalizando o estudo da competência no ensino no contexto dos saberes na base da prática docente.
Patrimonio y arqueología industrial: ?investigación vs. protección? Políticas del patrimonio industrial en Colombia
Apuntes: Revista de Estudios sobre Patrimonio Cultural - Journal of Cultural Heritage Studies , 2008,
Abstract: the fábrica de loza bogotana (a pottery industry founded in bogotá) research project, carried out during several years by an interdisciplinary team, made evident the necessity of identifying and valuing cultural heritage through multi-component and relational concepts, rather than through traditional isolated categories such as object/monument/site that still underlie the notion of tangible heritage. the case is used as a reflection on ideas about industrial heritage, and as a means of contrast with the corresponding heritage policies developed in colombia. today this unique example of colombia's industrialization process of the 19th century is at risk. paradoxically the current conservation policies have increased the threats to this pottery industry heritage instead of diminishing them. it is also stated that determining the different values conferred to this industrial heritage are fundamental when proposing interventions and construing its significance.
El Espacio Urbano de Cartagena en la Colonia
Monika Therrien
Historia Crítica , 1989,
La filature cotonnière qui a tissé une communauté
Jo?l Therrien
Voix Plurielles , 2013,
Abstract: Le travail de Jo l Therrien examine son héritage franco-ontarien ainsi que la population francophone de Welland autour de la fabrique de coton Empire. Sa recherche porte essentiellement sur l’émergence et le déclin relativement récent des communautés francophones du sud de l’Ontario. Ce phénomène est rendu par l’entropie inhérente à ses créations interactives, lesquelles invitent également les spectateurs à briser le décorum des galeries d’art et à éveiller en eux le sens ludique.
Absence of mercury effects on fish populations of boreal reservoirs despite 3 to 6 fold increases in mercury concentrations
Schetagne R.,Therrien J.
E3S Web of Conferences , 2013, DOI: 10.1051/e3sconf/20130134002
Abstract: At the La Grande hydroelectric complex located in northern Quebec, Canada, mercury concentrations were measured in over 25 000 fish as part of an ongoing environmental effects monitoring program. Five fish species were monitored over a 30-year period: the non-piscivorous lake whitefish (Coregonus clupeaformis) and longnose sucker (Catostomus catostomus) and the piscivorous northern pike (Esox lucius), walleye (Sander vitreus) and lake trout (Salvelinus namaycush). Total mercury concentrations were measured by standard cold vapour atomic absorption spectrophotometry. Fish population characteristics, such as fishing yields, growth rates and condition factors were also monitored over a 20-year period. In reservoirs, mercury concentrations in all species increased rapidly after impoundment, peaking after 5 to 9 years in non-piscivorous fishes, and after 9 to 11 years in piscivorous species, at levels 3 to 6 times those measured in surrounding natural lakes, then significantly and gradually declined. Concentrations in most species have returned to levels typical of natural lakes, 10 to 30 years after flooding. Despite such increases, the monitored fish showed no mercury-related ill effects at the population level. For most species, increases were observed in fishing yields (by factors ranging from 2 to over 20), in growth rates and in condition factors (for more than a decade). The fishing yield increase was highest for northern pike of the Robert-Bourassa Reservoir, for which the highest average mercury concentrations were measured (3.28 μg g-1 (ww) for 700-mm fish). The biological boom usually observed after reservoir impoundment, resulting from increased nutrients, may have prevented potential mercury-related ill effects.
The Biological Side of Water-Soluble Arene Ruthenium Assemblies
Bruno Therrien,Julien Furrer
Advances in Chemistry , 2014, DOI: 10.1155/2014/589686
Abstract: This review article covers the synthetic strategies, structural aspects, and host-guest properties of ruthenium metalla-assemblies, with a special focus on their use as drug delivery vectors. The two-dimensional metalla-rectangles show interesting host-guest possibilities but seem less appropriate for being used as drug carriers. On the other hand, metalla-prisms allow encapsulation and possible targeted release of bioactive molecules and consequently show some potential as drug delivery vectors. The reactivity of these metalla-prisms can be fine-tuned to allow a fine control of the guest’s release. The larger metalla-cubes can be used to stabilize the formation of G-quadruplex DNA and can be used to encapsulate and release photoactive molecules such as porphins. These metalla-assemblies demonstrate great prospective in photodynamic therapy. 1. Introduction Anticancer platinum complexes dominate the field of metals in cancer chemotherapy, mainly because of the considerable research effort that followed the fortuitous discovery of the anticancer property of cisplatin (Figure 1) in the late 1960s [1]. Unfortunately, the use of cisplatin is restricted because of severe dose-limiting side effects, which arise from the indiscriminate uptake of the drug into all rapidly dividing cells. Indeed the platinum atom is known to efficiently bind to serum proteins, especially human serum albumin (HsA) [2]. Once inside cells, aquated cisplatin species will mainly bind at the N7 position of guanine, leading to significant distortions of the DNA helix [3]. These DNA lesions are thought to prevent replication and transcription and ultimately to lead to cellular apoptosis [3]. Figure 1: The three platinum-based anticancer drugs, cisplatin, carboplatin, and oxaliplatin, which have gained worldwide marketing approval for humans [ 4]. The severe side effects of cisplatin have led to a massive investigation into the cytotoxicity and genotoxicity of platinum-based compounds, in order to elucidate their molecular mechanisms and identify key biomolecular targets for rational drug design [6–8]. In the 30 years since cisplatin’s first approval for human use, only two compounds have been approved worldwide (oxaliplatin and carboplatin, Figure 1) and another three gaining marketing approval in individual nations (Nedaplatin, Lobaplatin, and Heptaplatin) [4]. Currently, there are four mononuclear platinum drugs in various stages of clinical trials, with two of these being close to clinical recognition (satraplatin [9] and picoplatin [10]). Two other drugs (ProLindac and Lipoplatin)
Sergey S. Shapovalov,Bruno Therrien
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809042986
Abstract: In the title complex, [RuSn2(C10H14)Cl6(C6H15O3P)], the Ru—Sn bond lengths [2.5619 (3) and 2.5669 (3) ] are about 0.3 shorter than the sum of the covalent Ru and Sn radii (1.46 + 1.39 = 2.85 ), in line with other structurally characterized arene ruthenium trichloridostannyl derivatives. The Ru(II) atom is surrounded by a para-cymene, a triethylphosphite and two trichloridostannyl ligands in a typical piano-stool coordination.
Dark Energy as a Property of Dark Matter  [PDF]
Jacques Leibovitz
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.212181
Abstract: A novel model of dark matter (DM), elastically compressible, can contribute to the acceleration of our Universe expansion. While each galaxy compresses its own DM within its gravitation field, the DM bordering neighboring galaxies, far from their centers, is pulled apart. It is shown that, although the DM pressure tends to zero at such locations, the DM compressibility tends to infinity. This allows the DM to expand between galaxies without gravitation hindrance. The model is consistent with the coupled distributions of baryonic and dark matters, with black hole formation at the centers of large galaxies, with galactic flat rotation curves, with a Tully-Fisher relation, and with Milgrom’s MOND relation. Results are discussed.
Mechanism and evolution of multidomain aminoacyl-tRNA synthetases revealed by their inhibition by analogues of a reaction intermediate, and by properties of truncated forms  [PDF]
Jacques Lapointe
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.610115
Abstract: Many enzymes which catalyze the conversion of large substrates are made of several structural domains belonging to the same polypeptide chain. Transfer RNA (tRNA), one of the substrates of the multidomain aminoacyl-tRNA synthetases (aaRS), is an L-shaped molecule whose size in one dimension is similar to that of its cognate aaRS. Crystallographic structures of aaRS/tRNA complexes show that these enzymes use several of their structural domains to interact with their cognate tRNA. This mini review discusses first some aspects of the evolution and of the flexibility of the pentadomain bacterial glutamyl-tRNA synthetase (GluRS) revealed by kinetic and interaction studies of complementary truncated forms, and then illustrates how stable analogues of aminoacyl-AMP intermediates have been used to probe conformational changes in the active sites of Escherichia coli GluRS and of the nondiscriminating aspartyl-tRNA synthetase (ND-AspRS) of Pseudomonas aeruginosa.
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