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Search Results: 1 - 10 of 117690 matches for " T. Spiriev "
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Microsurgical Treatment of Optic Nerve Metastasis: Case Report and Review of the Literature  [PDF]
Sl. Kondoff, M. Milev, Chr. Tzekov, T. Spiriev, L. Laleva, G. Kirova, Chr. Kostadionova
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.411071
Abstract: Metastatic lesions to the eye and optic nerve have incidence of 12% and are observed predominantly in patients, diagnosed with breast and lung cancer. However, isolated involvement of the optic nerve by breast cancer metastasis is much rarely reported with only 13 cases reported in the literature by 2013, according to Cherkaev et al., that were often preoperatively misdiagnosed. Herewith we present a rare case of optic nerve metastasis in a previously diagnosed breast cancer patient. Review of the literature was done with analysis of the diagnostic difficulties that these cases present and the role of the neurosurgeon in the management of the patients.
New Molecular Knowledge Towards the Trigemino-Cardiac Reflex as a Cerebral Oxygen-Conserving Reflex
N. Sandu,T. Spiriev,F. Lemaitre,A. Filis
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.71
Management of the trigeminocardiac reflex: Facts and own experience
Arasho Belachew,Sandu Nora,Spiriev Toma,Prabhakar Hemanshu
Neurology India , 2009,
Abstract: The trigeminocardiac reflex (TCR) is defined as the sudden onset of parasympathetic dysrhythmia, sympathetic hypotension, apnea, or gastric hyper-motility during stimulation of any of the sensory branches of the trigeminal nerve. The proposed mechanism for the development of TCR is-the sensory nerve endings of the trigeminal nerve send neuronal signals via the Gasserian ganglion to the sensory nucleus of the trigeminal nerve, forming the afferent pathway of the reflex arc. It has been demonstrated that the TCR may occur with mechanical stimulation of all the branches of the trigeminal nerve anywhere along its course (central or peripheral). The reaction subsides with cessation of the stimulus. But, some patients may develop severe bradycardia, asystole, and arterial hypotension which require intervention. The risk factors already known to increase the incidence of TCR include: Hypercapnia; hypoxemia; light general anesthesia; age (more pronounced in children); the nature of the provoking stimulus (stimulus strength and duration); and drugs: Potent narcotic agents (sufentanil and alfentanil); beta-blockers; and calcium channel blockers. Because of the lack of full understanding of the TCR physiology, the current treatment options for patients with TCR include: (i) risk factor identification and modification; (ii) prophylactic measures; and (iii) administration of vagolytic agents or sympathomimetics.
Central trigeminocardiac reflex in pediatric neurosurgery: a case report and review of the literature
Spiriev Toma,Tzekov Christo,Laleva Lili,Kostadinova Christina
Journal of Medical Case Reports , 2012, DOI: 10.1186/1752-1947-6-372
Abstract: Introduction Trigeminocardiac reflex is a well-known phenomenon in neurosurgery, craniofacial surgery, ophthalmology and interventional neuroradiology. Even though the trigeminocardiac reflex has become an important factor in skull base surgery and neurosurgery, the central form of trigeminocardiac reflex has only been described in adult subpopulations until now. Case presentation We present a clear form of repetitive trigeminocardiac reflex expressed during revision surgery of a giant (110×61mm) right temporoparietal meningioma in an 18-month-old male Caucasian patient. After cessation of the surgical stimulus, his heart rate and mean arterial blood pressure returned to normal physiological levels. The further follow-up was uneventful. Conclusion Our case demonstrates that the central trigeminocardiac reflex also exists in pediatric patients, especially if manipulating trigeminal innervated structures or around the nerve itself. Whether the incidence and the behavior of the trigeminocardiac reflex is similar in pediatric neurosurgery compared with adult patients has to be shown in further studies.
Molecular imaging of potential bone metastasis from differentiated thyroid cancer: a case report
Nora Sandu, Gabriele P?pperl, Marie-Elisabeth Toubert, Belachew Arasho, Toma Spiriev, Mikael Orabi, Bernhard J Schaller
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-522
Abstract: We present the case of a 50-year-old Caucasian woman experiencing progressive spinal cord compression caused by a vertebral metastasis of a less well differentiated thyroid cancer. Following tumor resection and vertebral stabilization, total thyroidectomy was performed revealing follicular thyroid carcinoma pT2 pNxM1 (lung, bone). During follow-up our patient underwent five radioiodine therapy procedures (5.3 to 5.7 GBq each) over a two-year period. Post-therapeutic I-131 scans showed decreasing uptake in multiple Pulmonary metastases. However, following an initial decrease, stimulated thyroglobulin remained at pathologically increased levels, indicating further neoplastic activity. F18 Fludeoxyglucose positron emission tomography, which was performed in parallel, showed remaining hypermetabolism in the lungs but no hypermetabolism of the spinal lesions correlating with the stable neurological examinations. While on single photon emission computer tomography images Pulmonary hyperfixation of I-131 disappeared (most likely indicating dedifferentiation), there was persistent spinal hyperfixation at the operated level and even higher fixation at the spinal process of L3. Based on the negative results of the spinal F18 fludeoxyglucose positron emission tomography, a decision was made not to operate again on the spine since our patient was completely asymptomatic and the neurological risk seemed to be too high. During further follow-up our patient remained neurologically stable.Molecular imaging by F18 fludeoxyglucose positron emission tomography helps to exclude metabolically active spinal metastases and to spare further risky surgery.Fluorine-18 fludeoxyglucose (FDG) positron emission tomography (PET) is a well established diagnostic modality for standard oncological staging, restaging, and treatment monitoring evaluations, and has a major impact on patient management [1-3]. A key issue that is less well studied is the performance of FDG-PET in accurately depicting bon
A new predisposing factor for trigemino-cardiac reflex during subdural empyema drainage: a case report
Toma Spiriev, Nora Sandu, Belachew Arasho, Slavomir Kondoff, Christo Tzekov, Bernhard Schaller, Trigemino-Cardiac Reflex Examination Group (TCREG)
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-391
Abstract: We report the case of a 70-year-old Caucasian man who demonstrated a clearly expressed form of trigemino-cardiac reflex with severe bradycardia requiring intervention that was recorded during surgical removal of a large subdural empyema.To the best of our knowledge, this is the first report of an intracranial infection leading to perioperative trigemino-cardiac reflex. We therefore add a new predisposing factor for trigemino-cardiac reflex to the existing literature. Possible mechanisms are discussed in the light of the relevant literature.For more than a century, it has been well known that electrical, chemical, or mechanical stimulation of the trigeminal nerve leads to trigemino-respiratory reflexes followed by cardiac arrhythmias [1]. In the early 20th century, this phenomenon gained increased clinical attention in the form of the oculocardiac reflex (OCR), which represents the cardiac response associated with stimulation of the ophthalmic division of the trigeminal nerve during ocular surgery [2]. In 1999, Schaller [3] demonstrated for the first time that a similar reflex occurs with stimulation of the intracranial (central) portion of the trigeminal nerve during skull-base surgery and subsummarized all these trigemino-depressor responses under the term "trigemino-cardiac reflex (TCR)" [4]. He also defined the TCR in a way that is now generally accepted. Later, his group also described the TCR for intraoperative stimulation of the peripheral portion [5].Since then, there has been increasing discussion about the TCR itself, its provoking factors, and its treatment during intracranial or extracranial neurosurgical procedures. Several predisposing factors for intraoperative occurrence of TCR have been described [6-8], but until now no case of intracranial infection in combination with intraoperative TCR has been reported.A 70-year-old Caucasian man was admitted for the second time to the Department of Neurosurgery at our hospital. His personal history included symp
T.Г. Омельченко,Н.А. Джанджгава
Information Technologies and Learning Tools , 2010,
Abstract: The general characteristic of legal base of electronic document circulation is presented in the article. It legislatively regulates the relations which connected with the information and information communication technologies. There is presented the list of the basic acts of regulation of sphere of information relations. У робот подано загальну характеристику нормативно-правово бази, яка законодавчо регулю в дносини, пов'язан з нформац ю, нформац йно-комун кац йними технолог ями, представлено перел к основних законодавчих акт в регулювання сфери нформац йних в дносин.
T.П. Кобильник
Information Technologies and Learning Tools , 2010,
Abstract: In the paper the approach of competence at the study of mathematical informatics in a pedagogical university is considered. The special attention is paid to forming of professional pedagogical and educational-cognitive competences. The example of tasks on which formed a competence at the study of mathematical informatics is resulted. У статт розглянуто компетентн сний п дх д при вивченн математично нформатики у педагог чному ун верситет . Особливу увагу звернено на формування профес йно педагог чно та навчально-п знавальну компетентност . Наведено приклад завдань, як сприяють формуванню компетентностей при вивченн математично нформатики.
В.Ю. Биков,T.О. Дерба
Information Technologies and Learning Tools , 2010,
Abstract: In the article the automatic system of the document processing, created with use of Microsoft Access – a component part of Microsoft Office is offered. This system can be used at school and Institutions of education with one computer or with system of 15 ones connecting in the local net. У статт запропоновано для ознайомлення автоматизовану систему документооб гу, створену з використанням Microsoft Access – складово частини Microsoft Office. Ця система може використовуватися в школах установах осв тньо галуз на одному комп’ютер чи на систем до 15 комп’ютер в, пов’язаних локальною мережею.
Н.Т. Задорожна,T.Г. Омельченко
Information Technologies and Learning Tools , 2010,
Abstract: The paper presents the analysis of modern state of development and use of Internet portals, the peculiarities of approaches to creation and introduction of portals in educational system are described. В робот анал зуються принципи розробки та використання нтернет-портал в, описуються особливост п дход в до створення та впровадження портал в у систему осв ти.
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