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Search Results: 1 - 10 of 219036 matches for " T. O'Donnell "
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Connecting the Dots: Computer Systems Education using a Functional Hardware Description Language
John T. O'Donnell
Electronic Proceedings in Theoretical Computer Science , 2013, DOI: 10.4204/eptcs.106.2
Abstract: A functional hardware description language enables students to gain a working understanding of computer systems, and to see how the levels of abstraction fit together. By simulating circuits, digital design becomes a living topic, like programming, and not just a set of inert facts to memorise. Experiences gained from more than 20 years of teaching computer systems via functional programming are discussed.
NEMO Inhibits Programmed Necrosis in an NFκB-Independent Manner by Restraining RIP1
Marie Anne ODonnell, Hidenori Hase, Diana Legarda, Adrian T. Ting
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041238
Abstract: TNF can trigger two opposing responses: cell survival and cell death. TNFR1 activates caspases that orchestrate apoptosis but some cell types switch to a necrotic death when treated with caspase inhibitors. Several genes that are required to orchestrate cell death by programmed necrosis have been identified, such as the kinase RIP1, but very little is known about the inhibitory signals that keep this necrotic cell death pathway in check. We demonstrate that T cells lacking the regulatory subunit of IKK, NFκB essential modifier (NEMO), are hypersensitive to programmed necrosis when stimulated with TNF in the presence of caspase inhibitors. Surprisingly, this pro-survival activity of NEMO is independent of NFκB-mediated gene transcription. Instead, NEMO inhibits necrosis by binding to ubiquitinated RIP1 to restrain RIP1 from engaging the necrotic death pathway. In the absence of NEMO, or if ubiquitination of RIP1 is blocked, necrosis ensues when caspases are blocked. These results indicate that recruitment of NEMO to ubiquitinated RIP1 is a key step in the TNFR1 signaling pathway that determines whether RIP1 triggers a necrotic death response.
Effects Of Kaluza-Klein Excited W On Single Top Quark Production At Tevatron
A. Datta,P. J. O'Donnell,Z. -H. Lin,X. Zhang,T. Huang
Physics , 2000, DOI: 10.1016/S0370-2693(00)00554-2
Abstract: In extra dimension theories if the gauge bosons of the standard model propagate in the bulk of the extra dimensions then they will have Kaluza-Klein excitations that can couple to the standard model fermions. In this paper we study the effects of the first excited Kaluza-Klein mode of the W on single top production at the Tevatron. We find that the cross section for the single top production can be significantly reduced if the mass of the first Kaluza-Klein excited $W \sim 1$ TeV. Hence, a measurement of the single top production cross section smaller than the standard model prediction would not necessarily imply $V_{tb} <1$ or evidence of extra generation(s) of fermions mixed with the third generation.
Measuring $β$ in $B \to D^{*+}D^{*-}K_s$ Decays
T. E. Browder,A. Datta,Patrick. J. O'Donnell,S. Pakvasa
Physics , 1999, DOI: 10.1103/PhysRevD.61.054009
Abstract: We consider the possibility of measuring both $\sin (2 \beta)$ and $\cos (2 \beta)$ in the KM unitarity triangle using the process $B^0 \to D^{*+}D^{*-}K_s$. This decay mode has a higher branching fraction (O(1%)) than the mode $B^0 \to D^{*+}D^{*-}$. We use the factorization assumption and heavy hadron chiral perturbation theory to estimate the branching fraction and polarization. The time dependent rate for $B^0(t) \to D^{*+} D^{*-} K_s$ can be used to measure $\sin (2 \beta)$ and $\cos(2 \beta)$ . Furthermore, examination of the $D^{*+} K_s$ mass spectrum may be the best way to experimentally find the broad $1^+$ p-wave $D_s$ meson.
Scaling Effects for Electromagnetic Vibrational Power Generators
T. O'Donnell,C. Saha,S. -P. Beeby,M. -J. Tudor
Computer Science , 2007,
Abstract: This paper investigates how the power generated by electromagnetic based vibrational power generators scales with the dimension of the generator. The effects of scaling on the magnetic fields, the coil parameters and the electromagnetic damping are presented. An analysis is presented for both wire-wound coil technology and micro-fabricated coils.
The HB22.7 Anti-CD22 monoclonal antibody enhances bortezomib-mediated lymphomacidal activity in a sequence dependent manner
Shiloh M Martin, Eric Churchill, Hayes McKnight, Christopher M Mahaffey, Yunpeng Ma, Robert T O'Donnell, Joseph M Tuscano
Journal of Hematology & Oncology , 2011, DOI: 10.1186/1756-8722-4-49
Abstract: We previously validated CD22 as a potential target in treating NHL and have shown that the anti-CD22 ligand blocking antibody, HB22.7, has significant independent lymphomacidal properties in NHL xenograft models. We sought to determine whether or not these agents would work synergistically to enhance cytotoxicity. Our results indicate that treatment of NHL cell lines with HB22.7 six hours prior to bortezomib significantly diminished cell viability. These effects were not seen when the agents were administered alone or when bortezomib was administered prior to HB22.7. Additionally, HB22.7 treatment prior to bortezomib increased apoptosis in part through enhanced ROS generation. Finally, in a mouse xenograft model, administration of HB22.7 followed 24 hours later by bortezomib resulted in 23% smaller tumor volumes and 20% enhanced survival compared to treatment with the reverse sequence. Despite the increased efficacy of HB22.7 treatment followed by bortezomib, there was no corresponding decrease in peripheral blood cell counts, indicating no increase in toxicity. Our results suggest that pre-treatment with HB22.7 increases bortezomib cytotoxicity, in part through increased reactive oxygen species and apoptosis, and that this sequential treatment combination has robust efficacy in vivo.Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoid malignancies; the majority are of B-cell origin [1]. Incidence rates have almost doubled in the last 40 years and NHL is now the sixth most common cause of cancer-related death in the US [2]. Initial therapy for NHL includes chemotherapy, biologic therapy, and radiotherapy, but relapse is common and the efficacy of chemotherapy is limited by toxicity [1]. Therefore, novel, less toxic therapeutic combinations are needed to improve patient survival.Bortezomib (Velcade, PS-341) is a reversible inhibitor of the 26S proteasome [3] and is approved for the treatment of multiple myeloma and relapsed mantle cell lymphoma. The me
Extremely high negative electron affinity of diamond via magnesium adsorption
Kane M. O'Donnell,Mark T. Edmonds,Anton Tadich,Lars Thomsen,Alastair Stacey,Alex Schenk,Chris I. Pakes,Lothar Ley
Physics , 2015,
Abstract: We report large negative electron affinity (NEA) on diamond (100) using magnesium adsorption on a previously oxygen-terminated surface. The measured NEA is up to $(-2.01\pm0.05)$ eV, the largest reported negative electron affinity to date. Despite the expected close relationship between the surface chemistry of Mg and Li species on oxygen-terminated diamond, we observe differences in the adsorption properties between the two. Most importantly, a high-temperature annealing step is not required to activate the Mg-adsorbed surface to a state of negative electron affinity. Diamond surfaces prepared by this procedure continue to possess negative electron affinity after exposure to high temperatures, air and even immersion in water.
Step-up converter for electromagnetic vibrational energy scavenger
C. Saha,T. O'Donnell,J. Godsell,L. Carlioz,N. Wang,P. Mccloskey,S. Beeby,J. Tudor,Russel Torah
Computer Science , 2008,
Abstract: This paper introduces a voltage multiplier (VM) circuit which can step up a minimum voltage of 150 mV (peak). The operation and characteristics of this converter circuit are described. The voltage multiplier circuit is also tested with micro and macro scale electromagnetic vibrational generators and the effect of the VM on the optimum load conditions of the electromagnetic generator is presented. The measured results show that 85% efficiency can be achieved from this VM circuit at a power level of 18 ?W.
Macro and Micro Scale Electromagnetic Kinetic Energy Harvesting Generators
S. -P. Beeby,M. -J. Tudor,R. -N. Torah,E. Koukharenko,S. Roberts,T. O'Donnell,S. Roy
Computer Science , 2007,
Abstract: This paper is concerned with generators that harvest electrical energy from the kinetic energy present in the sensor nodes environment. These generators have the potential to replace or augment battery power which has a limited lifetime and requires periodic replacement which limits the placement and application of the sensor node.
Cardiovascular genomics: recent progress, current challenges, future promise
Christopher J O'Donnell
Genome Biology , 2000, DOI: 10.1186/gb-2000-1-1-reports409
Abstract: In the next decade, it is anticipated that the Human Genome Project and related human and animal genome sequencing projects will exert a profound influence on our understanding and management of human disease. A complete sequence of the human genome and a first-pass map of common genetic variants (single-nucleotide polymorphisms, SNPs) is expected within the next few years. Thus, attention has now turned to the many disease areas for which there may be applications for genomics, and the related subfields of functional genomics, proteomics, and bioinformatics. One important area of focus will be cardiovascular disease, the leading cause of death of men and women in the developed world and soon to be in the developing world. Traditional genetics has taught us much about genes underlying rare familial cardiovascular diseases, such as hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy is caused by a variety of mutations in genes encoding sarcomere proteins, the structural proteins in heart muscle. For 'complex' diseases, such as myocardial infarction and congestive heart failure, however, it remains unclear which genes are most responsible for disease onset, even though patients with these conditions often report a strong familial predisposition.Expectations are high for the potential of cardiovascular genomics to lead to major advances in our understanding of normal cardiovascular functioning and of cardiovascular disease pathogenesis, of interactions of genes with environment, of strategies for disease prediction, and in drug development. While the major findings have been few to date, this meeting provided a broad window into how far the field of cardiovascular genomics has come and where it is going. Among the areas receiving attention were genetic epidemiology and the array of approaches for identifying candidate genes for disease, emerging strategies - particularly transcriptional profiling - for identifying novel molecular targets and pathways, animal model
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