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Search Results: 1 - 10 of 117673 matches for " T Tewabe "
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ART-naive HIV patients at Feleg-Hiwot Referral Hospital Northwest, Ethiopia
B Abera, F Walle, T Tewabe, A Alem, M Yessin
Ethiopian Journal of Health Development , 2010,
Abstract: Objectives: To determine socio-demographic and immunological status of anti-retroviral treatment (ART)-na ve HIVpositive patients. Methods: This was a longitudinal survey of HIV-positive patients treated with ART at Felege-Hiwot Hospital. CD4 cell counts were enumerated at baseline and after 6 months of treatment using FACS count (Becton Dickinson). Socioeconomic data were collected using pre tested questionnaires. Results: Three hundred sixty eight (62% female), with median age 30 years were enrolled. Of these, 207 (56.5%) were uneducated and 233 (66.8%) had monthly income ≤ 250 birr. Three hundred fifteen (85.6%) started ART within 6 months of HIV diagnosis. The mean (95% CI) CD4 cell count at baseline was 153 (139-167); 156 (137-175) for females and 122 cells/μl (105-139) for males (p<0.01). At baseline, 280 (76.3%) and 134 (36.4%) patients had CD4 cell count <200 and ≤ 100 cells/μl, respectively. Six months follow-up CD4 counts were enumerated for 225 (61%) patients and their mean CD4 cells increased from 143-261 cells/μl (p < 0.05) with a mean cell gain of 117 cells/μl. Of the 166 follow-up patients withCD4 count <200 cells/μl at baseline, 130 (78%) attained a higher CD4 cells count after treatment compared to 50 (85.6%) of the 59 with CD4 cell >200 cells/μl (p=0.21). Conclusion: In this setting, HIV patients started ART with lower mean CD4 cell counts of 153 cells/μl and most patients with low baseline CD4 cells (<200 cells/μl) counts didn’t achieve an increase in the number of CD4 cells after treatment. The majority of ART-na ve HIV patients were from low levels of education and with minimum monthly income. Appropriate interventions should be implemented to promote and enable HIV positive individuals to enter into ART programs as early as possible [Ethiop. J. Health Dev 2010;24(1):3-8].
Assessment of factors associated with voluntary counseling and testing uptake among students in Bahir Dar University: A case control study
T Tewabe, B Destaw, M Admassu, B Abera
Ethiopian Journal of Health Development , 2012,
Abstract: Background: Voluntary counseling and testing (VCT) is one of the cornerstones for successful implementation of HIV prevention, care and support services among HIV negative and positive individuals. Objectives: This study was intended to assess the factors associated with the use of VCT service among students in Bahir Dar University Methods: Unmatched case-control study was conducted among 158 cases (who had received VCT services) and 318 control students from March 20 to May 10, 2010. The study subjects were selected randomly among 452 students who had received VCT and 2548 controls. Data were collected using a pre-tested self-administered questionnaire. Results: The findings indicated that male [OR= 1.84 (95% CI: 1.15, 2.92)], married [AOR=2.95 (95% CI: 1.23, 7.10)] and senior students [AOR=8.64 (2.70, 24.13)] were more likely to be tested than their counterparts. Knowledge, [AOR=2.44 (95% CI: 1.39, 4.28)], attitude [AOR=2.23 (95% CI: 1.19, 4.16)] and risk perception [AOR=5.43 (95% CI: 3.38, 8.72)] showed significant association with VCT service. Conclusion: In order to promote VCT service, more emphasis should be given to the knowledge and attitudes of students towards VCT, and to help the students to internalize the risk of HIV so that they can take preventive measures. Furthermore, strategies should be designed to help senior students to be tested. [Ethiop. J. Health Dev. 2012;26(1):16-21]
A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses
Juan García-Arriaza, José Luis Nájera, Carmen E. Gómez, Nolawit Tewabe, Carlos Oscar S. Sorzano, Thierry Calandra, Thierry Roger, Mariano Esteban
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024244
Abstract: The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown. Here, we have characterized the C6 protein and its effects in virus replication, innate immune sensing and immunogenicity in vivo. C6 is a 18.2 kDa protein, which is expressed early during virus infection and localizes to the cytoplasm of infected cells. Deletion of the C6L gene from the poxvirus vector MVA-B expressing HIV-1 Env, Gag, Pol and Nef antigens from clade B (MVA-B ΔC6L) had no effect on virus growth kinetics; therefore C6 protein is not essential for virus replication. The innate immune signals elicited by MVA-B ΔC6L in human macrophages and monocyte-derived dendritic cells (moDCs) are characterized by the up-regulation of the expression of IFN-β and IFN-α/β-inducible genes. In a DNA prime/MVA boost immunization protocol in mice, flow cytometry analysis revealed that MVA-B ΔC6L enhanced the magnitude and polyfunctionality of the HIV-1-specific CD4+ and CD8+ T-cell memory immune responses, with most of the HIV-1 responses mediated by the CD8+ T-cell compartment with an effector phenotype. Significantly, while MVA-B induced preferentially Env- and Gag-specific CD8+ T-cell responses, MVA-B ΔC6L induced more Gag-Pol-Nef-specific CD8+ T-cell responses. Furthermore, MVA-B ΔC6L enhanced the levels of antibodies against Env in comparison with MVA-B. These findings revealed that C6 can be considered as an immunomodulator and that deleting C6L gene in MVA-B confers an immunological benefit by enhancing IFN-β-dependent responses and increasing the magnitude and quality of the T-cell memory immune responses to HIV-1 antigens. Our observations are relevant for the improvement of MVA vectors as HIV-1 vaccines.
REGULARYFRAMWORK AND LEGAL BASE OF ELECTRONIC DOCUMENT CIRCULATION НОРМАТИВНО-ПРАВОВА БАЗА ЕЛЕКТРОННОГО ДОКУМЕНТООБ ГУ
T.Г. Омельченко,Н.А. Джанджгава
Information Technologies and Learning Tools , 2010,
Abstract: The general characteristic of legal base of electronic document circulation is presented in the article. It legislatively regulates the relations which connected with the information and information communication technologies. There is presented the list of the basic acts of regulation of sphere of information relations. У робот подано загальну характеристику нормативно-правово бази, яка законодавчо регулю в дносини, пов'язан з нформац ю, нформац йно-комун кац йними технолог ями, представлено перел к основних законодавчих акт в регулювання сфери нформац йних в дносин.
THE APPROACH OF COMPETENCE AT THE STUDY OF MATHEMATICAL INFORMATICS IN A PEDAGOGICAL UNIVERSITY КОМПЕТЕНТН СНИЙ П ДХ Д ПРИ ВИВЧЕНН МАТЕМАТИЧНО НФОРМАТИКИ” У ПЕДАГОГ ЧНОМУ УН ВЕРСИТЕТ
T.П. Кобильник
Information Technologies and Learning Tools , 2010,
Abstract: In the paper the approach of competence at the study of mathematical informatics in a pedagogical university is considered. The special attention is paid to forming of professional pedagogical and educational-cognitive competences. The example of tasks on which formed a competence at the study of mathematical informatics is resulted. У статт розглянуто компетентн сний п дх д при вивченн математично нформатики у педагог чному ун верситет . Особливу увагу звернено на формування профес йно педагог чно та навчально-п знавальну компетентност . Наведено приклад завдань, як сприяють формуванню компетентностей при вивченн математично нформатики.
SYSTEM OF THE AUTOMATIC DOCUMENT PROCESSING IN SHELL OF BASE SOFTWARE СИСТЕМА АВТОМАТИЗОВАНОГО ДОКУМЕНТООБ ГУ В ОБОЛОНЦ БАЗОВОГО ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ
В.Ю. Биков,T.О. Дерба
Information Technologies and Learning Tools , 2010,
Abstract: In the article the automatic system of the document processing, created with use of Microsoft Access – a component part of Microsoft Office is offered. This system can be used at school and Institutions of education with one computer or with system of 15 ones connecting in the local net. У статт запропоновано для ознайомлення автоматизовану систему документооб гу, створену з використанням Microsoft Access – складово частини Microsoft Office. Ця система може використовуватися в школах установах осв тньо галуз на одному комп’ютер чи на систем до 15 комп’ютер в, пов’язаних локальною мережею.
MODERN APPROACHES AND PRINCIPLES OF PORTAL BUILDING ТЕХНОЛОГ ЧН ОСНОВИ СТВОРЕННЯ ТА П ДТРИМКИ ПОРТАЛ В
Н.Т. Задорожна,T.Г. Омельченко
Information Technologies and Learning Tools , 2010,
Abstract: The paper presents the analysis of modern state of development and use of Internet portals, the peculiarities of approaches to creation and introduction of portals in educational system are described. В робот анал зуються принципи розробки та використання нтернет-портал в, описуються особливост п дход в до створення та впровадження портал в у систему осв ти.
REVIEW OF MODERN TOOLS OF INFORMATION AND COMMUNICATION TECHNOLOGIES IN THE MANAGEMENT OF SECONDARY EDUCATION ОГЛЯД СУЧАСНИХ ЗАСОБ В НФОРМАЦ ЙНО-КОМУН КАЦ ЙНИХ ТЕХНОЛОГ Й В УПРАВЛ НН СЕРЕДНЬОЮ ОСВ ТОЮ
T.О. Дерба
Information Technologies and Learning Tools , 2010,
Abstract: There are presented the up-to-date situation with information and communication technology use in the management of secondary education; information and communication technologies (ICT), that practically used in educational establishments are considered. There are some examples of educational institutions using IСT for the automation of management. У статт показаний зр з сучасного стану використання нформац йно-комун кац йних технолог й в управл нн середньою осв тою, розглянут нформац йно-комун кац йн технолог ( КТ), як на практиц використовуються в загальноосв тн х закладах, наведен в дгуки навчальних заклад в, як використовують КТ для автоматизац управл ння
EVALUATION OF INTEGRALS OF FUNCTIONS OF COMPLEX VARIABLE BY USING THE RESIDUES IN COMPUTER MATHEMATICS SYSTEMS ОБЧИСЛЕННЯ НТЕГРАЛ В В Д ФУНКЦ Й КОМПЛЕКСНО ЗМ ННО ЗА ДОПОМОГОЮ ЗАЛИШК В В СИСТЕМАХ КОМП’ЮТЕРНО МАТЕМАТИКИ
Н.Д. Парфьонова,T.В. Клочко
Information Technologies and Learning Tools , 2010,
Abstract: The article describes the methodology of teaching one of the major topics of the course of complex analysis using the system Maple. It also demonstrates how the use of computer mathematics systems facilitates the evaluation of students by the teacher during organization of independent work. В статт наведено методику викладання мабуть одн з найважлив ших тем курсу комплексного анал зу з використанням системи Maple; демонстру ться, як використання систем комп’ютерно математики полегшу викладачев оц нювання роботи студент в та при орган зац х самост йно роботи.
USE OF VEB 2.0 SOCIAL SERVICES FOR PLANNING OF INFORMATIVE SYSTEMS ВИКОРИСТАННЯ СОЦ АЛЬНИХ СЕРВ С В ВЕБ 2.0 ДЛЯ ПРОЕКТУВАННЯ НФОРМАЦ ЙНИХ СИСТЕМ
T.Г. Омельченко
Information Technologies and Learning Tools , 2010,
Abstract: In the article the definitions and the characteristic of Web 2.0 social networks and services are presented as well as tendencies of their development, approaches of use of Web 2.0 social services and technologies in information systems are considered and analyzed. Requirements to technological maintenance of information system “Planning of scientific researches in NPA of Ukraine” are analyzed. В робот представлен визначення характеристика соц альних мереж послуг Веб 2.0 та тенденц хнього розвитку, розглянуто проанал зовано напрямки використання соц альних послуг та технолог й Веб 2.0 в нформац йних системах. Проанал зовано вимоги до технолог чного забезпечення нформац йно системи “Планування наукових досл джень в АПН Укра ни”.
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