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Search Results: 1 - 10 of 463174 matches for " Sylvia A. Obermann-Borst "
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Periconceptional Maternal Folic Acid Use of 400 μg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child
Régine P. Steegers-Theunissen,Sylvia A. Obermann-Borst,Dennis Kremer,Jan Lindemans,Cissy Siebel,Eric A. Steegers,P. Eline Slagboom,Bastiaan T. Heijmans
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007845
Abstract: Countries worldwide recommend women planning pregnancy to use daily 400 μg of synthetic folic acid in the periconceptional period to prevent birth defects in children. The underlying mechanisms of this preventive effect are not clear, however, epigenetic modulation of growth processes by folic acid is hypothesized. Here, we investigated whether periconceptional maternal folic acid use and markers of global DNA methylation potential (S-adenosylmethionine and S-adenosylhomocysteine blood levels) in mothers and children affect methylation of the insulin-like growth factor 2 gene differentially methylation region (IGF2 DMR) in the child. Moreover, we tested whether the methylation of the IGF2 DMR was independently associated with birth weight.
In-medium effects on hypernuclear formation
T. Gaitanos,A. B. Larionov,H. Lenske,U. Mosel,A. Obermann
Physics , 2012, DOI: 10.1016/j.nuclphysa.2012.12.124
Abstract: We study strangeness dynamics in reactions relevant for the formation of multi-strange hypernuclei. In particular, we discuss the in-medium effects on elementary hyperon-nucleon ($YN$) channels, which are relevant for the production of hypernuclei at PANDA. The results indicate strong in-medium effects on $YN$-scattering, which might be important for hypernuclear studies at PANDA.
Network iso-elasticity and weighted $α$-fairness
S. C. Borst,N. S. Walton,A. P. Zwart
Mathematics , 2012,
Abstract: When a communication network's capacity increases, it is natural to want the bandwidth allocated to increase to exploit this capacity. But, if the same relative capacity increase occurs at each network resource, it is also natural to want each user to see the same relative benefit, so the bandwidth allocated to each route should remain proportional. We will be interested in bandwidth allocations which scale in this \textit{iso-elastic} manner and, also, maximize a utility function. Utility optimizing bandwidth allocations have been frequently studied, and a popular choice of utility function are the weighted $\alpha$-fair utility functions introduced by Mo and Walrand \cite{MoWa00}. Because weighted $\alpha$-fair utility functions possess this iso-elastic property, they are frequently used to form fluid models of bandwidth sharing networks. In this paper, we present results that show, in many settings, the only utility functions which are iso-elastic are weighted $\alpha$-fair utility functions. Thus, if bandwidth is allocated according to a network utility function which scales with relative network changes then that utility function must be a weighted $\alpha$-fair utility function, and hence, a control protocol that is robust to the future relative changes in network capacity and usage ought to allocate bandwidth inorder to maximize a weighted $\alpha$-fair utility function.
Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
Steffen Naegel,Mark Obermann
Neuropsychiatric Disease and Treatment , 2009,
Abstract: Steffen Naegel, Mark ObermannDepartment of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyAbstract: Migraine is a very common disorder characterized by the combination of typical headache with associated autonomic symptoms and/or the presence of aura. Considerable advances have been made in recent years to understand the pathophysiology of migraine, which has led to improved treatment options for the acute migraine attack as well as migraine prophylaxis. Unfortunately, preventive treatment is often insufficient to decrease migraine frequency substantially or is not well tolerated. Topiramate is an antipileptic drug with a complex mode of action which has proven its efficacy and safety in the prophylactic treatment of episodic migraine in a number of randomized controlled clinical trials. Topiramate is also effective in treating patients with chronic migraine. It has little pharmacological interaction with other drugs and is generally well tolerated by patients.Keywords: migraine, antiepileptic drugs, topiramate
Hepatitis crónica
Revista chilena de pediatría , 2002,
Usage and Impact of Controlled Vocabularies in a Subject Repository for Indexing and Retrieval
Timo Borst
Liber Quarterly : The Journal of European Research Libraries , 2012,
Abstract: Since 2009, the German National Library for Economics (ZBW) supports both indexing and retrieval of Open Access scientific publications like working papers, postprint articles and conference papers by means of a terminology web service. This web service is based on concepts organized as a ‘Standard Thesaurus for Economics’ (STW), which is modelled and regularly published as Linked Open Data. Moreover, it is integrated into the institution’s subject repository for automatically suggesting appropriate key words while indexing and retrieving documents, and for automatically expanding search queries on demand to gain better search results. While this approach looks promising to augment ‘off the shelf’ repository software systems in a lightweight manner with a disciplinary profile, there is still significant uncertainty about the effective usage and impact of controlled terms in the realm of these systems. To cope with this, we analyze the repository’s logfiles to get evidence of search behaviour which is potentially influenced by auto suggestion and expansion of scientific terms derived from a discipline’s literature.
How does nature program neuron types?
Alexander Borst
Frontiers in Neuroscience , 2008, DOI: 10.3389/neuro.01.016.2008
Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis
Ellen C Obermann, Philip Went, Annette Zimpfer, Alexandar Tzankov, Peter J Wild, Robert Stoehr, Stefano A Pileri, Stephan Dirnhofer
BMC Cancer , 2005, DOI: 10.1186/1471-2407-5-162
Abstract: Immunohistochemistry for Mcm2 was performed on TMAs constructed from 302 cases of DLBCL. A monoclonal mouse antibody was used after heat induced antigen retrieval. Mcm2 expression was scored quantitatively. Positivity for Mcm2 was defined as presence of nuclear expression of Mcm2 in greater than or equal to 40 % of tumour cells. A statistical analysis was carried out of the association of Mcm2 and the clinico-pathological characteristics.Mcm2 expression was clearly evident in the nuclei of proliferating non-neoplastic cells and tumour cells. Positivity for Mcm2 was found in 46% (98/211) of analysable cases. A significant correlation existed between Mcm2 expression and presence of bulky disease (p = 0.003). Poor disease specific survival was observed in patients with DLBCL positive for Mcm2 expression in the univariate analysis (p = 0.0424).Mcm2 expression can be used to assess tumour proliferation and may be useful as an additional prognostic marker to refine the prediction of outcome in DLBCL.In Western countries, diffuse large B-cell lymphoma (DLBCL) is the most common type of mature B-cell lymphomas with a frequency of approximately 30 to 40% [1]. DLBCL is an aggressive but potentially curable disease. However, only about 40 to 45% of patients are cured with combination chemotherapy [2]. Currently, the International Prognostic Index (IPI) is the generally accepted predictor of prognosis [3]. In order to avoid over-treatment of some patients and identify patients at high-risk for early relapse or poor response to standard treatment, individualised prediction of prognosis becomes more and more important.A number of biological markers have been studied for their predictive potential, but none has become universally accepted [4-7]. Gene expression profiling has helped to identify at least two subgroups of DLBCL, one with a germinal centre signature and the other with an activated B-cell signature, which show distinct clinical outcomes [3,8].The proliferative capacity
On Mellitella stokesii and Amphipholis geminata (Echinodermata), from an intertidal flat in the upper Gulf of Nicoya estuary, Pacific, Costa Rica
Vargas,José A; Solano,Sylvia;
Revista de Biología Tropical , 2011,
Abstract: information on changes over time in the biodiversity and ecology of tropical systems is of increasing importance against the background of local, regional, and global dynamics. this study aimed to contribute with long-term data on the abundance fluctuations of two species of echinoderms from a tropical tidal flat. from february 1984 to december 1986, march 1985 to april 1987, and july 1994 to september 1996 (total: 76 dates), core samples (17.7cm2, 15cm deep) were collected at low tide at a mud-sand flat in the mid upper gulf of nicoya estuary, costa rica, as part of a survey of the benthic community. among more than 100 taxa, the burrowing brittle star, amphipholis geminata, and the sand dollar, mellitella stokesii, consistently appeared in the samples over the study period. a total of 63 m. stokesii and 149 a. geminata were collected. the 43 sand dollars found during 1984-1985, give an approximate density of 35 ind./m2 , which is within the range reported for this species. m. stokesii was almost absent from 1994 to 1996, while a. geminata had its peak of abundance at the end of 1995. low abundances of the sand dollar during the rainy seasons (may-november) and slight increments in dry seasons (december-april) cores, also agrees with a report from the region. a. geminata also presented an irregular pattern of abundance, with slight increases at the end of the rainy seasons or during the dry seasons, when higher salinities are more suitable for echinoderms. the patchy spatial distribution of both species makes difficult the detection of patterns with a corer. nevertheless, this information is unique due to its extensive time coverage and provides a baseline for future surveys designed specifically for the study of tropical intertidal estuarine echinoderms. rev. biol. trop. 59 (1): 193-198. epub 2011 march 01.
DNA Damage Induced in the Germ and Bone Marrow Cells of Mice by Caffeine
Sylvia Utulu,Adekunle A. Bakare
Research Journal of Biological Sciences , 2012, DOI: 10.3923/rjbsci.2010.536.541
Abstract: Caffeine is a major constituent of many drugs and also widely and immensely consumed in beverages and soft drinks. The public health implication of the habitual and indiscriminate consumption of caffeine containing products has prompted studies on its safety evaluation. In this study, we investigated the potentials of caffeine to induce abnormal sperm cells in the testes and Micronuclei (MN) in the bone marrow cells using the sperm morphology and MN assays in mice. For these assays, mice were administered Intraperitoneally (IP) caffeine at dose levels of 0.39, 0.78, 1.56 and 3.12 mg kg-1 bwt (body weight) and normal saline and cyclophosphamide were used as negative and positive controls, respectively.
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