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Search Results: 1 - 7 of 7 matches for " Sylvi Vigmo "
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Language learning in a wiki: Student contributions in a web based learning environment
Linda Bradley,Berner Lindstr?m,Hans Rystedt,Sylvi Vigmo
Themes in Science and Technology Education , 2010,
Abstract: Emerging social writing platforms offer possibilities for language learners to collaboratearound joint assignments. One such environment is the wiki, generally hosting two prominentmodes of usage, web pages and discussion forums. This study investigates softwareengineering students’ use of a wiki as an integrated tool within the frames of a languagecourse. The purpose of the case study was to investigate the student interaction in a studentdriven design setting and what the implications are for language learning in such anenvironment. The findings show that the two modes of interaction host primarily three typesof activity, contributing and writing together, evaluating and peer reviewing, and arguing anddiscussing. These three activities convey different ways of collaborating and sharing textonline. Once a group had chosen a mode for their collaboration, they tend to stay with itthroughout their work.
A Health Impairment Process of Sickness Presenteeism in Norwegian Physicians: The Mediating Role of Exhaustion  [PDF]
Sylvi Thun, Lise T. L?vseth
Health (Health) , 2016, DOI: 10.4236/health.2016.89089
Abstract: Although work factors have been associated with both presenteeism and exhaustion among hospital physicians, we lack knowledge on the dynamic relationship between demands in the work context and presenteeism and how this can be mediated by symptoms of exhaustion when controlling for job resources. The objective of this study is to examine a health impairment process of presenteeism among university hospital physicians. A cross-sectional survey of 545 university hospital physicians in Norway was conducted. Variables included in the model were presenteeism, exhaustion, work-family conflict, role conflict, social support and control over work pace. Findings from structural equation modeling indicated that exhaustion mediates the relationship between job demands and presenteeism. Job resources had no direct effect on presenteeism in the hypothesized model. The variables in the study explained 17% of the variance in presenteeism. The study is one of the first to demonstrate that the relationship between job demands and presenteeism is mediated by exhaustion when controlling for job resources. The results highlight the importance of considering the link between health symptoms and job demands to reduce the negative effects of presenteeism.
Use of Synthetic DNA as New Tracers for Tracing Groungwater Flow and Multiple Contaminants
Iftikhar H. Sabir,Peter Alestrom,Sylvi Haldorsen
Journal of Applied Sciences , 2001,
Abstract: It has recently been possible to trace groundwater and contaminants flow paths by using synthetic DNA molecules as tracers. The DNA tracers injected in groundwater can be as distinctive and traceable as a person’s fingerprint. Alphanumeric information like names, dates, batch numbers, can be defined into the DNA sequence. This novel tracing technique can provide an unlimited number of uniquely labelled tracers with different sizes and valances. Using these tracers is a great advangtage because they allow us to evaluate a number of origins of pollutants simultaneously but released over different times. The ability to figure out where water or a pollutant originated and where it has traveled, and such flow paths are a big concern for hydrogeologists trying to predict presence of multiple contaminants in the subsurface environments. Short pieces of single-stranded DNA produced by automated standard oligonucleotide synthesis have successfully been used in groundwater flow and contaminant transport studies. Polymerase Chain Reaction (PCR) is utilized to detect and read information in unique DNA tracers. PCR has extremely low detection limit and allows specific detection of one DNA sequence in a mixture of tracer signatures. Synthetic DNA tracer analyze could simplify interpretations of groundwater pollution problems and should be routinely performed in groundwater studies where there is a demand of simultaneous use of two or more tracers. In this chapter the DNA tracing technique is briefly reviewed.
Psychometric evaluation of a Swedish version of Krantz Health Opinion Survey  [PDF]
Petra Svedberg, Bodil Ivarsson, Ulrica G Nilsson, Asa Roxberg, Amir Baigi, David Brunt, Margareta Brannstrom, Bengt Fridlund, Sylvi Persson, Mikael Rask, Carin Alm-Roijer
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.23028
Abstract: The purpose of this study was to evaluate the psychometric properties of a Swedish version of The Krantz Health Opinion Survey (KHOS). A convenience sample of 79 persons (47 men and 32 women) was recruited from The Heart and Lung Patients’ National Association at ten local meeting places in different areas in Sweden. The questionnaire was examined for face and content validity, internal consistency and test-retest reliability. The findings showed that the Swedish version of KHOS is acceptable in terms of face and content validity, internal consistency and test-retest reliability over time among 79 individuals >65 years of age and with a cardiac disease. In conclusion, wider evaluations of the psychometric use of KHOS for other populations and settings are recommended.
Distinct and Conserved Prominin-1/CD133–Positive Retinal Cell Populations Identified across Species
József Jászai,Christine A. Fargeas,Sylvi Graupner,Elly M. Tanaka,Michael Brand,Wieland B. Huttner,Denis Corbeil
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017590
Abstract: Besides being a marker of various somatic stem cells in mammals, prominin-1 (CD133) plays a role in maintaining the photoreceptor integrity since mutations in the PROM1 gene are linked with retinal degeneration. In spite of that, little information is available regarding its distribution in eyes of non-mammalian vertebrates endowed with high regenerative abilities. To address this subject, prominin-1 cognates were isolated from axolotl, zebrafish and chicken, and their retinal compartmentalization was investigated and compared to that of their mammalian orthologue. Interestingly, prominin-1 transcripts—except for the axolotl—were not strictly restricted to the outer nuclear layer (i.e., photoreceptor cells), but they also marked distinct subdivisions of the inner nuclear layer (INL). In zebrafish, where the prominin-1 gene is duplicated (i.e., prominin-1a and prominin-1b), a differential expression was noted for both paralogues within the INL being localized either to its vitreal or scleral subdivision, respectively. Interestingly, expression of prominin-1a within the former domain coincided with Pax-6–positive cells that are known to act as progenitors upon injury-induced retino-neurogenesis. A similar, but minute population of prominin-1–positive cells located at the vitreal side of the INL was also detected in developing and adult mice. In chicken, however, prominin-1–positive cells appeared to be aligned along the scleral side of the INL reminiscent of zebrafish prominin-1b. Taken together our data indicate that in addition to conserved expression of prominin-1 in photoreceptors, significant prominin-1–expressing non-photoreceptor retinal cell populations are present in the vertebrate eye that might represent potential sources of stem/progenitor cells for regenerative therapies.
Spatial Distribution of Prominin-1 (CD133) – Positive Cells within Germinative Zones of the Vertebrate Brain
József Jászai, Sylvi Graupner, Elly M. Tanaka, Richard H. W. Funk, Wieland B. Huttner, Michael Brand, Denis Corbeil
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063457
Abstract: Background In mammals, embryonic neural progenitors as well as adult neural stem cells can be prospectively isolated based on the cell surface expression of prominin-1 (CD133), a plasma membrane glycoprotein. In contrast, characterization of neural progenitors in non-mammalian vertebrates endowed with significant constitutive neurogenesis and inherent self-repair ability is hampered by the lack of suitable cell surface markers. Here, we have investigated whether prominin-1–orthologues of the major non-mammalian vertebrate model organisms show any degree of conservation as for their association with neurogenic geminative zones within the central nervous system (CNS) as they do in mammals or associated with activated neural progenitors during provoked neurogenesis in the regenerating CNS. Methods We have recently identified prominin-1 orthologues from zebrafish, axolotl and chicken. The spatial distribution of prominin-1–positive cells – in comparison to those of mice – was mapped in the intact brain in these organisms by non-radioactive in situ hybridization combined with detection of proliferating neural progenitors, marked either by proliferating cell nuclear antigen or 5-bromo-deoxyuridine. Furthermore, distribution of prominin-1 transcripts was investigated in the regenerating spinal cord of injured axolotl. Results Remarkably, a conserved association of prominin-1 with germinative zones of the CNS was uncovered as manifested in a significant co-localization with cell proliferation markers during normal constitutive neurogenesis in all species investigated. Moreover, an enhanced expression of prominin-1 became evident associated with provoked, compensatory neurogenesis during the epimorphic regeneration of the axolotl spinal cord. Interestingly, significant prominin-1–expressing cell populations were also detected at distinct extraventricular (parenchymal) locations in the CNS of all vertebrate species being suggestive of further, non-neurogenic neural function(s). Conclusion/Interpretation Collectively, our work provides the first data set describing a comparative analysis of prominin-1–positive progenitor cells across species establishing a framework for further functional characterization in the context of regeneration.
Conformational Selection Underlies Recognition of a Molybdoenzyme by Its Dedicated Chaperone
Magali Lorenzi, Léa Sylvi, Guillaume Gerbaud, Elisabetta Mileo, Frédéric Halgand, Anne Walburger, Hervé Vezin, Valérie Belle, Bruno Guigliarelli, Axel Magalon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049523
Abstract: Molecular recognition is central to all biological processes. Understanding the key role played by dedicated chaperones in metalloprotein folding and assembly requires the knowledge of their conformational ensembles. In this study, the NarJ chaperone dedicated to the assembly of the membrane-bound respiratory nitrate reductase complex NarGHI, a molybdenum-iron containing metalloprotein, was taken as a model of dedicated chaperone. The combination of two techniques ie site-directed spin labeling followed by EPR spectroscopy and ion mobility mass spectrometry, was used to get information about the structure and conformational dynamics of the NarJ chaperone upon binding the N-terminus of the NarG metalloprotein partner. By the study of singly spin-labeled proteins, the E119 residue present in a conserved elongated hydrophobic groove of NarJ was shown to be part of the interaction site. Moreover, doubly spin-labeled proteins studied by pulsed double electron-electron resonance (DEER) spectroscopy revealed a large and composite distribution of inter-label distances that evolves into a single preexisting one upon complex formation. Additionally, ion mobility mass spectrometry experiments fully support these findings by revealing the existence of several conformers in equilibrium through the distinction of different drift time curves and the selection of one of them upon complex formation. Taken together our work provides a detailed view of the structural flexibility of a dedicated chaperone and suggests that the exquisite recognition and binding of the N-terminus of the metalloprotein is governed by a conformational selection mechanism.
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