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Search Results: 1 - 10 of 355852 matches for " Suzanne S.; van der Peet "
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Laparoscopic versus open transhiatal esophagectomy for distal and junction cancer
Maas,Kirsten W.; Biere,Surya S.A.Y.; Scheepers,Joris J.G.; Gisbertz,Suzanne S.; van der Peet,Donald L.; Cuesta,Miguel A.;
Revista Espa?ola de Enfermedades Digestivas , 2012, DOI: 10.4321/S1130-01082012000400005
Abstract: background: the only curative treatment for esophageal cancer is surgical resection. this treatment is associated with a high morbidity rate and long in-hospital recovery period. both transthoracic and transhiatal esophagectomies are performed worldwide. the transhiatal approach may reduce the respiratory infection rate in compromised patients with distal esophageal and gastro-esophageal (ge) cancers. minimally invasive esophagectomy could further improve post-operative outcome. two cohorts of laparoscopic and open transhiatal esophagectomy for cancer were compared for short- and long-term outcome. methods: from january 2001 through december 2004, 50 patients who underwent laparoscopic transhiatal esophagectomy were compared to a historical group of 50 patients who had undergone open transhiatal esophagectomy between january 1998 and december 2000. post-operative management was identical in both groups. results: no significant differences were seen between the two groups with regard to baseline characteristics and oncological parameters including resection margin (r0 82 vs. 74%, p = 0.334) and 5-year survival. operation time did not differ significantly between the groups. (300 vs. 280 min, p = 0.110). median hospital stay and intensive care unit stay were significantly shorter in the laparoscopic group (13 vs. 16 days, p = 0.001 and 1 vs. 3 days, p = 0.000 respectively). conclusion: minimally invasive transhiatal esophagectomy is feasible and has the same oncological outcome as open transhiatal esophagectomy. faster recovery without a significant longer operation time could be the major benefit of the laparoscopic transhiatal approach. to our knowledge, this is the largest comparative study in literature comparing laparoscopic transhiatal with open transhiatal esophagectomy for cancers of distal and ge junction. randomized trials are needed to further clarify the role of laparoscopic transhiatal approach for esophageal cancer.
Travel motivations of tourists visiting Kruger National Park
Peet van der Merwe,Melville Saayman
Koedoe : African Protected Area Conservation and Science , 2008, DOI: 10.4102/koedoe.v50i1.140
Abstract: The Kruger National Park (KNP) one of the largest conservation areas in South Africa, attracts in excess of one million visitors a year and is regarded as an icon destination in international tourism. Since this park attracts more tourists than any other park in South Africa, the purpose of this article is to determine the reasons (the travel motives) why tourists visit the park. Little research has been done on travel motives to national parks and this was the first of its kind in South Africa. The research was conducted by means of questionnaires. A factor analysis was used to determine the travel motives. Six factors were identified, namely nature, activities, attractions, nostalgia, novelty and escape from routine. Some of these motives were confirmed by similar research in other countries, although the similarities are not significant. This research confirmed that different attractions and destinations fed different travel motives, hence the need for more studies of this nature to be conducted.
Laparoscopy versus open surgery for advanced and resectable gastric cancer: a meta-analysis
Martínez-Ramos,David; Miralles-Tena,Juan Manuel; Cuesta,Miguel A.; Escrig-Sos,Javier; van der Peet,Donald; Hoashi,Jane S.; Salvador-Sanchis,José Luis;
Revista Espa?ola de Enfermedades Digestivas , 2011, DOI: 10.4321/S1130-01082011000300005
Abstract: background: there are few studies in the literature comparing laparoscopic versus open gastrectomy, predominantly for advanced gastric cancer (agc). most of the available studies and meta-analysis compare both approaches in the early gastric cancer. the meta-analysis, here presented, compares the clinical outcomes between these two procedures for agc. objectives: to evaluate the current status of both partial and total laparoscopic gastrectomy (lg), with regard to its short and long-term outcomes by comparing it to conventional open gastrectomy (og) for agc. data sources and review methods: original articles published in english language from january 1991 to october 2009 were searched in the medline, embase, current contents, science citation index databases and cochrane controlled trials register. all articles comparing lg and og for agc were included, and those comparing outcomes only for early gastric cancer (egc) were excluded. clinical appraisal and data extraction were conducted independently by 3 reviewers. statistical analysis was carried out following the dersimonian-laird random effects model. results: out of 2,344 studies, 7 studies were selected. one prospective randomized controlled trial, one comparative prospective study and five comparative retrospective studies were analyzed. these studies include a total of 452 patients with gastric cancer, 174 patients in the lg and 278 in the og. the analyzed result variables were operative time, operative blood loss, hospital postoperative stay, number of dissected lymph nodes and cancer-related mortality risk. compared to og, lg was a longer procedure: weighted mean difference (wmd) 44 minutes; 95% confidence interval (ci) 20 to 69; i-squared = 91.6%, but was associated with a lower blood loss (wmd -122 cc; 95% ci -208 to -37; i-squared = 90.8%); this was more significant for hospital operative stay (wmd -6.2 days; 95% ci -9.4 to -2.8; i-squared = 67.8%). moreover there were no significant differences between t
Thoracoscopic resection for esophageal cancer: A review of literature
Scheepers Joris,van der Peet Donald,Veenhof Alexander,Cuesta Miguel
Journal of Minimal Access Surgery , 2007,
Abstract: Esophageal resection remains the only curative option in high grade dysplasia of the Barrett esophagus and non metastasized esophageal cancer. In addition, it may also be an adequate treatment in selected cases of benign disease. A wide variety of minimally invasive procedures have become available in esophageal surgery. Aim of the present review article is to evaluate minimally invasive procedures for esophageal resection, especially the approach performed through right thoracoscopy.
Characterization of Functional and Structural Integrity in Experimental Focal Epilepsy: Reduced Network Efficiency Coincides with White Matter Changes
Willem M. Otte, Rick M. Dijkhuizen, Maurits P. A. van Meer, Wilhelmina S. van der Hel, Suzanne A. M. W. Verlinde, Onno van Nieuwenhuizen, Max A. Viergever, Cornelis J. Stam, Kees P.J. Braun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039078
Abstract: Background Although focal epilepsies are increasingly recognized to affect multiple and remote neural systems, the underlying spatiotemporal pattern and the relationships between recurrent spontaneous seizures, global functional connectivity, and structural integrity remain largely unknown. Methodology/Principal Findings Here we utilized serial resting-state functional MRI, graph-theoretical analysis of complex brain networks and diffusion tensor imaging to characterize the evolution of global network topology, functional connectivity and structural changes in the interictal brain in relation to focal epilepsy in a rat model. Epileptic networks exhibited a more regular functional topology than controls, indicated by a significant increase in shortest path length and clustering coefficient. Interhemispheric functional connectivity in epileptic brains decreased, while intrahemispheric functional connectivity increased. Widespread reductions of fractional anisotropy were found in white matter regions not restricted to the vicinity of the epileptic focus, including the corpus callosum. Conclusions/Significance Our longitudinal study on the pathogenesis of network dynamics in epileptic brains reveals that, despite the locality of the epileptogenic area, epileptic brains differ in their global network topology, connectivity and structural integrity from healthy brains.
Adaptive Bayesian credible sets in regression with a Gaussian process prior
Suzanne Sniekers,Aad van der Vaart
Statistics , 2015,
Abstract: We investigate two empirical Bayes methods and a hierarchical Bayes method for adapting the scale of a Gaussian process prior in a nonparametric regression model. We show that all methods lead to a posterior contraction rate that adapts to the smoothness of the true regression function. Furthermore, we show that the corresponding credible sets cover the true regression function whenever this function satisfies a certain extrapolation condition. This condition depends on the specific method, but is implied by a condition of self-similarity. The latter condition is shown to be satisfied with probability one under the prior distribution.
Increased Excretion of C4-Carnitine Species after a Therapeutic Acetylsalicylic Acid Dose: Evidence for an Inhibitory Effect on Short-Chain Fatty Acid Metabolism
Catharina M. C. Mels,Peet Jansen van Rensburg,Francois H. van der Westhuizen,Pieter J. Pretorius
ISRN Pharmacology , 2011, DOI: 10.5402/2011/851870
Discovery of Inhibitors of Leishmania β-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library
Phillip van der Peet, Julie E. Ralton, Malcolm J. McConville, Spencer J. Williams
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032642
Abstract: Leishmania spp. are a medically important group of protozoan parasites that synthesize a novel intracellular carbohydrate reserve polymer termed mannogen. Mannogen is a soluble homopolymer of β-1,2-linked mannose residues that accumulates in the major pathogenic stages in the sandfly vector and mammalian host. While several steps in mannogen biosynthesis have been defined, none of the enzymes have been isolated or characterized. We report the development of a simple assay for the GDP-mannose–dependent β-1,2-mannosyltransferases involved in mannogen synthesis. This assay utilizes octyl α-d-mannopyranoside to prime the formation of short mannogen oligomers up to 5 mannose residues. This assay was used to screen a focussed library of 44 GMP-triazole adducts for inhibitors. Several compounds provided effective inhibition of mannogen β-1,2-mannosyltransferases in a cell-free membrane preparation. This assay and inhibitor compounds will be useful for dissecting the role of different mannosyltransferases in regulating de novo biosynthesis and elongation reactions in mannogen metabolism.
A Duality Based 2-Approximation Algorithm for Maximum Agreement Forest
Frans Schalekamp,Anke van Zuylen,Suzanne van der Ster
Computer Science , 2015,
Abstract: We give a 2-approximation algorithm for the Maximum Agreement Forest problem on two rooted binary trees. This NP-hard problem has been studied extensively in the past two decades, since it can be used to compute the Subtree Prune-and-Regraft (SPR) distance between two phylogenetic trees. Our result improves on the very recent 2.5-approximation algorithm due to Shi, Feng, You and Wang (2015). Our algorithm is the first approximation algorithm for this problem that uses LP duality in its analysis.
Primary hemiarthroplasty versus conservative treatment for comminuted fractures of the proximal humerus in the elderly (ProCon): A Multicenter Randomized Controlled trial
Dennis Den Hartog, Esther MM Van Lieshout, Wim E Tuinebreijer, Suzanne Polinder, Ed F Van Beeck, Roelf S Breederveld, Maarten WGA Bronkhorst, Jan Eerenberg, Steven Rhemrev, W Herbert Roerdink, Gerrit Schraa, Harm M Van der Vis, Thom PH Van Thiel, Peter Patka, Stefaan Nijs, Niels WL Schep
BMC Musculoskeletal Disorders , 2010, DOI: 10.1186/1471-2474-11-97
Abstract: A prospective, multi-center RCT will be conducted in nine centers in the Netherlands and Belgium. Eighty patients over 65 years of age, who have sustained a three-or four part, or split head proximal humeral fracture will be randomized between primary hemiarthroplasty and conservative treatment. The primary outcome is the Constant score, which indicates pain and function. Secondary outcomes include the Disability of the Arm and Shoulder (DASH) score, Visual Analogue Scale (VAS) for pain, radiographic healing, health-related quality of life (Short-form-36, EuroQol-5D) and healthcare consumption. Cost-effectiveness ratios will be determined for both trial arms. Outcome will be monitored at regular intervals over the subsequent 24 months (1, 3 and 6 weeks, and 3, 6, 12, 18, and 24 months). Data will be analyzed on an intention to treat basis, using univariate and multivariable analyses.This trial will provide level-1 evidence on the effectiveness of the two mostly applied treatment options for three-or four part and split head proximal humeral fractures in the elderly. These data may support the development of a clinical guideline for treatment of these traumatic injuries.Netherlands Trial Register (NTR): NTR2040Fractures of the proximal humerus are one of the most frequently encountered fractures in the elderly. The incidence is approximately 66 per 10,000 person years [1]. Most of these fractures are treated non-operatively and careful early motion with varying results. Especially, the treatment of three-or four-part fractures and split head humeral fractures is an unresolved problem [1-4].Locking plates have been used during the last decade. They appear to offer improved fixation, however at considerable rates of complications such as non-union, malunion, or complaints of hardware (e.g., impingement). Also, the prevalence of screw cut-out ranges from 11 to 43% due to osteoporosis and avascular necrosis of the humeral head [5]. According to Hertel et al. [6] fracture
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