Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 24 )

2018 ( 39 )

2017 ( 29 )

2016 ( 40 )

Custom range...

Search Results: 1 - 10 of 17606 matches for " Susana Sim?es "
All listed articles are free for downloading (OA Articles)
Page 1 /17606
Display every page Item
Modular Hydrogels for Drug Delivery  [PDF]
Susana Simes, Ana Figueiras, Francisco Veiga
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32025
Abstract: The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body through minimally invasive means and, these vehicles should be capable of releasing drug to their intended location at a controlled rate. Furthermore, it is desirable to develop drug delivery systems that are capable of in vivo to suffer degradation and to deliver the drug completely, avoiding the need to surgically remove the vehicle at the end of its useful lifetime. Hydrogels are of particular interest for drug delivery applications due to their ability to address these needs in addition to their good biocompatibility, tunable network structure to control the diffusion of drugs and, tunable affinity for drugs. However, hydrogels are also limited for drug delivery applications due to the often quick elution of drug from their highly swollen polymer matrices as well as the difficulty inherent in the injection of macroscopic hydrogels into the body. This paper presents an overview to the advances in hydrogels based drug delivery. Different types of hydrogels can be used for drug delivery to specific sites in the gastrointestinal tract ranging from the oral cavity to the colon. These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations. Moreover, such materials are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues.
Optic Neuritis in an Adult Patient with Chickenpox
Ana Rita Azevedo,Rita Simes,Filipe Silva,Susana Pina,Cristina Santos,Peter Pêgo,Filomena Silva,Susana Teixeira
Case Reports in Ophthalmological Medicine , 2012, DOI: 10.1155/2012/371584
Abstract: Central nervous system involvement in a patient with primary infection with Varicella zoster virus is rare, especially in the immunocompetent adult. In particular, isolated optic neuritis has been described in a small number of cases. The authors present a case of optic neuritis in an immunocompetent patient. A 28-year-old woman presented to the emergency room with a history of headaches during the previous week, without visual symptoms. The examination was unremarkable, except for a rash suggestive of chickenpox and hyperemic and edematous optic disc, bilaterally. Visual acuity and neurological examination were normal. Two days later, she complained of pain on eye movement and decreased visual acuity, which was 20/32 in her right eye and 20/60 in her left eye. Four days after admission, her visual acuity started to improve, and two months later, she had 20/20 visual acuity in both eyes. To our knowledge, this is the first reported case of an immunocompetent adult in which a Varicella zoster virus associated optic neuritis presented with fundoscopic changes before decreased visual acuity. This suggests that this condition may be underdiagnosed in asymptomatic patients. 1. Introduction Varicella zoster virus (VZV) causes two distinct clinical entities: chickenpox and zoster. Chickenpox is the result of primary infection and is more frequent in children. Reactivation of the virus is more common in adults after the sixth decade of life or in the immunosupressed patient. The most common complication of VZV primary infection is the secondary bacterial infection of cutaneous lesions. Central nervous system involvement is rare, especially in the immunocompetent adult [1]. In particular, isolated optic neuritis has been described in a small number of cases. We report a case of an adult immunocompetent patient with optic neuritis in the context of primary infection with Varicella zoster virus. 2. Case Report A 28-year-old caucasian woman presented to the emergency room with a history of a pressure-type frontal headache during the previous week; there was no exacerbation when lying down nor with Valsalva maneuvers and no accompanying features, namely, visual symptoms. Medical history was unremarkable except for venous thrombosis on her left leg 5 years before. She was not taking any drugs other than oral contraceptives. She had a son who was diagnosed with chickenpox two weeks before. She was febrile (temperature of 38°C), and there was a rash suggestive of chickenpox. Uncorrected visual acuity was 20/20 in both eyes, and the optic discs were swollen and
The life history of Pygidiopsis macrostomum Travassos, 1928 (Digenea: Heterophyidae)
Simes, Susana Balmant Emerique;Barbosa, Helene Santos;Santos, Cláudia Portes;
Memórias do Instituto Oswaldo Cruz , 2009, DOI: 10.1590/S0074-02762009000100016
Abstract: the life history of the trematode pygidiopsis macrostomum travassos, 1928 is described for the first time. rediae and cercariae were obtained from naturally infected snails heleobia australis (d′orbigny), a new first intermediate host. metacercariae were found encysted in the mesenteries of three naturally infected guppies, phalloptychus januarius (hensel), jenynsia multidentata (jenyns) (new host records) and poecilia vivipara bloch and schneider. experimental infections were successfully completed in the intermediate hosts h. australis and poe. vivipara reared in the laboratory and hamsters mesocricetus auratus waterhouse were utilised as a definitive host.
Altera??es gastrointestinais no diabetes mellitus: estresse oxidativo e fluxo sangüíneo da artéria mesentérica - estudo experimental
Dias, Alexandre Simes;Llesuy, Susana;Marroni, Cláudio Augusto;Marroni, Norma;
Arquivos de Gastroenterologia , 2004, DOI: 10.1590/S0004-28032004000200008
Abstract: background: gastrointestinal symptoms are frequent in diabetes mellitus and may be related to the oxidative stress, which is defined by an imbalance between the pro-oxidant and antioxidant systems. aims: to assess some of the gastrointestinal changes in the diabetes mellitus model, such as the oxidative stress in the stomach and liver of diabetic animals and the blood flow in the superior mesenteric artery at different times of study. material and methods: male wistar rats weighing 250-350 g were used and ascribed to four different groups as follows: group i - 7 days of diabetes, group ii - 30 days of diabetes, group iii - 60 days of diabetes, and group iv - 90 days of diabetes. diabetes was obtained by administering streptozotocin (70 mg/kg) intraperitoneally. results: a significant increase in liver and stomach lipoperoxidation of diabetic animals was found only at 90 days. a significant decrease in the activity of antioxidant enzymes catalase e glutathione transferase was found in stomach, whereas in liver only glutathione transferase was significantly decreased. the blood flow in the superior mesenteric artery of animals with 90 days of diabetes was increased as compared to controls. conclusions: it is possible to suppose that the increase in the oxidative stress in stomach and liver as well as the change in the blood flow in the superior mesenteric artery are affected by the length of diabetes and the hyperglycemia found in the animals studied, which would determine gastrointestinal changes.
Ethics issues experienced in HBM within Portuguese health surveillance and research projects
Simes Helena,Melim J Maurício,Reis M Fátima,Segurado Susana
Environmental Health , 2008,
Abstract: Background In keeping with the fundamental practice of transparency in the discussion and resolution of ethics conflicts raised by research, a summary of ethics issues raised during Portuguese biomonitoring in health surveillance and research is presented and, where applicable, their resolution is described. Methods Projects underway aim to promote the surveillance of public health related to the presence of solid waste incinerators or to study associations between human exposure to environmental factors and adverse health effects. The methodological approach involves biomonitoring of heavy metals, dioxins and/or other persistent organic pollutants in tissues including blood, human milk and both scalp and pubic hair in groups such as the general population, children, pregnant women or women attempting pregnancy. As such, the projects entail the recruitment of individuals representing different demographic and health conditions, the collection of body tissues and personal data, and the processing of the data and results. Results The issue of autonomy is raised during the recruitment of participants and during the collection of samples and data. This right is protected by the requirement for prior written, informed consent from the participant or, in the case of children, from their guardian. Recruitment has been successful, among eligible participants, in spite of incentives rarely being offered. The exception has been in obtaining guardians' consent for children's participation, particularly for blood sampling. In an attempt to mitigate the harm-benefit ratio, current research efforts include alternative less invasive biomarkers. Surveys are currently being conducted under contract as independent biomonitoring actions and as such, must be explicitly disclosed as a potential conflict of interests. Communication of results to participants is in general only practised when a health issue is present and corrective action possible. Concerning human milk a careful approach is taken, considering breast-feeding's proven benefits. Conclusion No national legislation currently accounts for the surveillance component of biomonitoring as distinct from research. Ethics issues arising within the domain of research are resolved according to available regulations. For issues encountered during surveillance, the same principles are used as guidance, completed by the authors' best judgement and relevant ethics committees' findings.
Optic Neuritis in an Adult Patient with Chickenpox
Ana Rita Azevedo,Rita Simões,Filipe Silva,Susana Pina
Case Reports in Ophthalmological Medicine , 2012, DOI: 10.1155/2012/371584
Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens
Ricardo Vieira,Maria José Simes,Susana Carmona,Concei??o Egas,Carlos Faro,Américo Figueiredo
Journal of Skin Cancer , 2013, DOI: 10.1155/2013/469671
Abstract: DLEC1 has been suggested as a tumor suppressor gene in several cancers. DLEC1 D215N somatic mutation (COSM36702) was identified in a melanoma cell line through whole genome sequencing. However, little is known about the implication and prevalence of this mutation in primary melanomas or in melanocytic nevi. The aim of this study was to genotype DLEC1 D215N mutation in melanoma tissue and melanocytic nevi samples to confirm its occurrence and to estimate its prevalence. Primary melanomas ( ) paired with synchronous or asynchronous metastases ( ) from 81 melanoma patients and melanocytic nevi ( ) were screened for DLEC1 D215N mutation. We found the mutation in 3 primary melanomas and in 2 melanocytic nevi, corresponding to a relatively low prevalence (3.7% and 7.1%, resp.). The pathogenic role of DLEC1 215N mutation is unclear. However, since the mutation has not been previously described in general population, its involvement in nevogenesis and melanoma progression remains a possibility to be clarified in future studies. 1. Introduction Mutations in deleted in lung and esophageal cancer 1 (DLEC1) gene or its inactivation by epigenetic silencing, namely, promoter CpG island hypermethylation or histone hypoacetylation, were previously reported in several cancers (lung [1], esophagus [2], kidney [3], stomach [4], colon [4], ovary [5], breast [6], head and neck [7], and lymphoma [8]). Furthermore, a negative impact on the prognosis related with DLEC1 inactivation was demonstrated in lung [9], kidney [10], and ovary [5] carcinomas. DLEC1 D215N mutation (COSM36702) is a substitution in codon 641 (ENST00000308059) which was identified in whole genome sequencing of a tumor cell line derived from melanoma metastases [11]. To establish the catalogue of somatic mutations in cancer cells, a lymphoblastoid line derived from the same patient was also sequenced [11]. Three different missense mutations were found in other genome or exome sequencing studies, making DLEC1 a candidate tumor suppressor gene in cutaneous melanoma, probably acting by inhibition of cell proliferation [12, 13]. Nevertheless, the prevalence of DLEC1 mutations among primary melanomas, melanoma metastases, or benign melanocytic nevi remains undetermined. The aim of this study was to confirm the occurrence and estimate the prevalence of DLEC1 D215N mutation in formalin fixed and paraffin embedded tissue samples from melanoma and melanocytic nevi. 2. Patients and Methods 2.1. Melanoma Patients In all, 102 formalin fixed paraffin embedded tumor tissues from 81 patients with melanoma were screened.
Infec??o por Bordetella pertussis com hipertens?o pulmonar grave num recém -nascido com boa evolu??o clínica - Caso clínico
Soares,Sérgia; Rocha,Gustavo; Pissarra,Susana; Carri?o,Ana; Azevedo,Inês; Simes,Joana Sobrinho; Guimar?es,Hercília;
Revista Portuguesa de Pneumologia , 2008,
Abstract: in spite of the availability and widespread use of vaccines, pertussis is far from controlled. newborns and infants too young to be fully vaccinated, born from mothers with low antibody titers to bordetella pertussis, are highly susceptible to infection and at risk of severe disease and death. pertussis associated with pulmonary hypertension in the newborn is often fatal. the authors report a clinical case of severe pertussis-induced respiratory failure associated to severe pulmonary hypertension in a neonate successfully treated with sildenafil and inhaled nitric oxide.
Biodistribution Study of the Anaesthetic Sodium Phenobarbital Labelled with Technetium-99m in Swiss Mice Infected with Schistosoma mansoni Sambon, 1907
Simes Susana Balmant Emerique,Machado-Silva José Roberto,Gutfilen Bianca,Presgrave Octávio Augusto Fran?a
Memórias do Instituto Oswaldo Cruz , 1997,
Abstract: Technetium-99m (99mTc) is a radionuclide that has negligible enviromnental impact, is easily available, inexpensive and can be used as a radioactive tracer in biological experiences. In order to know the mode of action of sodium phenobarbital in moving adult Schistosoma mansoni worms from mesenteric veins to the liver, we labelled sodium phenobarbital (PBBT) with 99mTc and a biodistribution study in infected and non-infected Swiss mice was performed. The PBBT was incubated with stannous chloride used as reducing agent and with 99mTc, as sodium pertechnetate. The radioactivity labelling (%) was determined by paper ascending chromatography perfomed with acetone (solvent). The 99mTc-PBBT was administered by intraperitoneal route to Swiss mice infected eight weeks before. The animals were perfused after diferent periods of time (0,1,2,3,4 hr) when blood, spleen, liver, portal vein, mesenteric veins, stomach, kidneys and adult worms were isolated. The radioactivity present in these samples was counted in a well counter and the percentage was determined. The radioactivity was mainly taken up by the blood, kidney, liver and spleen. No radioactivity was found on the adult worms. We concluded that the worm shift was due to an action on the host of the sodium phenobarbital
Voz do professor: uma revis?o de 15 anos de contribui??o fonoaudiológica
Dragone, Maria Lúcia Suzigan;Ferreira, Léslie Piccolotto;Giannini, Susana Pimentel Pinto;Simes-Zenari, Marcia;Vieira, Vanessa Pedrosa;Behlau, Mara;
Revista da Sociedade Brasileira de Fonoaudiologia , 2010, DOI: 10.1590/S1516-80342010000200023
Abstract: the purpose of this study was to review brazilian publication regarding teachers' voice produced by speech-language pathologists (slps) within the period from 1994 to 2008. this transversal study of bibliographic nature was carried out in three stages. the first consisted of data compilation from different sources; the second comprehended the search for the abstracts of the selected references; in the third stage, the publications were classified into four categories: individuals' assessment, treatment outcome evaluation, intervention description, and bibliographical/theoretical/documental researches. the final sample consisted of 500 publications, from which 415 (83%) were related to the assessment categories. among these, 357 (86%) evaluated individuals and/or their working conditions, and 58 (14%) had the aim to evaluate treatment outcome. regarding analyses dimensions of the assessments, 202 studies (48.7%) had more than one. teachers' perspective (self-assessment) was the predominant dimension (52.5% of the analyses), followed by auditory-perceptual analyses performed by slps (15.2%), and evaluation of working environment and organization (14.9%). the category intervention description had 31 (6.2%) studies, and there were 54 (10.8%) bibliographical/theoretical/documental researches. this literature review confirms that vocal assessment has been privileged in brazilian researches regarding teachers' voice. publications about treatment outcome evaluations are more recent and less representative, indicating a tendency of change of focus that might help the comprehension of the complex use of voice in teaching, and guide future studies on speech-language pathology intervention with these individuals.
Page 1 /17606
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.