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Search Results: 1 - 10 of 26642 matches for " Susana Daniela Sousa Fernandes "
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Polyphenol Oxidase Activity and Colour Changes of ‘Starking’ Apple Cubes Coated with Alginate and Dehydrated with Air  [PDF]
Susana Daniela Sousa Fernandes, Catarina Araújo da Silva Ribeiro, Maria Filomena de Jesus Raposo, Rui Manuel Santos Costa de Morais, Alcina Maria Miranda Bernardo de Morais
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.25064
Abstract: The objective was to study the effect of alginate coating on polyphenol oxidase (PPO) activity and colour of ‘Starking’ apple cubes during dehydration with hot air. Apple cubes were dehydrated at 20oC, 35oC, or 40oC, with a parallel airflow. Analysis of PPO activity, colour (L*, a*, b*) and dry matter were performed along the dehydration process at each temperature. All samples presented a peak in relative PPO activity in the beginning of the drying. Exponential models fitted well the experimental data after the peak. Cubes without coating presented lower PPO activity, suggesting lower browning, than coated samples throughout the dehydration process, for all temperatures. Better results for coated samples were obtained with a perpendicular airflow drying at 40oC, after dipping the whole apple in water at 60oC for 10 min. In order to prevent coated samples from browning, drying by perpendicular airflow preceded by a thermal treatment of the whole apple is required.
Edible Seeds and Nuts Grown in Brazil as Sources of Protein for Human Nutrition  [PDF]
Jullyana B. Freitas, Daniela C. Fernandes, Ludmila P. Czeder, Jean Carlos R. Lima, Amanda G. O. Sousa, Maria Margareth V. Naves
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.36114
Abstract: Edible seeds and nuts can contribute to an adequate intake of protein, particularly in vegetable-based diets. However, there are relatively few reports with insufficient data regarding the protein quality of these foods, especially of edible seeds and nuts from Brazil. The aim of this study was to investigate the chemical composition and in vivo protein quality of two edible seeds (baru almond and peanut) and two nuts (Brazil nut and cashew nut) grown in Brazil. The proximate composition and the amino acid profile were analyzed. The true protein digestibility and the protein quality of these foods were evaluated by bioassay with male weanling Wistar rats over a period of 14 days, and the Protein Digestibility Corrected Amino Acid Score (PDCAAS) was estimated. Edible seeds and nuts presented high contents of proteins (16.3 to 32.3 g/100g), lipids (42.7 to 57.9 g/100g) and dietary fibers (6.5 to 14.3 g/100g). Lysine was found to be the limiting amino acid in baru almond, peanut and Brazil nut, which had amino acid scores ranging from 71% to 76%. Cashew nut had no limiting amino acid. These foods showed high protein digestibility (around 90%) except for baru almond (75%), and their PDCAAS values varied significantly (57%, for baru almond, and 90%, for cashew nut). The edible seeds and nuts grown in Brazil provide a high density of energy and nutrients and they can be used as complementary sources of proteins.
Influence of different durations of estrogen deficiency on alveolar bone loss in rats
Amadei, Susana Ungaro;Souza, Daniela Martins de;Brand?o, Adriana Aigotti Haberbeck;Rocha, Rosilene Fernandes da;
Brazilian Oral Research , 2011, DOI: 10.1590/S1806-83242011000600011
Abstract: the purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. sixty female wistar rats were randomly assigned to ovariectomy (ovx test group) or sham operation (sham control group). the ovx and sham groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). in all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. the maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. a comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). no significant differences were observed among the unligated groups (p > 0.05). a significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). these results demonstrate that long-term estrogen deficiency affects ligature-induced alveolar bone loss.
Behcet’s disease and IgA nephropathy: report of this association in a patient from Brazil and literature review Enfermedad de Behcet y nefropatía por IgA: reporte de tal asociación en un paciente de Brasil y revisión de literatura
Paula FCBC Fernandes,Geraldo B Silva Júnior,Fernando AS Barros,Daniela C Sousa
Investigación Clínica , 2006,
Abstract: Behcet’s disease (BD) is associated with renal involvement in about one-third of the cases and a variety of renal lesions have been reported. A 27-year-old man presented a history of recurrent oral and genital ulcers, associated with pseudofoliculitis and arthritis in his left knee. The first laboratory tests revealed: urea = 53mg/dL, creatinine = 1.8mg/dL. The urinalysis showed leukocyturia. Initial treatment with ceftriaxone, thalidomide and prednisone was instituted. He became clinically stable, with normal renal function, but presenting hematuria and proteinuria. One year later the patient presented dark urine. The new laboratory tests showed urea = 58mg/dL, creatinine = 1.4mg/dL, and mild proteinuria (500-1000mg/24h). Two years later the proteinuria was 2230mg/day. The renal biopsy showed one glomerulus with severe glomerular sclerosis, mild tubular atrophy, mild interstitial fibrosis and thickening of arterial walls. Treatment with captopril was started to decrease proteinuria. Two years later, the patient presented creatinine = 1.7mg/dL and proteinuria = 2509mg/day. A new renal biopsy evidenced proliferative crescentic glomerulonephritis, with diffuse granullary deposits of IgA, IgM and C3. It was instituted pulsotherapy with metilprednisolone, monthly endovenous cyclophosphamide and maintenance prednisone. The patient became clinically stable, with creatinine of 1.3mg/dL and proteinuria of 500mg/day. BD could be one of the various causes of secondary IgA nephritis. It is important to periodically perform renal function evaluation in patients with BD, through urinalysis and measurement of serum creatinine and its clearance, in order to detect any abnormality and provide an early adequate treatment. La enfermedad de Behcet (EB) está asociada a da o renal en cerca de un tercio de los casos y una variedad de lesiones renales han sido descritas. Un hombre de 27 a os presentaba historia de ulceraciones orales y genitales, en asociación con pseudofoliculitis y artritis en su rodilla izquierda. Los primeros exámenes evidenciaban urea = 53mg/dL, creatinina = 1,8mg/dL. El análisis de orina presentaba leucocituria. El tratamiento inicial fue ceftriaxone, talidomida y prednisona. El enfermo se quedó clínicamente estable, con función renal normal, pero presentando hematuria y proteinuria. Pasado un a o, su orina resultó oscura. Nuevos exámenes mostraban urea = 58mg/dL, creatinina = 1,4mg/dL y proteinuria (500-1000mg/día). Dos a os después la proteinuria aumentó para 2230mg/día. La biopsia renal mostraba uno glomérulo con esclerosis severa, atrofia tubular bl
PARAMETERS FOR NUTRITIVE VALUE OF NINE SUGARCANE VARIETIES CULTIVATED UNDER IRRIGATION PAR METROS DO VALOR NUTRITIVO DE NOVE VARIEDADES DE CANA-DE-A úCAR CULTIVADAS SOB IRRIGA O
Susana Queiroz Santos Mello,Aldi Fernandes de Souza Fran?a,Milton Luiz Moreira Lima,Daniela Sergio Ribeiro
Ciência Animal Brasileira , 2006,
Abstract: The objective of this trial was to evaluate parameters of the nutritional value of nine sugar cane varieties cultivated under irrigation. The treatments constituted of the varieties: RB 72454, RB 835486, RB 845257, SP 813250, RB 855536, SP 835073, SP 801842, SP 801816 and SP 79101. The experimental design was the completely randomized with three replications. The sucrose value (POL) and the relationship neutral detergent fiber NDF/POL differed (P<0.05) among varieties, with smaller relationship NDF/POL on RB 835486 variety. The percentile of fraction C of carbohydrates value was higher (P<0,05) on SP 801816 than for RB 72454, SP 813250 and SP 791011 and of fraction B2 was highest (P<0,05) for SP 835073 than for other varieties evaluated. The fractions A+B1 were highest (P<0.05) on RB 835486 and SP 813250 varieties than for SP 835073, SP 801842 and SP 801816. KEY WORDS: Forage, carbohydrates fraction, neutral detergent fiber, sucrose. Avaliaram-se alguns parametros do valor nutritivo de nove variedades de cana-de-a úcar cultivadas sob irriga o, a saber: RB 72454, RB 835486, RB 845257, SP 813250, RB 855536, SP 835073, SP 801842, SP 801816 e SP 791011. O delineamento experimental foi o inteiramente casualizado com três repeti es. Os teores de sacarose (POL) e a rela o FDN/POL diferiram (P<0,05) entre as variedades, com menor rela o FDN/POL para a variedade RB 835486. O percentual da fra o C dos carboidratos foi maior (P<0,05) para SP 801816 do que para RB 72454, SP 813250 e SP 791011 e da fra o B2 foi maior (P<0,05) para a SP 835073 do que para as demais variedades. As fra es A+B1 foram maiores (P<0,05) para RB 835486 e SP 813250 em rela o a SP 835073, SP 801842 e SP 801816. PALAVRAS-CHAVE: Fibra em detergente neutro, forragem, fra o de carboidra
Altera??o transmissível do Imprinting Genómico em pacientes inférteis por Oligozoospermia e Azoospermia
Marques,Cristina Joana; Vaz,Bruno; Costa,Paula; Sousa,Sónia; Carvalho,Filipa; Fernandes,Susana; Silva,Joaquina; Sousa,Mário; Barros,Alberto;
Arquivos de Medicina , 2007,
Abstract: introduction: we studied infertile patients with oligozoospermia and azoospermia to determine if these conditions of decreased sperm production are associated with defective genomic imprinting. methods: we included 23 semen samples from men undergoing investigation of infertility as follows: 7 with normozoospermia (controls) and 16 with oligozoospermia (9 moderate; 7 severe); and 7 testicular biopsies, before intracytoplasmic sperm injection: 3 with conserved spermatogenesis (controls: 2 anejaculation, 1 secondary obstructive azoospermia) and 4 with hypospermatogenesis (hp). sperm dna was decondensed, purified and treated with sodium bisulfite. the differential methylated region (18 cpgs) of the h19 gene (paternally methylated) was amplified by pcr (polymerase chain reaction), including the ctcf (parental-allele specific ccctc-binding factor) binding site-6 that also controls the expression of igf2 (insulin-like growth factor 2) gene. pcr fragments were then cloned in plasmids and the methylation status of each cytosine was determined by automated sequencing. results: we found a significant higher proportion of 1) global h19 hypomethylation in hp (p=0.001), 2) attainment of ≥3 cpgs in severe oligozoospermia and hp (pimprinting is defective in the male germ line of patients with severe oligozoospermia and hypospermatogenesis, being aggravated as the testicular injury worsens.
Behcet?s disease and IgA nephropathy: report of this association in a patient from Brazil and literature review
Fernandes,Paula FCBC; Silva Júnior,Geraldo B; Barros,Fernando AS; Sousa,Daniela C; Franco,Luciano M; Patrocínio,Régia MSV;
Investigación Clínica , 2006,
Abstract: behcet?s disease (bd) is associated with renal involvement in about one-third of the cases and a variety of renal lesions have been reported. a 27-year-old man presented a history of recurrent oral and genital ulcers, associated with pseudofoliculitis and arthritis in his left knee. the first laboratory tests revealed: urea = 53mg/dl, creatinine = 1.8mg/dl. the urinalysis showed leukocyturia. initial treatment with ceftriaxone, thalidomide and prednisone was instituted. he became clinically stable, with normal renal function, but presenting hematuria and proteinuria. one year later the patient presented dark urine. the new laboratory tests showed urea = 58mg/dl, creatinine = 1.4mg/dl, and mild proteinuria (500-1000mg/24h). two years later the proteinuria was 2230mg/day. the renal biopsy showed one glomerulus with severe glomerular sclerosis, mild tubular atrophy, mild interstitial fibrosis and thickening of arterial walls. treatment with captopril was started to decrease proteinuria. two years later, the patient presented creatinine = 1.7mg/dl and proteinuria = 2509mg/day. a new renal biopsy evidenced proliferative crescentic glomerulonephritis, with diffuse granullary deposits of iga, igm and c3. it was instituted pulsotherapy with metilprednisolone, monthly endovenous cyclophosphamide and maintenance prednisone. the patient became clinically stable, with creatinine of 1.3mg/dl and proteinuria of 500mg/day. bd could be one of the various causes of secondary iga nephritis. it is important to periodically perform renal function evaluation in patients with bd, through urinalysis and measurement of serum creatinine and its clearance, in order to detect any abnormality and provide an early adequate treatment.
The Treatment of Liver Metastases in Patients with Neuroendocrine Tumors in 2012
Daniela Macedo,Teresa Amaral,Isabel Fernandes,Ana Rita Sousa,Ana Lúcia Costa,Isabel Távora,António Quintela,Paulo Cortes,Luís Costa
ISRN Hepatology , 2013, DOI: 10.1155/2013/702167
Abstract: Neuroendocrine tumors (NETs) comprise a heterogeneous group of tumors that form a distinct entity. Approximately 75–80% of patients present with liver metastases at the time of their diagnosis, and 20%–25% will develop these lesions in the course of their disease. The presence of secondary deposits in the liver significantly increases the morbidity and mortality in these patients. The only potentially curative treatment is the surgical resection of the primary tumor and hepatic lesions. However, only 10% of patients presents under ideal conditions for that approach. Several techniques aimed at localized liver lesions have been applied also with interesting results in terms of survival and symptom control. The same has been demonstrated with new systemic therapies (target therapies). However, these are still under study, in order to define their true role in the management of these patients. This paper intends to address, in a general way, the various treatment options in patients with liver metastases from neuroendocrine tumors. 1. Introduction The neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that share some biological characteristics, that have been addressed as a common entity [1]. In 62%–82% of the cases, the NETs are located in the digestive system, being designated as gastroenteropancreatic neuroendocrine tumors (GEP-NETs) [2]. The latest figures from the UK, Sweden, and Switzerland suggested that their incidence is 2-3/100000 with a higher prevalence in females [1]. Also data from the Surveillance, Epidemiology, and End Results (SEER) Program Database report an increased incidence between 1973 and 2004 of 1.09 to 5,25/100000 [3, 4]. NETs are classically characterized by their ability to secrete hormones and/or vasoactive peptides, which results in many of their clinical manifestations, ganging up on specific hormonal syndromes. The most frequent syndrome is the carcinoid syndrome, which results from the secretion of serotonin and includes symptoms such as skin flushing, severe diarrhea, abdominal cramping, and electrolyte abnormalities [4, 5]. Their clinical course is variable, having been considered traditionally with an indolent natural history [1, 4]. However, some NETs have aggressive behavior regarding the rapid progression of metastatic lesions. All of them have the potential of metastatic dissemination and, therefore, are currently recognized as malignant neoplasms [6]. The prognosis and the approach of NETs are guided mainly according to the histological classification. The tumors with grade 3, mitotic count
Hipotermia terapêutica na encefalopatia hipóxico-isquémica
Sousa,Susana; Vilan,Ana;
Nascer e Crescer - Revista do Hospital de Crian?as Maria Pia , 2011,
Abstract: hypoxic-ischemic encephalopathy is a prevalent pathology with high morbid-mortality, and resulting in high personal, social and financial costs. besides the intensive support care, there is now compelling clinical evidence that hypothermia initiated within a few hours after severe hypoxia-ischemia and maintained for 72 hours, can reduce neuronal loss and improve neurological outcome. timely recognition of infants at risk, proper stabilization and control of body temperature, allowing passive cooling, communication with referral centers with resources to provide this therapy and proper care on transport will contribute to the benefits of this intervention. the aim of this review is to spread information about the use of therapeutic hypothermia in hypoxic-ischemic encephalopathy to the paediatric community, since pediatricians have an important role in recognition and rapid referral of these babies.
A relevancia da liberdade de religi o nas rela eses laborais: contributos para a sua compreens o à luz do Direito da Uni o Europeia
Susana Sousa Machado
International Journal on Working Conditions , 2011,
Abstract: O presente estudo reflecte sobre uma temática de enorme actualidade, quer porque se verifica uma crescente influência da legisla o europeia com referência ao fenómeno religioso, quer porque as sociedades actuais est o cada vez mais longe de um modelo de monolitismo religioso, evoluindo para modelos multiétnicos nos quais prolifera a diversidade religiosa. Esta problemática coloca-nos desafios delicados quanto à tutela da liberdade de religi o no seio das rela es laborais. As sociedades actuais s o cada vez mais heterogéneas, mais diversificadas e a mobilidade humana n o pára de crescer. Tudo isto tem repercuss es no mundo do trabalho já que as empresas podem ser um verdadeiro palco de interculturalidade e, por isso, merece ser estudado o protagonismo das cren as religiosas do trabalhador assalariado. Para o efeito, o problema aqui colocado é estudado na perspectiva da influência do Direito da Uni o Europeia na regulamenta o das condi es de trabalho dos trabalhadores que pretendem afirmar as suas convic es religiosas no domínio da rela o de trabalho assalariado.
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