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Search Results: 1 - 10 of 405096 matches for " Susan M. Frayne "
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Mental illness-related disparities in length of stay: Algorithm choice influences results
Susan M. Frayne, MD, MPH,Eric Berg, MS,Tyson H. Holmes, PhD,Kaajal Laungani, BA
Journal of Rehabilitation Research and Development , 2010,
Abstract: Methodological challenges arise when one uses various Veterans Health Administration (VHA) data sources, each created for distinct purposes, to characterize length of stay (LOS). To illustrate this issue, we examined how algorithm choice affects conclusions about mental health condition (MHC)-related differences in LOS for VHA patients with diabetes nationally (n = 784,321). We assembled a record-level database of all fiscal year (FY) 2003 inpatient care. In 10 steps, we sequentially added instances of inpatient care from various VHA sources. We processed databases in three stages, truncating stays at the beginning and end of FY03 and consolidating overlapping stays. For patients with MHCs versus those without MHCs, mean LOS was 17.7 versus 13.6 days, respectively (p < 0.001), for the crudest algorithm and 37.2 versus 21.7 days, respectively (p < 0.001), for the most refined algorithm. Researchers can improve the quality of data applied to VHA systems redesign by applying methodological considerations raised by this study to inform LOS algorithm choice.
Who are the women and men in Veterans Health Administration’s current spinal cord injury population?
Catherine M. Curtin, MD,Paola A. Suarez, MPH,Lisa A. Di Ponio, MD,Susan M. Frayne, MD, MPH
Journal of Rehabilitation Research and Development , 2012,
Abstract: Spinal cord injury (SCI) care is a high priority for the Veterans Health Administration (VHA). Aging Veterans, new cases of SCI from recent conflicts, and increasing numbers of women Veterans have likely changed the profile of the VHA SCI population. This study characterizes the current Veteran population with SCI with emphasis on healthcare utilization and women Veterans. We analyzed VHA administrative data from 2002–2003 and 2007–2008, analyzing composition, demographics, and healthcare use. The population is mostly male (>97%) and largely between 45 and 64 years old. Over 30% are over the age of 65. They are frequent users of healthcare, with an average of 21 visits per year. Women Veterans with SCI form a small but distinct subpopulation, being younger and less likely to be married and having a higher burden of disease. We must understand how the VHA population with SCI is changing to anticipate and provide the best care for these complex patients.
Birthing and Mining in John Donne’s “To His Mistress Going to Bed”  [PDF]
Ashleigh Frayne
Advances in Literary Study (ALS) , 2017, DOI: 10.4236/als.2017.54006
Abstract: This paper uncovers an aspect of “To His Mistress Going to Bed” that has largely been ignored by critics of the poem, namely, the poem’s interest in the interrelationship between power, geological exploration, and childbirth. Over the past twenty years, social historians and historians of medicine have explored early modern accounts of childbirth, making it possible for scholars to recover the historical context framing Donne’s depictions of childbirth. Placing “To His Mistress” within this historical context forces us to rethink a number of critical assumptions about the poem: in particular that the poem concerns sex but not procreation. In this paper, I explore the implications that medical beliefs about reproduction and the medical politics of childbirth had for Donne as he set about trying to dramatize male desire and uncover the hidden interior of the female body. My historical analysis reveals how the poem fits within the early modern conversation about women’s reproductive power and artificial birth. By illuminating interwoven references to childbirth with references to mining, I situate Donne’s poem within the larger early modern conversation about women’s reproductive power and artificial birth. This repositioning has important implications for Donne’s sexual politics and the medical context informing his work.
Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
Michael D Hill, Philip A Barber, Andrew M Demchuk, Robert J Sevick, Richard Frayne, Alastair M Buchan
BMC Neurology , 2001, DOI: 10.1186/1471-2377-1-1
Abstract: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem.Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.A 66-year-old right-handed man awoke from sleep feeling well. At 06:55, while having breakfast, he developed sudden onset of painless weakness of his left arm associated with left facial droop and a subtle change in sensation over the left face and arm. He went directly to his local Emergency room where a diagnosis of stroke was made. He was transferred immediately to our centre for consideration of thrombolytic therapy, arriving at 08:28 (1 h 33 min from onset). He had a past history of a minor stroke with full recovery 3 years previously and longstanding hypertension. He was taking no medication having elected to discontinue his anti-hypertensive therapy two years earlier.On examination, he was alert with no hemi-neglect or aphasia. He had a left facial droop and slight dysarthria. He was proximally weak but able to hold his left arm up against gravity, but had completely absent left distal hand function. He had reduced left leg power but was able to walk unsteadily. There was a reduction in pinprick sensation over the left arm and face. He was in normal sinus rhythm with a blood pressure of 200/115. A brain CT scan was performed, which demonstrated a small old right anterior parietal infarct which was interpreted as consistent with his previous minor stroke. There were no other acute changes. His National Institutes of Health Stroke Scale Score was 3.Based on his clinical syndrome of severe distal weakness, it was postulated that his stroke involved the primary motor cortex or underlying fibres. After careful discussion with the patient includi
Microwave saturation of the Rydberg states of electrons on helium
E. Collin,W. Bailey,P. Fozooni,P. G. Frayne,P. Glasson,K. Harrabi,M. J. Lea,G. Papageorgiou
Physics , 2002, DOI: 10.1103/PhysRevLett.89.245301
Abstract: We present measurements of the resonant microwave excitation of the Rydberg energy levels of surface state electrons on superfluid helium. The temperature dependent linewidth agrees well with theoretical predictions and is very small below 300 mK. Absorption saturation and power broadening were observed as the fraction of electrons in the first excited state was increased to 0.49, close to the thermal excitation limit of 0.5. The Rabi frequency was determined as a function of microwave power. The high values of the ratio of the Rabi frequency to linewidth confirm this system as an excellent candidate for creating qubits.
Means of Knowledge Dissemination: Are the Café Scientifique and the Artistic Performance Equally Effective?  [PDF]
Darquise Lafrenière, Susan M. Cox
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.22025
Abstract: An increasing number of health researchers are opting for innovative approaches to communicate research findings. This article compares two methods for disseminating findings to various audiences: the Café scientifique and the artistic performance. Analysis of surveys completed by 78 respondents indicates that the artistic performance is more effective in communicating research findings based on three of the four evaluation criteria used: it generates more questions and emotion among audience members and influences a greater number of individuals to alter their initial understanding of and opinion on an issue. The Café scientifique and the artistic performance both help participants to better understand the topic examined. The arts, however, shine a different light on the issue.
The Importance of Adjuvant Agents in Acute Intrathecal Baclofen Withdrawal: Case Report and Review of the Literature  [PDF]
Christopher M. Wang, Susan E. Opper
Open Journal of Anesthesiology (OJAnes) , 2012, DOI: 10.4236/ojanes.2012.24024
Abstract: Objective: Baclofen (β-p-chlorophenyl-GABA) selectively activates the GABAB subtype of γ-aminobutyric acid (GABA) receptors, a group of receptors known to provide inhibitory neurotransmission in the central nervous system. Available for over thirty years in oral form for the treatment of skeletal muscle spasticity, its availability now includes continuous intrathecal infusion via an internally implanted pump. While ideal for long-term attenuation of symptoms, this treatment modality can also become disastrous should the pump empty and withdrawal subsequently ensue. Case Report: A 48-year-old male with a past medical history of T8 spinal cord injury from a motor vehicle crash originally presented with altered mental status. Because of resultant paraplegia and spasticity from his injuries, a neurosurgeon implanted an intrathecal baclofen pump three years prior to presentation with symptomatic relief. Further exploration revealed that he had missed his scheduled pump refill appointment and interrogation of his pump confirmed a completely empty reservoir. The patient endured a protracted hospital course that included rhabdomyolysis, acute renal failure, lactic acidosis, respiratory failure, and systemic inflammatory response syndrome. Treatment included benzodiazepines, dantrolene, aggressive hydration, opiates, and refill of his intrathecal baclofen pump. His mentation and ventilatory status improved with recovery from his critical illness and eventual discharge. Conclusions: Treatment of intrathecal baclofen withdrawal should focus on restoration of previous intrathecal baclofen levels by refill of the intrathecal pump. Adjuvant medications such as benzodiazepines, propofol, cyproheptadine, dantrolene, tizanidine, and opiates may prove crucial in helping with muscle spasticity while these levels are reestablished. A high index of suspicion, leading to timely initiation of proper treatment, may serve as the most important factor in successful recovery from this life-threatening syndrome.
Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS
Kongtana Trakarnsanga, Marieangela C. Wilson, Rebecca E. Griffiths, Ashley M. Toye, Lee Carpenter, Kate J. Heesom, Steve F. Parsons, David J. Anstee, Jan Frayne
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100874
Abstract: Induced pluripotent stem cells (iPSC) are an attractive progenitor source for the generation of in vitro blood products. However, before iPSC-derived erythroid cells can be considered for therapeutic use their similarity to adult erythroid cells must be confirmed. We have analysed the proteome of erythroid cells differentiated from the iPSC fibroblast derived line (C19) and showed they express hallmark RBC proteins, including all those of the ankyrin and 4.1R complex. We next compared the proteome of erythroid cells differentiated from three iPSC lines (C19, OCE1, OPM2) with that of adult and cord blood progenitors. Of the 1989 proteins quantified <3% differed in level by 2-fold or more between the different iPSC-derived erythroid cells. When compared to adult cells, 11% of proteins differed in level by 2-fold or more, falling to 1.9% if a 5-fold threshold was imposed to accommodate slight inter-cell line erythropoietic developmental variation. Notably, the level of >30 hallmark erythroid proteins was consistent between the iPSC lines and adult cells. In addition, a sub-population (10–15%) of iPSC erythroid cells in each of the iPSC lines completed enucleation. Aberrant expression of some cytoskeleton proteins may contribute to the failure of the majority of the cells to enucleate since we detected some alterations in cytoskeletal protein abundance. In conclusion, the proteome of erythroid cells differentiated from iPSC lines is very similar to that of normal adult erythroid cells, but further work to improve the induction of erythroid cells in existing iPSC lines or to generate novel erythroid cell lines is required before iPSC-derived red cells can be considered suitable for transfusion therapy.
Counting Individual Electrons on Liquid Helium
G. Papageorgiou,P. Glasson,K. Harrabi,V. Antonov,E. Collin,P. Fozooni,P. G. Frayne,M. J. Lea,Y. Mukharsky,D. G. Rees,.
Physics , 2004, DOI: 10.1063/1.1900301
Abstract: We show that small numbers of electrons, including a single electron, can be held in a novel electrostatic trap above the surface of superfluid helium. A potential well is created using microfabricated electrodes in a 5 micron diameter pool of helium. Electrons are injected into the trap from an electron reservoir on a helium microchannel. They are individually detected using a superconducting single-electron transistor (SET) as an electrometer. A Coulomb staircase is observed as electrons leave the trap one-by-one until the trap is empty. A design for a scalable quantum information processor using arrays of electron traps is presented
Inquiry Learning: Instructor Perspectives
Susan Vajoczki,Susan Watt,Michelle M. Vine
Canadian Journal for the Scholarship of Teaching and Learning , 2011,
Abstract: The rise of the research intensive university has led some critics to argue that teaching has been discounted in favour of research, and thus the academy has “failed...their undergraduate populations” (Boyer Commission, 1998, p .5). This paper examines instructor perceptions of inquiry at an institution with a significant history of providing inquiry learning opportunities to undergraduate students. Inquiry learning is typically seen as a pedagogical approach, both a method and a process, delivered in small class settings. Qualitative data were collected through interviews (n=16) with instructors who used inquiry in their teaching to elicit instructor perceptions of inquiry teaching. Content analysis was performed on the interviews to extract themes. Results suggest that instructors approached their inquiry teaching differently - some adopting an intentional and some an unintentional approach. There was general consensus that teaching and learning academic skills is valuable, inquiry instructors are facilitators, technology has only a modest place in the inquiry classroom, and larger classes inhibit inquiry. Responses were mixed about the importance of stand-alone inquiry courses. Teaching such courses appears to change the instructor’s perspective about inquiry.L’augmentation des universités qui sont de plus en plus axées sur la recherche a soulevé quelques critiques à l’effet que l’enseignement ait été délaissé au profit de la recherche et que, conséquemment, les institutions d’enseignement ont laissé tomber… leurs étudiants de premier cycle (Boyer Commission 1998, p. 5). Le présent article porte sur la perception des enseignants d’un établissement qui préconise depuis longtemps des pratiques pédagogiques notamment la - méthode d’enquête- pour favoriser l’apprentissage de leurs étudiants de premier cycle. Cette méthode est généralement considérée comme une approche pédagogique qui se préoccupe tant de l’objet que du procesus d’apprentissage. Des entrevues réalisées auprès d’enseignants qui utilisent cette méthode ont permis de recueillir des données qualitatives (n=16) afin de savoir ce qu’ils en pensaient. Les chercheurs ont analysé le contenu des entrevues pour en extraire des thèmes. Les résultats indiquent que les enseignants abordent la méthode d’enquête de manière différente : certains adoptant une approche intentionnelle et d’autres une approche non intentionnelle. Les enseignants s’entendent sur les éléments suivants : l’enseignement et l’apprentissage des stratégies pédagogiques sont utiles, les enseignants qui utilisent la méthode d’enqu
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