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Search Results: 1 - 10 of 228259 matches for " Susan C. Jones "
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Contact Toxicity and Residual Efficacy of Indoxacarb against the European Earwig (Dermaptera: Forficulidae)
Susan C. Jones,Joshua L. Bryant
Insects , 2012, DOI: 10.3390/insects3030593
Abstract: Indoxacarb (Arilon 20WG) was evaluated against a nuisance pest, the European earwig ( Forficula auricularia), and was found to be an effective contact toxicant with residual activity on substrates commonly encountered in urban environments. Within 16 h of being directly sprayed with indoxacarb, ≥90% of earwigs from two populations were either ataxic, moribund, or dead, and 100% displayed these symptoms of severe intoxication at 1 d. Brief exposure (5 min or 1 h) to dried residues on either a porous (pine wood) or non-porous (ceramic tile) substrate also was sufficient to cause severe intoxication of earwigs within 1 d. In all bioassays, indoxacarb-treated earwigs showed no signs of recovery during the 21-d observation period. In outdoor urban habitats, intoxicated earwigs would be more vulnerable to desiccation, predation, or pathogens leading to higher mortality than in a laboratory setting.
Metabolic Resistance in Bed Bugs
Praveen Mamidala,Susan C. Jones,Omprakash Mittapalli
Insects , 2011, DOI: 10.3390/insects2010036
Abstract: Blood-feeding insects have evolved resistance to various insecticides (organochlorines, pyrethroids, carbamates, etc.) through gene mutations and increased metabolism. Bed bugs ( Cimex lectularius) are hematophagous ectoparasites that are poised to become one of the major pests in households throughout the United States. Currently, C. lectularius has attained a high global impact status due to its sudden and rampant resurgence. Resistance to pesticides is one factor implicated in this phenomenon. Although much emphasis has been placed on target sensitivity, little to no knowledge is available on the role of key metabolic players (e.g., cytochrome P450s and glutathione S-transferases) towards pesticide resistance in C. lectularius. In this review, we discuss different modes of resistance (target sensitivity, penetration resistance, behavioral resistance, and metabolic resistance) with more emphasis on metabolic resistance.
Behavioral Responses of the Bed Bug to Permethrin-Impregnated ActiveGuard? Fabric
Susan C. Jones,Joshua L. Bryant,Scott A. Harrison
Insects , 2013, DOI: 10.3390/insects4020230
Abstract: ActiveGuard? Mattress Liners have been used to control house dust mites, and they also are commercially available as an integrated pest management tool for use against bed bugs ( Cimex lectularius). The aim of our study was to evaluate responses of numerous populations of the bed bug to the permethrin-impregnated fabric, with particular regard to contact toxicity, repellency, and feeding inhibition. Continuous exposure to ActiveGuard fabric resulted in rapid intoxication for three of four populations, with 87 to 100% of moderately pyrethroid-resistant and susceptible bed bugs succumbing by 1 d. In comparison, a highly resistant population reached 22% mortality at 10 d. Video data revealed that bed bugs readily traversed ActiveGuard fabric and spent a considerable amount of time moving about and resting on it during a 12-h period. ActiveGuard fabric was non-repellent to bed bugs from five tested populations. Furthermore, significantly fewer bed bugs successfully fed to repletion through ActiveGuard fabric than through blank fabric for the five populations. With just 30 min of feeding exposure, mortality ranged from 4% to 83%, depending upon the bed bug strain. These laboratory studies indicate that ActiveGuard liners adversely affected bed bugs from diverse populations.
An overview of the basic helix-loop-helix proteins
Susan Jones
Genome Biology , 2004, DOI: 10.1186/gb-2004-5-6-226
Abstract: The basic helix-loop-helix (bHLH) proteins form a large superfamily of transcriptional regulators that are found in organisms from yeast to humans and function in critical developmental processes, including sex determination and the development of the nervous system and muscles. Because of their functional diversity and importance, this superfamily has been the subject of a number of recent reviews covering many species [1,2], and also a number of reviews specific to individual species, including Saccharomyces cerevisiae [3], Drosophila [4,5], human [6] and Arabidopsis [7-9]. The main emphasis in the recent literature has been on phylogenetic sequence analysis of bHLH families. This article gives an overview of how bHLH proteins are classified by sequence and summarizes their structures and functions.Members of the bHLH superfamily have two highly conserved and functionally distinct domains, which together make up a region of approximately 60 amino-acid residues. At the amino-terminal end of this region is the basic domain, which binds the transcription factor to DNA at a consensus hexanucleotide sequence known as the E box. Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxy-terminal end of the region is the HLH domain, which facilitates interactions with other protein subunits to form homo- and hetero-dimeric complexes. Many different combinations of dimeric structures are possible, each with different binding affinities between monomers. The heterogeneity in the E-box sequence that is recognized and the dimers formed by different bHLH proteins determines how they control diverse developmental functions through transcriptional regulation [10].The bHLH motif was first observed by Murre and colleagues [11] in two murine transcription factors known as E12 and E47. With the subsequent identification of many other bHLH proteins, a classification was formulated on the basis of their tissue distributions, DNA-binding specific
Mapping the landscape: Gender and the writing classroom
Susan Jones
Journal of Writing Research , 2012,
Abstract: This article maps the diverse theoretical disciplines that inform writing research and in particular, how these disciplines have researched the relationship between writing and gender. This is presented against the background of a changing theoretical landscape in research in gender. In particular, it will consider the paradigm shift from discourses of difference and disadvantage to discourses of diversity. Research on writing has not always acknowledged this changing lens, and gender research rarely focuses on writing. The aim therefore is to map out these different approaches, explore how they have impacted writing classrooms and to add to the call for a reconfiguring of gender in writing research as a complex and diverse category rather than as a fixed and essential characteristic we each possess.
Transcriptomics of the Bed Bug (Cimex lectularius)
Xiaodong Bai,Praveen Mamidala,Swapna P. Rajarapu,Susan C. Jones,Omprakash Mittapalli
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016336
Abstract: Bed bugs (Cimex lectularius) are blood-feeding insects poised to become one of the major pests in households throughout the United States. Resistance of C. lectularius to insecticides/pesticides is one factor thought to be involved in its sudden resurgence. Despite its high-impact status, scant knowledge exists at the genomic level for C. lectularius. Hence, we subjected the C. lectularius transcriptome to 454 pyrosequencing in order to identify potential genes involved in pesticide resistance.
Mobility of Vulnerable Elders (MOVE): study protocol to evaluate the implementation and outcomes of a mobility intervention in long-term care facilities
Susan E Slaughter, Carole A Estabrooks, C Allyson Jones, Adrian S Wagg
BMC Geriatrics , 2011, DOI: 10.1186/1471-2318-11-84
Abstract: This longitudinal, quasi-experimental study is designed to demonstrate the effect of the sit-to-stand activity carried out by residents in the context of daily care with health care aides. In three intervention facilities health care aides will prompt residents to repeat the sit-to-stand action on two separate occasions during each day and each evening shift as part of daily care routines. In three control facilities residents will receive usual care. Intervention and control facilities are matched on the ownership model (public, private for-profit, voluntary not-for-profit) and facility size. The dose of the mobility intervention is assessed through the use of daily documentation flowsheets in the health record. Resident outcome measures include: 1) the 30-second sit-to-stand test; 2) the Functional Independence Measure; 3) the Health Utilities Index Mark 2 and 3; and, 4) the Quality of Life - Alzheimer's Disease.There are several compelling reasons for this study: the widespread prevalence of limited mobility in this population; the rapid decline in mobility after admission to a long-term care facility; the importance of mobility to quality of life; the increased time (and therefore cost) required to care for residents with limited mobility; and, the increased risk of injury for health workers caring for residents who are unable to stand. The importance of these issues is magnified when considering the increasing number of people living in long-term care facilities and an aging population.This clinical trial is registered with ClinicalTrials.gov (trial registration number: NCT01474616).Immobility is a major factor contributing to a reduced quality of life and preventable adverse events among older adults living in residential long-term care (LTC). Of the more than 150,000 older Canadians living in LTC facilities [1] almost 90% have some type of reduced mobility, [2] with approximately 40% of LTC residents with dementia losing their ability to walk annually [3,4].
Using surveillance data to monitor entry into care of newly diagnosed HIV-infected persons: San Francisco, 2006–2007
Nicola M Zetola, Kyle Bernstein, Katherine Ahrens, Julia L Marcus, Susan Philip, Giuliano Nieri, Diane Jones, C Bradley Hare, Ling Hsu, Susan Scheer, Jeffrey D Klausner
BMC Public Health , 2009, DOI: 10.1186/1471-2458-9-17
Abstract: Since July 1, 2006, the San Francisco Department of Public Health (SFDPH) incorporated monitoring initial primary care visit into standard HIV public health investigation for newly diagnosed HIV-infected patients in select clinics. Entry into care was defined as having at least one visit to a primary HIV care provider after the initial diagnosis of HIV infection. Investigators collected reports from patients, medical providers, laboratories and reviewed medical records to determine the date of the initial health care visit after HIV diagnosis. We identified factors associated with increased likelihood of entering care after HIV diagnosis.One -hundred and sixty new HIV-infected cases were diagnosed between July 1, 2006 and June 30, 2007. Routine surveillance methods found that 101 of those cases entered HIV medical care and monitoring of CD4 T cell counts and plasma HIV viral load confirmed entry to care of 25 more cases, representing a 25% increase over routine data collection methods. We found that being interviewed by a public health investigator was associated with higher odds of entry into care after HIV diagnosis (OR 18.86 [1.83–194.80], p = .001) compared to cases not interviewed. Also, HIV diagnosis at the San Francisco county hospital versus diagnosis at the county municipal STD clinic was associated with higher odds of entry into care (OR 101.71 [5.29–1952.05], p < .001).The time from HIV diagnosis to initial CD4 T cell count, CD4 T cell value and HIV viral load testing may be appropriate surveillance measures for evaluating entry into care, as well as performance outcomes for local public health departments' HIV testing programs. Case investigation performed by the public health department or case management by clinic staff was associated with increased and shorter time to entry into HIV medical care.It is estimated that up to a third of HIV-infected patients aware of their infection are not receiving specialized HIV medical care in the U.S., and a similar
The cohesin complex: sequence homologies, interaction networks and shared motifs
Susan Jones, John Sgouros
Genome Biology , 2001, DOI: 10.1186/gb-2001-2-3-research0009
Abstract: Searches of protein sequence databases have revealed new homologs of cohesin proteins. In mouse, Mmip1 (Mad member interacting protein 1) and Smc3 share 99% sequence identity and are products of the same gene. A phylogenetic tree of SMC homologs reveals five families: Smc1, Smc2, Smc3, Smc4 and an ancestral family that includes the sequences from the Archaea and Eubacteria. This ancestral family also includes sequences from eukaryotes. A cohesion interaction network, comprising 17 proteins, has been constructed using two proteomic databases. Genes encoding six proteins in the cohesion network share a common upstream region that includes the MluI cell-cycle box (MCB) element. Pairs of the proteins in this network share common sequence motifs that could represent common structural features such as binding sites. Scc2 shares a motif with Chk1 (kinase checkpoint protein), that comprises part of the serine/threonine protein kinase motif, including the active-site residue.We have combined genomic and proteomic data into a comprehensive network of information to reach a better understanding of the function of the cohesin complex. We have identified new SMC homologs, created a new SMC phylogeny and identified shared DNA and protein motifs. The potential for Scc2 to function as a kinase - a hypothesis that needs to be verified experimentally - could provide further evidence for the regulation of sister-chromatid cohesion by phosphorylation mechanisms, which are currently poorly understood.Cohesin is a macromolecular complex that holds sister chromatids together at the metaphase plate during mitosis. The links between the sister chromatids are formed during DNA replication and destroyed during the metaphase to anaphase transition, when sister chromatids separate to opposite poles of the cell. In budding yeast, the 14S cohesin complex comprises at least two SMC (structural maintenance of chromosomes) proteins - Smc1 [1] and Smc3 [2] - and two SCC (sister-chromatid cohesion) pr
Evaluation of Instructor Knowledge on Structuring and Facilitating Effective Online Discourses.
Susan L. Jones
Journal of Educators Online , 2006,
Abstract: This study starts with the premise that in an online environment, meaningful discourse drives student learning. Specifically, the contribution of instructor knowledge on structuring and facilitating online discourse and “meaningful” online discourse. Findings from 57 university instructors indicate that instructors need a clearer working definition of “meaningful” online discourse and instructors need to be trained that “meaningful” online discourse does not only occur between themselves and their students’ but can occur between student and student and with course content (i.e. online experts, online guests, etc.).
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