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Thyroid Function Test Imbalance in Epileptic Children Under Anticonvulsive Therapy
Iranian Journal of Child Neurology , 2012,
Abstract: Letter to Editor has not abstract.
A Repot of Surgical Complications in a Series of 262 Consecutive Pediatric Cochlear Implantations in Iran
Mohammad Ajalloueyan,Susan Amirsalari,Jaleh Yousefi,Mohammad-Ali Raeessi
Iranian Journal of Pediatrics , 2011,
Abstract: Objective: Cochlear implantations have become a routinely performed and successful surgical intervention in both adults and children. The current article reports the complications encountered in various age groups of consecutive children who underwent implantation in our center.Methods: We performed a prospective analysis of all profoundly deaf children who underwent cochlear implantation from March 2006 to July 2009 at Baqhiyatallah Cochlear Implantation Center. All patients were younger than 5 years old at the time of implantation.Findings: The minor complications occurred in 49 (18.7%) cases, The most common postoperative complications were temporary facial weakness detected in 15 cases (5.7%) all of which were reversible. Magnet wound was observed in 14 (5.3%) patients, keloid formation in 10 (3.8%), wound infection in 2 (0.8%), otitis media in 5 (2%), and electrode movement, meningitis, vertigo, Laryngospasm each in 1 (0.4%) case was detected among our patients.Conclusion: Cochlear implantation in children continues to be reliable and safe in experienced hands, with a low percentage of severe complications as long as the patient is monitored closely.
A Case of Congenital Leukemia with Nasal Hemorrhage and Jaundice
Zahra Khalili Matinzadeh,Zohreh Kavehmanesh,Susan Amirsalari,Shahla Afsharpeyman
Iranian Journal of Pediatrics , 2010,
Frequency of Multiple Pregnancy and its Complications in Three Educational Hospitals,Tehran
Zohreh Kavehmanesh,Susan Amirsalari,Mohammad Torkaman,Zahra Khalili Matinzadeh
Iranian Journal of Pediatrics , 2007,
Abstract: Objective: Multiple pregnancies is a high-risk pregnancy since it is associated with increased perinatal and maternal problems .The aim of our study to determine the frequency of multiple pregnancy and its maternal and perinatal complications.Material & Methods: In a cross –sectional study we assessed 94 multiple pregnancies and 199 neonates in three educational hospitals in Tehran (Baghiyatallah , Najmie and Mahdie) in first half of 2006. The information was collected from hospital registries of mothers and their neonates.Findings: Of 4584 deliveries, 84(1.8%) were twins, 9(0.19%) were triplets and 1(0.02%) was quadruplets. 59 (62.7%) of mothers had preterm labor and 14 (14.8%) had pre-eclampsia. We found discordant birth weigh ≥ 20% in 24 (25.4%) and TTTS (Twin-To-Twin Transfusion) in 3(3.1%) of mothers .174 (87.4%) of all neonates were admitted in NICU or pediatric department. The frequency of mortality and respiratory distress in neonates were 27 (13.5%) and 107 (53.7 %), respectively.39 (19.5%) of neonates had Apgar scores<7 and seizure was not observed in neonates. 65 (32.6%) of neonates were normal weight (> 2500 gram), 104 (52.4%) LBV, 21(10.5%) VLBV and 9(4.5%) ELBV. Hypocalcaemia, hypoglycemia and anemia detected in 45 (22.6%), 24 (12%) and 48 (24.1%) of neonates respectively.Conclusion: Regard to increasing the prevalence of multiple pregnancies, better use of infertility modalities, early diagnosis of the multiple pregnancies, prevention of preterm birth, close fetal surveillance, atraumatic labor and delivery can improve maternal and perinatal outcome.
Tehran University of Medical Sciences: Participation in Twenty Five Percent of Pediatric Science Production in Iran
Susan Amirsalari,Zahra Khalili Matinzadeh,Shahla Afsharpayman,Morteza Javadipour
Iranian Journal of Pediatrics , 2008,
Abstract: Objective: Scientific articles are indicators of research interests and efforts in every country. The aim of our study was to compare the scientific output between universities of medical sciences in Iran on pediatrics in the Pubmed database.Methods: In a descriptive study, we searched in Pubmed in order to assess the Iranian pediatrics publications with these words: "(Pediatric [*MeSH] OR Neonate [MeSH] OR Newborn[MeSH] OR Infant [MeSH] OR Child [MeSH] OR Children [MeSH] OR Adolescent[MeSH] OR Adolescence [MeSH])" AND (Iran [*AD] OR Iranian [AD] OR Persian [AD]). The identified articles were published May 1957 to December 2007 and we selected all articles from universities of medical sciences in Iran. We extracted year of publication, affiliation of authors and impact factor from hard copy of articles.Findings: From 819 papers published, 565 were authored by members of universities of medical sciences. Tehran University of Medical Sciences with 142 articles (17.3% of all, 25.1% from publications of universities of medical sciences) held the first place, Shiraz University of Medical Sciences with 116 (14.2% of all, 20.5% from publications of universities of medical sciences) the second place and Shaheed Beheshti University of Medical Sciences with 88 (10.7% of all, 15.5% from publications of universities of medical sciences) the third place. Regarding Impact Factors (IF) Tehran, Shaheed Beheshti and Shiraz Universities of Medical Sciences with 153, 93 and 81 were in the first, second and third place, respectively.Conclusion: Tehran University of Medical Sciences had twenty five percent of pediatric science production in Iran. This university had published higher number of papers on pediatrics among universities of medical sciences in Iran.
Leukocyte Adhesion Deficiency: Report of Two Family Related Newborn Infants
Zohreh Kavehmanesh,Zahra Khalili Matinzadeh,Susan Amirsalari,Mohammad Torkaman
Acta Medica Iranica , 2010,
Abstract: "nLeukocyte adhesion deficiency type 1 (LAD 1) is an autosomal recessive hereditary disorder resulting from deficiency of CD18, characterized by recurrent bacterial infections. We report two consanguineous patients with Leukocyte adhesion deficiency type 1( LAD1). These two infant boy patients were referred to us, within a short period of time, with the complaints of recurrent infections at the age of 38 and 75 days -old, respectively. Parents of two patients were first cousins and their grandmothers also were first cousins. The history of delayed umbilical cord separation was shown in both patients. Patient 1 had history of omphalitis, conjunctivitis, skin lesion of groin area and abscess formation of vaccination site, and had infective wound of eye-lid at the last admission. Patient 2 had history of omphalitis and soft tissue infection of right wrist at the last admission. Laboratory findings showed marked leukocytosis and low CD18 levels (6.6% in Patient 1 and 2.4 % in Patient 2). In Patient 1 recurrent infections were treated with antibiotic regimens and received bone marrow transplantation but Patient 2 died because of septicemia, generalized edema, ascites and progression to acute renal failure at 4 months of age. Due to considerable rate of consanguineous marriages in parents of Leukocyte adhesion deficiency patients, sequence analysis especially for prenatal diagnosis in subsequent pregnancies and genetic counseling is recommended.
Magnetic Resonance Imaging Findings in Epileptic Children and Its Relation to Clinical and Demographic Findings
Susan Amirsalari,Amin Saburi,Reza Hadi,Mohammad Torkaman
Acta Medica Iranica , 2012,
Abstract: Epilepsy is an important disease with a cumulative incidence of 3% all over the life and more than half of them are started from childhood. In this study we surveyed magnetic resonance imaging (MRI) findings in epileptic children and its relation with clinical and demographic findings in order to find better diagnostic and treatment modalities for these children in the future. In this cross sectional study, we investigated consecutively all 1 to 15-year-old epileptic children who referred to the pediatric neurology outpatient clinic from 2004 to 2010. Two hundred children were enrolled for investigation. There were 85 (42.5%) girls and 115 (57.7%) boys, aged 1 to 15-year-old (7.7±4). 196 (98%) of the children had abnormal electroencephalography (EEG). Abnormal MRI was seen in 57 (28.5%) patients and consisted of brain atrophy (10%), increasing white matter signal intensity in T2-weighted images (8%), benign cysts (5%), brain tumors (4%) and vascular abnormalities (1.5%). Abnormal MRI findings had significant relation with abnormal EEG, age, positive family history for epilepsy, dysmorphic appearance, and abnormal physical exam. Considering 98% EEG abnormalities in these epileptic children, benign nature of MRI findings in most of our cases, the high price of MRI and the small minority of patients who benefit from active intervention as a result of MRI, we suggest to use EEG for confirmation of epilepsy and perform MRI for patient with abnormal physical exams, focal neurologic deficits or focal EEG abnormalities.
Thyroid Function in Epileptic Children who Receive Carbamazepine, Primidone, Phenobarbital and Valproic Acid
Susan Amirsalari,Zarrin Taj Kayhani Dost,Zohreh Kavehmanesh,Mohammad Torkaman
Iranian Journal of Child Neurology , 2011,
Abstract: ObjectiveIn this study, we investigated the changes of the serum levels of thyroidhormones including Thyroxine (T4), Triiodothyronine (T3), T3 resin uptake andThyroid stimulating hormone (TSH) in epileptic children during treatment withanti-epileptic drugs (AEDs) including carbamazepine (CBZ), primidone (PRM),phenobarbital and valproic acid (VPA).Materials and MethodsThis study consisted of four case-series comparisons, was conducted on 115epileptic children (37 girls and 78 boys with an age range between 2 monthsand 15 years, mean: 62.06 ± 44.97 months). These children were divided into4 groups who took either phenobarbital (n=29), PRM (n=28), CBZ (n=29), orVPA (n=29) for 3 months. Thyroid hormone levels (T3, T3 resin uptake, T4 andTSH) were measured at the beginning and three months after starting the study.ResultsAt first, all patients were euthyroid and there were no clinical or laboratoryfindings suggestive of hypothyroidism. Regarding thyroid hormones before andafter the administration of phenobarbital, carbamazepine, valproic acid andprimidone, there were no significant changes in serum T3, T4, T3 resin uptakeand TSH levels.ConclusionOur findings showed that short term therapy with phenobarbital, carbamazepine,valproic acid and primidone had no effect on thyroid function etsts.
Iranian Journal of Child Neurology , 2010,
Abstract: Febrile seizure is the most common convulsive disorder in childhood. The role of iron in metabolism of neurotransmitters and carrying oxygen to the brain suggests the possibility of a relationship between iron deficiency anemia and febrile seizures.The aim of this study was to investigate the relationship between iron deficiency anemia and febrile seizures.Materials & MethodsThis case - control study was performed on 132 cases and 88 controls, aged 9 months to 5 years, from July 2007 to June 2009 in Baqyiatallah Hospital. Patients were selected using simple random sampling. The case group included children with first febrile seizure (core temperature over 38.5 C during seizure) without a central nervous system infection or an acute brain insult. The control group included children suffering from a febrile illness without seizure. Iron deficiency anemia was defined with one of these laboratory indexes: 1) Hemoglobin (Hb) <10.5mg/dl 2) Plasma ferritin <12ng/dl 3) Mean corpuscular volume (MCV) <70 fl. The data collected from patients were analyzed with SPSS.13 software.ResultsLow plasma ferritin was found in 35 cases (26.5%) compared to 26 controls (29.5%), low Hb level was found in 4 cases (3%) compared to 6 controls (6.8%) and low MCV was found in 5 cases (3.8%) compared to 6 controls (6.8%).There was no significant difference in plasma ferritin , Hb level and MCV indices between the two group.ConclusionConsidering the above-mentioned results, there is no relationship between iron deficiency anemia and febrile seizures.
Prevalence of Readmission for Hyperbilirubinemia in Healthy Newborns
Zohreh Kavehmanesh,?Nahid Ebrahimi Mohammadieh,Ali Akbar Karimi Zarchi,Susan Amirsalari
Iranian Journal of Pediatrics , 2008,
Abstract: Objective: The aim of this study was estimation of prevalence of jaundice readmission and observes neonatal jaundice risk factors in singleton infant with birth weight more than 2500 gr.Material & Methods: This study was done among women who delivered a normal singleton infant with birth weight of ≥2500 gr in Najmieh Hospital, Tehran, from 2004-2005. Maternal age, race, blood group and Rh, drug consumption during pregnancy, oxytocin consumption during labour, rupture of membranes together with neonatal sex, weight, maturity, gravity and length of nursery stay were recorded. The infants were followed during neonatal period to see if they were readmitted, and the reason of admission. The prevalence of readmission for neonatal jaundice was assessed and the risk factors for neonatal jaundice were compared between the icteric and non-icteric babies.Findings: The prevalence of readmission because of jaundice was 12.6%. The maternal data recorded from all mother-baby pairs were not significantly different except for maternal race, Rh group and drug consumption during pregnancy. Arab mothers compared with other race groups had more icteric babies (P=0.001). Rh-negative mothers had more icteric infants (17.9%) compared with Rh-positive mothers (12%) (P=0.01). Premature infants were hospitalized significantly more than mature babies (20.3% versus 12.1%, P=0.04). The length of primary nursery stay differed significantly between two groups [mean (SD) 27 (9.8) hours for icterics versus 30 (2.5) hours for non-icterics, P<0.001]. The mean age of readmission was fifth postnatal day.Conclusion: We conclude that infants, especially infants of Arab or negative Rh group mothers and premature babies, discharged early from the nursery should be advised to visit a pediatrician within the next 48-72 hours of birth to avoid complications of severe jaundice.
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