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Search Results: 1 - 10 of 249 matches for " Supna Sandhu "
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Incidence of pancreatitis, secondary causes, and treatment of patients referred to a specialty lipid clinic with severe hypertriglyceridemia: a retrospective cohort study
Supna Sandhu, Ahmad Al-Sarraf, Catalin Taraboanta, Jiri Frohlich, Gordon A Francis
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-157
Abstract: A retrospective cohort study was conducted on patients presenting non-acutely to the Healthy Heart Program Lipid Clinic at St. Paul's Hospital with a TG level > 20 mM (1772 mg/dl) between 1986 and 2007. Ninety-five patients with TG > 20 mM at the time of referral were identified, in who follow up data was available for 84. Fifteen patients (15.8%), with a mean outpatient TG level of 38.1 mM, had a history of acute pancreatitis. Among 91 additional patients with less severe HTG, none had a history of pancreatitis when TG were between 10 and 20 mM. Among patients with TG > 20 mM on presentation, 8 (8.5%), with a mean TG level of 67.8 mM, exhibited eruptive xanthomata. A diet high in carbohydrates and fats (79%) and obesity (47.6%) were the two most frequent secondary causes of HTG at initial visit. By 2009, among patients with follow up data 53% exhibited either pre-diabetes or overt Type 2 diabetes mellitus. Upon referral only 23 patients (24%) were receiving a fibrate as either monotherapy or part of combination lipid-lowering therapy. Following initial assessment by a lipid specialist this rose to 84%, and remained at 67% at the last follow up visit.These results suggest hypertriglyceridemia is unlikely to be the primary cause of acute pancreatitis unless TG levels are > 20 mM, that dysglycemia, a diet high in carbohydrates and fats, and obesity are the main secondary causes of HTG, and that fibrates are frequently overlooked as the drug of first choice for severe HTG.Hypertriglyceridemia (HTG), classically defined as fasting plasma triacylglycerols (triglycerides, TG) > 2.3 mM or 200 mg/dl, or 1.7 mM (150 mg/dl) in the definition of metabolic syndrome [1], is a common laboratory finding. Severe hypertriglyceridemia, e.g., TG > 20 mM (1772 mg/dl), is much rarer and almost always caused by a combination of inherited and secondary factors [2,3]. Genetic disorders leading to hypertriglyceridemia include familial combined hyperlipidemia, familial hypertriglyceridemia,
Reinke’s Oedema Presenting as Stridor: Implications for Otolaryngologists in Difficult Airway  [PDF]
Atta Mohyuddin, Gurpeet Sandhu
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2017, DOI: 10.4236/ijohns.2017.62003
Abstract: We demonstrated the importance of managing a patient who presented with stridor due to severe Reinke’s oedema. The concept of managing difficult airway has thus been introduced for the otolaryngologists according to a plan of action as described by the American Society of Anaesthesiologist’s difficult airway algorithm. Methods: A case report of interest and review of literature. PubMed search with keywords of difficult airway, stridor, awake intubation and Reinke’s oedema was used. Result: Management of an anticipated difficult airway with awake fiberoptic intubation with backup strategies of direct laryngoscopies with Eshmann stylet and awake invasive intubation is highlighted. Conclusion: This case report demonstrated a definitive strategy of securing a difficult airway with obstruction at the glottis and highlighted the role of teamwork between otolaryngologist and anaesthesiologist to secure difficult airway.
Wrong Potential Energy Term in Schr?dinger’s Equation for Hydrogen Atom  [PDF]
Gurcharn S. Sandhu
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.94042
Abstract: Even after nine decades of successful run of the Quantum Mechanics (QM), different viewpoints on foundational problems of Quantum Physics are still being actively debated. That is because mathematical logic of QM often defies the physical intuition which constitutes the main spirit of Physics. De Broglie’s hypothesis of matter waves implied that the dynamic characteristics of a micro particle in motion, can be ascribed to the wave characteristics of the wavelet accompanying the particle. The Schrödinger equation models the matter-wave interactions through wavefunction ψ?and effectively serves as the foundation of QM. Even though mathematical structure of the Schrödinger equation is sound and elegant, here we show a conceptual mistake in the development of this equation wherein the physical situation has not been correctly modeled in the equation. The Coulomb potential energy of the proton electron pair in Hydrogen atom is essentially the negative interaction energy between their superposed electrostatic fields which is inversely proportional to their instantaneous separation distance. Assuming the proton to be relatively fixed at the origin of an appropriate coordinate system, the potential energy of the orbiting electron will be a function of instantaneous position coordinates of the electron. This has not been properly modeled in the Schrödinger equation. The resulting errors in the solution have been quantitatively demonstrated in this paper. We have stressed the necessity of incorporating a specific correction in the potential energy term of the Schrödinger equation, after which it may facilitate the adoption of Bohmian QM.
ZnO Nanobelts: An Efficient Catalyst for Synthesis of 5-Arylidine-2,4-Thiazolidinediones and 5-Arylidine-Rhodanines  [PDF]
Jagir S. Sandhu, Suresh  
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.223042
Abstract: A facile preparation of ZnO nanobelts by chemical precipitation technique and its utility as catalyst in Knoevenagel condensation of 2,4-thiazolidinedione/rhodanine has been described. X-ray diffraction and transmission electron microscopy techniques revealed the formation ZnO nanobelts. Scanning electron microscopic observations indicate that the lengths of nanobelts are ranging from a few hundreds of micrometers to a few millimeters. Its use for the condensation of aldehydes and active methylene compounds under solvent free reaction condition at 90℃ afforded the corresponding products in excellent yields in minute time.
A Kunitz trypsin inhibitor from chickpea (Cicer arietinum L.) that exerts an antimicrobial effect on Fusarium oxysporum f.sp. ciceris  [PDF]
Meera Nair, Sardul Singh Sandhu
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.411079

Fusarium oxysporum f.sp. ciceris (Foc) is one of the most important fungal pathogens of chickpea and is regarded as a constant threat in tropical and subtropical countries. In order to correlate Fusarium wilt resistance/susceptibility in Cicer arietinum to the presence or absence of trypsin inhibitor (TI) in the crude extract, trypsin inhibitory assay (TIA) and in vitro activity of TI against Foc were studied. In the present study, a 20 kDa trypsin inhibitor was purified from Fusarium wilt resistant cultivar (viz. JG 2001-12) by ammonium sulfate precipitation, dialysis and chromatographies with Sephadex G-100 and Diethyl aminoethyl cellulose (DEAE-cellulose-52) ion-exchange column. Results of pathogenecity assay were found to be in correlation to the trypsin inhibitor assay where the Fusarium wilt resistant cultivar showed high trypsin inhibitory activity (99%) in the presence of trypsin enzyme using both natural and synthetic substrates. Preliminary studies using crude extracts of JG 2001-12 showed a decrease in radial growth of Foc. A 45%-82% reduction in conidium germination at 20 μg·mL-1 Cicer arietinum trypsin in

Rabies : What We Know and What We Need to Know
Sandhu TS
Indian Journal of Community Medicine , 2004,
Management of fracture neck of femur
Sandhu Hardas
Indian Journal of Orthopaedics , 2005,
West nile virus: Do we need its surveillance and control program in Punjab State of India?
Sandhu Tejbir,Sidhu Dalbinder,Sandhu Gursimrat
Indian Journal of Community Medicine , 2010,
Ultrasound-assisted synthesis of 2,4-thiazolidinedione and rhodanine derivatives catalyzed by task-specific ionic liquid: [TMG][Lac]
Suresh and Jagir Singh Sandhu
Organic and Medicinal Chemistry Letters , 2013, DOI: 10.1186/2191-2858-3-2
Abstract: Best results were obtained with 1,1,3,3-tetramethylguanidine lactate ([TMG][Lac]) 1c. The TSIL used can be easily recovered and recycled, yielding products 4–5 in excellent yields under ultrasonic environment without the formation of any side products or toxic waste.
Therapeutic options in the treatment of benign prostatic hyperplasia
Jaspreet S Sandhu
Patient Preference and Adherence , 2009, DOI: http://dx.doi.org/10.2147/PPA.S4028
Abstract: apeutic options in the treatment of benign prostatic hyperplasia Review (4605) Total Article Views Authors: Jaspreet S Sandhu Published Date August 2009 Volume 2009:3 Pages 213 - 223 DOI: http://dx.doi.org/10.2147/PPA.S4028 Jaspreet S Sandhu Department of Surgery, Division of Urology, Memorial Sloan-Kettering Cancer Center New York, NY 10065, USA Abstract: Current theraputic options for the treatment of symptomatic benign prostatic hyperplasia (BPH) are reviewed. Therapeutic options for mild lower urinary tract symptoms (LUTS), as defined by the American Urological Association, are generally treated medically. Moderate to severe LUTS can be treated medically or with surgical therapy. Current medical and surgical treatments for LUTS secondary to BPH are reviewed and evolving treatments are explored.
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