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Search Results: 1 - 10 of 325364 matches for " Sunitha S "
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STUDY ON EFFECT OF SOLVENTS AND NON-SOLVENTS ON THE RELEASE OF ONDANSETRON FROM MICROSPHERES PREPARED BY VARIOUS COACERVATION PHASE SEPARATION TECHNIQUES
Sunitha S.
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: The study was to determine the effect of solvents like acetone, dimethyldigol, 1,4-dioxan and non-solvents like n-hexane and chloroform on microencapsulation of ondansetron hydrochloride.The microspheres were prepared by following coacervation phase separation using various non- aqueous solvents and non solvents like solvent evaporation and non-solvent addition method with rate retarding cellulose polymers. Microspheres were characterized for the particle size distribution, wall thickness by scanning electron microscopy (SEM), angle of repose, bulk density, percent drug content, entrapment efficiency and in vitro dissolution studies. Drug excipient compatibility was determined by FTIR and DSC. Accelerated stability studies were also carried out following ICH Guidelines. SEM revealed that microspheres were found spherical, free flowing and porous. The entrapment efficiency and wall thickness was found in between 61.18% & 97.31%, 126.198μ & 65.161 μ respectively. The drug release was extended maximum up to 12hours with cellulose acetate using 1-4 dioxan as solvent and up to 12 hours with cellulose acetate phthalate using 1,4-dioxan and dimethyldigol. FTIR and DSC results showed ondansetron hydrochloride was compatible with excipients. The curve fitting data revealed that the release followed first order kinetics and higuchi’s and peppas plots stated non-fickian and diffusion controlled. The study proved the solvents like dimethyldigol and 1,4 dioxan effected a lot over the size and release kinetics.
Evaluation of salivary nitric oxide levels in oral mucosal diseases : A controlled clinical trial.
Sunitha M,Shanmugam S
Indian Journal of Dental Research , 2006,
Abstract: Lichen planus is a common dermatologic disease to manifest in the oral cavity. Recurrent aphthous ulcers are the most common ulcers of the oral cavity causing discomfort to the patients. These two diseases have different clinical manifestations which require appropriate treatment after correct diagnosis. Though numerous etiological factors have been proposed for these diseases, their true etio-pathogenesis is not yet established and therefore all therapies are palliative and none is effective universally. In light of this, the role of nitric oxide as a mediator in the etio-pathogenesis of these diseases was considered. The present study was undertaken to note the salivary nitric oxide levels as measured through its product nitrite in oral mucosal diseases like lichen planus and recurrent aphthous ulcers and also to ascertain whether salivary nitric oxide level has a role to play as a pathophysiological mediator in these diseases
Obstructive sleep apnea: Clinical and diagnostic features
Sunitha C,Aravindkumar S
Indian Journal of Dental Research , 2009,
Abstract: Obstructive sleep apnea (OSA) is an increasingly common disorder. It is characterized by frequent episodes of airway obstruction associated with a reduced caliber of the upper airway and is vulnerable to further narrowing and collapse. Acute and repetitive effects of apnea and hypopnea include oxygen desaturation, reduction in intrathoracic pressure, excessive daytime sleepiness, impaired executive function and central nervous system arousals. The apnea-hypopnea index and respiratory distress index help quantify the severity of the condition. The condition is associated with several clinical symptoms of which daytime sleepiness is considered the cardinal symptom. Obesity is one of the major predisposing factors. Three types of apneas have been recognized -obstructive, central and mixed; OSA is the commonest. This review will cover aspects of their radiologic features, diagnosis and management.
Obstructive sleep apnea and its management
Sunitha C,Kumar S
Indian Journal of Dental Research , 2010,
Abstract: Obstructive sleep apnea (OSA) is an increasingly common disorder. It is characterized by frequent episodes of airway obstruction associated with a reduced caliber of the upper airway and is vulnerable to further narrowing and collapse. Acute and repetitive effects of apnea and hypopnea include oxygen desaturation, reduction in intrathoracic pressure, excessive daytime sleepiness, impaired executive function and central nervous system arousals. The apnea-hypopnea index and respiratory distress index help quantify the severity of the condition. The condition is associated with several clinical symptoms of which daytime sleepiness is considered the cardinal symptom. Obesity is one of the major predisposing factors. Three types of apneas have been recognized - obstructive, central and mixed; OSA is the commonest. This review will cover aspects of their radiologic features, diagnosis and management.
FUZZY GRAPHS IN FUZZY NEURAL NETWORKS
Sameena,K; S. Sunitha,M;
Proyecciones (Antofagasta) , 2009, DOI: 10.4067/S0716-09172009000300005
Abstract: in this paper we observe that, the fuzzy neural network architecture is isomorphic to the fuzzy graph model and the output of a fuzzy neural network with or fuzzy neuron is equal to the strength of strongest path between the input layer (particular input neuron/neurons) and the out put layer(particular output neuron). we explain this result through an example, which describes the marketability of text books of kindergarten classes.
FUZZY GRAPHS IN FUZZY NEURAL NETWORKS
K Sameena,M S. Sunitha
Proyecciones (Antofagasta) , 2009,
Abstract: In this paper we observe that, the fuzzy neural network architecture is isomorphic to the fuzzy graph model and the output of a fuzzy neural network with OR fuzzy neuron is equal to the strength of strongest path between the input layer (particular input neuron/neurons) and the out put layer(particular output neuron). We explain this result through an example, which describes the marketability of text books of kindergarten classes.
Converting Relational Database Into Xml Document
Kanagaraj.S,Sunitha Abburu
International Journal of Computer Science Issues , 2012,
Abstract: XML (Extensible Markup Language) is emerging and gradually accepted as the standard for data interchange in the Internet world. Interoperation of relational database and XML database involves schema and data translations. Through EER (extended entity relationship) model can convert the schema of relational database into XML. The semantics of the relational database, captured in EER diagram, are mapped to XML schema using stepwise procedures and mapped to XML document under the definitions of the XML schema. Converting Relational Database into XML Document is a process of converting the existing databases into XML file format. Existing conversion techniques convert a single database into xml. The proposed approach performs the conversion of databases like Ms-Access, MS-SQL to XML file format. Read the tables information from the corresponding database and generate code for the appropriate databases and convert the tables into XML flat file format. This converted XML file is been presented to the user.
Synthesis, characterization and antimicrobial studies on transition metal complexes of n-[phenyl(methylphenyl-5-pyrazolyl)methylidene]aniline
S. Sunitha,K.K. Aravindakshan
International Journal of Pharmacy and Biomedical Sciences , 2011,
Abstract: The novel Schiff base N-phenyl(methylphenyl-5-pyrazolyl)methylidene]aniline was synthesised in three stages. Ethylacetoacetate and phenylhydrazine were allowed to react together to form 3-methyl-1-phenyl-5-pyrazolone. This was benzoylated at the 4- position to get 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone. This was condensed with aniline to get the novel Schiff base. Though there are four potential ligating sites, only two of the ligating sites are involved in coordination. The ligand was characterised by IR and 1H NMR spectra. Co(II), Ni(II) and Cu(II) complexes of the neutral bidentate chelating Schiff base ligand were synthesized using acetates, chlorides and nitrates of the metals. They were characterised by elemental analysis, conductance and magnetic susceptibility measurements, UV-VIS and IR spectra. The ligand exhibited tautomerism and the complexes were found to have octahedral geometry. The in vitro antibacterial activity against Escherichia coli and in vitro antifungal activity against Aspergillus niger of the ligand and the complexes were investigated using nutrient agar medium.
Synthesis, characterisation and antimicrobial studies on transition metal complexes of n-[phenyl(methylphenyl-5-pyrazolyl)methylidene] pyridine-4-carbohydrazide
S. Sunitha,K.K. Aravindakshan
International Journal of Pharmacy and Biomedical Sciences , 2012,
Abstract: The novel Schiff base N′-[phenyl(methylphenyl-5-pyrazolyl)methylidene] pyridine-4-carbohydrazide was synthesised in three stages. Ethylacetoacetate and phenylhydrazine were allowed to react together to form 3-methyl-1-phenyl-5-pyrazolone. This was benzoylated at the 4- position to get 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone. This was condensed with isonicotinic acid hydrazide to get the novel Schiff base. Though there are four potential ligating sites, only two of the ligating sites are involved in coordination. The ligand was characterised by elemental analysis and IR spectrum. Co(II), Ni(II) and Cu(II) complexes of the neutral bidentate chelating Schiff base ligand were synthesized using acetates, chlorides and nitrates of the metals. They were characterised by elemental analysis, conductance and magnetic susceptibility measurements, UV, VIS and IR spectra. The ligand exhibited tautomerism and the complexes were found to have octahedral geometry. The in vitro antibacterial activity against Escherichia coli and in vitro antifungal activity against Aspergillus niger of the ligand and the complexes were investigated using nutrient agar medium.
An analysis of concentration of sucrose, endogenous pH, and alteration in the plaque pH on consumption of commonly used liquid pediatric medicines
Sunitha S,Prashanth G,Shanmukhappa,Chandu G
Journal of the Indian Society of Pedodontics and Preventive Dentistry , 2009,
Abstract: Background: Many parents are often unaware of the hidden, added sugars in many foods and drinks including pediatric liquid medicines; thus, hidden sugar in the form of pediatric medications has not been focused upon as cariogenic agents. Objective: (i) assess concentration of sucrose in six pediatric drugs, (ii) determine endogenous pH of these drugs, and (iii) estimate drop in the plaque pH in the oral cavity in first 30 minutes after consumption of the drugs. Materials and Methods: Ten adult volunteers with mean age of 22 years were double blinded for the study. Concentration of sucrose was assessed by volumetric method at Department of Chemical Branch of Engineering. Endogenous pH and drop in the plaque pH after consumption of the drugs were assessed using digital pH meter. Statistical analysis: SPSS software was used to assess the pH level at different time intervals and expressed as mean ± SD. Changes in pH were assessed by one-way ANOVA followed by Wilcoxons signed rank test. P-value was set at 0.05. Result: There were varying amounts of fermentable sucrose detected in the drugs; all the drugs were acidic. There is a significant drop of plaque pH after consumption of the drug. Conclusion: These sweeteners along with their low endogenic pH form a high cariogenic formulation. Thus, nonsucrose (noncariogenic) or sugar-free medications are needed to be prescribed along with proper oral hygiene care to the children under medication.
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