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Search Results: 1 - 10 of 317877 matches for " Sung-Mao Wu;Chun-Ting Kuo;Pei-Yu Lyu;Yu Li Shen;Ching-I Chien "
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Miniaturization Design of Full Differential Bandpass Filter with Coupled Resonators Using Embedded Passive Device Technology
Sung-Mao Wu;Chun-Ting Kuo;Pei-Yu Lyu;Yu Li Shen;Ching-I Chien
PIER , 2011, DOI: 10.2528/PIER11091404
Abstract: This paper presents two full differential bandpass filters with small occupied areas. Both filters are designed with the same basic structure which consists of two double coupled resonators with magnetic coupling. The resonators are stacked up and have the advantage of high coupling efficiency, reducing the area. Nevertheless, in the basic structure, the insertion loss in the high stopband is above -10 dB and therefore does not meet the requirement for bandpass filter design. Thus, two solutions are introduced to form the proposed filters. The first one integrates the ground plane, while the second one makes the use of an extra transmission zero. With the help of these solutions, two types of full differential bandpass filters are implemented on an FR4 using the embedded passive device technology, with the additional purpose of being designed for SiP applications. The passband of the filters conforms to the WLAN IEEE 802.11a (5 GHz) standard. Most importantly, the occupied areas of the two proposed bandpass filters are only 6 mm х 6.7 mm and 6.6 mm х 8.3 mm respectively. Compared with previous research, area reductions of up to 98.05% and 97.76% can be achieved.
Very Compact Full Differential Bandpass Filter with Transformer Integrated Using Integrated Passive Device Technology
Sung-Mao Wu;Chun-Ting Kuo;Chien-Hsun Chen
PIER , 2011, DOI: 10.2528/PIER10121701
Abstract: In this study, a very compact, second-order, full differential bandpass filter is presented. To achieve compact circuit area and system-in-package (SiP) applications, the transformer structure is integrated using integrated passive device (IPD) technology on a glass substrate. The coupled resonator synthesis method is used to achieve the bandpass filter design and suitably adjust the tapped feed-lines to obtain good impedance match at all ports. The area (1.27 mm×1.27 mm) of the bandpass filter is effectively reduced, and the performance, as measured by insertion loss (2.5 dB) and CMRR (>30 dB), is still acceptable with such a compact area. Most importantly, this full differential bandpass filter is also suitable for SiP applications, as other studies implemented using glass IPD technology have demonstrated.
Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don) Endl
Ing-Feng Chang, Peng-Jen Chen, Chin-Hui Shen, Tsung-Ju Hsieh, Ya-Wen Hsu, Bau-Lian Huang, Ching-I Kuo, Yu-Ting Chen, Hsiu-An Chu, Kai-Wun Yeh, Li-Chun Huang
Proteome Science , 2010, DOI: 10.1186/1477-5956-8-64
Abstract: Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2), glycine-rich RNA-binding protein (RNP), and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK) was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting.Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens.Plant maturation involves sequential developmental stages or phases that can be categorized as embryo, juvenile, transitional, and adult. The development of reproductively mature adult plants usually begins with a strictly vegetative juvenile phase. Maturation or a phase change is completed within weeks among annuals but can proceed for several years among perennials. In trees, the process is frequently accompanied by ancillary morphological and physiological traits, most commonly a loss of competence for adventitious rooting and a loss of overall vigor. Because a plant's developmental phase is determined in its shoot apical meristems, reversing the phase of the meristems should result in the emergence of rejuvenated shoots [1]. Indeed, new growths with reversed phases have been obtained by applying gibberellin [2] and cytokinin [3,4], continuously subculturing shoots, especially in cytokinin-containing media [5-7], and repeatedly grafting shoot apices from mature trees onto juvenile rootstocks in vivo [8,9] and in vitro [10-15].Sequoia sempe
Multiple Hypovascular Tumors in Kidney: A Rare Case Report and Differential Diagnosis
Pei-Yu Wu,Sheng-Fung Lin,Ping-Hsun Wu,Yi-Chun Tsai,Yu-Ting Kuo,Mei-Chuan Kuo,Hung-Chun Chen
Case Reports in Medicine , 2013, DOI: 10.1155/2013/595193
Abstract: The most common malignant renal tumor is renal cell carcinoma and surgery is the standard treatment. The proportion of lymphoma with renal involvement is 2~15% and lymphoma could be cured by chemotherapy without nephrectomy. Sonography, computed tomography (CT), and magnetic resonance imaging (MRI) can detect and characterize a renal mass. We present a case of right renal hypovascular tumors and differential diagnosis of hypovascular tumors by image study. CT scan showed hypovascular tumors and MRI image revealed multifocal hypovascular solid tumors with significantly increased apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI). Based on image finding, renal lymphoma was highly suspected. Renal lymphoma was confirmed by renal biopsy and this patient received chemotherapy without surgery. The noninvasive CT scan and MRI image can help clinicians to diagnose the characteristics of renal mass and to avoid unnecessary nephrectomy. 1. Introduction The most common incidental renal malignant tumor is renal cell carcinoma and renal lymphoma is rare. Sonography, computed tomography (CT), and magnetic resonance imaging (MRI) can detect and characterize a renal mass. The accurate diagnosis of a renal mass depends on many factors, including the clinical history, physical examination, image study, and sometimes renal biopsy may be considered. Thus, we present a case of right renal hypovascular tumors, which was confirmed as renal lymphoma by renal biopsy. Further differential diagnosis of a hypovascular tumor from image study was also discussed in this paper. 2. Case Presentation A 52-year-old female had experienced intermittent epigastralgia with hunger pain and right flank pain without radiation for three months. Urine routine revealed microscopic hematuria with RBC count of 3–5 in high power field. Normocytic anemia with hemoglobin level of 11.3?g/dL without leukopenia or thrombocytopenia was shown. Neither abnormal coagulopathy nor liver and renal dysfunction were found. Abdominal sonography demonstrated a right hypo-echogenic renal mass at right upper and lower pole without hydronephrosis or kidney enlargement. Furthermore, abdominal CT showed multiple hypovascular tumors at the upper and lower pole and middle portions of the right kidney with sizes 3.3?cm, 2.5?cm, and 2.8?cm, respectively, without metastatic lymphadenopathy (Figure 1). Abdominal MRI revealed multifocal hypovascular solid tumors with significantly increased apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) with enhancement during arterial phase of
Surgical treatment and prognostic analysis for gastrointestinal stromal tumors (GISTs) of the small intestine: before the era of imatinib mesylate
Ting-Jung Wu, Li-Yu Lee, Chun-Nan Yeh, Pei-Yu Wu, Tzu-Chieh Chao, Tsann-Long Hwang, Yi-Yin Jan, Miin-Fu Chen
BMC Gastroenterology , 2006, DOI: 10.1186/1471-230x-6-29
Abstract: The clinicopathologic and follow-up records of 100 small intestine GIST patients who were treated at Chung Gung Memorial Hospital between 1983 and 2002 were retrospectively reviewed. Clinical and pathological factors were assessed for long-term DFS and OS by using a univariate log-rank test and a multivariate Cox proportional hazard model.The patients included 52 men and 48 women. Their ages ranged from 27 to 82 years. Among the 85 patients who underwent curative resection, 44 (51.8%) developed disease recurrence (liver metastasis was the most common form of recurrence). The follow-up period ranged from 5 to 202 months (median: 33.2 months). The 1-, 3-, and 5-year DFS and OS rates were 85.2%, 53.8%, and 43.7%, and 91.5%, 66.6%, and 50.5%, respectively. Using multivariate analysis, it was found that high tumor cellularity, mitotic count >5/50 high-power field, and a Ki-67 index ≧10% were three independent factors that were inversely associated with DFS. However, absence of tumor perforation, mitotic count < 5/50 high power field, and tumor with low cellularity were predictors of long-term favorable OS.Tumors with low cellularity, low mitotic count, and low Ki-67 index, which indicate low risk, predict a more favorable DFS for small intestine GIST patients undergoing curative resection. Absence of tumor perforation with low mitotic count and low cellularity, which indicates low risk, can predict long-term OS for small intestine GIST patients who have undergone curative resection.Mesenchymal tumors of the gastrointestinal (GI) tract are rare, comprising only 0.1% to 3% of all GI neoplasms [1]. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract. These tumors are composed of tumor cells from the interstitial cells of Cajal [2,3], which are considered to be GI pacemaker cells.Gain-of-function mutations in the c-kit proto-oncogene and overexpression of the kit protein can occur [4,5], and result in a constitutive stimulus to tumo
Isokinetic eccentric exercise can induce skeletal muscle injury within the physiologic excursion of muscle-tendon unit: a rabbit model
Yang-Hwei Tsuang, Shui-Ling Lam, Lien-Chen Wu, Chang-Jung Chiang, Li-Ting Chen, Pei-Yu Chen, Jui-Sheng Sun, Chien-Che Wang
Journal of Orthopaedic Surgery and Research , 2007, DOI: 10.1186/1749-799x-2-13
Abstract: Biomechanical parameters of the muscle-tendon unit were monitored during isokinetic eccentric loading in 12 rabbits. In each animal, one limb (control group) was stretched until failure. The other limb (study group) was first subjected to isokinetic and eccentric cyclic loading at the rate of 10.0 cm/min to 112% (group I) or 120% (group II) of its initial length for 1 hour and then stretched to failure. Load-deformation curves and biomechanical parameters were compared between the study and control groups.When the muscle-tendon unit received eccentric cyclic loading to 112%, changes in all biomechanical parameters – except for the slope of the load-deformation curve – were not significant. In contrast, most parameters, including the slope of the load-deformation curve, peak load, deformation at peak load, total energy absorption, and energy absorption before peak load, significantly decreased after isokinetic eccentric cyclic loading to 120%.We found a threshold for eccentrically induced injury of the rabbit triceps surae muscle at between 12% and 20% strain, which is within the physiologic excursion of the muscle-tendon units. Our study provided evidence that eccentric exercise may induce changes in the biomechanical properties of skeletal muscles, even within the physiologic range of the excursion of the muscle-tendon unit.In the musculoskeletal system, muscle is the only tissue that can actively develop tension. When skeletal muscle is stimulated, it rapidly changes from passive tissue to active tissue. This change can cause muscular injuries, primarily strains or tears, which are extremely common in professional and amateur athletes [1,2]. In sports medicine, stretching exercises are often recommended to prevent injury and to improve performance [3,4]. However, intensive exercise training can result in muscular damage and soreness, especially when the exercise involves eccentric contraction [5,6].Researchers have demonstrated that eccentric contractions create m
Isoflavones prevent bone loss following ovariectomy in young adult rats
Yang-Hwei Tsuang, Li-Ting Chen, Chang-Jung Chiang, Lien-Chen Wu, Yueh-Feng Chiang, Pei-Yu Chen, Jui-Sheng Sun, Chien-Che Wang
Journal of Orthopaedic Surgery and Research , 2008, DOI: 10.1186/1749-799x-3-12
Abstract: Dietary isoflavones did not prevent the development of post-ovariectomy bone loss, but long-term ingestion of an isoflavone-rich diet increased the bone mineral contents after ovariectomy in young rats.Osteoporosis is a complex disease characterized by a reduction in bone mass with associated microarchitectural deterioration and a correspondingly high risk of fractures. It is a serious and costly public health problem in the elderly population [1]. Osteoporotic fractures are an important cause of disability. Osteoporosis and the consequences of compromised bone strength, particularly vertebral and hip fractures, is a significant cause of increased morbidity and even mortality. Hip fractures are associated with a 20% mortality in the year following the fracture [2]. As driven by the aging of the baby boomers and by the increasing longevity, the size of the population aged 50 years or older will increase markedly during the next several decades. Consequently, the cost of managing fractures is substantial and will continue to rise [3]. Thus, the direct, as well as indirect, costs of fractures are expected to increase correspondingly worldwide [4].Recent epidemiological studies have suggested that the incidence of osteoporosis varies among populations, as the result of the complex interactions of a variety of genetic, geographic, and ethnic factors [5-7]. Although family and twin studies have suggested that there is a strong genetic component which predisposes to osteoporosis, environmental factors like nutrition, mechanical load, and lifestyle are also important [8]. The relative impact of environmental and genetic factors on the predisposition to osteoporosis is still a matter of debate.Investigation of the role of dietary habits on the development and prevention of postmenopausal osteoporosis has focused primarily on calcium intake and vitamin D repletion. These two factors, albeit important, only account for the development of osteoporosis in part. Indeed, the incid
The B7-1 Cytoplasmic Tail Enhances Intracellular Transport and Mammalian Cell Surface Display of Chimeric Proteins in the Absence of a Linear ER Export Motif
Yi-Chieh Lin, Bing-Mae Chen, Wei-Cheng Lu, Chien-I Su, Zeljko M. Prijovich, Wen-Chuan Chung, Pei-Yu Wu, Kai-Chuan Chen, I-Chiao Lee, Ting-Yi Juan, Steve R. Roffler
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075084
Abstract: Membrane-tethered proteins (mammalian surface display) are increasingly being used for novel therapeutic and biotechnology applications. Maximizing surface expression of chimeric proteins on mammalian cells is important for these applications. We show that the cytoplasmic domain from the B7-1 antigen, a commonly used element for mammalian surface display, can enhance the intracellular transport and surface display of chimeric proteins in a Sar1 and Rab1 dependent fashion. However, mutational, alanine scanning and deletion analysis demonstrate the absence of linear ER export motifs in the B7 cytoplasmic domain. Rather, efficient intracellular transport correlated with the presence of predicted secondary structure in the cytoplasmic tail. Examination of the cytoplasmic domains of 984 human and 782 mouse type I transmembrane proteins revealed that many previously identified ER export motifs are rarely found in the cytoplasmic tail of type I transmembrane proteins. Our results suggest that efficient intracellular transport of B7 chimeric proteins is associated with the structure rather than to the presence of a linear ER export motif in the cytoplasmic tail, and indicate that short (less than ~ 10-20 amino acids) and unstructured cytoplasmic tails should be avoided to express high levels of chimeric proteins on mammalian cells.
Immunomodulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in a Swine Hemi-Facial Allotransplantation Model
Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Yu-Ting Huang, Chun-Ting Wang, Chia-Chun Tsai, Chao-Long Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035459
Abstract: Background In this study, we investigated whether the infusion of bone marrow-derived mesenchymal stem cells (MSCs), combined with transient immunosuppressant treatment, could suppress allograft rejection and modulate T-cell regulation in a swine orthotopic hemi-facial composite tissue allotransplantation (CTA) model. Methodology/Principal Findings Outbred miniature swine underwent hemi-facial allotransplantation (day 0). Group-I (n = 5) consisted of untreated control animals. Group-II (n = 3) animals received MSCs alone (given on days ?1, +1, +3, +7, +14, and +21). Group-III (n = 3) animals received CsA (days 0 to +28). Group-IV (n = 5) animals received CsA (days 0 to +28) and MSCs (days ?1, +1, +3, +7, +14, and +21). The transplanted face tissue was observed daily for signs of rejection. Biopsies of donor tissues and recipient blood sample were obtained at specified predetermined times (per 2 weeks post-transplant) or at the time of clinically evident rejection. Our results indicated that the MSC-CsA group had significantly prolonged allograft survival compared to the other groups (P<0.001). Histological examination of the MSC-CsA group displayed the lowest degree of rejection in alloskin and lymphoid gland tissues. TNF-α expression in circulating blood revealed significant suppression in the MSC and MSC-CsA treatment groups, as compared to that in controls. IHC staining showed CD45 and IL-6 expression were significantly decreased in MSC-CsA treatment groups compared to controls. The number of CD4+/CD25+ regulatory T-cells and IL-10 expressions in the circulating blood significantly increased in the MSC-CsA group compared to the other groups. IHC staining of alloskin tissue biopsies revealed a significant increase in the numbers of foxp3+T-cells and TGF-β1 positive cells in the MSC-CsA group compared to the other groups. Conclusions These results demonstrate that MSCs significantly prolong hemifacial CTA survival. Our data indicate the MSCs did not only suppress inflammation and acute rejection of CTA, but also modulate T-cell regulation and related cytokines expression.
Genome-Wide Association Study of Treatment Refractory Schizophrenia in Han Chinese
Ying-Jay Liou, Hui-Hung Wang, Ming-Ta Michael Lee, Sheng-Chang Wang, Hung-Lun Chiang, Cheng-Chung Chen, Ching-Hua Lin, Ming-Shun Chung, Chien-Cheng Kuo, Ding-Lieh Liao, Ching-Kuan Wu, Chih-Min Liu, Yu-Li Liu, Hai-Gwo Hwu, I-Ching Lai, Shih-Jen Tsai, Chia-Hsiang Chen, Hui-Fen Liu, Yi-Chun Chou, Chien-Hsiun Chen, Yuan-Tsong Chen, Chen-Jee Hong, Jer-Yuarn Wu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033598
Abstract: We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04×10?7) and rs11265461 (P = 1.94×10?7) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 (P = 1.94×10?6) and rs230529 (P = 1.74×10?7) are located in the gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); and rs13049286 (P = 3.05×10?5) and rs3827219 (P = 1.66×10?5) fall in receptor-interacting serine/threonine-protein kinase 4 (RIPK4). One isolated single nucleotide polymorphism (SNP), rs739617 (P = 3.87×10?5) was also identified to be associated with TRS. The -94delATTG allele (rs28362691) located in the promoter region of NFKB1 was identified by resequencing and was found to associate with TRS (P = 4.85×10?6). The promoter assay demonstrated that the -94delATTG allele had a significant lower promoter activity than the -94insATTG allele in the SH-SY5Y cells. This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS.
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