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Search Results: 1 - 10 of 28501 matches for " Sun Dongxiao "
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Forecasting Monthly Electric Energy Consumption Using Feature Extraction
Ming Meng,Dongxiao Niu,Wei Sun
Energies , 2011, DOI: 10.3390/en4101495
Abstract: Monthly forecasting of electric energy consumption is important for planning the generation and distribution of power utilities. However, the features of this time series are so complex that directly modeling is difficult. Three kinds of relatively simple series can be derived when a discrete wavelet transform is used to extract the raw features, namely, the rising trend, periodic waves, and stochastic series. After the elimination of the stochastic series, the rising trend and periodic waves were modeled separately by a grey model and radio basis function neural networks. Adding the forecasting values of each model can yield the forecasting results for monthly electricity consumption. The grey model has a good capability for simulating any smoothing convex trend. In addition, this model can mitigate minor stochastic effects on the rising trend. The extracted periodic wave series, which contain relatively less information and comprise simple regular waves, can improve the generalization capability of neural networks. The case study on electric energy consumption in China shows that the proposed method is better than those traditionally used in terms of both forecasting precision and expected risk.
Anthropogenic climate change revealed by coral gray values in the South China Sea
Xin Wang,DongXiao Wang,RongZhen Gao,DongHuai Sun
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-009-0534-3
Abstract: The authors analyze the coral growth band from a colony in the northwestern South China Sea. The coral growth band can provide comprehensive environmental information on climate. The trend from the two-century-long annual density of the coral is in a good agreement with that of the global CO2 concentration. Both trends were small prior to the end of the 19th century; after that, trends became clear, more so from the 1960s to the 1990s (the end of the coral record). The overall coral density shows a steady decrease from the late 19th century to the late 20th century. Therefore, the trend from the annual density of the coral reveals the history of the anthropogenic climate change, which is coherent with instrumental and other proxy records. We propose a simple coral-based proxy for reconstructing the anthropogenic climate change over the past two centuries.
The coral grayness in northern South China Sea and its description of interdecadal variation of precipitation in south China
Dejun Gu,Dongxiao Wang,Donghuai Sun,Rongzhen Gao,Zhongping Ji
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-9059-1
Abstract: The interdecadal variation of coral grayness in northern South China Sea (SCS) is studied using the annual mean coral grayness in northern SCS from 1789 to 1992 and annual precipitation at Guangzhou from 1908 to 1992 by Singular Spectrum Analysis (SSA), correlation analysis, Mann-Kendall’s abrupt change analysis and composite analysis. The interdecadal variation of south China precipitation as reflected by the series of Guangzhou precipitation rebuilt with the coral grayness is discussed. The results show that the variation of coral grayness in SCS has significant terms of tendency, much-weighted interdecadal variation and weak interannual variation. There was a century-scale abrupt change of coral grayness at the end of the 1880s that changed from positive anomalies to negative anomalies. The global field of SST difference corresponding to the point of abrupt change was negative anomalies over the SCS and neighboring northern Indian Ocean, most of central and western Pacific Ocean and coastal areas of the northern Atlantic Ocean. The large-scale distribution of SST anomalies is concomitant with the century-scale abrupt change of coral grayness in SCS. Negative correlation exists between the coral grayness in SCS and precipitation in Guangzhou on the interdecadal scale and the interdecadal precipitation in Guangzhou as reflected by the interdecadal data of SCS coral grayness shows that the interdecadal variation of south China precipitation changes significantly from phase to phase. The current study aims at contributing in the effort of identifying alternative indexes for climate change in south China on the interdecadal scale and beyond.
Estimation of Economic Values for Production and Functional Traits in Chinese Holstein
Jun Chen,Yachun Wang,Yi Zhang,Dongxiao Sun,Yuan Zhang
Journal of Animal and Veterinary Advances , 2012,
Abstract: Bio-economic profit models were used on Chinese Holstein production system to evaluate economic values for production traits Milk Yield (MY), Fat Percentage (FP), Protein Percentage (PP)) growth traits Mature Live Weight (LW) and functional traits Age at First Calving (AFC), Calving Interval (CI), Production Lifetime (PL) and Somatic Cell Count (SCC) traits. Economic and production parameters were derived from large scale dairy farms located in Beijing in 2008 to characterize Chinese Holstein production system, which were described according to their growth stage and levels of feed and management environment. Revenue and cost were calculated according to different age group in dairy production. With a fixed number of cows per herd as a basis of evaluation, two milk payment systems were considered. Under payment system based on milk volume, estimated economic values were RMB 1.99 (MY, kg),-4.72 (PP, %), -8.00 (FP,%), 0 (SCC), -4.96 (AFC, days), 1.71 (CI, days), -2.73 (LW, kg) and 1.58 (PL, days), respectively. Under payment system based on milk composition and quality (fat percentage, Protein Percentage, SCC), changes in the economic values were only observed for PP (64.21), FP (41.24), SCC (-393.88), respectively. Sensitivity of economic values was studied, factors considered included the price of milk, price of beef, price of feed and other production variables. Economic values of MY, PP and FP increased significantly with higher price of milk and the beef price had no effect on the economic values of milk production traits. With higher feed price, the economic value for the grow traits and functional traits increased, but that for milk production traits decreased. In summary, evaluated economical value for different traits showed that production and functional traits would have a positive effect, while growth traits would have a negative effect on profitability of Chinese Holstein production system and price of milk and feed were identified as the main factors influencing profit. The bio-economic profit model constructed for Chinese Holstein breeding system could provide general ideas for breeding goals setting in Chinese dairy breeding system in the future.
Detection of genetic association and functional polymorphisms of UGDH affecting milk production trait in Chinese Holstein cattle
Xu Qing,Mei Gui,Sun Dongxiao,Zhang Qin
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-590
Abstract: Background We previously localized a quantitative trait locus (QTL) on bovine chromosome 6 affecting milk production traits to a 1.5-Mb region between BMS483 and MNB-209 via genome scanning followed by fine mapping. Results Totally 15 genes were mapped within such linkage region through bioinformatic analysis of the cattle-human comparative map and bovine genome assembly. Of them, the UDP-glucose dehydrogenase (UGDH) was suggested as a potential positional candidate gene for milk production traits based on its corresponding physiological and biochemical functions and genetic effects. By sequencing all the coding exons and the untranslated regions in UGDH with pooled DNA of 8 sires represented the separated families detected in our previous studies, a total of ten SNPs were identified and genotyped in 1417 Holstein cows of 8 separation families. Individual SNP-based association analysis revealed 4 significant associations of SNP Ex1-1, SNP Int3-1, SNP Int5-1, and SNP Ex12-3 with milk yield (P < 0.05), and 2 significant associations of SNP Ex1-1 and SNP Ex12-3 with protein yield (P < 0.05). Furthermore, our haplotype-based association analyses indicated that haplotypes G-C-C, formed by SNP Ex12-2-SNP Int11-1-SNP Ex11-1, T-G, formed by SNP Int9-3-SNP Int9-2, and C-C, formed by SNP Int5-1-SNP Int3-1, are significantly associated with protein percentage (F=4.15; P=0.0418) and fat percentage (F=5.18~7.25; P=0.0072~0.0231). Finally, by using an in vitro expression assay, we demonstrated that the A allele of SNP Ex1-1 and T allele of SNP Ex11-1of UGDH significantly decreases the expression of UGDH by 68.0% at the RNA, and 50.1% at the protein level, suggesting that SNP Ex1-1 and Ex11-1 represent two functional polymorphisms affecting expression of UGDH and may partly contributed to the observed association of the gene with milk production traits in our samples. Conclusions Taken together, our findings strongly indicate that UGDH gene could be involved in genetic variation underlying the QTL for milk production traits.
A novel method for rapid and reliable detection of complex vertebral malformation and bovine leukocyte adhesion deficiency in Holstein cattle
Zhang Yi,Fan Xuehua,Sun Dongxiao,Wang Yachun
Journal of Animal Science and Biotechnology , 2012, DOI: 10.1186/2049-1891-3-24
Abstract: Background Complex vertebral malformation (CVM) and bovine leukocyte adhesion deficiency (BLAD) are two autosomal recessive lethal genetic defects frequently occurring in Holstein cattle, identifiable by single nucleotide polymorphisms. The objective of this study is to develop a rapid and reliable genotyping assay to screen the active Holstein sires and determine the carrier frequency of CVM and BLAD in Chinese dairy cattle population. Results We developed real-time PCR-based assays for discrimination of wild-type and defective alleles, so that carriers can be detected. Only one step was required after the DNA extraction from the sample and time consumption was about 2 hours. A total of 587 Chinese Holstein bulls were assayed, and fifty-six CVM-carriers and eight BLAD-carriers were identified, corresponding to heterozygote carrier frequencies of 9.54% and 1.36%, respectively. The pedigree analysis showed that most of the carriers could be traced back to the common ancestry, Osborndale Ivanhoe for BLAD and Pennstate Ivanhoe Star for CVM. Conclusions These results demonstrate that real-time PCR is a simple, rapid and reliable assay for BLAD and CVM defective allele detection. The high frequency of the CVM allele suggests that implementing a routine testing system is necessary to gradually eradicate the deleterious gene from the Chinese Holstein population.
Genome Wide Association Studies for Milk Production Traits in Chinese Holstein Population
Li Jiang,Jianfeng Liu,Dongxiao Sun,Peipei Ma,Xiangdong Ding,Ying Yu,Qin Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013661
Abstract: Genome-wide association studies (GWAS) based on high throughput SNP genotyping technologies open a broad avenue for exploring genes associated with milk production traits in dairy cattle. Motivated by pinpointing novel quantitative trait nucleotide (QTN) across Bos Taurus genome, the present study is to perform GWAS to identify genes affecting milk production traits using current state-of-the-art SNP genotyping technology, i.e., the Illumina BovineSNP50 BeadChip. In the analyses, the five most commonly evaluated milk production traits are involved, including milk yield (MY), milk fat yield (FY), milk protein yield (PY), milk fat percentage (FP) and milk protein percentage (PP). Estimated breeding values (EBVs) of 2,093 daughters from 14 paternal half-sib families are considered as phenotypes within the framework of a daughter design. Association tests between each trait and the 54K SNPs are achieved via two different analysis approaches, a paternal transmission disequilibrium test (TDT)-based approach (L1-TDT) and a mixed model based regression analysis (MMRA). In total, 105 SNPs were detected to be significantly associated genome-wise with one or multiple milk production traits. Of the 105 SNPs, 38 were commonly detected by both methods, while four and 63 were solely detected by L1-TDT and MMRA, respectively. The majority (86 out of 105) of the significant SNPs is located within the reported QTL regions and some are within or close to the reported candidate genes. In particular, two SNPs, ARS-BFGL-NGS-4939 and BFGL-NGS-118998, are located close to the DGAT1 gene (160bp apart) and within the GHR gene, respectively. Our findings herein not only provide confirmatory evidences for previously findings, but also explore a suite of novel SNPs associated with milk production traits, and thus form a solid basis for eventually unraveling the causal mutations for milk production traits in dairy cattle.
Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants
Dongxiao Sun, Gang Chen, Ryan W Dellinger, Kimberly Duncan, Jia-Long Fang, Philip Lazarus
Breast Cancer Research , 2006, DOI: 10.1186/bcr1539
Abstract: HPLC was used to detect glucuronide conjugates in microsomes from UGT1A4-overexpressing HK293 cells. The UGT1A4 wild-type cDNA was synthesized by RT-PCR using normal human liver total RNA. The UGT1A424Thr/48Leu and UGT1A424Pro/48Val variants were generated by site-directed mutagenesis of the pcDNA3.1/V5-His-TOPO plasmid expressing wild-type UGT1A424Pro/48Leu. Levels of UGT1A4 expression in UGT-overexpressing cell lines were measured by western blot analysis.Microsomes from wild-type UGT1A424Pro/48Leu-overexpressing HK293 cells exhibited significant levels of activity against TAM, trans-4-OH-TAM and cis-4-OH-TAM, forming exclusively the tamoxifen quaternary ammonium glucuronide (TAM-N+-glucuronide) and the 4-hydroxytamoxifen quaternary ammonium glucuronides (trans-4-OH-TAM-N+-glucuronide and cis-4-OH-TAM-N+-glucuronide) with apparent Km values of 2.0 μM, 2.2 μM, and 2.1 μM, respectively. Higher glucuronidation activities were found by kinetic analysis for microsomes from the variant UGT1A424Pro/48Val-overexpressing cell line as compared with microsomes from wild-type UGT1A424Pro/48Leu-overexpressing cells against TAM and against both the trans and cis isomers of 4-OH-TAM. A significantly (P < 0.02) lower Km value (~1.6-fold to 1.8-fold) was observed for both 4-OH-TAM isomers, while a near-significant (P = 0.053) decrease in Km was observed for TAM for the UGT1A424Pro/48Val variant as compared with wild-type UGT1A4. The Vmax/Km ratio for the UGT1A424Pro/48Val variant was significantly (P ≤ 0.005) higher than that observed for the wild-type UGT1A4 isoform for both the trans and cis isomers of 4-OH-TAM after normalization for UGT1A4 expression by western blotting. No significant effect on enzyme kinetics was observed for the UGT1A424Thr/48Leu variant against either isomer of 4-OH-TAM or with TAM.These data suggest that the UGT1A4 codon 48 Leu>Val polymorphism significantly alters glucuronidation rates against TAM and its active hydroxylated metabolites, and that this po
Genome-Wide Bovine H3K27me3 Modifications and the Regulatory Effects on Genes Expressions in Peripheral Blood Lymphocytes
Yanghua He, Ying Yu, Yuan Zhang, Jiuzhou Song, Apratim Mitra, Yi Zhang, Yachun Wang, Dongxiao Sun, Shengli Zhang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039094
Abstract: Background Gene expression of lymphocytes was found to be influenced by histone methylation in mammals and trimethylation of lysine 27 on histone H3 (H3K27me3) normally represses genes expressions. Peripheral blood lymphocytes are the main source of somatic cells in the milk of dairy cows that vary frequently in response to the infection or injury of mammary gland and number of parities. Methods The genome-wide status of H3K27me3 modifications on blood lymphocytes in lactating Holsteins was performed via ChIP-Seq approach. Combined with digital gene expression (DGE) technique, the regulation effects of H3K27me3 on genes expressions were analyzed. Results The ChIP-seq results showed that the peaks of H3K27me3 in cows lymphocytes were mainly enriched in the regions of up20K (~50%), down20K (~30%) and intron (~28%) of the genes. Only ~3% peaks were enriched in exon regions. Moreover, the highest H3K27me3 modification levels were mainly around the 2 Kb upstream of transcriptional start sites (TSS) of the genes. Using conjoint analysis with DGE data, we found that H3K27me3 marks tended to repress target genes expressions throughout whole gene regions especially acting on the promoter region. A total of 53 differential expressed genes were detected in third parity cows compared to first parity, and the 25 down-regulated genes (PSEN2 etc.) were negatively correlated with H3K27me3 levels on up2Kb to up1Kb of the genes, while the up-regulated genes were not showed in this relationship. Conclusions The first blueprint of bovine H3K27me3 marks that mediates gene silencing was generated. H3K27me3 plays its repressed role mainly in the regulatory region in bovine lymphocytes. The up2Kb to up1Kb region of the down-regulated genes in third parity cows could be potential target of H3K27me3 regulation. Further studies are warranted to understand the regulation mechanisms of H3K27me3 on somatic cell count increases and milk losses in latter parities of cows.
Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein
Cong Li, Dongxiao Sun, Shengli Zhang, Sheng Wang, Xiaoping Wu, Qin Zhang, Lin Liu, Yanhua Li, Lv Qiao
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096186
Abstract: Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a genome-wide association study (GWAS) for 22 milk fatty acids in 784 Chinese Holstein cows with the PLINK software. Genotypes were obtained with the Illumina BovineSNP50 Bead chip and a total of 40,604 informative, high-quality single nucleotide polymorphisms (SNPs) were used. Totally, 83 genome-wide significant SNPs and 314 suggestive significant SNPs associated with 18 milk fatty acid traits were detected. Chromosome regions that affect milk fatty acid traits were mainly observed on BTA1, 2, 5, 6, 7, 9, 13, 14, 18, 19, 20, 21, 23, 26 and 27. Of these, 146 SNPs were associated with more than one milk fatty acid trait; most of studied fatty acid traits were significant associated with multiple SNPs, especially C18:0 (105 SNPs), C18 index (93 SNPs), and C14 index (84 SNPs); Several SNPs are close to or within the DGAT1, SCD1 and FASN genes which are well-known to affect milk composition traits of dairy cattle. Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1. Our findings provide a groundwork for unraveling the key genes and causal mutations affecting milk fatty acid traits in dairy cattle.
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