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Search Results: 1 - 10 of 17287 matches for " Suk-Bin Seo "
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TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
Suk-Bin Seo, Jung-Gu Hur, Mi-Ju Kim, Jae-Won Lee, Hak-Bong Kim, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-199
Abstract: MDR variants, CEM/VLB10-2, CEM/VLB55-8 and CEM/VLB100 cells, with gradually increased levels of P-gp derived from human lymphoblastic leukemia CEM cells, were gradually more susceptible to TRAIL-induced apoptosis and cytotoxicity than parental CEM cells. The P-gp level of MDR variants was positively correlated with the levels of DNA-PKcs, pAkt, pGSK-3β and c-Myc as well as DR5 and negatively correlated with the level of c-FLIPs. Hypersensitivity of CEM/VLB100 cells to TRAIL was accompanied by the activation of mitochondrial apoptotic pathway as well as the activation of initiator caspases. In addition, TRAIL-induced down-regulation of DNA-PKcs/Akt/GSK-3β pathway and c-FLIP and up-regulation of cell surface expression of death receptors were associated with the increased susceptibility to TRAIL of MDR cells. Moreover, TRAIL inhibited P-gp efflux function via caspase-3-dependent degradation of P-gp as well as DNA-PKcs and subsequently sensitized MDR cells to MDR-related drugs such as vinblastine and doxorubicin. We also found that suppression of DNA-PKcs by siRNA enhanced the susceptibility of MDR cells to vincristine as well as TRAIL via down-regulation of c-FLIP and P-gp expression and up-regulation of DR5.This study showed for the first time that the MDR variant of CEM cells was hypersensitive to TRAIL due to up-regulation of DR5 and concomitant down-regulation of c-FLIP, and degradation of P-gp and DNA-PKcs by activation of caspase-3 might be important determinants of TRAIL-induced sensitization of MDR cells to MDR-related drugs. Therefore, combination of TRAIL and chemotherapeutic drugs may be a good strategy for treatment of cancer with multidrug resistance.Acquired resistance to chemotherapeutic agents remains a major obstacle for the effective treatment of many advanced and metastatic cancers. Several mechanisms are thought to be involved in the development of multidrug resistance (MDR), defined by simultaneous cross-resistance to a variety of anticancer drugs
Directed In Vitro Myogenesis of Human Embryonic Stem Cells and Their In Vivo Engraftment
Yongsung Hwang, Samuel Suk, Susan Lin, Matthew Tierney, Bin Du, Timothy Seo, Aaron Mitchell, Alessandra Sacco, Shyni Varghese
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072023
Abstract: Development of human embryonic stem cell (hESC)-based therapy requires derivation of in vitro expandable cell populations that can readily differentiate to specified cell types and engraft upon transplantation. Here, we report that hESCs can differentiate into skeletal muscle cells without genetic manipulation. This is achieved through the isolation of cells expressing a mesodermal marker, platelet-derived growth factor receptor-α (PDGFRA), following embryoid body (EB) formation. The ESC-derived cells differentiated into myoblasts in vitro as evident by upregulation of various myogenic genes, irrespective of the presence of serum in the medium. This result is further corroborated by the presence of sarcomeric myosin and desmin, markers for terminally differentiated cells. When transplanted in vivo, these pre-myogenically committed cells were viable in tibialis anterior muscles 14 days post-implantation. These hESC-derived cells, which readily undergo myogenic differentiation in culture medium containing serum, could be a viable cell source for skeletal muscle repair and tissue engineering to ameliorate various muscle wasting diseases.
Biomass and Community Structure of Epilithic Biofilm on the Yellow and East Coasts of Korea  [PDF]
Bo Yeon Kim, Seo Kyoung Park, Jin Suk Heo, Han Gil Choi, Young Sik Kim, Ki Wan Nam
Open Journal of Marine Science (OJMS) , 2014, DOI: 10.4236/ojms.2014.44026
Abstract: Spatial biomass variation and community structure of epilithic biofilms were examined using cell counts, chlorophyll a extraction, and remote-sensing techniques. Samples were collected at two levels of wave exposure along the Yellow and East Coasts of Korea in December 2010. Cyanobacteria were dominant, occupying about 88% of biofilm, irrespective of wave exposure levels. The cyanobacteria species, Aphanotece spp. was abundant in the Yellow Coast location and Lyngbya spp. was abundant in the East coast location. The representative diatoms were Navicula spp. and Achnanthes spp. on the rocky shores of all study sites. Average Normalized Difference Vegetation Index (NDVI) was significantly greater in the Yellow Coast (mean 0.46) than that in the East Coast (mean 0.21); a similar pattern was observed in Vegetation Index (VI). Chlorophyll a content was three times greater on the Yellow Coast (20.50 μg/cm2) than that on the East Coast (8.21 μg/cm2), and it was greater at the Gosapo and Bangpo shore sites than that at the Gyeokpo site, on the Yellow Coast. However, chlorophyll a contents were not different between 23.33 and 17.66 μg/cm2 at exposed- and sheltered-shores of Yellow Coast, and were 9.62 μg/cm2 and 6.80 μg/cm2 on the East Coast. Vegetation indices were positively correlated with chlorophyll a contents. In conclusion, biofilm of Korean upper rocky shore was mainly composed of cyanobacteria and biofilm biomass that differed between the Yellow and East Coast.
A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
Seong-Heon Wie, Byung Hak So, Joon Young Song, Hee Jin Cheong, Yu Bin Seo, Sung Hyuk Choi, Ji Yun Noh, Ji Hyeon Baek, Jin Soo Lee, Hyo Youl Kim, Young Keun Kim, Won Suk Choi, Jacob Lee, Hye Won Jeong, Woo Joo Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062685
Abstract: Background During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B. Methodology/Principal Findings We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05). Conclusions The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.
Characterization of Metal Artifacts in X-ray Computed Tomography
Hyoung Suk Park,Jae Kyu Choi,Jin Keun Seo
Mathematics , 2014,
Abstract: Metal streak artifacts in X-ray computerized tomography (CT) are rigorously characterized here using the notion of the wavefront set from microlocal analysis. The metal artifacts are caused mainly from the mismatch of the forward model of the filtered back-projection; the presence of metallic subjects in an imaging subject violates the model's assumption of the CT sinogram data being the Radon transform of an image. The increasing use of metallic implants has increased demand for the reduction of metal artifacts in the field of dental and medical radiography. However, it is a challenging issue due to the serious difficulties in analyzing the X-ray data, which depends nonlinearly on the distribution of the metallic subject. In this paper, we found that the metal streaking artifacts cause mainly from the boundary geometry of the metal region. The metal streaking artifacts are produced only when the wavefront set of the Radon transform of the characteristic function of a metal region does not contain the wavefront set of the square of the Radon transform. We also found a sufficient condition for the non-existence of the metal streak artifacts.
Additive Effect between IL-13 Polymorphism and Cesarean Section Delivery/Prenatal Antibiotics Use on Atopic Dermatitis: A Birth Cohort Study (COCOA)
So-Yeon Lee, Jinho Yu, Kang-Mo Ahn, Kyung Won Kim, Youn Ho Shin, Kyung-shin Lee, Seo Ah Hong, Young-ho Jung, Eun Lee, Song-I Yang, Ju-hee Seo, Ji-Won Kwon, Byoung-Ju Kim, Hyo-Bin Kim, Woo-Kyung Kim, Dae Jin Song, Gwang Cheon Jang, Jung Yeon Shim, Soo-Young Lee, Ja-Young Kwon, Suk-Joo Choi, Kyung-Ju Lee, Hee Jin Park, Hye-Sung Won, Ho-Sung Yoo, Mi-Jin Kang, Hyung-Young Kim, Soo-Jong Hong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096603
Abstract: Background Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19–27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.
A hybrid decision support model to discover informative knowledge in diagnosing acute appendicitis
Chang Sik Son, Byoung Kuk Jang, Suk Tae Seo, Min Soo Kim, Yoon Nyun Kim
BMC Medical Informatics and Decision Making , 2012, DOI: 10.1186/1472-6947-12-17
Abstract: We enrolled 326 patients who attended an emergency medical center complaining mainly of acute abdominal pain. Statistical analysis approaches were used as a feature selection process in the design of decision support models, including the Chi-square test, Fisher's exact test, the Mann-Whitney U-test (p < 0.01), and Wald forward logistic regression (entry and removal criteria of 0.01 and 0.05, or 0.05 and 0.10, respectively). The final decision support models were constructed using the C5.0 decision tree algorithm of Clementine 12.0 after pre-processing.Of 55 variables, two subsets were found to be indispensable for early diagnostic knowledge discovery in acute appendicitis. The two subsets were as follows: (1) lymphocytes, urine glucose, total bilirubin, total amylase, chloride, red blood cell, neutrophils, eosinophils, white blood cell, complaints, basophils, glucose, monocytes, activated partial thromboplastin time, urine ketone, and direct bilirubin in the univariate analysis-based model; and (2) neutrophils, complaints, total bilirubin, urine glucose, and lipase in the multivariate analysis-based model. The experimental results showed that the model with univariate analysis (80.2%, 82.4%, 78.3%, 76.8%, 83.5%, and 80.3%) outperformed models using multivariate analysis (71.6%, 69.3%, 73.7%, 69.7%, 73.3%, and 71.5% with entry and removal criteria of 0.01 and 0.05; 73.5%, 66.0%, 80.0%, 74.3%, 72.9%, and 73.0% with entry and removal criteria of 0.05 and 0.10) in terms of accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and area under ROC curve, during a 10-fold cross validation. A statistically significant difference was detected in the pairwise comparison of ROC curves (p < 0.01, 95% CI, 3.13-14.5; p < 0.05, 95% CI, 1.54-13.1). The larger induced decision model was more effective for identifying acute appendicitis in patients with acute abdominal pain, whereas the smaller induced decision tree was less accurate with the test
The Galactic Wind Haze and its $\gamma$-spectrum
Gupta, Nayantara;Nath, Biman B.;Biermann, Peter L.;Seo, Eun -Suk;Stanev, Todor;Tjus, Julia Becker
High Energy Physics - Phenomenology , 2013,
Abstract: The spectrum observed by Fermi-LAT from the Galactic centre region shows a gamma ray feature near 130 GeV, that in some analyses appears as a possible line. We discuss the possibility that this gamma ray feature has a cosmic ray origin. We argue that the cosmic ray electrons steepen near 1 TeV from $E^{-3}$ to about $E^{-4.2}$, and are all secondary derived from the knee-feature of normal cosmic rays. We argue that the observed feature at $\sim 130$ GeV could essentially be a noise feature on top of a sharp turn-off in the $\gamma$ ray spectrum at $\sim 130$ GeV. This match suggests that the knee of normal cosmic rays is the same everywhere in the Galaxy. We suggest that it follows that all supernovae contributing give the same cosmic ray spectrum, with the knee feature given by common stellar properties; in fact, this is consistent with the supernova theory proposed by Bisnovatyi-Kogan (1970), a magneto-rotational mechanism: Massive stars converge to common properties in terms of rotation and magnetic fields just before they explode.
Bee venom acupuncture for the treatment of chronic low back pain: study protocol for a randomized, double-blinded, sham-controlled trial
Seo Byung-Kwan,Lee Jun-Hwan,Sung Won-Suk,Song Eun-Mo
Trials , 2013, DOI: 10.1186/1745-6215-14-16
Abstract: Background Chronic non-specific low back pain is the most common medical problem for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. However, the effectiveness and safety of such treatments have not been fully established by randomized clinical trials. The aim of this study is to determine whether bee venom acupuncture is effective for improving pain intensity, functional status and quality of life of patients with chronic non-specific low back pain. Methods/design This study is a randomized, double-blinded, sham-controlled clinical trial with two parallel arms. Fifty-four patients between 18 and 65 years of age with non-radicular chronic low back pain experiencing low back pain lasting for at least the previous three months and ≥4 points on a 10-cm visual analog scale for bothersomeness at the time of screening will be included in the study. Participants will be randomly allocated into the real or sham bee venom acupuncture groups and treated by the same protocol to minimize non-specific and placebo effects. Patients, assessors, acupuncturists and researchers who prepare the real or sham bee venom acupuncture experiments will be blinded to group allocation. All procedures, including the bee venom acupuncture increment protocol administered into predefined acupoints, are designed by a process of consensus with experts and previous researchers according to the Standards for Reporting Interventions in Clinical Trials of Acupuncture. Bothersomeness measured using a visual analogue scale will be the primary outcome. Back pain-related dysfunction, pain, quality of life, depressive symptoms and adverse experiences will be measured using the visual analogue scale for pain intensity, the Oswestry Disability Index, the EuroQol 5-Dimension, and the Beck’s Depression Inventory. These measures will be recorded at baseline and 1, 2, 3, 4, 8 and 12 weeks. Discussion The results from this study will provide clinical evidence on the efficacy and safety of bee venom acupuncture in patients with chronic non-specific low back pain. Trial registration This study is registered with the United States National Institutes of Health Clinical Trials Registry: NCT01491321
Right trisegmentectomy with thoracoabdominal approach after transarterial embolization for giant hepatic hemangioma
Hyung-Il Seo, Hong Jae Jo, Mun Sup Sim, Suk Kim
World Journal of Gastroenterology , 2009,
Abstract: Hepatic hemangiomas need to be treated surgically in cases where they are accompanied with symptoms, have a risk of rupture, or are hardly distinguishable from malignancy. The present authors conducted embolization of the right hepatic artery one day before an operation for a huge hemangioma accompanied with symptoms and confirmed a decrease in its size. The authors performed a right trisegmentectomy through a J-shape incision, using a thoracoabdominal approach, and safely removed a giant hemangioma of 32.0 cm × 26.5 cm × 8.0 cm in size and 2300 g in weight. Even for inexperienced surgeons, a J-shape incision with a thoracoabdominal approach is considered a safe and useful method when right-side hepatectomy is required for a large mass in the right liver.
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