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Search Results: 1 - 10 of 21732 matches for " Sujit Kumar Sahu "
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2. Formulation and in vitro evaluation of mucoadhesive buccal tablets of Timolol maleate
Satyabrata Bhanja,P. Ellaiah,Sujit Kumar Martha,Pratit Kanchan Sahu
International Journal of Pharmaceutical and Biomedical Research (IJPBR) , 2010,
Abstract: The present investigation is concerned with formulation and evaluation of mucoadhesive buccal tablets containing antihypertensive drug, Timolol maleate to circumvent the first pass effect and to improve its bioavailability with reduction indosing frequency and dose related side effects. The tablets were prepared by direct compression method. Eight formulations were developed with varying concentrations of polymers like Carbopol 934, Polyethylene oxide and Hydroxy Propyl Methyl Cellulose. The tablets were tested for weight variation, hardness, surface pH, drug Content uniformity, swelling index, and bioadhesive strength and in-vitro drug dissolution study. FTIR studies showed no evidence on interactions between drug, polymers, and excipients. The in vitro release of Timolol maleate was performed under sink conditions (Phosphate buffer PH 6.8, 37±0.5oC, rpm 50) using USP-XXIV dissolution apparatus type II. The best in-vitro drug release profile was achieved with the formulation F5 which contains the drug, Carbopol 934p and HPMC K4M in the ratio of 1:2.5:10. The surface pH, bioadhesive strength and swelling index of formulation F5 was found to be 6.34, 36.5 g and 80.3 %, respectively. The formulation F5, containing 10 mg of Timolol maleate exhibited 7 h sustained drug release i.e. 98.18 % with desired therapeutic concentration. The in vitro release kinetics studies reveal that all formulations fits well with zero order kinetics followed by Korsmeyer-Peppas, first order and then Higuchi’s model and the mechanism of drug release is non-Fickian diffusion.
Evaluation of Anthelmintic Activity of Pistia stratiotes Linn
H. K. Sundeep Kumar,Anindya Bose,Arundhuti Raut,Sujit Kumar Sahu
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: The ethanolic extract of the plant Pistia stratiotes (Araceae) was investigated for activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piperazine citrate (15 mg/ml) and Albendazole(20 mg/ml) as standard reference and normal saline as control. The study indicated the potential usefulness of Pistia stratiotes against earthworm infections
Mathematical Model to Locate Interference of Blast Waves from Multi-Hole Blasting Rounds  [PDF]
Sujit Kumar Mandal
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.43019
Abstract: Maximum charge per delay in a blasting round is universally accepted as the influencing parameter to quantify magni-tude of vibration for any distance of concern. However, for any blasting round experimental data reveals that for same charge per delay magnitude of vibration varies with total charge. Considering linear transmission of blast waves, the paper firstly investigates into the influence of explosive weight, blast design parameters and geology of strata on magnitude and characteristics of vibration parameters and thereafter communicates that possibly interference of blast waves generated from same and different holes of a blasting round result into variation in vibration magnitude. The paper lastly developed a mathematical model to evaluate points of interference of blast waves generated from single- and multi-hole blasting round.
Tilted Bianchi Type VI0 Cosmological Model in Saez and Ballester Scalar Tensor Theory of Gravitation  [PDF]
Subrata Kumar Sahu
Journal of Modern Physics (JMP) , 2010, DOI: 10.4236/jmp.2010.11008
Abstract: Tilted Bianchi type VI0 cosmological model is investigated in a new scalar tensor theory of gravitation pro-posed by Saez and Ballester (Physics Letters A 113:467, 1986). Exact solutions to the field equations are derived when the metric potentials are functions of cosmic time only. Some physical and geometrical proper-ties of the solutions are also discussed.
Finite Temperature Asymmetric Nuclear Matter Using Pion Dressing  [PDF]
Saroj Kumar Sahu
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.310159
Abstract: We study the asymmetric nuclear matter in a nonperturvative manner at finite temperatures using thermofield dynamics method. The nucleon-meson interaction is taken to examine the binding energy (EB), pressure (P) for various proton fractions.
Multidisciplinary approach in child and adolescent depression: Experience from a tertiary mental health institution in India  [PDF]
Deepak Kumar, Uday K. Sinha, Amit Khanna, Sujit Kumar Kar
Open Journal of Psychiatry (OJPsych) , 2013, DOI: 10.4236/ojpsych.2013.33A002
Abstract:

The concept of Multidisciplinary approach is not new to Medical Science. It is an evolving concept that is widely appreciated and adopted in most of the disciplines of medicine. It’s rational and applicable in the management of Child and Adolescent Depression,which needs to be revisited focusing on the interplay of various contextual factors that are entwined and tend to affect the course of the illness. The limitations of any one mental health professional in envisioning all possible dimensions of Child and Adolescent Depression make this approach all the more important wherein Psychiatrists, Clinical Psychologists, Psychiatric Social Workers collaborate with each other and other allied professionals in the treatment and management of the disorder. India, being a heavily populated country, where multidisciplinary management approach is in a phase of expansion and is practiced in many leading institutes to meet the quality needs of patients. This article focuses on the Indian scene of multidisciplinary management approach in child and adolescent depression.

Magnetohydrodynamic stability of stochastically driven accretion flows
Sujit Kumar Nath
Physics , 2014,
Abstract: We investigate the evolution of magnetohydrodynamic perturbations in presence of stochastic noise in rotating shear flows. The particular emphasis is the flows whose angular velocity decreases but specific angular momentum increases with increasing radial coordinate. Such flows, however, are Rayleigh stable, but must be turbulent in order to explain astrophysical observed data and, hence, reveal a mismatch between the linear theory and observations/experiments. The mismatch seems to have been resolved, at least in certain regimes, in presence of weak magnetic field revealing magnetorotational instability. The present work explores the effects of stochastic noise on such magnetohydrodynamic flows, in order to resolve the above mismatch generically for the hot flows. It is found that such stochastically driven flows exhibit large temporal and spatial autocorrelations and cross-correlations of perturbation and hence large energy dissipations of perturbation, which generate instability.
A Bayesian localised conditional auto-regressive model for estimating the health effects of air pollution
Duncan Lee,Alastair Rushworth,Sujit K. Sahu
Statistics , 2013,
Abstract: Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial correlation structure in these data, which is accounted for using random effects modelled by a globally smooth conditional autoregressive model. These smooth random effects confound the effects of air pollution, which are also globally smooth. To avoid this collinearity a Bayesian localised conditional autoregressive model is developed for the random effects. This localised model is flexible spatially, in the sense that it is not only able to model step changes in the random effects surface, but also is able to capture areas of spatial smoothness in the study region. This methodological development allows us to improve the estimation performance of the covariate effects, compared to using traditional conditional auto-regressive models. These results are established using a simulation study, and are then illustrated with our motivating study on air pollution and respiratory ill health in Greater Glasgow, Scotland in 2010. The model shows substantial health effects of particulate matter air pollution and income deprivation, whose effects have been consistently attenuated by the currently available globally smooth models.
Economics of Yield and Production of Alkaloid of Withania somnifera (L.) Dunal  [PDF]
Atul Kumar Shrivastava, Pankaj K. Sahu
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.410253
Abstract:

The yield parameters and cost economics of Withania somnifera were studied using Integrated Nutrient Management (INM) treatments. Withania somnifera is cultivated in around 10,780 ha with a production of 8429 tones in India. The annual demand of this herb increased from 7028 tones (2001-2002) to 9127 tones (2004-2005). The field experiment was conducted at the research farm of Department of Plant Physiology, College of Agriculture, Jabalpur during Kharif season of 2008-2009 (1st year) and 2009-2010 (2nd year), whereas the laboratory work was carried out in Quality Laboratory, College of Agriculture, Jabalpur. The soil of experimental field was sandy loam in texture with pH 7.5, EC 0.18 dsm-1 having good drainage. Soil analysis revealed that available nitrogen was low (202.0 kg·ha-1) whereas available phosphorus

Recrystallization of tubules from natural lotus (Nelumbo nucifera) wax on a Au(111) surface
Sujit Kumar Dora,Klaus Wandelt
Beilstein Journal of Nanotechnology , 2011, DOI: 10.3762/bjnano.2.30
Abstract: We present here the first results on the self-assembly of tubules of natural wax from lotus leaves on a single crystal Au(111) surface. A comparison of the tubule growth on Au(111) to that on HOPG is discussed. Although the tubule formation on both Au(111) and HOPG takes place on an intermediate wax film which should mask the substrate properties, the tubule orientations differ. In contrast to a vertical tubule orientation on HOPG, the tubules lie flat on Au(111). Taking into account the physical properties of HOPG and Au(111), we put forward a hypothesis which can explain the different tubule orientations on both substrates.
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