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Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin
Shakilur Rahman,Rizwan Ahmed Ansari,Hasibur Rehman,Suhel Parvez,Sheikh Raisuddin
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep076
Abstract: Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It has a long history of traditional medicinal use by the Native Americans and Mexicans. The modulatory effects of topically applied NDGA was studied on acute inflammatory and oxidative stress responses in mouse skin induced by stage I tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA). Double TPA treatment adversely altered many of the marker responses of stage I skin tumor promotion cascade. Pretreatment of NDGA in TPA-treated mice mitigated cutaneous lipid peroxidation and inhibited production of hydrogen peroxide. NDGA treatment also restored reduced glutathione level and activities of antioxidant enzymes. Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response. Furthermore, results of histological study demonstrated inhibitory effect of NDGA on cellular inflammatory responses. This study provides a direct evidence of antioxidative and anti-inflammatory properties of NDGA against TPA-induced cutaneous inflammation and oxidative stress corroborating its chemopreventive potential against skin cancer.
Nuclear Translocation of Jacob in Hippocampal Neurons after Stimuli Inducing Long-Term Potentiation but Not Long-Term Depression
Thomas Behnisch,PingAn YuanXiang,Philipp Bethge,Suhel Parvez,Ying Chen,Jin Yu,Anna Karpova,Julietta U. Frey,Marina Mikhaylova,Michael R. Kreutz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017276
Abstract: In recent years a number of potential synapto-nuclear protein messengers have been characterized that are thought to be involved in plasticity-related gene expression, and that have the capacity of importin- mediated and activity-dependent nuclear import. However, there is a surprising paucity of data showing the nuclear import of such proteins in cellular models of learning and memory. Only recently it was found that the transcription factor cyclic AMP response element binding protein 2 (CREB2) transits to the nucleus during long-term depression (LTD), but not during long-term potentiation (LTP) of synaptic transmission in hippocampal primary neurons. Jacob is another messenger that couples NMDA-receptor-activity to nuclear gene expression. We therefore aimed to study whether Jacob accumulates in the nucleus in physiological relevant models of activity-dependent synaptic plasticity.
Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes
Yunzhao R. Ren, Fan Pan, Suhel Parvez, Andrea Fleig, Curtis R. Chong, Jing Xu, Yongjun Dang, Jin Zhang, Hongsi Jiang, Reinhold Penner, Jun O. Liu
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0004009
Abstract: The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes. A number of potent small molecule inhibitors of Kv1.3 channel have been reported, some of which were found to be effective in various animal models of autoimmune diseases. We report herein the identification of clofazimine, a known anti-mycobacterial drug, as a novel inhibitor of human Kv1.3. Clofazimine was initially identified as an inhibitor of intracellular T cell receptor-mediated signaling leading to the transcriptional activation of human interleukin-2 gene in T cells from a screen of the Johns Hopkins Drug Library. A systematic mechanistic deconvolution revealed that clofazimine selectively blocked the Kv1.3 channel activity, perturbing the oscillation frequency of the calcium-release activated calcium channel, which in turn led to the inhibition of the calcineurin-NFAT signaling pathway. These effects of clofazimine provide the first line of experimental evidence in support of a causal relationship between Kv1.3 and calcium oscillation in human T cells. Furthermore, clofazimine was found to be effective in blocking human T cell-mediated skin graft rejection in an animal model in vivo. Together, these results suggest that clofazimine is a promising immunomodulatory drug candidate for treating a variety of autoimmune disorders.
To Eat and Not Be Eaten: Modelling Resources and Safety in Multi-Species Animal Groups
Umesh Srinivasan, Suhel Quader
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042071
Abstract: Using mixed-species bird flocks as an example, we model the payoffs for two types of species from participating in multi-species animal groups. Salliers feed on mobile prey, are good sentinels and do not affect prey capture rates of gleaners; gleaners feed on prey on substrates and can enhance the prey capture rate of salliers by flushing prey, but are poor sentinels. These functional types are known from various animal taxa that form multi-species associations. We model costs and benefits of joining groups for a wide range of group compositions under varying abundances of two types of prey–prey on substrates and mobile prey. Our model predicts that gleaners and salliers show a conflict of interest in multi-species groups, because gleaners benefit from increasing numbers of salliers in the group, whereas salliers benefit from increasing gleaner numbers. The model also predicts that the limits to size and variability in composition of multi-species groups are driven by the relative abundance of different types of prey, independent of predation pressure. Our model emphasises resources as a primary driver of temporal and spatial group dynamics, rather than reproductive activity or predation per se, which have hitherto been thought to explain patterns of multi-species group formation and cohesion. The qualitative predictions of the model are supported by empirical patterns from both terrestrial and marine multi-species groups, suggesting that similar mechanisms might underlie group dynamics in a range of taxa. The model also makes novel predictions about group dynamics that can be tested using variation across space and time.
Object Oriented Design Security Quantification
Suhel Ahmad Khan
Journal of Global Research in Computer Science , 2011,
Abstract: Quantification of security at early phase produces a significant improvement to understand the management of security artifacts for best possible results. The proposed study discusses a systematic approach to quantify security based on complexity factors which having impact on security attributes. This paper provides a road-map to researchers and software practitioner to assess, and preferably, quantify software security in design phase. A security assessment through complexity framework (SVDF) has been proposed in order to incorporate security to develop quality products. It may be used to benchmark software products according to their severity.
Vector Variational-Like Inequalities with Generalized Semimonotone Mappings
Suhel Ahmad Khan
International Journal of Analysis , 2013, DOI: 10.1155/2013/762380
Abstract: We introduce the concepts of generalized relaxed monotonicity and generalized relaxed semimonotonicity. We consider a class of generalized vector variationa-llike inequality problem involving generalized relaxed semimonotone mapping. By using Kakutani-Fan-Glicksberg’s fixed-point theorem, we prove the solvability for this class of vector variational-like inequality with relaxed monotonicity assumptions. The results presented in this paper generalize some known results for vector variational inequality in recent years. 1. Introduction Vector variational inequalities were initially introduced and considered by Giannessi [1] in a finite-dimensional Euclidean space in 1980. Due to its wide application the theory of the vector variational inequality is generalized in different directions and many existence results and algorithms for vector variational inequality problems have been established under various conditions; see for examples [2–7] and references therein. The concept monotonicity and the compactness operators are very useful in nonlinear functional analysis and its applications. In 1968, Browder [8] first combined the compactness and accretion of operators and posed the concept of a semiaccretive operator. Motivated by this idea, Chen [9] studied the concept of a semimonotone operator, which combines the compactness and monotonicity of an operator and posed it to the study of variational inequalities. Recently in 2003, Fang and Huang [10] introduced relaxed - -semimonotone mapping, a generalized concept of semimonotonicity, and they established several existence results for the variational-like inequality problem. In this paper, we pose two new concepts of generalized relaxed monotonicity and generalized relaxed semimonotonicity as well as two classes of generalized vector variational-like inequalities with generalized relaxed monotone mappings and generalized relaxed semimonotone mappings. We investigate the solvability of vector variational-like inequalities with generalized relaxed semimonotone mappings by means of the Kakutani-Fan-Glicksberg fixed-point theorem. The results presented in this paper generalize the results of Chen [9], Fang and Huang [10], Usman and Khan [11], and Zheng [7]. 2. Preliminaries Throughout the paper unless otherwise specified, let and be two real Banach spaces, be a nonempty closed and convex subset of . is said to be a closed convex and pointed cone with its apex at the origin, if the following conditions hold: (i) , for?all , (ii) ,(iii) . The partial order in , induced by the pointed cone , is defined by declaring
System of Operator Quasi Equilibrium Problems
Suhel Ahmad Khan
International Journal of Analysis , 2014, DOI: 10.1155/2014/848206
Abstract: We consider a system of operator quasi equilibrium problems and system of generalized quasi operator equilibrium problems in topological vector spaces. Using a maximal element theorem for a family of set-valued mappings as basic tool, we derive some existence theorems for solutions to these problems with and without involving -condensing mappings. 1. Introduction In 2002, Domokos and Kolumbán [1] gave an interesting interpretation of variational inequality and vector variational inequalities (for short, VVI) in Banach space settings in terms of variational inequalities with operator solutions (for short, OVVI). The notion and viewpoint of OVVI due to Domokos and Kolumbán [1] look new and interesting even though it has a limitation in application to VVI. Recently, Kazmi and Raouf [2] introduced the operator equilibrium problem which generalizes the notion of OVVI to operator vector equilibrium problems (for short, OVEP) using the operator solution. They derived some existence theorems of solution of OVEP with pseudomonotonicity, without pseudomonotonicity, and with -pseudomonotonicity. However, they dealt with only the single-valued case of the bioperator. It is very natural and useful to extend a single-valued case to a corresponding set-valued one from both theoretical and practical points of view. The system of vector equilibrium problems and the system of vector quasi equilibrium problems were introduced and studied by Ansari et al. [3, 4]. Inspired by above cited work, in this paper, we consider a system of operator quasi equilibrium problems (for short, SOQEP) in topological vector spaces. Using a maximal element theorem for a family of set-valued mappings according to [5] as basic tool, we derive some existence theorems for solutions to SOQEP with and without involving -condensing mappings. Further, we consider a system of generalized quasi operator equilibrium problems (for short, SGQOEP) in topological vector spaces and give some of its special cases and derive some existence theorems for solutions to SOQEP with and without involving -condensing mappings by using well-known maximal element theorem [5] for a family of set-valued mappings, and, consequently, we also get some existence theorems for solutions to a system of operator equilibrium problems. 2. Preliminaries Let be an index set, for each , and let be a Hausdorff topological vector space. We denote , the space of all continuous linear operators from into , where is topological vector space for each . Consider a family of nonempty convex subsets with in . Let Let be a set-valued mapping
Effect of Rotation, Magnetic Field and Initial Stresses on Propagation of Plane Waves in Transversely Isotropic Dissipative Half Space  [PDF]
Sushant Shekhar, Imtiyaz A. Parvez
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48A015

The problem regarding the reflection of plane waves in a transversely isotropic dissipative medium is considered, in which we are studying about the reflection of incidence waves in initially stressed dissipative half space. After solving the governing equations, we find the two complex quasi-P (qP) and quasi-SV (qSV) waves. The occurrence of reflected waves is studied to calculate the reflection coefficient and the energy partition of incidence wave at the plane boundary of the dissipative medium. Numerical example is considered for the reflection coefficient and the partition of incident energy, in which we study about the effect of rotation, initial stresses and magnetic field.

Application of Lean Manufacturing in a Sewing Line for Improving Overall Equipment Effectiveness (OEE)  [PDF]
Shawkat Imam Shakil, Mahmud Parvez
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.89131
Abstract: The purpose of this paper is to implement lean in a sewing line, analyzing the layout, process flow and batch size, in order to improve Overall Equipment Effectiveness (OEE). To understand the overall performance and scope of improvement the existing layout and process flow are analyzed exquisitely. After that, the authors proposed a new layout reorganizing the process flow that eliminated backflows and reduced transportation time. The authors found that batch size has significant effect on waiting time and transportation time. Smaller batch size increases transportation time and decreases waiting time, and vice versa. For batch size optimization, summation of waiting time and transportation time for different batch size is calculated and the smallest one is selected as optimum. Through the application of reorganized process flow in proposed layout and optimum batch size, reduction in transportation time by 30.95% and increment in OEE by 3.75% have been achieved. Following the instruction of this paper, any organization can measure OEE and improve it by optimizing batch size, reorganizing process flows, redesigning layout and eliminating back flows. In this research the authors only redesigned layout, reorganized process flows and optimized batch size that lead to an improvement in OEE but it is still far behind as compared to world class OEE. Lean is enormous with its numerous tools and philosophies and it says that there is no ultimate destination on the improvement journey. There are many other tools and philosophies of lean which can be applied for further improvement.
A Wiener-Hopf Dynamical System for Mixed Equilibrium Problems
Farhat Suhel,S. K. Srivastava,Suhel Ahmad Khan
International Journal of Mathematics and Mathematical Sciences , 2014, DOI: 10.1155/2014/102578
Abstract: We suggest and analyze dynamical systems associated with mixed equilibrium problems by using the resolvent operator technique. We show that these systems have globally asymptotic property. The concepts and results presented in this paper extend and unify a number of previously known corresponding concepts and results in the literature. 1. Introduction Equilibrium problems theory has emerged as an interesting and fascinating branch of applicable mathematics. This theory has become a rich source of inspiration and motivation for the study of a large number of problems arising in economics, optimization, and operation research in a general and unified way. There are a substantial number of papers on existence results for solving equilibrium problems based on different-relaxed monotonicity notions and various compactness assumptions; see, for example, [1–6]. In 2002, Moudafi [5] considered a class of mixed equilibrium problems which includes variational inequalities as well as complementarity problems, convex optimization, saddle point problems, problems of finding a zero of a maximal monotone operator, and Nash equilibria problems as special cases. He studied sensitivity analysis and developed some iterative methods for mixed equilibrium problems. In recent years, much attention has been given to consider and analyze the projected dynamical systems associated with variational inequalities and nonlinear programming problems, in which the right-hand side of the ordinary differential equation is a projection operator. Such types of the projected dynamical system were introduced and studied by Dupuis and Nagurney [7]. Projected dynamical systems are characterized by a discontinuous right-hand side. The discontinuity arises from the constraint governing the question. The innovative and novel feature of a projected dynamical systems is that the set of stationary points of dynamical system correspond to the set of solution of the variational inequality problems. It has been shown in [8–14] that the dynamical systems are useful in developing efficient and powerful numerical technique for solving variational inequalities and related optimization problems. Xia and Wang [13], Zhang and Nagurney [14], and Nagurney and Zhang [11] have studied the globally asymptotic stability of these projected dynamical systems. Noor [15–17] has also suggested and analyzed similar resolvent dynamical systems for variational inequalities. It is worth mentioning that there is no such type of the dynamical systems for mixed equilibrium problems. In this paper, we show that such type of
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